KYLA ORTVED
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New Bolton Center Kennett Square, PA
Emergencies & Appointments:
610-444-5800
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Ryan Hospital Philadelphia, PA
Emergencies:
215-746-8911
Appointments:
215-746-8387
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KYLA ORTVED, B.Sc., DVM, PhD

Diplomate, American College of Veterinary Surgeons

Diplomate, American College of Veterinary Sports Medicine & Rehabilitation

Associate Professor Of Large Animal Surgery, University of Pennsylvania School of Veterinary Medicine

Jacques Jenny Endowed Term Chair in Orthopedic Surgery, University of Pennsylvania School of Veterinary Medicine
Contact Information:
382 W. Street Road

Establishing regenerative therapies to improve musculoskeletal healing using the horse as a model for human disease. Specifically, my research program is targeted towards developing gene and cell therapies to improve cartilage repair and prevent osteoarthritis; establishment of a chondrogenically superior mesenchymal stem cell source for treatment of chondral defects; elucidating the pathophysiology of posttraumatic osteoarthritis; and adeno-associated virus mediated overexpression of immunomodulatory cytokines in the joint.

Equine orthopedic surgery
Fracture repair
Arthroscopy
Tenoscopy
Regenerative medicine

Chapman HS, Gale AL, Dodson ME, Linardi RL, Ortved KF The effect of autologous platelet lysate on the differentiation potential of equine bone marrow-derived mesenchymal stem cells Stem Cells Dev 29: 144-155, 2020.

Brown KA, Davidson EJ, Johnson A, Wulster KB, Ortved KF Assessment of intra-synovial inflammatory cytokines in horses with standing cone bean computed tomographic evidence of cervical articular process joint osteoarthritis EVJ 49: 590-599, 2021.

Boorman S, Hofmeister EH, Ross MW, Ralston S, Bell S, Mackie S, Ortved KF Osteochondrosis decreases the longevity and racing performance of Standardbred trotters and pacers Vet Surg : , 2021.

Farnham M, Ortved KF, Homer JS, Wagner NJ, Burris DL, Price C Lubricant effects on articular cartilage sliding biomechanics under physiological fluid load support Tribology Letters : , 2021.

Farnham M, Ortved KF, Burris DL, Price C Articular cartilage friction, strain, and viability under physiological to pathological benchtop sliding conditions Cellular and Molecular Bioengineering : , 2021.

Connard SS, Linardi RL, Even KM, Berglund AK, Schnabel LV, Ortved KF Effects of continuous passage on the immunomodulatory properties of equine bone marrow-derived mesenchymal stem cells in vitro Vet Immunol Immunopathol : , 2021.

Cameron AD, Even KM, Linardi RL, Berglund AK, Schnabel LV, Engiles JE Investigation of the effects of AAV-mediated overexpression of IL-10 on the immunomodulatory properties of equine BM-MSCs. Human Gene Therapy Human Gene Therapy : , 2021.

Gaesser AM, Underwood C, Linardi RL, Even KM, Reef VB, Shetye SS, Mauck RL, King WJ, Engiles JE, Ortved KF Evaluation of autologous protein solution injection for treatment of superficial digital flexor tendonitis in an equine model Frontiers Vet Sci 8:a697551: , 2021.

Cianci JM, Wulster KB, Richardson DW, Stefanovski D, Ortved KF Computed tomographic assessment of fracture characteristics and subchondral bone injury in Thoroughbred racehorses with lateral condylar fractures and their relationship to outcome Vet Surg 51: 426-437, 2022.

Redding LE, Elzer EJ, Ortved KF Effects of regional limb perfusion technique on concentrations of antibiotic achieved at the target site: a meta-analysis PLoS One 17:e0265971: , 2022.

Even KM, Gaesser AM, Ciamillo SA, Linardi RL, Ortved KF Comparing the immunomodulatory properties of equine BM-MSCs culture expanded in autologous platelet lysate, pooled platelet lysate, equine serum and fetal bovine serum supplemented culture media Frontiers Vet Sci 9:958724: , 2022.

Ciamillo SA, Pownder SL, Potter HG, Stefanovski D, Nixon AJ, Ortved KF. Correlation of magnetic resonance imaging (MRI) and optical coherence tomography (OCT) with healing of cartilage defects implanted with chondrocytes overexpressing IGF-I online ahead of print : , 2023.

B.Sc. (Animal Biology) University of British Columbia, 2001

DVM (Veterinary Medicine) University of Guelph, 2006

PhD (Comparative Biomedical Sciences) Cornell University, 2014

Diplomate, American College of Veterinary Surgeons

Diplomate, American College of Veterinary Sports Medicine & Rehabilitation