ANDREW E. VAUGHAN
Contact
New Bolton Center Kennett Square, PA
Emergencies & Appointments:
610-444-5800
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Ryan Hospital Philadelphia, PA
Emergencies:
215-746-8911
Appointments:
215-746-8387
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ANDREW E. VAUGHAN, BS, PhD

Assistant Professor, Biomedical Sciences, University of Pennsylvania School of Veterinary Medicine

Assistant Professor, Institute for Regenerative Medicine


Contact Information:
3800 Spruce St.
Old Vet 370 E (office) 372 E (lab)

Dr. Vaughan’s research is focused on defining and understanding the relevant cell types and molecular mechanisms by which the mammalian lung
is able to regenerate after severe injury. He is especially interested in elucidating the means by which epithelial progenitors contribute to repaired airway and alveolar units after various lung insults (influenza, ARDS, fibrosis). His studies suggest that physiological lung function is in fact dictated by progenitor cell fate choices after injury. Dr. Vaughan and his group have developed a novel orthotopic cell transplantation assay which allows for the direct assessment of engraftment, proliferation, and differentiation potential of these stem cells. Further, he is actively investigating the roles of the Notch, Wnt, and BMP pathways in regulating the differentiation potential and fate of expanded progenitor cells post-injury. His office and laboratory are located on the 3rd floor, office 370E Old Vet.

Singh Snahlata, Elenio Emily, Leu Nicolae A, Romano Rose-Anne, Vaughan Andrew E, DeRiso Jennifer, Surendran Kameswaran, Chakrabarti Rumela A new Elf5 BAC transgenic mouse model for tracing Elf5 cell lineages in adult tissues. [PMID 31002388] FEBS letters 593: 1030-1039, 2019.

Rane Chetan K, Jackson Sergio R, Pastore Christopher F, Zhao Gan, Weiner Aaron I, Patel Neil N, Herbert De'Broski R, Cohen Noam A, Vaughan Andrew E Development of solitary chemosensory cells in the distal lung after severe influenza injury.[PMID 30908939] American journal of physiology. Lung cellular and molecular physiology 316: L1141-L1149, 2019.

Hung Li-Yin, Sen Debasish, Oniskey Taylor K, Katzen Jeremey, Cohen Noam A, Vaughan Andrew E, Nieves Wildaliz, Urisman Anatoly, Beers Michael F, Krummel Matthew F, Herbert De'Broski R Macrophages promote epithelial proliferation following infectious and non-infectious lung injury through a Trefoil factor 2-dependent mechanism.[PMID 30337651] Mucosal immunology 12: 64-76, 2019.

Hung Li-Yin, Oniskey Taylor K, Sen Debasish, Krummel Matthew F, Vaughan Andrew E, Cohen Noam A, Herbert De'Broski R Trefoil Factor 2 Promotes Type 2 Immunity and Lung Repair through Intrinsic Roles in Hematopoietic and Nonhematopoietic Cells.[PMID 29458008] The American journal of pathology 188: 1161-1170, 2018.

Xi Ying, Kim Thomas, Brumwell Alexis N, Driver Ian H, Wei Ying, Tan Victor, Jackson Julia R, Xu Jianming, Lee Dong-Kee, Gotts Jeffrey E, Matthay Michael A, Shannon John M, Chapman Harold A, Vaughan Andrew E Local lung hypoxia determines epithelial fate decisions during alveolar regeneration.[PMID 28737769] Nature cell biology 19: 904-914, 2017.

Vaughan Andrew E, Chapman Harold A Failure of Alveolar Type 2 Cell Maintenance Links Neonatal Distress with Adult Lung Disease.[PMID 28362148] American journal of respiratory cell and molecular biology 56: 415-416, 2017.

Miller A Dusty, De Las Heras Marcelo, Yu Jingyou, Zhang Fushun, Liu Shan-Lu, Vaughan Andrew E, Vaughan Thomas L, Rosadio Raul, Rocca Stefano, Palmieri Giuseppe, Goedert James J, Fujimoto Junya, Wistuba Ignacio I Evidence against a role for jaagsiekte sheep retrovirus in human lung cancer.[PMID 28107820] Retrovirology 14: 3, 2017.

Kanegai Cindy M, Xi Ying, Donne Matthew L, Gotts Jeffrey E, Driver Ian H, Amidzic Gorica, Lechner Andrew J, Jones Kirk D, Vaughan Andrew E, Chapman Harold A, Rock Jason R Persistent Pathology in Influenza-Infected Mouse Lungs.[PMID 27689795] American journal of respiratory cell and molecular biology 55: 613-615, 2016.

Vaughan Andrew E, Brumwell Alexis N, Xi Ying, Gotts Jeffrey E, Brownfield Doug G, Treutlein Barbara, Tan Kevin, Tan Victor, Liu Feng Chun, Looney Mark R, Matthay Michael A, Rock Jason R, Chapman Harold A Lineage-negative progenitors mobilize to regenerate lung epithelium after major injury.[PMID 25533958] Nature 517: 621-5, 2015.

Vaughan Andrew E, Chapman Harold A Regenerative activity of the lung after epithelial injury.[PMID 23219956] Biochimica et biophysica acta 1832: 922-30, 2013.

Vaughan Andrew E, Mendoza Ramon, Aranda Ramona, Battini Jean-Luc, Miller A Dusty Xpr1 is an atypical G-protein-coupled receptor that mediates xenotropic and polytropic murine retrovirus neurotoxicity.[PMID 22090134] Journal of virology 86: 1661-9, 2012.

Vaughan Andrew E, Halbert Christine L, Wootton Sarah K, Miller A Dusty Lung cancer in mice induced by the jaagsiekte sheep retrovirus envelope protein is not maintained by rare cancer stem cells, but tumorigenicity does correlate with Wnt pathway activation.[PMID 22064658] Molecular cancer research : MCR 10: 86-95, 2012.

Mendoza Ramon, Vaughan Andrew E, Miller A Dusty The left half of the XMRV retrovirus is present in an endogenous retrovirus of NIH/3T3 Swiss mouse cells.[PMID 21697491] Journal of virology 85: 9247-8, 2011.

Halbert Christine L, Madtes David K, Vaughan Andrew E, Wang Zejing, Storb Rainer, Tapscott Stephen J, Miller A Dusty Expression of Human a1-Antitrypsin in Mice and Dogs Following AAV6 Vector-mediated Gene Transfer to the Lungs.[PMID 20372105] Molecular therapy : the journal of the American Society of Gene Therapy 18: 1165-1172, 2010.

BS (Biochemistry) University of Nebraska - Lincoln, 2004

PhD (Molecular and Cellular Biology) University of Washington, 2011

University of California - San Francisco (2012 to 2017)
Postdoctoral Fellow