MARGRET L. CASAL
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New Bolton Center Kennett Square, PA
Emergencies & Appointments:
610-444-5800
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Ryan Hospital Philadelphia, PA
Emergencies:
215-746-8911
Appointments:
215-746-8387
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MARGRET L. CASAL, DVM, MS, PhD

European College of Animal Reproduction

 Professor of Medical Genetics, Reproduction, and Pediatrics, University of Pennsylvania School of Veterinary Medicine
Clinical Specialties: Genetics, Reproduction, Pediatrics,
Research Areas: Canine genetic skin disorders, X-linked ectodermal dysplasia, lupoid dermatosis, ichthyosis, Canine and feline mucopolysaccharidoses, Gene therapy for genetic disorders, Recombinant protein therapy for genetic disorders
PubMed Link
Contact Information:
Section of Medical Genetics, Room 4033 VHUP
School of Veterinary Medicine
University of Pennsylvania
3900 Delancey Street

Dr. Casal is specialized in veterinary genetics, pediatrics and reproduction. Her research interests are focused on the characterization, genetic basis, and treatment of canine genetic skin disorders and lysosomal storage disorders in dogs that also occur in humans. The skin disorders being studied in collaboration with Dr. Elizabeth Mauldin include cutaneous exfoliative lupus erythematosus of the German shorthaired pointer, Ehlers Danlos syndrome (a collagen defect), and non-epidermolytic ichthyosis (fish-scale disease). Furthermore, more extensive collaborative investigations are underway into the morphologic manifestations of canine X-linked hypohidrotic ectodermal dysplasia and response to neonatal therapy using a recombinant protein, as this disorder in dogs is identical to that seen in humans. Clinical and cognitive responses to gene therapy are being examined in the dogs with mucopolysaccharidosis type I and type VII, both lysosomal storage diseases that are quite devastating in humans. These studies are performed in collaboration with other researchers at Penn and outside of the University.

Canine and feline pediatrics
Canine and feline reproduction
Canine and feline genetics

Ellinwood, N. M., Colle, M-A., Weil, M., Casal, M., Vite, C., Weimelt, S., Hasson, C., O’Malley, T., He, X., Verot., L., Prociuk, U., Melniczek., J., Lannon, A., Aguirre, G., Knox, V., Evans, S., Vanier, M., Schuchman, E., Walkley, S., Haskins, M. Bone marrow transplantation for feline MPS I. Mol Genet Metabol 91: 239-250, 2007.

Grider, A., Mouat, M. F., Mauldin,E. A., Casal, M. L. Analysis of the Liver Soluble Proteome from Bull Terriers Affected with Inherited Lethal Acrodermatitis. Mol Genet Metabol 92: 249-257, 2007.

Beall, B., Casal, M. L. XXX rated: the cycling but infertile dog. Society for Theriogenology. Monterey, CA. : , 2007.

Casal ML, Lewis JR, Mauldin EA, Tardivel A, Ingold K, Favre M, Paradies F, Demotz S, Gaide O, Schneider P. Significant correction of disease after postnatal administration of recombinant ectodysplasin a in canine x-linked ectodermal dysplasia. Am J Hum Genet. 81: , 2007.

Traas, A. M., Casal, M., Haskins, M., Henthorn, P. Genetic counseling in the era of molecular diagnostics. Theriogenology 66: 599-605, 2006.

Casal, M. L., Munuve, R. M., Janis, M. A., Werner, P., Henthorn, P. S. Idiopathic epilepsy in the Irish wolfhound. J Vet Int Med 20: 131-135., 2006.

von Bomhard, W., Mauldin, E.A., Schmutz, S.M., Leeb, T., Casal, M.L. Black hair follicular dysplasia in Large Münsterländer dogs: clinical, histological and ultrastructural features. Veterinary Dermatology 17: 182-188, 2006.

Casal, M. L. Effects of pregnancy on complete blood cell counts and serum biochemical profiles in dogs. Society for Theriogenology. St. Paul, MN. : , 2006.

Casal, M. L. Erbrankheiten (Inherited Diseases). Praktikum der Hundeklinik 10th ed.: , 2006.

Goldschmidt, M. H., Kennedy, J. S., Kennedy, D. R., Yuan, H., Holt, D. S., Casal, M. L., Traas, A. M., Mauldin, E. A., Moore, P. F., Henthorn, P. S., Hartnett, B., J., Weinberg, K. I., Schlegel, R., Felsburg, P. J. Severe papillomavirus infection progressing to metastatic squamous cell carcinoma in bone marrow transplanted X-linked SCID dogs. J Virol 80: 6621-6628, 2006.

DVM (Medicus Veterinariae degree ) University of Zürich, Switzerland, 1984

MS (Dr. phil. II degree ) University of Bern, Switzerland, 1988

PhD (Pathology ) University of Pennsylvania, 1999

European College of Animal Reproduction

University of Zürich, Switzerland (1984 to 1985)
Fellowship in the Department of Pathology

Basle, Switzerland (1985 to 1988)
Doctoral Thesis Research, Federal Institute of Vaccines

University Hospital and staff veterinarian at the Department of Reproduction, School of Veterinary Medicine, University of Zürich, Switzerland (1987 to 1989)
Veterinarian in charge of the research colony, Biological Central Laboratory

Department of Reproduction, School of Veterinary Medicine, University of Zürich, Switzerland (1989 to 1991)
Clinical instructor

School of Veterinary Medicine, University of Pennsylvania (1991 to 1994)
Resident in Medical Genetics

School of Veterinary Medicine, University of Pennsylvania and Children’s Hospital of Philadelphia (1994 to 1999)
Post-doctoral fellow

Department of Hematology/Oncology, University of Illinois at Chicago. (1999)
Post-doctoral fellowship