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    Clinical trials are a crucial step in the often cyclical “benchtop to bedside” process of translating clinical questions into laboratory research and then into patient care.

    At Penn Vet, the Veterinary Clinical Investigations Center (VCIC), in collaboration with the Penn Vet Cancer Center, provides the necessary infrastructure and clinical skills to allow clinician scientists to perform clinical trials in our patients – both for the benefit of those individual patients and for the betterment of future veterinary and human patients.

    Pathology plays an integral role in patient focused research by providing the necessary diagnostic and biocorrelative data.  The Comparative Pathology Core supports clinical trials at Penn Vet by providing expertise in tissue evaluation and state-of-the-art molecular and digital pathology techniques.

    Clinical Trials

    Cell Therapy for Metastatic Osteosarcoma

    In this study we will investigate the therapeutic potential of a type of white blood cell known as invariant natural killer T (iNKT) cells that are made from the blood…

    PSMA Ligand Based Theranostic to Treat Canine Prostatic Cancer

    The purpose of this study is to assess a new targeted investigational agent called PSMA-MMAE-Pc413 combined with a laser in local and metastatic disease in dogs diagnosed with prostate cancer.

    Social determinants of dog behavior

    The environments where people are born, live, learn, work, and age can have drastic impacts on their health. As humans and pets share physical and social environments, these same environmental…

    Feasibility and perioperative outcomes regarding ultra-low dose indocyanine green for indirect cholangiography during laparoscopic cholecystectomy in dogs

    Laparoscopic cholecystectomy is a minimally invasive surgery to remove the gallbladder. This is commonly performed in people with gallbladder disease such as inflammation, infection, or mucocele formation.

    Equine Lameness Study Osteoarthritis

    In this double-masked, sham-controlled, randomized study, VH-750 will be administered intra-articularly to horses with mild to moderate limb lameness caused by joint OA (fetlock, carpal, or coffin joints).

    Pilot study of Frunevetmab (Solensia) and Meloxicam for palliative therapy of feline bone-invasive oral squamous cell carcinomas

    This study will be the first to assess whether Solensia, in combination with meloxicam, provides superior pain relief compared to meloxicam alone. Meloxicam, a non-steroidal anti-inflammatory drug, is a standard-of-care…

    Embolization or chemoembolization in dogs with hepatocellular carcinoma and utility of contrast-enhanced ultrasound versus CT angiogram in post-embolization assessment

    This trial will compare outcomes in dogs treated with embolization vs. chemoembolization and will also evaluate the accuracy of contrast enhanced ultrasound verses CT angiogram for post-embolization assessment.

    Evaluation of VetResQ® Hemoperfusion Cartridge for Treatment of Non-Steroidal Anti-Inflammatory Drug (NSAID) Toxicity in Dogs and Cats

    The aim of this study is to document how much NSAID is removed from the blood during treatment with VetResQ® hemoperfusion cartridge.

    Intraoperative assessment of marginal tissue after BCS resection using in-vivo topical application of a cathepsin-targeted molecular probe.

    Evaluating the efficacy of a new near-infrared imaging agent when applied topically to tumor during surgery in dogs with mammary gland tumors.

    Amantadine in conjunction with carprofen for improvement of lameness and pain secondary to osteoarthritis in dogs

    The purpose of this study is to determine the efficacy of amantadine in combination with carprofen, a non-steroidal anti-inflammatory drug (NSAID) already approved for use in dogs, to manage refractory…