Dr. Vaughan’s research is focused on defining and understanding the relevant cell types and molecular mechanisms by which the mammalian lung
is able to regenerate after severe injury. He is especially interested in elucidating the means by which epithelial progenitors contribute to repaired airway and alveolar units after various lung insults (influenza, ARDS, fibrosis). His studies suggest that physiological lung function is in fact dictated by progenitor cell fate choices after injury. Dr. Vaughan and his group have developed a novel orthotopic cell transplantation assay which allows for the direct assessment of engraftment, proliferation, and differentiation potential of these stem cells. Further, he is actively investigating the roles of the Notch, Wnt, and BMP pathways in regulating the differentiation potential and fate of expanded progenitor cells post-injury. His office and laboratory are located on the 3rd floor, office 370E Old Vet.
Zhao G, Weiner AI, Neupauer KM, de Mello Costa MF, Palashikar G, Adams-Tzivelekidis S, Mangalmurti NS, Vaughan AE. Regeneration of the pulmonary vascular endothelium after viral pneumonia requires COUP-TF2 Sci Adv 6: eabc4493, 2020.Fernanda de Mello Costa M, Weiner AI, Vaughan AE. Basal-like Progenitor Cells: A Review of Dysplastic Alveolar Regeneration and Remodeling in Lung Repair Stem Cell Reports 15: 1015-1025, 2020.Mangalmurti NS, Reilly JP, Cines DB, Meyer NJ, Hunter CA, Vaughan AE. COVID-19-associated Acute Respiratory Distress Syndrome Clarified: A Vascular Endotype? Am J Respir Crit Care Med 202: 750-753, 2020.Garcia GL, Valenzuela A, Manzoni T, Vaughan AE, López CB. Distinct Chronic Post-Viral Lung Diseases upon Infection with Influenza or Parainfluenza Viruses Differentially Impact Superinfection Outcome Am J Pathol 190: 543-553, 2020.Jackson SR, Costa MFDM, Pastore CF, Zhao G, Weiner AI, Adams S, Palashikar G, Quansah K, Hankenson K, Herbert DR, Vaughan AE. R-spondin 2 mediates neutrophil egress into the alveolar space through increased lung permeability BMC Res Notes 13: 54, 2020.Weiner AI, Jackson SR, Zhao G, Quansah KK, Farshchian JN, Neupauer KM, Littauer EQ, Paris AJ, Liberti DC, Scott Worthen G, Morrisey EE, Vaughan AE. Mesenchyme-free expansion and transplantation of adult alveolar progenitor cells: steps toward cell-based regenerative therapies NPJ Regen Med 4: 17, 2019.Rane Chetan K, Jackson Sergio R, Pastore Christopher F, Zhao Gan, Weiner Aaron I, Patel Neil N, Herbert De'Broski R, Cohen Noam A, Vaughan Andrew E Development of solitary chemosensory cells in the distal lung after severe influenza injury.[PMID 30908939] American journal of physiology. Lung cellular and molecular physiology 316: L1141-L1149, 2019.Singh Snahlata, Elenio Emily, Leu Nicolae A, Romano Rose-Anne, Vaughan Andrew E, DeRiso Jennifer, Surendran Kameswaran, Chakrabarti Rumela A new Elf5 BAC transgenic mouse model for tracing Elf5 cell lineages in adult tissues. [PMID 31002388] FEBS letters 593: 1030-1039, 2019.Hung Li-Yin, Sen Debasish, Oniskey Taylor K, Katzen Jeremey, Cohen Noam A, Vaughan Andrew E, Nieves Wildaliz, Urisman Anatoly, Beers Michael F, Krummel Matthew F, Herbert De'Broski R Macrophages promote epithelial proliferation following infectious and non-infectious lung injury through a Trefoil factor 2-dependent mechanism.[PMID 30337651] Mucosal immunology 12: 64-76, 2019.Hung Li-Yin, Oniskey Taylor K, Sen Debasish, Krummel Matthew F, Vaughan Andrew E, Cohen Noam A, Herbert De'Broski R Trefoil Factor 2 Promotes Type 2 Immunity and Lung Repair through Intrinsic Roles in Hematopoietic and Nonhematopoietic Cells.[PMID 29458008] The American journal of pathology 188: 1161-1170, 2018.