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    Coagulation in Septic Peritonitis in Dogs

    Summary:

    Study Description:

    The SPOT (Septic Peritonitis ODSH Trial) study is a prospective, dose escalation, pilot study evaluating the therapeutic value of ODSH in dogs presenting with septic peritonitis. ODSH is a modified (desulfated) high molecular weight heparin. In murine (mouse) studies, ODSH has been shown to to neutralize the production of excess inflammatory molecules (histones and PF4) without causing a prolongation in PTT.

    Patients enrolled in this study will receive up to 5 doses, based on PTT monitoring.  We expect that ODSH will be of clinical benefit in ameliorating this severe disease without causing bleeding. The results of this study may guide further research and treatment for this severe disease process.

    Owner Benefits:

    Weight >5kg

    Serial PTT monitoring

    10-day recheck examination with surgeon

    $1500 financial benefit off of final bill

    Note this benefit will be applied after the 10 day recheck examination

    Enrollment Criteria:

    Spontaneously occurring, first time septic abdomen

    Contact the VCIC at 215-573-0302 or email vcic@vet.upenn.edu for more information.