JULIE B. ENGILES
Contact
New Bolton Center Kennett Square, PA
Emergencies & Appointments:
610-444-5800
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Ryan Hospital Philadelphia, PA
Emergencies:
215-746-8911
Appointments:
215-746-8387
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JULIE B. ENGILES, B.A., VMD, DACVP

American College of Veterinary Pathologists

USDA-APHIS Federally Accredited Veterinarian

The Wharton School, Aresty Institute of Executive Education, Penn Executive Veterinary Leadership Program

FBI-APHIS Joint Criminal-Epidemiological Investigations Course

USDA National Animal Health Laboratory Network Quality Management System Training

Associate Professor of Pathology, Department of Pathobiology- New Bolton Center

Associate Professor of Pathology, Clinical Studies, New Bolton Center

Clinical Specialties: Veterinary anatomic pathology, Veterinary orthopedic pathology, Equine laminitis, Equine gastrointestinal pathology, Equine microbiome Experimental Animal Models
Research Areas: Gastrointestinal pathology, Orthopedic pathology, Laminitis,
PubMed Link
Contact Information:
University of Pennsylvania
New Bolton Center
Murphy Laboratory
382 West Street Road

My clinical, diagnostic and research expertise is veterinary anatomic pathology with special focus on orthopedic and gastrointestinal pathology. Current and past research projects have included clinical research, translational animal models of human and animal disease, and exploratory investigations including academic and industrial collaborations.

One focus of my orthopedic research includes translational animal models evaluating bone, joint and tendonous tissues. Current and past projects include analyses of orthopedic surgical procedures, biomaterials, and devices utilizing large animal models of human orthopedic disease including swine, sheep, goats, horses and dogs. Internal collaborations include Penn Vet's Comparative Orthopedic Research Laboratory (CORL: Drs. Dean Richardson, Tom Schaer, and Kyla Ortved) and the Penn Center for Musculoskeletal Disorders (PCMD). A collaboration with Dr. Nicky Mason (Department of Clinical Studies- Philadelphia) investigated a canine model of osteosarcoma investigating T-cell mediated immunotherapy targeting tumor osteoblasts expressing Her2/neu antigen. External collaborations include academic institutions and industry investigating murine fracture healing and gene-therapy for large animal models of naturally occurring osteoarthritis.

Another focus of orthopedic research is equine laminitis, including internal collaborations (Drs. van Eps and Galantino-Homer) and external collaborations (University of Queensland, Ohio State University, Oklahoma State University). Through correlation of clinical and pathological data with transcriptomic and proteomic data, the goals of the research are 1) to better understand the pathogenesis of laminitis and 2) to identify potential early biomarkers and molecular targets of laminitis for disease prevention and early therapeutic intervention. One unique aspect of the research involves the interaction among different tissue interfaces including epidermal and dermal lamellae, neurovascular structurs, and the distal phalanx.

My secondary research focus involves equine gastrointestinal pathology and the equine intestinal microbiome. Collaborators include Dr. Southwood (Large Animal Emergency and Critical Care service), and Dr. Pitta (Agricultural Systems and Microbial Genomics laboratory) from the Department of Clinical Studies-New Bolton Center. Current and past investigations include establishment of normal parameters for gastrointestinal architecture and resident inflammatory cell populations, evaluation of the effect of peri-operative antimicrobials on the equine fecal microbiome for elective surgical procedures, and the differences in fecal microbiome and intestinal micro-architecture in horses presenting for acute and recurrent colic.

Engiles JB, Fanzone N, Wulster KB, Schumacher J, Pierdon MK. Gross, histopathologic, microbiologic, and radiologic characterization of lesions associated with clinical lameness in a cohort of group-housed sows euthanized for lameness Vet Pathol : , 2022.

Gilbertie JM, Schaer TP, Engiles JB, Seiler GS, Deddens BL, Schubert AG, Jacob ME, Stefanovski D, Ruthel G, Hickok NJ, Stowe DM, Frink A, Schnabel LV. A Platelet-Rich Plasma-Derived Biologic Clears Staphylococcus aureus Biofilms While Mitigating Cartilage Degeneration and Joint Inflammation in a Clinically Relevant Large Animal Infectious Arthritis Model Front Cell Infect Microbiol 12: 895022, 2022.

Gullbrand Sarah E, Ashinsky Beth G, Bonnevie Edward D, Kim Dong Hwa, Engiles Julie B, Smith Lachlan J, Elliott Dawn M, Schaer Thomas P, Smith Harvey E, Mauck Robert L Long-term mechanical function and integration of an implanted tissue-engineered intervertebral disc. Science translational medicine 10: , 2018.

Lee NN, Salzer E, Bach FC, Bonilla AF, Cook JL, Gazit Z, Grad S, Ito K, Smith LJ, Vernengo A, Wilke HJ, Engiles JB, Tryfonidou MA. A comprehensive tool box for large animal studies of intervertebral disc degeneration JOR Spine 4: e1162, 2021.

Engiles JB, Uzal FA, Navarro MA, Reef VB, Bender SJ. Phlegmonous gastritis in 2 yearling horses J Vet Diagn Invest : , 2022.

Stewart H L, Southwood L L, Indugu N, Vecchiarelli B, Engiles J B, Pitta D Differences in the equine faecal microbiota between horses presenting to a tertiary referral hospital for colic compared to an elective surgical procedure. Equine veterinary journal : , 2018.

Sateriale Adam, Šlapeta Jan, Baptista Rodrigo, Engiles Julie B, Gullicksrud Jodi A, Herbert Gillian T, Brooks Carrie F, Kugler Emily M, Kissinger Jessica C, Hunter Christopher A, Striepen Boris A Genetically Tractable, Natural Mouse Model of Cryptosporidiosis Offers Insights into Host Protective Immunity. Cell host & microbe 26: 135-146.e5, 2019.

Cassimeris L, Engiles JB, Galantino-Homer H. Interleukin-17A pathway target genes are upregulated in Equus caballus supporting limb laminitis PLoS One 15: e0232920, 2020.

Klein CE, Engiles JB, Roessner HA, Hopster K, Hurcombe SD. Comparison of the zip skin closure system with conventional suture for skin closure of ventral midline incisions in horses Am J Vet Res : , 2022.

Casal Margret L, Engiles Julie B, Zakošek Pipan Maja, Berkowitz Asaf, Porat-Mosenco Yael, Mai Wilfried, Wurzburg Kirsten, Xu Mei-Qi, Allen Robyn, ODonnell Patricia A, Henthorn Paula S, Thompson Keith, Shore Eileen M Identification of the Identical Human Mutation in in 2 Cats With Fibrodysplasia Ossificans Progressiva. Veterinary pathology 56: 614-618, 2019.

B.A. (Biophysics, Dean's Scholar Program) University of Delaware, 1994

VMD School of Veterinary Medicine, University of Pennsylvania, 2002

DACVP (Veterinary Anatomic Pathology ) University of Pennsylvania, 2006

American College of Veterinary Pathologists

USDA-APHIS Federally Accredited Veterinarian

The Wharton School, Aresty Institute of Executive Education, Penn Executive Veterinary Leadership Program

FBI-APHIS Joint Criminal-Epidemiological Investigations Course

USDA National Animal Health Laboratory Network Quality Management System Training

New Jersey Equine Clinic, Millstone, NJ (2002 to 2003)
Internship in Equine Surgery

University of Pennsylvania, School of Veterinary Medicine (2003 to 2006)
Residency, Veterinary Anatomic Pathology