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Current Clinical Trials at Penn Vet


IMMUNE-MEDIATED HEMOLYTIC ANEMIA: Evaluating the intestinal microbiome as a possible trigger for IMHA in dogs

The purpose of this study is to investigate whether the bacterial population of the GI tract may be a contributing factor to the onset of immune-mediated hemolytic anemia in dogs.

active immune-mediated hemolytic anemia IMHA anemia

MENINGIOMA - Study of two oral medications in treament of canine brain tumors

Evaluating safety and anti-cancer activity of oral PAC-1 used with hydroxyurea for canine meningioma

meningioma seizure brain tumor active

Clinical trial for dogs with atrial fibrillation

The goal of this study is to determine whether slowing down the heart rate in canine atrial fibrillation improves survival.

cardiac issue in dogs dog heart problem active canine atrial fibrilation

CANCER - Trial for Dogs with Mast Cell Tumors, B Cell Lymphoma, or Histocytic Sarcoma

Seeking dogs with specific tumors to help us further cancer research.

active tumor sarcoma Oncology mct mast cell tumor lymphoma immunotherapy immune histiocytic sarcoma canine cancer b cell

OSTEOSARCOMA - Use of a Novel Immunotherapy for Dogs with Bone Cancer of the Leg

Further evaluation of the Listeria vaccine in dogs with osteosarcoma.

bacteria OSA vaccine osteosarcoma Mason Osteosarcoma mason Listeria cancer active cancer bone cancer active

HEART MURMUR - New study evaluating a novel prescription diet for dogs with heart murmurs.

A study evaluating whether a new prescription diet will slow the progression of mitral valve disease in dogs.

bad heart dog heart failure ECG mitral valve disease heart murmur heart disease heart echocardiogram cardiology cardiac active

ARTHRITIS - Pilot Study Evaluating a Therapeutic Mattress in Dogs

Assessing the Big Barker therapeutic mattress in dogs with osteoarthritis

limping pain osteoarthritis OA joint pain joint hip pain hip dysplasia dog bed discomfort arthritis active

Perianal Fistula Clinical Trial

A study of the cutaneous and rectal microbiome and the effect of cyclosporine therapy.

active microbiome cyclosporine therapy perianal fistula German Shepherd

TRANSITIONAL CELL CARCINOMA - Clinical Trial Using Immunotherapy For Female Dogs With Bladder Cancer

A modified Listeria vaccine for female dogs with bladder cancer.

cancer active transitional cell carcinoma TCC Mason TCC carcinoma Mason Active canine carcinoma canine bladder cancer bladder cancer in dogs bladder cancer active

CRUCIATE TEAR - Clinical Trial for dogs who had a Cranial Cruciate Ligament (CCL) Rupture & TPLO Surgery

Assessing novel therapeutic that will be evaluated for its effect on the development and progression of osteoarthritis in dogs following CCL rupture and TPLO surgery

ligament ACL cruciate tear cruciate meniscal tear TPLO knee surgery CCL rupture CCL arthritis active

Coagulation in Septic Peritonitis in Dogs

We are testing a heparin derivative that is anti-inflammatory without being anticoagulant.

abdomen septic belly septic abdomen septic peritonitis active

Use of Near-infrared Imaging in Surgical Accuracy for Feline Soft-Tissue Sarcomas

Penn Vet is conducting a study to determine if near-infrared imaging can improve the surgeon’s ability to see cancer and cancer margins during surgery to remove feline soft tissue sarcomas.

cancer active ryan surgery infrared imaging feline soft tissue sarcoma david holt active

FIBROSARCOMA - Trial of ALVAC® IL-2 Treatment in Cats with Feline Fibrosarcoma

Clinical trial evaluating surgery in combination with immunotherapy for cats with fibrosarcoma

cancer active VAS vaccine tumor surgery sarcoma FSA cancer active

LYMPHOMA - Re-directed Autologous T cell Therapy for drug resistant or refractory CD20+ B cell lymphoma

Immune cells (known as T cells) are taken from the peripheral blood, stimulated, expanded and genetically modified in the laboratory to express a surface receptor that recognizes B cells

cancer active Mason lymphoma Mason Cancer Studies Mason Active mason immunotherapy canine lymphoma canine cancer cancer b-cell malignancies B-cell lymphoma active

ARTHRITIS - Long term study assessing outcome of knee arthritis in dogs with cruciate ligament (CCL) rupture

A clinical trial evaluating the outcome of dogs with patellofemoral osteoarthritis due to the rupture of the Cranial Cruciate Ligament in one stifle, then stabilized with the Tibial Plateau Leveling Osteotomy (TPLO) procedure

arthritis limping stifle ACL cruciate VCIC TPLO tibial plateau leveling osteotomy osteoarthritis orthopedic ligament rupture knee joint cruciate tear cranial cruciate ligament CCL Agnello active

Effect of duration of red blood cell storage on transfusion-associated inflammation in dogs with IMHA and IMT

We propose to evaluate markers of inflammation, hemolysis, and endothelial activation in a randomized clinical trial in which dogs with primary immune-mediated hemolytic anemia and immune-mediated thrombocytopenia would receive fresh or old RBCs.

active anemia blood type hemodyalisis IMHA IMT red blood cell thrombocytopenia transfusion

HEMANGIOSARCOMA - Supplement for Dogs with Cancer of the Spleen

In this trial, we will be comparing I’m-Yunity’s® effect on survival time and quality of life to the standard chemotherapy treatment.

cancer active VCIC turkey tail mushroom splenic HSA spleen mushroom I’m-Yunity HSA hemangiosarcoma cancer alternative medicine active