New Bolton Center Kennett Square, PA
Emergencies & Appointments:
Ryan Hospital Philadelphia, PA


Diplomate, American College of Veterinary Internal Medicine, Cardiology

Chair, Department of Clinical Sciences & Advanced Medicine, University of Pennsylvania School of Veterinary Medicine

Charlotte Newton Sheppard Endowed Chair of Medicine, University of Pennsylvania School of Veterinary Medicine

Professor, Department of Clinical Sciences & Advanced Medicine, University of Pennsylvania School of Veterinary Medicine

Associate Scholar, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania

Clinical Specialties: Cardiology, Cardiac Examinations, Echocardiograms, ECG, Non-invasive & Invasive Surgeries,
Research Areas: Animal models of heart disease Heart Disease Myxomatous mitral valve disease Cardiac biomarkers Clinical trials Epidemiology Biostatistics Diuretic resistance
PubMed Link
Contact Information:
Department of Clinical Studies-Philadelphia
Ryan Veterinary Hospital of the University of Pennsylvania
School of Veterinary Medicine
University of Pennsylvania
3900 Spruce St.

Cardiac biomarkers (troponin, natriuretic peptides [BNP, ANP])
Diuretic resistance
Clinical trials
Serotonin signaling and myxomatous valve disease
Animal models of heart disease and heart failure
Epidemiology and biostatistics

Canine and feline models of heart disease
Molecular mechanisms of myxomatous mitral valve disease
Diuretic resistance
Epidemiology and biostatistics

Pedro B, Dukes-McEwan J, Oyama MA, Kraus MS, Gelzer AR Retrospective evaluation of the effect of heart rate on survival in dogs with atrial fibrillation J Vet Intern Med : , 2017.

Wallner M, Eaton DM, Berretta RM, Borghetti G. Wu J, Baker ST, Feldstott EA, Shart TE, Mohsin S, Oyama MA, von Lewinski D, Wolfson MR, Houser SR A feline HFpEF model with pulmonary hypertension and compromised pulmonary function Sci Rep 29: 16587, 2017.

Oyama MA, Ellenberg SS, Shaw PA Clinical trials in veterinary medicine: a new era brings new challenges J Vet Intern Med 31: 970-978, 2017.

Oyama MA, Solter PF, Thorn CL, Stern JA Feasibility, safety, and tolerance of subcutaneous synthetic canine B-type natriuretic peptide (syncBNP) in healthy dogs and dogs with stage B1 mitral valve disease J Vet Cardiol 19: 211-217, 2017.

Hezzell M J, Rush J E, Humm K, Rozanski E A, Sargent J, Connolly D J, Boswood A, Oyama M A Differentiation of Cardiac from Noncardiac Pleural Effusions in Cats using Second-Generation Quantitative and Point-of-Care NT-proBNP Measurements. Journal of veterinary internal medicine / American College of Veterinary Internal Medicine 30: 536-42, 2016.

Solter Philip F, Oyama Mark A, Machen Maggie C, Trafny Dennis J, Sisson D David Detection by ELISA of C-terminal proBNP in plasma from cats with cardiomyopathy. Veterinary journal (London, England : 1997) 206: 213-7, 2015.

Pouchelon J L, Atkins C E, Bussadori C, Oyama M A, Vaden S L, Bonagura J D, Chetboul V, Cowgill L D, Elliot J, Francey T, Grauer G F, Fuentes V Luis, Moise N Sydney, Polzin D J, Van Dongen A M, Van Israël N Cardiovascular-renal axis disorders in the domestic dog and cat: a veterinary consensus statement. The Journal of small animal practice 56: 537-52, 2015.

Oyama Mark A Perioperative Monitoring of Heart Rate and Rhythm. The Veterinary clinics of North America. Small animal practice 45: 953-63, 2015.

Oyama Mark A Using Cardiac Biomarkers in Veterinary Practice. Clinics in laboratory medicine 35: 555-66, 2015.

Cremer S E, Moesgaard S G, Rasmussen C E, Zois N E, Falk T, Reimann M J, Cirera S, Aupperle H, Oyama M A, Olsen L H Alpha-smooth muscle actin and serotonin receptors 2A and 2B in dogs with myxomatous mitral valve disease. Research in veterinary science 100: 197-206, 2015.

DVM (Doctor Veterinary Medicine) University of Illinois, 1994

MSCE (Masters of Science in Clinical Epidemiology) University of Pennslyvania, 2015

Diplomate, American College of Veterinary Internal Medicine, Cardiology

Animal Medical Center New York, NY (1994 to 1995)
Small Animal Internship

University of California Davis, CA (1995 to 1997)
Cardiology Residency