Kristin Gardiner, VMD

Testard C, Tremblay S, Parodi F, DiTullio RW, Acevedo-Ithier A, Gardiner KL, Kording K, Platt ML. Neural signatures of natural behaviour in socializing macaques. Nature. 2024 Mar 13. doi: 10.1038/s41586-024-07178-6.

Ilia Fishbein, Vaishali V Inamdar, Ivan S Alferiev, George Bratinov, Menekhem M. Zviman, Anna Yekhilevsky, Chandrasekaran Nagaswami, Kristin L. Gardiner, Robert J Levy, Stanley J Stachelek. Hypercholesterolemia aggravates in-stent restenosis in rabbits: a mitigating effect of stent surface modification with CD47-derived peptide. Atherosclerosis. 24Dec2023, 117432, ISSN 0021-9150. 

Salimando GJ, Tremblay S, Kimmey BA, Li J, Rogers SA, Wojick JA, McCall NM, Wooldridge LM, Rodrigues A, Borner T, Gardiner KL, Jayakar SS, Singeç I, Woolf CJ, Hayes MR, De Jonghe BC, Bennett FC, Bennett ML, Blendy JA, Platt ML, Creasy KT, Renthal WR, Ramakrishnan C, Deisseroth K, Corder G. Human OPRM1 and murine Oprm1 promoter driven viral constructs for genetic access to μ-opioidergic cell types. Nat Commun. 2023 Sep 13;14(1):5632.

Frankel JS, Gardiner KL, Brice AK, Hagan L, Manzi TJ, Makaron L. Avascular necrosis of the femoral head in a cynomolgus macaque (Macaca fascicularis). J Med Primatol. 2023 Aug;52(4):283-285. doi: 10.1111/jmp.12653. Epub 2023 May 29. PMID: 37248799. 

Assenmacher, C.-A.; Lanza, M.; Tarrant, J.C.; Gardiner, K.L.; Blankemeyer, E.; Radaelli, E. Post Mortem Study on the Effects of Routine Handling and Manipulation of Laboratory Mice. Animals 2022, 12, 3234.

Merlo, L. M. F., Sprouffske, K., Howard, T. C., Gardiner, K. L., Caulin, A. F., Blum, S. M., Evans, P., Bedalov, A., Sniegowski, P. D., Maley, C. C. Application of simultaneous selective pressures slows adaptation Evol Appl 13: 1615-1625, 2020.

Gardiner, K. L., Cideciyan, A. V., Swider, M., Dufour, V. L., Sumaroka, A., Komaromy, A. M., Hauswirth, W. W., Iwabe, S., Jacobson, S. G., Beltran, W. A., Aguirre, G. D. Long-term structural outcomes of late-stage RPE65 gene therapy Molecular Therapy 28: 266-278, 2020.

Bright, L. A., Gardiner, K. L., Veeder, C. L., Brice, A. K. Hepatic hemangiosarcoma in a cynomolgus macaque (Macaca fascicularis) Comparative Medicine 69: 240-248, 2019.

Downs, L. M., Scott, E. M., Cideciyan, A. V., Iwabe, S., Dufour, V., Gardiner, K. L., Genini, S., Marinho, L. F., Sumaroka, A., Kosyk, M. S., Swider, M., Aguirre, G. K., Jacobson, S. G., Beltran, W. A., Aguirre, G. D. Overlap of abnormal photoreceptor development and progressive degeneration in Leber congenital amaurosis caused by NPHP5 mutation Hum Mol Genet 25: 4211-4226, 2016.

Gardiner, K. L., Downs, L., Berta-Antalics, A. I., Santana, E., Aguirre, G. D., Genini, S.Photoreceptor proliferation and dysregulation of cell cycle genes in early onset inherited retinal degenerations BMC Genomics 17: 221, 2016.

Kosoff, R. E., Gardiner, K. L., Merlo, L. M., Pavlov, K., Rustgi, A. K., Maley, C. C. Development and characterization of an organotypic model of Barrett”s esophagus J Cell Physiol 227: 2654-9, 2012.

Merlo, L. M., Kosoff, R. E., Gardiner, K. L., Maley, C. C. An in vitro co-culture model of esophageal cells identifies ascorbic acid as a modulator of cell competition BMC Cancer 11: 461, 2011.

The study of long-term outcomes (safety/efficacy) of gene therapy in retinal, liver-directed, and neurologic diseases (includes subretinal, intra-cisterna magna, intracerebral, and intravascular vector administration, with concurrent analysis of functional and gross/histopathologic patient outcomes). Surgical implantation of biomedical devices for neurologic disease applications (Utah and Matrix arrays). Optogenetics (AAV-mediated) and chemogenetics (DREADDs/PSAMs) for behavioral/neurologic modulation delivered via MRI guidance (Brainsight and ClearPoint). Translational surgical model development (orthopedics, cerebrovascular).

University of Pennsylvania School of Veterinary Medicine (2014 to 2015)
Internship, Exotic Companion Animal Medicine & Surgery Services

University of Pennsylvania (2015 to 2018)
Residency in Laboratory Animal Medicine, University Laboratory Animal Resources