New Bolton Center Kennett Square, PA
Emergencies & Appointments:
Ryan Hospital Philadelphia, PA


American College of Veterinary Pathologists

Associate Professor, Laboratory Animal Medicine, University of Pennsylvania School of Veterinary Medicine

Director of Diagnostics and Quality Assurance, University of Pennsylvania Laboratory Animal Resources (ULAR)
Contact Information:
University Laboratory Animal Resources
Old Vet Quadrangle, Suite 177E
School of Veterinary Medicine
3800 Spruce Street

• Anti-vascular Endothelial Growth Factor Receptor-2 Antibody Accelerates Renal Disease Progression in the NZB/W F1 Murine Systemic
Lupus Erythematosus Model

• Coordinated Regulation of SIV replication and
Immune Responses in the CNS
• Systemic Activation of K-ras Rapidly Induces Gastric Hyperplasia and Metaplasia

• Deletion of the Mitochondrial Chaperone TRAP-1 Uncovers Global Reprogramming of Metabolic Networks.

Brent, J. M., Tian, Z., Yao, L., Huang, J., Markova, D. Z., Shofer, F. S., Brice, A. K., Qin, L., Scanzello, C. R., Vitale, F., Chen, D., Zhang, Y. Functional deficits in mice expressing human interleukin 8 Comp Med 70: 205-215, 2020.

Wilson, J. M., Wallace, C. K., Brice, A. K., Makaron, L. Mineralized trichobezoars in a Rhesus Macaque (Macaca Mulatta) J Med Primatol 49: 158-161, 2020.

Karmacharya, M. B., Sultan, L. R., Kirkham, B. M., Brice, A. K., Wood, A. K. W., Sehgal, C. M. Photoacoustic imaging for assessing tissue oxygenation changes in rat hepatic fibrosis Diagnostics (Basel) 10: , 2020.

Ortiz, A., Gui, J., Zahedi, F., Yu, P., Cho, C., Bhattacharya, S., Carbone, C. J., Yu, Q., Katlinski, K. V., Katlinskaya, Y. V., Handa, S., Haas, V., Volk, S. W., Brice, A. K., Wals, K., Matheson, N. J., Antrobus, R., Ludwig, S., Whiteside, T. L., Sander, C., Tarhini, A. A., Kirkwood, J. M., Lehner, P. J., Guo, W., Rui, H., Minn, A. J., Koumenis, C., Diehl, J. A., Fuchs, S. Y. An interferon-driven oxysterol-based defense against tumor-derived extracellular vesicles Cancer Cell 35: 33-45 e6, 2019.

D'Souza, J. C., Sultan, L. R., Hunt, S. J., Schultz, S. M., Brice, A. K., Wood, A. K. W., Sehgal, C. M. B-mode ultrasound for the assessment of hepatic fibrosis: a quantitative multiparametric analysis for a radiomics approach Sci Rep 9: 8708, 2019.

D'Souza, J. C., Sultan, L. R., Hunt, S. J., Gade, T. P., Karmacharya, M. B., Schultz, S. M., Brice, A. K., Wood, A. K. W., Sehgal, C. M. Microbubble-enhanced ultrasound for the antivascular treatment and monitoring of hepatocellular carcinoma Nanotheranostics 3: 331-341, 2019.

Bright, L. A., Gardiner, K. L., Veeder, C. L., Brice, A. K. Hepatic hemangiosarcoma in a Cynomolgus Macaque (Macaca Fascicularis) Comp Med 69: 240-248, 2019.

Misic, A. M., Miedel, E. L., Brice, A. K., Cole, S., Zhang, G. F., Dyer, C. D., Secreto, A., Smith, A. L., Danet-Desnoyers, G., Beiting, D. P. Culture-independent profiling of the fecal microbiome to identify microbial species associated with a diarrheal outbreak in immunocompromised mice Comp Med 68: 261-268, 2018.

de Souza Dyer, C., Brice, A. K., Marx, J. O. Intraperitoneal administration of ethanol as a means of euthanasia for neonatal mice (Mus Musculus) J Am Assoc Lab Anim Sci 56: 299-306, 2017.

Johnston, J. M., Dyer, C. D., Madison-Antenucci, S., Mergen, K. A., Veeder, C. L., Brice, A. K. Neurocysticercosis in a Rhesus Macaque (Macaca mulatta) Comp Med 66: 499-502, 2016.

Mice and Men : , .

BS North Carolina Agricultural and Technical State University, 1998

DVM Tuskegee University School of Veterinary Medicine, 2002

PhD Johns Hopkins University, 2009

American College of Veterinary Pathologists

Johns Hopkins University (2002 to 2006)
Postdoctoral Fellowship