New Bolton Center Kennett Square, PA
Emergencies & Appointments:
Ryan Hospital Philadelphia, PA

ARTHRITIS - Long term study assessing outcome of knee arthritis in dogs with cruciate ligament (CCL) rupture

Jul 25, 2014

The VCIC is now enrolling forty (40) dogs with a torn cranial cruciate ligament (CCL) for a clinical trial assessing the clinical outcome of dogs with varying degrees of knee joint arthritis due to the rupture of the CCL in one knee joint, which is stabilized with the tibial plateau leveling osteotomy (TPLO) surgical procedure.  Dogs enrolled will make seven (7) visits in one year to the University of Pennsylvania Veterinary Hospital.

Inclusion Criteria:

  • Dogs weighing 20 kgs (44 pounds) or more
  • Confirmed diagnosis of a unilateral cranial cruciate ligament rupture
  • No evidence of other concurrent orthopedic diseases
  • Clinical signs of a CCL tear
  • Ability to attend all study visits


  • Financial coverage for pre- and post-operative blood work, x-rays, and all study visits
  • Follow up care including: orthopedic examinations, activity monitoring, gait analysis, and imaging (x-rays and CT scan)

Enrollment Information:

If interested in enrolling your dog in this study, or would like to learn more, contact the VCIC at 215-573-0302 or for more information about this or other studies.