Penn Vet Preclinical Service Core & Comparative Orthopedic Research Laboratory (PSC-CORL) can assist with any stage of translational research from early stage product development, proof of concept, lead optimization, and pivotal trials for regulatory submission.
- Project planning
- Test article prototyping and testing
- Model development and refinement
- Feasibility / pilot studies
- Execution of pivotal studies
- Acute and chronic data collection
- Data mining and analysis
- Support of regulatory submissions
- Reports and publication
- GLP archive
Compliance: Penn Vet PSC-CORL has a well-established infrastructure to ensure studies are conducted in compliance with Good Laboratory Practices (21 CFR, Part 58 - GLP). The internal Quality Assurance Unit works to maintain adherence to study protocols and SOPs and produce robust data. All laboratory team members are continuously trained in this rigorous process. Additionally, regulated studies with the goal of FDA submission are monitored by an external Q/A entity.
The Penn Vet Preclinical Service Core & Comparative Orthopedic Research Laboratory is part of New Bolton Center’s 700-acre campus. Animal housing is designed to the highest standards for humane treatment and hygienic conditions. Species that can be accommodated include sheep, goats, pigs, horses, dogs, rabbits and rodents. Dedicated large animal housing provides the capability for large-scale, long-term studies lasting up to two years.
A fully-equipped surgery suite with separate prep and recovery areas can accommodate a wide range of surgical procedures. Intra-operative imaging capabilities include CT, C-arm fluoroscopy, arthroscopy and laparoscopy.
All animals under the care of the PSC-CORL are monitored daily by dedicated veterinarians. In addition to routine care, the veterinarians perform examinations and treatments of animals enrolled in studies. As part of New Bolton Center, we have the unique opportunity to employ clinical services not available to most pre-clinical laboratories. Large animal hospital facilities such as the Intensive Care Unit are utilized as needed. Board-certified specialists in internal medicine and neurology, anesthesiology, imaging, ophthalmology, etc. are available for consultations. The resultant collaborative resources and expertise ensures the highest standard of care possible.
The laboratory includes a purpose-built space for mechanical testing, cadaveric studies and ex vivo analysis. Acute in vivo exercises can be arranged for training purposes.
The specialized in-house histology team is supported by state-of-the-art equipment for calcified and non-calcified tissue processing and imaging.
The affiliation with the University of Pennsylvania provides a myriad of resources from advanced diagnostics to cutting-edge data extraction.
- Clinical Pathology Laboratory
- Pathology and Necropsy Service
- Microbiology, Toxicology and ISO certified Drug Laboratories
- Additional imaging modalities including MRI and nuclear scintigraphy
- Treadmill facility
- Telemetric accelerometer systems
- Advanced imaging including SEM, micro-CT and specialized microscopy
- Bioinformatics, proteomics and sequencing
PSC-CORL has extensive experience with in vivo evaluation of biocompatibility and bioperformance of novel materials in acute and chronic animal models. Safety and efficacy evaluation of test articles follows ISO 10993 standards.
- Segmental defects
- Intervertebral fusion
- Non-fusion stabilization
- Intervertebral disc degeneration
- Nucleus pulposus replacement
- Vertebral body augmentation
- Craniofacial fixation
- Dural defects
- Alveolar ridge augmentation
- Articular cartilage resurfacing
- Meniscal defects
- Meniscal replacement
- Septic arthritis
- Periprosthetic joint infection
- Synovial fluid sampling
- Vascular injury
- Skin-implant interface
- Wound healing
- Anti-infection technology
- Biomarker assays
- Implant-associated infections
Ziehm Vision R
- Mobile C-arm fluoroscopic unit
- Portable 8-slice computed tomography
Logiq 200 Pro Ultrasound
In addition to the laboratory’s own imaging systems, we have access to all modalities housed at New Bolton Center. Board-certified veterinary imaging specialists consult as needed.
- Digital radiography
- Nuclear scintigraphy
Histology Services are performed by a highly trained technical team under the supervision of veterinary pathologists.
The Histology Laboratory is equipped with state-of-the-art equipment for tissue sampling and processing. Tools include tissue processors for plastic and paraffin embedding, EXAKT systems, microtome and cryotome.
Routine and specialized techniques for both hard and soft tissues and tissue-device interface histology are available.
Data analyses can be performed in-house for non-regulated studies.
Specimens of projects supporting regulatory submission are analyzed by one of our collaborating test sites.
Please contact us for more information about our Histology Services.