New Bolton Center Kennett Square, PA
Emergencies & Appointments:
Ryan Hospital Philadelphia, PA
Surgical techniques

Animal Model Core

The Animal Model Core at Penn Vet New Bolton Center is an ecosystem for medical translation and multidisciplinary collaboration. It is a bridge supporting the continuum from discovery to invention to innovation in medical translation across a broad range of disciplines in the medical field, from orthopedics and trauma to infection and cardiovascular research.

The core currently supports a large number of research consortia at the University of Pennsylvania and outside of Penn. We develop and refine animal models (rodent, rabbit, sheep, goat, pig, minipig, and horse), with a particular interest in model optimization towards clinical relevance, scientific rigor, and reproducibility. As clinicians and translational scientists, we have the familiarity of working with multiple species in a clinical and experimental setting.

The core is staffed by 4-5 veterinarians with surgical experience, a Study Director (GLP), a Quality Assurance and Quality Control Officer (GLP), 2-3 research technicians, and 5-10 research assistants. The core supports the mentoring of graduate and undergraduate students in translational sciences through our unique training opportunities (hyperlink). Our staff are responsible for day to day operations (24/7 365 days), project management, animal care, data collection, and evaluation of in vivo and ex vivo components of a given study.

AMC-CORL is supported by the various departments at the New Bolton Center, including Anesthesia, Radiology, Emergency and Critical Care, Surgery, and the Department of Clinical Studies. Studies starting on a small scale may take advantage of our large biobank of specimens prior to moving into in vivo trials which may culminate in pivotal non-clinical trials (GLP/VICH GL-9) in support of FDA or OUS-FDA submissions.

We host PI’s, trainees, and sponsors during clinical procedures to support and enrich their experience in a cross-functional team setting. This animal model core platform at Penn Vet New Bolton Center has a deep and multifaceted subject matter expertise and logistical capabilities in translational research. Thus, it benefits principal investigators, associated faculty, and industry sponsors to continue to pioneer, enhance, and support translational research enterprise with the University of Pennsylvania.

Robotic Diagnostics

Learn how these four-dimensional diagnostic imaging are changing the way we look at large animals and humans.

Postdoctoral Fellowship

The need for preclinical and clinical investigators has never been greater. The Postdoctoral Fellowship in Translational Research with the Penn Vet Animal Model Core provides veterinarians with hands-on training and experience in preclinical translational research and regulatory science.