New Bolton Center Kennett Square, PA
Emergencies & Appointments:
Ryan Hospital Philadelphia, PA


Assistant Professor of Biostatistics, University of Pennsylvania School of Veterinary Medicine

Research Areas: Obesity, Diabetes, Mechanisms of Independent Glucose Disposal, Insulin Resistance

Contact Information:
Penn Vet
New Bolton Center
382 West Street Road

Dr. Stefanovski’s research focus is in the field of the biomedical sciences, at the intersection of integrative physiology, statistics and computational biology. For over a decade, he has been involved in research studying obesity and its association with insulin resistance, a state of impaired glucose tolerance, and subsequent pathologies, such as Type 2 Diabetes. Current research indicates that the metabolic syndrome, as a combination of medical disorders, is not only associated with the cardiovascular disease and diabetes, but also with some types of cancer. His diverse background has enabled him to approach the complexity of the metabolic syndrome with a multitude of methodologies, including mathematical modeling, statistical analysis, molecular dynamics, molecular biology, and animal model experiments. His current research involves the study of the effects of rear variants of hepatic glucokinase and its repressor protein GKRP on glucose metabolism and development of novel mathematical model of free fatty acids (FFA) kinetics capable of quantifying whole-body insulin sensitivity of FFA metabolism. Additionally, he is studying the biophysical principles of ions selectivity.

Biostatistical analysis using STATA and R packages. Mathematical Modeling of Biological Systems. PK/PD Analysis. Molecular Dynamics study of proteins and In-silico design of small-peptide probes.

Nathanson Olivia, McGonigle Kathryn, Michel Kathryn, Stefanovski Darko, Clarke Dana Esophagostomy tube complications in dogs and cats: Retrospective review of 225 cases. Journal of veterinary internal medicine : , 2019.

Luethy Daniela, Johnson Amy L, Stefanovski Darko, Boston Raymond C, Orsini James Anthony Glucose and insulin response after intravenous and subcutaneous somatostatin administration in healthy horses. Journal of veterinary pharmacology and therapeutics : , 2019.

Agnew Morgan E, Slack JoAnn, Stefanovski Darko, Linton Jennifer K, Sertich Patricia L Sonographic appearance of the late gestation equine fetal intestine. Theriogenology 138: 121-126, 2019.

Brown K, Stefanovski D, Davidson E Prevalence of adverse events and their effect on completion of high speed treadmill exercise tests at a single institution (2000-2015). Equine veterinary journal : , 2019.

Muta Kenjiro, Matsen Miles E, Acharya Nikhil K, Stefanovski Darko, Bergman Richard N, Schwartz Michael W, Morton Gregory J Glucoregulatory responses to hypothalamic preoptic area cooling. Brain research 1710: 136-145, 2019.

Sorenmo Karin U, Durham Amy C, Kristiansen Veronica, Pena Laura, Goldschmidt Michael H, Stefanovski Darko Developing and testing prognostic bio-scoring systems for canine mammary gland carcinomas. Veterinary and comparative oncology : , 2019.

Boorman Sophie, Stefanovski Darko, Southwood Louise L Clinical findings associated with development of postoperative reflux and short-term survival after small intestinal surgery in geriatric and mature nongeriatric horses. Veterinary surgery : VS 48: 795-802, 2019.

Curtiss Alexandra L, Stefanovski Darko, Richardson Dean W Surgical site infection associated with equine orthopedic internal fixation: 155 cases (2008-2016). Veterinary surgery : VS 48: 685-693, 2019.

Morris Katherine P, Singh Ameet, Holt David E, Stefanovski Darko, Singhal Sunil, Bosco Jessica, Capps Michelle, McCallum Michael, Runge Jeffrey J Hybrid single-port laparoscopic cisterna chyli ablation for the adjunct treatment of chylothorax disease in dogs. Veterinary surgery : VS 48: O121-O129, 2019.

Doering Alyssa K, Reesink Heidi L, Luedke Lauren K, Moore Christina, Nixon Alan J, Fortier Lisa A, Ducharme Norm G, Ross Michael W, Levine David G, Richardson Dean W, Stefanovski Darko, Ortved Kyla F Return to racing after surgical management of third carpal bone slab fractures in thoroughbred and standardbred racehorses. Veterinary surgery : VS 48: 513-523, 2019.

BS (Computer and Information Sciences) Shepherd College, Shepherdstown, WV, 1999

M.S. (Bioengineering) University of Pennsylvania, 2003

Ph.D. (Physiology and Biophysics) University of Southern California, Los Angeles, CA, 2009

Keck School of Medicine, University of Souther California, Los Angeles CA (2009 to 2010)
Physiology and Biophysics