Clinical trials are a crucial step in the often cyclical “benchtop to bedside” process of translating clinical questions into laboratory research and then into patient care.

    At Penn Vet, the Veterinary Clinical Investigations Center (VCIC), in collaboration with the Penn Vet Cancer Center, provides the necessary infrastructure and clinical skills to allow clinician scientists to perform clinical trials in our patients – both for the benefit of those individual patients and for the betterment of future veterinary and human patients.

    Pathology plays an integral role in patient focused research by providing the necessary diagnostic and biocorrelative data.  The Comparative Pathology Core supports clinical trials at Penn Vet by providing expertise in tissue evaluation and state-of-the-art molecular and digital pathology techniques.

    Clinical Trials

    Examination of Neurologic Disease in Companion Animals

    PennVet’s Neurology Service is currently enrolling up to fifteen (15) dogs with suspected meningoencephalitis of unknown origin (MUO). Your pet will first be evaluated by the Neurology team. If the…

    Intraoperative assessment of surgical margins after simulated breast conserving surgery using topical application of cathepsin-targeted molecular pribes

    This trial is enrolling dogs with mammary tumors for a clinical trial assessing the safety and efficacy of a new topical near-infrared imaging agent applied directly to the tumor during…

    Randomized Controlled Trial of One Versus Two Lung Ventilation in Elective Open Lung Lobectomy

    One-lung ventilation (OLV) is an anesthesia technique by which only the lung not undergoing surgery receives oxygen and gas. When the lung that is undergoing surgery is no longer inflated…

    Correlation of liver and splenic stiffness to portal venous pressure in dogs with intrahepatic portosystemic shunts (IHPSS) undergoing percutaneous transvenous coil embolization (PTCE)

    Dogs with intrahepatic portosystemic shunts (IHPSS) have an abnormal blood vessel that connects their portal system (the system of blood vessels draining from the spleen, stomach, and small intestines) to…

    Evaluation of Proton FLASH-RT in Naturally Occurring Canine Extremity Sarcoma

    Proton FLASH radiation therapy (FLASH-RT) is an investigational approach using ultra-high dose “RATE” radiation therapy. This means that the dose(s) of radiation is delivered in a fraction of a second.…

    Cell Therapy for Metastatic Osteosarcoma

    In this study we will investigate the therapeutic potential of a type of white blood cell known as invariant natural killer T (iNKT) cells that are made from the blood…

    PSMA Ligand Based Theranostic to Treat Canine Prostatic Cancer

    The purpose of this study is to assess a new targeted investigational agent called PSMA-MMAE-Pc413 combined with a laser in local and metastatic disease in dogs diagnosed with prostate cancer.

    Social determinants of dog behavior

    The environments where people are born, live, learn, work, and age can have drastic impacts on their health. As humans and pets share physical and social environments, these same environmental…

    Feasibility and perioperative outcomes regarding ultra-low dose indocyanine green for indirect cholangiography during laparoscopic cholecystectomy in dogs

    Laparoscopic cholecystectomy is a minimally invasive surgery to remove the gallbladder. This is commonly performed in people with gallbladder disease such as inflammation, infection, or mucocele formation.

    Equine Lameness Study Osteoarthritis

    In this double-masked, sham-controlled, randomized study, VH-750 will be administered intra-articularly to horses with mild to moderate limb lameness caused by joint OA (fetlock, carpal, or coffin joints).