Dr. Vaughan’s research is focused on defining and understanding the relevant cell types and molecular mechanisms by which the mammalian lung
is able to regenerate after severe injury. He is especially interested in elucidating the means by which epithelial progenitors contribute to repaired airway and alveolar units after various lung insults (influenza, ARDS, fibrosis). His studies suggest that physiological lung function is in fact dictated by progenitor cell fate choices after injury. Dr. Vaughan and his group have developed a novel orthotopic cell transplantation assay which allows for the direct assessment of engraftment, proliferation, and differentiation potential of these stem cells. Further, he is actively investigating the roles of the Notch, Wnt, and BMP pathways in regulating the differentiation potential and fate of expanded progenitor cells post-injury. His office and laboratory are located on the 3rd floor, office 370E Old Vet.
Xi Ying, Kim Thomas, Brumwell Alexis N, Driver Ian H, Wei Ying, Tan Victor, Jackson Julia R, Xu Jianming, Lee Dong-Kee, Gotts Jeffrey E, Matthay Michael A, Shannon John M, Chapman Harold A, Vaughan Andrew E Local lung hypoxia determines epithelial fate decisions during alveolar regeneration. Nature cell biology 19: 904-914, 2017.Vaughan Andrew E, Chapman Harold A Failure of Alveolar Type 2 Cell Maintenance Links Neonatal Distress with Adult Lung Disease. American journal of respiratory cell and molecular biology 56: 415-416, 2017.Miller A Dusty, De Las Heras Marcelo, Yu Jingyou, Zhang Fushun, Liu Shan-Lu, Vaughan Andrew E, Vaughan Thomas L, Rosadio Raul, Rocca Stefano, Palmieri Giuseppe, Goedert James J, Fujimoto Junya, Wistuba Ignacio I Evidence against a role for jaagsiekte sheep retrovirus in human lung cancer. Retrovirology 14: 3, 2017.Kanegai Cindy M, Xi Ying, Donne Matthew L, Gotts Jeffrey E, Driver Ian H, Amidzic Gorica, Lechner Andrew J, Jones Kirk D, Vaughan Andrew E, Chapman Harold A, Rock Jason R Persistent Pathology in Influenza-Infected Mouse Lungs. American journal of respiratory cell and molecular biology 55: 613-615, 2016.Vaughan Andrew E, Brumwell Alexis N, Xi Ying, Gotts Jeffrey E, Brownfield Doug G, Treutlein Barbara, Tan Kevin, Tan Victor, Liu Feng Chun, Looney Mark R, Matthay Michael A, Rock Jason R, Chapman Harold A Lineage-negative progenitors mobilize to regenerate lung epithelium after major injury. Nature 517: 621-5, 2015.Vaughan Andrew E, Chapman Harold A Regenerative activity of the lung after epithelial injury. Biochimica et biophysica acta 1832: 922-30, 2013.Vaughan Andrew E, Mendoza Ramon, Aranda Ramona, Battini Jean-Luc, Miller A Dusty Xpr1 is an atypical G-protein-coupled receptor that mediates xenotropic and polytropic murine retrovirus neurotoxicity. Journal of virology 86: 1661-9, 2012.Vaughan Andrew E, Halbert Christine L, Wootton Sarah K, Miller A Dusty Lung cancer in mice induced by the jaagsiekte sheep retrovirus envelope protein is not maintained by rare cancer stem cells, but tumorigenicity does correlate with Wnt pathway activation. Molecular cancer research : MCR 10: 86-95, 2012.Mendoza Ramon, Vaughan Andrew E, Miller A Dusty The left half of the XMRV retrovirus is present in an endogenous retrovirus of NIH/3T3 Swiss mouse cells. Journal of virology 85: 9247-8, 2011.Halbert Christine L, Madtes David K, Vaughan Andrew E, Wang Zejing, Storb Rainer, Tapscott Stephen J, Miller A Dusty Expression of Human a1-Antitrypsin in Mice and Dogs Following AAV6 Vector-mediated Gene Transfer to the Lungs. Molecular therapy : the journal of the American Society of Gene Therapy 18: 1165-1172, 2010.