KYLA ORTVED
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New Bolton Center Kennett Square, PA
Emergencies & Appointments:
610-444-5800
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Ryan Hospital Philadelphia, PA
Emergencies:
215-746-8911
Appointments:
215-746-8387
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KYLA ORTVED, DVM, PhD

Diplomate, American College of Veterinary Surgeons

Diplomate, American College of Veterinary Sports Medicine & Rehabilitation

Jacques Jenny Endowed Term Chair in Orthopedic Surgery, University of Pennsylvania School of Veterinary Medicine

Assistant Professor of Large Animal Surgery, University of Pennsylvania School of Veterinary Medicine
Contact Information:
382 W. Street Road

Establishing gene and cell therapies to improve cartilage repair and prevent osteoarthritis using the horse as a model for human joint disease

Establishment of a chondrogenically superior mesenchymal stem cell source for treatment of chondral defects

Immunomodulation of the posttraumatic joint using intra-articular adeno-associated virus (AAV) gene therapy

Mechanisms of post-traumatic osteoarthritis (PTOA)

Equine orthopedic surgery
Fracture repair
Arthroscopy
Tenoscopy
Regenerative medicine

Moss KL, Jiang Z, Linardi RL, Gale AL, Dodson ME, Grzybowski C, Haughan J, Robinson M, Ortved KF Sustained interleukin-10 transgene expression following intraarticular AAV5-IL-10 administration to horses. Human Gene Therapy 31: 110-118, 2020.

Chapman HS, Gale AL, Dodson ME, Linardi RL, Ortved KF The effect of autologous platelet lysate on the differentiation potential of equine bone marrow-derived mesenchymal stem cells Stem Cells Dev 29: 144-155, 2020.

Haughan J, Jiang Z, Stefanovski D, Moss KL, Ortved KF, Robinson MA. Detection of intra-articular gene therapy in horses using quantitative real time PCR in synovial fluid and plasma Drug Testing and Analysis 12: 743-751, 2020.

Doering AK, Reesink HR, Leudke LK, Moore C, Nixon AJ, Fortier LA, Ducharme NG, Ross MW, Richardson DW, Ortved KF Return to racing after internal fixation of carpal slab fractures in Thoroughbred and Standardbred racehorses. Veterinary Surgery : , 2019.

Linardi RL, Dodson ME, Moss KL, King WJ. Ortved KF The effect of autologous protein solution on the inflammatory cascade in stimulated equine chondrocytes Frontiers Vet Regen Med : , 2019.

Gale AL, Mammone RM, Linardi RL, McClung G, Ortved KF Comparison of the chondrogenic differentiation potential of equine synovial membrane-derived and bone marrow-derived mesenchymal stem cells Frontiers Vet Regen Med 6: , 2019.

Gale AL, Linardi RL, Dodson ME, Ortved KF The effect of hypoxia on chondrogenesis of equine synovial membrane-derived and bone marrow-derived mesenchymal stem cells. BMC Vet Research 15: , 2019.

Ortved KF, Begum L, Stefanovski D, Nixon AJ AAV-mediated Overexpression of IL-10 Mitigates the Inflammatory Cascade in Stimulated Equine Chondrocyte Pellets. Current Gene Therapy 18: 171-179, 2018.

Ortved KF, Goodale MB, Ober C, Maylin GA, Fortier LA. Plasma firocoxib concentrations after intra-articular injection of IRAP prepared from firocoxib positive horses. Veterinary Surgery 230: , 2017.

Ortved KF, Austin BS, Scimeca MS, Nixon AJ RNA interference mediated interleukin-1ß silencing in inflamed chondrocytes decreases target and downstream catabolic responses. Arthritis : , 2016.

Ortved KF, Wagner B, Calcedo R, Wilson JM, Schaefer DM, Nixon AJ Humoral and cell-mediated immune response, and growth factor synthesis after direct intra-articular injection of rAAV2-IGF-I or rAAV5-IGF-I in the equine middle carpal joint. Human Gene Therapy 26: 161-171, 2015.

Ortved KF, Begum L, Mohammed HO, Nixon AJ. Implantation of rAAV5-IGF-I transduced autologous chondrocytes improves cartilage repair in full-thickness defects in the equine model. Molecular Therapy 23: 363-373, 2015.

DVM (Veterinary Medicine) University of Guelph, 2006

PhD (Comparative Biomedical Sciences) Cornell University, 2014

Diplomate, American College of Veterinary Surgeons

Diplomate, American College of Veterinary Sports Medicine & Rehabilitation