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DARKO STEFANOVSKI, Ph.D., M.S. , BS

Assistant Professor of Biostatistics, University of Pennsylvania School of Veterinary Medicine

Member, Search Committee for Epidemiology Position Department of Clinical Studies New Bolton Center

Member, Institute for Diabetes, Obesity, and Metabolism (IDOM), Perelman School of Medicine University of Pennsylvania

Research Areas: Obesity, Diabetes, Mechanisms of Independent Glucose Disposal, Insulin Resistance

Contact Information:
Penn Vet
New Bolton Center
382 West Street Road

Biostatistical analysis using STATA and R packages. Mathematical Modeling of Biological Systems. PK/PD Analysis. Molecular Dynamics study of proteins and In-silico design of small-peptide probes.

Dr. Stefanovski’s research focus is in the field of the biomedical sciences, at the intersection of integrative physiology, statistics and computational biology. For over a decade, he has been involved in research studying obesity and its association with insulin resistance, a state of impaired glucose tolerance, and subsequent pathologies, such as Type 2 Diabetes. Current research indicates that the metabolic syndrome, as a combination of medical disorders, is not only associated with the cardiovascular disease and diabetes, but also with some types of cancer. His diverse background has enabled him to approach the complexity of the metabolic syndrome with a multitude of methodologies, including mathematical modeling, statistical analysis, molecular dynamics, molecular biology, and animal model experiments. His current research involves the study of the effects of rear variants of hepatic glucokinase and its repressor protein GKRP on glucose metabolism and development of novel mathematical model of free fatty acids (FFA) kinetics capable of quantifying whole-body insulin sensitivity of FFA metabolism. Additionally, he is studying the biophysical principles of ions selectivity.

Scarlett Jarrad M, Muta Kenjiro, Brown Jenny M, Rojas Jennifer M, Matsen Miles E, Acharya Nikhil K, Secher Anna, Ingvorsen Camilla, Jorgensen Rasmus, Høeg-Jensen Thomas, Stefanovski Darko, Bergman Richard N, Piccinini Francesca, Kaiyala Karl J, Shiota Masakazu, Morton Gregory J, Schwartz Michael W Peripheral Mechanisms Mediating the Sustained Anti-Diabetic Action of FGF1 in the Brain. Diabetes : , 2018.

Drinkhouse Macy, Brooks Marjory B, Stefanovski Darko, Marryott Kimberly, Callan Mary Beth Influence of canine donor plasma hemostatic protein concentration on quality of cryoprecipitate. Journal of veterinary internal medicine : , 2018.

Cole Stephen D, Stefanovski Darko, Towl Simon, Boyle Ashley G Factors associated with prolonged treatment days, increased veterinary visits and complications in horses with subsolar abscesses. The Veterinary record : , 2018.

Aitken Maia R, Stefanovski Darko, Southwood Louise L Serum amyloid A concentration in postoperative colic horses and its association with postoperative complications. Veterinary surgery : VS : , 2018.

Nyirjesy Sarah C, Sheikh Saba, Hadjiliadis Denis, De Leon Diva D, Peleckis Amy J, Eiel Jack N, Kubrak Christina, Stefanovski Darko, Rubenstein Ronald C, Rickels Michael R, Kelly Andrea ß-Cell secretory defects are present in pancreatic insufficient cystic fibrosis with 1-hour oral glucose tolerance test glucose =155?mg/dL. Pediatric diabetes 19: 1173-1182, 2018.

Gilbertie Jessica M, Schnabel Lauren V, Stefanovski Darko, Kelly Donna J, Jacob Megan E, Schaer Thomas P Gram-negative multi-drug resistant bacteria influence survival to discharge for horses with septic synovial structures: 206 Cases (2010-2015). Veterinary microbiology 226: 64-73, 2018.

Ruetten Hartmut, Gebauer Mathias, Raymond Ralph H, Calle Roberto A, Cobelli Claudio, Ghosh Atalanta, Robertson R Paul, Shankar Sudha S, Staten Myrlene A, Stefanovski Darko, Vella Adrian, Wright Kathryn, Fryburg David A Mixed Meal and Intravenous L-Arginine Tests Both Stimulate Incretin Release Across Glucose Tolerance in Man: Lack of Correlation with ß Cell Function. Metabolic syndrome and related disorders 16: 406-415, 2018.

Mittelman Neil S, Stefanovski Darko, Johnson Amy L Utility of C-reactive protein and serum amyloid A in the diagnosis of equine protozoal myeloencephalitis. Journal of veterinary internal medicine 32: 1726-1730, 2018.

Kelly Andrea, De Leon Diva D, Sheikh Saba, Camburn Devaney, Kubrak Christina, Peleckis Amy J, Stefanovski Darko, Hadjiliadis Denis, Rickels Michael R, Rubenstein Ronald C Islet Hormone and Incretin Secretion in Cystic Fibrosis Following 4-months of Ivacaftor Therapy. American journal of respiratory and critical care medicine : , 2018.

VanderBroek A R, Reef V B, Aitken M R, Stefanovski D, Southwood L L Assessing gastrointestinal motility in healthy horses comparing auscultation, ultrasonography and an acoustic gastrointestinal surveillance biosensor: a randomised, blinded, controlled crossover proof of principle study. Equine veterinary journal : , 2018.

Ph.D. (Physiology and Biophysics) University of Southern California, Los Angeles, CA, 2009

M.S. (Bioengineering) University of Pennsylvania, 2003

BS (Computer and Information Sciences) Shepherd College, Shepherdstown, WV, 1999