Establishing regenerative therapies to improve musculoskeletal healing using the horse as a model for human disease. Specifically, my research program is targeted towards developing gene and cell therapies to improve cartilage repair and prevent osteoarthritis; establishment of a chondrogenically superior mesenchymal stem cell source for treatment of chondral defects; elucidating the pathophysiology of posttraumatic osteoarthritis; and adeno-associated virus mediated overexpression of immunomodulatory cytokines in the joint.
Equine orthopedic surgery
Kupratis ME, Gure A, Ortved KF, Burris DL, Price C Comparative tribology: Articulation-induced rehydration of cartilage across species Biotribiology : , 2021.Cameron AD, Even KM, Linardi RL, Berglund AK, Schnabel LV, Engiles JE Investigation of the effects of AAV-mediated overexpression of IL-10 on the immunomodulatory properties of equine BM-MSCs. Human Gene Therapy Human Gene Therapy : , 2021.Cardona G, Uribe A, Ortved KF Determination of positional parameters of the distal phalanx within the hoof capsule in sound Colombian Paso Horses Journal of Equine Veterinary Science : , 2021.Boorman S, Hofmeister EH, Ross MW, Ralston S, Bell S, Mackie S, Ortved KF Osteochondrosis decreases the longevity and racing performance of Standardbred trotters and pacers Vet Surg : , 2021.Irwin RM, Gao T, Boys AJ, Ortved KF, Cohen I, Bonassar LJ Microscale strain mapping demonstrates the importance of interface slope in the mechanics of cartilage repair J Biomech : , 2021.Farnham M, Ortved KF, Homer JS, Wagner NJ, Burris DL, Price C Lubricant effects on articular cartilage sliding biomechanics under physiological fluid load support Tribology Letters : , 2021.Farnham M, Ortved KF, Burris DL, Price C Articular cartilage friction, strain, and viability under physiological to pathological benchtop sliding conditions Cellular and Molecular Bioengineering : , 2021.Connard SS, Linardi RL, Even KM, Berglund AK, Schnabel LV, Ortved KF Effects of continuous passage on the immunomodulatory properties of equine bone marrow-derived mesenchymal stem cells in vitro American College of Veterinary Surgeons 27th Annual Symposium : , 2020.Curtiss AL, Ortved KF, Dallap-Schaer B, Gouzeev S, Stefanovski D, Richardson DW, Wulster KB Validation of standing cone beam computed tomography for diagnosing subchondral fetlock pathology in the Thoroughbred racehorse Equine Vet J : , 2020.Brown KA, Davidson EJ, Johnson A, Wulster KB, Ortved KF Assessment of intra-synovial inflammatory cytokines in horses with standing cone bean computed tomographic evidence of cervical articular process joint osteoarthritis EVJ 49: 590-599, 2020.
B.Sc. (Animal Biology) University of British Columbia, 2001DVM (Veterinary Medicine) University of Guelph, 2006PhD (Comparative Biomedical Sciences) Cornell University, 2014Diplomate, American College of Veterinary Surgeons
Diplomate, American College of Veterinary Sports Medicine & Rehabilitation