New Bolton Center Kennett Square, PA
Emergencies & Appointments:
Ryan Hospital Philadelphia, PA

Animal Model Core

The Animal Model Core at Penn Vet New Bolton Center is an ecosystem for medical translation and multidisciplinary collaboration, including the mentoring of graduate and undergraduate students in the translational sciences. 

This ecosystem represents the bridge that supports the continuum from discovery to invention to innovation in medical translation. 

The core currently supports a number of large research consortia at the University of Pennsylvania and outside of Penn. We are very involved in the development and refinement of animal models (rat, rabbit, sheep, goat, pig, minipig and horse), with a particular interest in model optimization towards clinical relevance, scientific rigor and reproducibility. 

As clinicians and translational scientists, we have the familiarity of working with multiple species in a clinical and experimental setting. 

The core is supported by the Section of Anesthesia and Emergency and Critical Care, Department of Clinical Studies-New Bolton Center. Studies start on a small scale and may take advantages of the large biobank of specimen prior to moving into in vivo trials, which may culminate in pivotal non-clinical trials (GLP/VICH GL-9) in support of FDA or OUS-FDA submissions. 

Additionally, the Core supports and participates in many federal grants collaborating on the large animal model work. The program director regularly leads and contributes with study design and proposal development. 

The core is staffed by 4-5 veterinarians with surgical experience, a Study Director (GLP), a Quality Assurance and a Quality Control Officer (GLP), 2-3 research technicians and around 10 research assistants. They are responsible for the day to day operations (24/7 365 days) with project management, animal care, data collection and evaluation of in vivo and ex vivo components of a given study. 

The core hosts PIs, trainees and sponsors during clinical procedures to support and enrich their experience in a cross-functional team setting. This animal model core platform at Penn Vet New Bolton Center has a deep and multifaceted subject matter expertise and logistical capabilities in translational research. Thus, it benefits principal investigators, associated faculty and industry sponsors to continue to pioneer, enhance and support the translational research enterprise at the University of Pennsylvania.

Robotic Diagnostics

Learn how these four-dimensional diagnostic imaging are changing the way we look at large animals and humans.

Postdoctoral Fellowship

The need for preclinical and clinical investigators has never been greater. The Postdoctoral Fellowship in Translational Research with the Penn Vet Animal Model Core provides veterinarians with hands-on training and experience in preclinical translational research and regulatory science.