Establishing gene and cell therapies to improve cartilage repair and prevent osteoarthritis using the horse as a model for human joint disease

Establishment of a chondrogenically superior mesenchymal stem cell source for treatment of chondral defects

Immunomodulation of the posttraumatic joint using intra-articular adeno-associated virus (AAV) gene therapy

Mechanisms of post-traumatic osteoarthritis (PTOA)

Gale AL, Linardi RL, Dodson ME, Ortved KF The effect of hypoxia on chondrogenesis of equine synovial membrane-derived and bone marrow-derived mesenchymal stem cells BMC Vet Research 15: , 2019.

Linardi RL, Dodson ME, Moss KL, King WJ. Ortved KF The effect of autologous protein solution on the inflammatory cascade in stimulated equine chondrocytes Frontiers Vet Regen Med : , 2019.

Doering AK, Reesink HR, Leudke LK, Moore C, Nixon AJ, Fortier LA, Ducharme NG, Ross MW, Richardson DW, Ortved KF Return to racing after internal fixation of carpal slab fractures in Thoroughbred and Standardbred racehorses. Veterinary Surgery : , 2019.

Gale AL, Mammone RM, Linardi RL, McClung G, Ortved KF Comparison of the chondrogenic differentiation potential of equine synovial membrane-derived and bone marrow-derived mesenchymal stem cells Frontiers Vet Regen Med 6: , 2019.

Ortved KF, Begum L, Stefanovski D, Nixon AJ AAV-mediated Overexpression of IL-10 Mitigates the Inflammatory Cascade in Stimulated Equine Chondrocyte Pellets Current Gene Therapy 18: 171-179, 2018.

Beste KJ, Ortved KF, Rossignol F, Ducharme NG. Transendoscopic axial division of epiglottic entrapments using a silicone covered hook and diode laser in 29 horses. Vet Surg. : , 2018.

Chapman HS, Richardson DW, Ortved KF Arthrodesis of the metacarpophalangeal and metatarsophalangeal joint to treat osteoarthritis in 17 horses Veterinary Surgery : , 2018.

Griffin D, Ortved KF, Nixon AJ, Bonassar L Mechanical properties and structure-function relationships in articular cartilage repair using IGF-I gene therapy. Journal of Orthopedic Research 34: 149-153, 2016.

Ortved KF, Nixon AJ Cell-based cartilage repair strategies for horses. Vet J : 1-12, 2016.

Ortved KF, Wagner B, Calcedo R, Wilson JM, Schaefer DM, Nixon AJ Humoral and cell-mediated immune response, and growth factor synthesis after direct intra-articular injection of rAAV2-IGF-I or rAAV5-IGF-I in the equine middle carpal joint. Human Gene Therapy 26: 161-171, 2015.

Ortved KF, Begum L, Mohammed HO, Nixon AJ. Implantation of rAAV5-IGF-I transduced autologous chondrocytes improves cartilage repair in full-thickness defects in the equine model. Molecular Therapy 23: 363-373, 2015.

Ortved KF, Nixon AJ, Mohammed HO, Fortier LA Treatment of subchondral bone cysts of the medial femoral condyle in mature horses with growth factor enhanced chondrocyte grafts: A retrospective study of 49 cases Equine Vet J 44: 606-613, 2012.

DVM (Veterinary Medicine) University of Guelph, 2006

PhD (Comparative Biomedical Sciences) Cornell University, 2014