Kristin Gardiner, VMD

Merlo, L. M. F., Sprouffske, K., Howard, T. C., Gardiner, K. L., Caulin, A. F., Blum, S. M., Evans, P., Bedalov, A., Sniegowski, P. D., Maley, C. C. Application of simultaneous selective pressures slows adaptation Evol Appl 13: 1615-1625, 2020.

Gardiner, K. L., Cideciyan, A. V., Swider, M., Dufour, V. L., Sumaroka, A., Komaromy, A. M., Hauswirth, W. W., Iwabe, S., Jacobson, S. G., Beltran, W. A., Aguirre, G. D. Long-term structural outcomes of late-stage RPE65 gene therapy Molecular Therapy 28: 266-278, 2020.

Bright, L. A., Gardiner, K. L., Veeder, C. L., Brice, A. K. Hepatic hemangiosarcoma in a cynomolgus macaque (Macaca fascicularis) Comparative Medicine 69: 240-248, 2019.

Downs, L. M., Scott, E. M., Cideciyan, A. V., Iwabe, S., Dufour, V., Gardiner, K. L., Genini, S., Marinho, L. F., Sumaroka, A., Kosyk, M. S., Swider, M., Aguirre, G. K., Jacobson, S. G., Beltran, W. A., Aguirre, G. D. Overlap of abnormal photoreceptor development and progressive degeneration in Leber congenital amaurosis caused by NPHP5 mutation Hum Mol Genet 25: 4211-4226, 2016.

Gardiner, K. L., Downs, L., Berta-Antalics, A. I., Santana, E., Aguirre, G. D., Genini, S.Photoreceptor proliferation and dysregulation of cell cycle genes in early onset inherited retinal degenerations BMC Genomics 17: 221, 2016.

Kosoff, R. E., Gardiner, K. L., Merlo, L. M., Pavlov, K., Rustgi, A. K., Maley, C. C. Development and characterization of an organotypic model of Barrett”s esophagus J Cell Physiol 227: 2654-9, 2012.

Merlo, L. M., Kosoff, R. E., Gardiner, K. L., Maley, C. C. An in vitro co-culture model of esophageal cells identifies ascorbic acid as a modulator of cell competition BMC Cancer 11: 461, 2011.

The study of long-term outcomes (safety/efficacy) of gene therapy administration in animal models of retinal, liver-directed, and neurologic diseases. This includes subretinal, intra-cisterna magna, intracerebral, and intravascular vector administration, with concurrent analysis of functional and gross/histopathologic patient outcomes.

University of Pennsylvania School of Veterinary Medicine (2014 to 2015)
Internship, Exotic Companion Animal Medicine & Surgery Services

University of Pennsylvania (2015 to 2018)
Resisdency in Laboratory Animal Medicine, University Laboratory Animal Resources