Comparative Pathology Image Gallery

Inflammatory and Infectious Disease Models: Lung

Multifocal lung inflammation in a mouse knockout model.

Penn Vet Comparative Pathology, GMS stain

Histological Staining

Our histology laboratory performs numerous services including routine hematoxylin & eosin staining (H&E) and a variety of histochemical stains.

This is an example of a Gomori methenamine silver (GMS) stain of pneumocystis organisms in an immunosuppressed animal.

Eosinophilic crystalline pneumonia, Penn Vet

Eosinophilic crystalline pneumonia (aka acidophilic macrophage pneumonia)

Our pathologists have extensive training in comparative pathology which includes understanding of background lesions of commonly used mouse strains.

Eosinophilic crystalline pneumonia is an idiopathic disease that occurs in many strains and stocks of mice, more commonly in strains on a C57BL/6 background. Crystals are composed predominantly of Ym1 protein, a chitinase-like protein associated with neutrophil granule products and secreted by activated macrophages.

Immunohistochemistry Staining (A)

Our experienced immunohistochemistry research specialist has more than 20 years of experience with immunohistochemistry in a variety of animal species. Board-certified veterinary pathologists are available for immunohistochemistry consultation and interpretation.

Pictured here is T cell lymphoma stained with CD3.

Penn Vet Comparative Pathology, Trichrome stain

Histochemical stains: Trichrome stain

Our histology laboratory performs numerous services including routine hematoxylin & eosin staining (H&E) and a variety of histochemical stains.

Here is an example of a trichrome stain highlighting the epidermis and the collagen within the dermis.

Immunohistochemistry Staining (B)

Mouse Model of Pancreatic Intraepithelial Neoplasia (PanIN)

Our board-certified veterinary pathologists are trained in the most current classification and grading systems for mouse models of neoplasia.

Inflammatory and Infectious Disease Models: Intestinal

Inflammatory & Infectious Disease Models: Intestinal nematode infection (Strongyloides).

Mouse Pulmonary Carcinoma sample, Penn Vet

Pulmonary carcinoma in a mouse knockout model

Our board-certified veterinary pathologists can provide detailed histopathologic interpretations and descriptions, and qualitative or quantitative data based on the specific needs of each individual research project.