Establishing gene and cell therapies to improve cartilage repair and prevent osteoarthritis using the horse as a model for human joint disease

Establishment of a chondrogenically superior mesenchymal stem cell source for treatment of chondral defects

Immunomodulation of the posttraumatic joint using intra-articular adeno-associated virus (AAV) gene therapy

Mechanisms of post-traumatic osteoarthritis (PTOA)

Ortved KF Regenerative Medicine and Rehabilitation for Tendinous and Ligamentous Injuries in Sport Horses Vet Clin North Am Equine Pract 34: 20-23, 2018.

Chapman HS, Richardson DW, Ortved KF Arthrodesis of the metacarpophalangeal and metatarsophalangeal joint to treat osteoarthritis in 17 horses Veterinary Surgery : , 2018.

Ortved KF, Begum L, Stefanovski D, Nixon AJ AAV-mediated Overexpression of IL-10 Mitigates the Inflammatory Cascade in Stimulated Equine Chondrocyte Pellets Current Gene Therapy 18: 171-179, 2018.

Ortved KF Surgical management of osteochondrosis in foals Veterinary Clinics of North America Equine 33: , 2017.

Ortved KF, Goodale MB, Ober C, Maylin GA, Fortier LA. Plasma firocoxib concentrations after intra-articular injection of IRAP prepared from firocoxib positive horses. Veterinary Surgery 230: , 2017.

Ortved KF, Nixon AJ Cell-based cartilage repair strategies for horses. Vet J : 1-12, 2016.

Griffin D, Ortved KF, Nixon AJ, Bonassar L Mechanical properties and structure-function relationships in articular cartilage repair using IGF-I gene therapy. Journal of Orthopedic Research 34: 149-153, 2016.

Ortved KF, Austin BS, Scimeca MS, Nixon AJ RNA interference mediated interleukin-1ß silencing in inflamed chondrocytes decreases target and downstream catabolic responses. Arthritis : , 2016.

Ortved KF, Wagner B, Calcedo R, Wilson JM, Schaefer DM, Nixon AJ Humoral and cell-mediated immune response, and growth factor synthesis after direct intra-articular injection of rAAV2-IGF-I or rAAV5-IGF-I in the equine middle carpal joint. Human Gene Therapy 26: 161-171, 2015.

Ortved KF, Begum L, Mohammed HO, Nixon AJ. Implantation of rAAV5-IGF-I transduced autologous chondrocytes improves cartilage repair in full-thickness defects in the equine model. Molecular Therapy 23: 363-373, 2015.

DVM (Veterinary Medicine) University of Guelph, 2006

PhD (Comparative Biomedical Sciences) Cornell University, 2014