Comparative Pathology Image Gallery

Mouse Pathology Workshop

Natalie Hoepp, DVM

Neurofilament, Cell Signaling Technology, Catalog #2837, Rb mAb (IHCp)

Vimentin, Abcam, Catalog #ab92547, Rabbit mAb (IHCc)

CD204, TransGenic Inc, KT022, Ms mAb (IHCc)

S100, Leica Bond, Catalog #PA09000, Rabbit pAb (IHCp)

Peanut Agglutinin (PNA) Cy5-labeled, Vector Labs, Catalog #CL-1075 (IFp)

NeuN, CST, Catalog #24307, Rb mAb (IHCp)

PD-1, Cell Signaling Technology, Catalog #84651, Rb mAb (IHCp)

Lyve1, AngioBio, Catalog #11-034, Rb mAb (IHCp)

Cleaved Caspase 3, Cell Signaling Technology, Catalog #9661, Rb mAb (IHCp)

MHC class II IHCp

gp100 #ab137078 IFp

GFAP #Z0334 IFp

CD45R-B220 #550286 IFp

Peanut Agglutinin (PNA) #CL-1075

gp100 #ab137078

CD45R-B220 #550286

GFAP #Z0334

RFP IFp

IBA1 IHCp

CD8α IHCp

CD4 IFp

CD8A

Comparative Pathology Core

Comparative Pathology Core

Inflammatory and Infectious Disease Models: Lung

Multifocal lung inflammation in a mouse knockout model.

Histological Staining

Our histology laboratory performs numerous services including routine hematoxylin & eosin staining (H&E) and a variety of histochemical stains.

This is an example of a Gomori methenamine silver (GMS) stain of pneumocystis organisms in an immunosuppressed animal.

Eosinophilic crystalline pneumonia (aka acidophilic macrophage pneumonia)

Our pathologists have extensive training in comparative pathology which includes understanding of background lesions of commonly used mouse strains.

Eosinophilic crystalline pneumonia is an idiopathic disease that occurs in many strains and stocks of mice, more commonly in strains on a C57BL/6 background. Crystals are composed predominantly of Ym1 protein, a chitinase-like protein associated with neutrophil granule products and secreted by activated macrophages.

Immunohistochemistry Staining (A)

Our experienced immunohistochemistry research specialist has more than 20 years of experience with immunohistochemistry in a variety of animal species. Board-certified veterinary pathologists are available for immunohistochemistry consultation and interpretation.

Pictured here is T cell lymphoma stained with CD3.

Histochemical stains: Trichrome stain

Our histology laboratory performs numerous services including routine hematoxylin & eosin staining (H&E) and a variety of histochemical stains.

Here is an example of a trichrome stain highlighting the epidermis and the collagen within the dermis.

Immunohistochemistry Staining (B)

Our experienced immunohistochemistry research specialist has more than 20 years of experience with immunohistochemistry in a variety of animal species. Board-certified veterinary pathologists are available for immunohistochemistry consultation and interpretation.

Pictured here is B cell lymphoma, stained with CD20.

Mouse Model of Pancreatic Intraepithelial Neoplasia (PanIN)

Our board-certified veterinary pathologists are trained in the most current classification and grading systems for mouse models of neoplasia.

Inflammatory and Infectious Disease Models: Intestinal

Inflammatory & Infectious Disease Models: Intestinal nematode infection (Strongyloides).

Pulmonary carcinoma in a mouse knockout model

Our board-certified veterinary pathologists can provide detailed histopathologic interpretations and descriptions, and qualitative or quantitative data based on the specific needs of each individual research project.