Over the last decade, the members of the van Eps Laboratory have recognized key differences (and some similarities) in the initial events that lead to the three types of laminitis:
Sepsis-related laminitis (SRL)
Endocrinopathic laminitis (associated with insulin dysregulation/hyperinsulinemia)
Supporting limb laminitis (SLL)
A focus on these early events is leading to a better understanding of why laminitis occurs in different clinical situations and is helping to identify therapeutic targets.
Our goal is to identify the key pathophysiological events that lead to different forms of laminitis in order to develop clinically applicable means of preventing this crippling equine disease.
Stokes Simon M, Bertin Francois R, Stefanovski Darko, Belknap James K, Medina-Torres Carlos E, Pollitt Christopher C, van Eps Andrew W Lamellar energy metabolism and perfusion in the euglycaemic hyperinsulinaemic clamp model of equine laminitis. Equine veterinary journal : , 2019.Jukic Chantelle C, Cowling Nicholas R, Perkins Nigel R, van Eps Andrew W, Ahern Benjamin J Evaluation of the effect of laser salpingopharyngostomy on the guttural pouch environment in horses. Equine veterinary journal : , 2019.Stokes Simon M, Bertin Francois-Rene, Stefanovski Darko, Poulsen Lea, Belknap James K, Medina-Torres Carlos E, Pollitt Christopher C, van Eps Andrew W The effect of continuous digital hypothermia on lamellar energy metabolism and perfusion during laminitis development in two experimental models. Equine veterinary journal : , 2019.Khan A, Hallowell G D, Underwood C, van Eps A W Continuous fluid infusion per rectum compared with intravenous and nasogastric fluid administration in horses. Equine veterinary journal 51: 767-773, 2019.Dern K, Burns T A, Watts M R, van Eps A W, Belknap J K Influence of digital hypothermia on lamellar events related to IL-6/gp130 signalling in equine sepsis-related laminitis. Equine veterinary journal : , 2019.Stokes S M, Belknap J K, Engiles J B, Stefanovski D, Bertin F R, Medina-Torres C E, Horn R, van Eps A W Continuous digital hypothermia prevents lamellar failure in the euglycaemic hyperinsulinaemic clamp model of equine laminitis. Equine veterinary journal 51: 658-664, 2019.Hodge Elizabeth, Kowalski Alycia, Torcivia Catherine, Lindborg Sue, Stefanovski Darko, Hart Kelsey, Frank Nicholas, van Eps Andrew Effect of thyrotropin-releasing hormone stimulation testing on the oral sugar test in horses when performed as a combined protocol. Journal of veterinary internal medicine 33: 2272-2279, 2019.Secombe C J, van Eps A W, Bruce M, Lester G D The relationship between bronchoalveolar lavage fluid cytology and airway hyper-reactivity in a population of Australian horses presented for poor performance. Australian veterinary journal 97: 343-350, 2019.van Eps Andrew W, Burns Teresa A Are There Shared Mechanisms in the Pathophysiology of Different Clinical Forms of Laminitis and What Are the Implications for Prevention and Treatment? The Veterinary clinics of North America. Equine practice 35: 379-398, 2019.Ahern Benjamin J, Lukas Emily, Lam Kimberly, Wilke Emma, Bertin Francois-Rene, Van Eps Andrew, Franklin Samantha Evaluation of a prototype dynamic laryngoplasty system in vitro with an equine vacuum airflow system. Veterinary surgery : VS 48: 173-179, 2019.
BVSc (Veterinary Medicine) The University of Queensland, 1999PhD (Equine & Veterinary Medicine) The University of Queensland, 2008Diplomate, American College of Veterinary Internal Medicine (Large Animal)
Member, Australian College of Veterinary Scientists (Equine Medicine)