JULIE B. ENGILES
Contact
New Bolton Center Kennett Square, PA
Emergencies & Appointments:
610-444-5800
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Ryan Hospital Philadelphia, PA
Emergencies:
215-746-8911
Appointments:
215-746-8387
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JULIE B. ENGILES, B.A., VMD, DACVP

American College of Veterinary Pathologists

USDA-APHIS Federally Accredited Veterinarian

The Wharton School, Aresty Institute of Executive Education, Penn Executive Veterinary Leadership Program

FBI-APHIS Joint Criminal-Epidemiological Investigations Course

USDA National Animal Health Laboratory Network Quality Management System Training

Associate Professor of Pathology, Department of Pathobiology- New Bolton Center

Associate Professor of Pathology, Clinical Studies, New Bolton Center

Clinical Specialties: Veterinary anatomic pathology, Veterinary orthopedic pathology, Equine laminitis, Equine gastrointestinal pathology, Equine microbiome Experimental Animal Models
Research Areas: Gastrointestinal pathology, Orthopedic pathology, Laminitis,
PubMed Link
Contact Information:
University of Pennsylvania
New Bolton Center
Murphy Laboratory
382 West Street Road

My clinical, diagnostic and research expertise is veterinary anatomic pathology with special focus on orthopedic and gastrointestinal pathology. Current and past research projects have included clinical research, translational animal models of human and animal disease, and exploratory investigations including academic and industrial collaborations.

One focus of my orthopedic research includes translational animal models evaluating bone, joint and tendonous tissues. Current and past projects include analyses of orthopedic surgical procedures, biomaterials, and devices utilizing large animal models of human orthopedic disease including swine, sheep, goats, horses and dogs. Internal collaborations include Penn Vet's Comparative Orthopedic Research Laboratory (CORL: Drs. Dean Richardson, Tom Schaer, and Kyla Ortved) and the Penn Center for Musculoskeletal Disorders (PCMD). A collaboration with Dr. Nicky Mason (Department of Clinical Studies- Philadelphia) investigated a canine model of osteosarcoma investigating T-cell mediated immunotherapy targeting tumor osteoblasts expressing Her2/neu antigen. External collaborations include academic institutions and industry investigating murine fracture healing and gene-therapy for large animal models of naturally occurring osteoarthritis.

Another focus of orthopedic research is equine laminitis, including internal collaborations (Drs. van Eps and Galantino-Homer) and external collaborations (University of Queensland, Ohio State University, Oklahoma State University). Through correlation of clinical and pathological data with transcriptomic and proteomic data, the goals of the research are 1) to better understand the pathogenesis of laminitis and 2) to identify potential early biomarkers and molecular targets of laminitis for disease prevention and early therapeutic intervention. One unique aspect of the research involves the interaction among different tissue interfaces including epidermal and dermal lamellae, neurovascular structurs, and the distal phalanx.

My secondary research focus involves equine gastrointestinal pathology and the equine intestinal microbiome. Collaborators include Dr. Southwood (Large Animal Emergency and Critical Care service), and Dr. Pitta (Agricultural Systems and Microbial Genomics laboratory) from the Department of Clinical Studies-New Bolton Center. Current and past investigations include establishment of normal parameters for gastrointestinal architecture and resident inflammatory cell populations, evaluation of the effect of peri-operative antimicrobials on the equine fecal microbiome for elective surgical procedures, and the differences in fecal microbiome and intestinal micro-architecture in horses presenting for acute and recurrent colic.

Moss KL; Jiang Z; Dodson ME; Linardi RL; Haughan J; Gale AL; Grzybowski C; Engiles JB; Stefanovski D; Robinson MA; Ortved KF. Sustained Interleukin-10 Transgene Expression Following Intra-Articular AAV5-IL-10 Administration to Horses. Human Gene Therapy 31: 110-118, 2020.

Cassimeris Lynne, Engiles Julie B, Galantino-Homer Hannah Detection of endoplasmic reticulum stress and the unfolded protein response in naturally-occurring endocrinopathic equine laminitis. BMC veterinary research 15: 24, 2019.

Stokes S M, Belknap J K, Engiles J B, Stefanovski D, Bertin F R, Medina-Torres C E, Horn R, van Eps A W Continuous digital hypothermia prevents lamellar failure in the euglycaemic hyperinsulinaemic clamp model of equine laminitis. Equine veterinary journal 51: 658-664, 2019.

Sateriale Adam, Šlapeta Jan, Baptista Rodrigo, Engiles Julie B, Gullicksrud Jodi A, Herbert Gillian T, Brooks Carrie F, Kugler Emily M, Kissinger Jessica C, Hunter Christopher A, Striepen Boris A Genetically Tractable, Natural Mouse Model of Cryptosporidiosis Offers Insights into Host Protective Immunity. Cell host & microbe 26: 135-146.e5, 2019.

Casal Margret L, Engiles Julie B, Zakošek Pipan Maja, Berkowitz Asaf, Porat-Mosenco Yael, Mai Wilfried, Wurzburg Kirsten, Xu Mei-Qi, Allen Robyn, ODonnell Patricia A, Henthorn Paula S, Thompson Keith, Shore Eileen M Identification of the Identical Human Mutation in in 2 Cats With Fibrodysplasia Ossificans Progressiva. Veterinary pathology 56: 614-618, 2019.

Tomlinson Joy E, Tennant Bud C, Struzyna Alyssa, Mrad Dawn, Browne Nimet, Whelchel Dorothy, Johnson Philip J, Jamieson Camilla, Löhr Christiane V, Bildfell Robert, McKenzie Erica C, Laverack Melissa, Renshaw Randall W, Dubovi Edward, Kapoor Amit, Meirs Richard S, Belgrave Rodney, Engiles Julie, Van de Walle Gerlinde R, Divers Thomas J Viral testing of 10 cases of Theiler's disease and 37 in-contact horses in the absence of equine biologic product administration: A prospective study (2014-2018). Journal of veterinary internal medicine : , 2018.

Gullbrand Sarah E, Ashinsky Beth G, Bonnevie Edward D, Kim Dong Hwa, Engiles Julie B, Smith Lachlan J, Elliott Dawn M, Schaer Thomas P, Smith Harvey E, Mauck Robert L Long-term mechanical function and integration of an implanted tissue-engineered intervertebral disc. Science translational medicine 10: , 2018.

Stewart H L, Southwood L L, Indugu N, Vecchiarelli B, Engiles J B, Pitta D Differences in the equine faecal microbiota between horses presenting to a tertiary referral hospital for colic compared to an elective surgical procedure. Equine veterinary journal : , 2018.

Stewart Holly L, Pitta Dipti, Indugu Nagaraju, Vecchiarelli Bonnie, Engiles Julie B, Southwood Louise L Characterization of the fecal microbiota of healthy horses. American journal of veterinary research 79: 811-819, 2018.

Stewart Holly L, Engiles Julie B, Stefanovski Darko, Southwood Louise Clinical and intestinal histologic features of horses treated for recurrent colic: 66 cases (2006-2015). Journal of the American Veterinary Medical Association 252: 1279-1288, 2018.

B.A. (Biophysics, Dean's Scholar Program) University of Delaware, 1994

VMD School of Veterinary Medicine, University of Pennsylvania, 2002

DACVP (Veterinary Anatomic Pathology ) University of Pennsylvania, 2006

American College of Veterinary Pathologists

USDA-APHIS Federally Accredited Veterinarian

The Wharton School, Aresty Institute of Executive Education, Penn Executive Veterinary Leadership Program

FBI-APHIS Joint Criminal-Epidemiological Investigations Course

USDA National Animal Health Laboratory Network Quality Management System Training

New Jersey Equine Clinic, Millstone, NJ (2002 to 2003)
Internship in Equine Surgery

University of Pennsylvania, School of Veterinary Medicine (2003 to 2006)
Residency, Veterinary Anatomic Pathology