New Bolton Center Kennett Square, PA
Emergencies & Appointments:
Ryan Hospital Philadelphia, PA


Diplomate European College of Veterinary Internal Medicine-Companion Animals (Oncology)

Assistant Professor of Immuno-Oncology, University of Pennsylvania School of Veterinary Medicine

Clinical Specialties: T cell-based immunotherapy, canine cancer
Research Areas: T cells in hematologic neoplasms, T cell-based immunotherapy
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Defining the prognostic and therapeutic role of T cells in hematologic neoplasms utilizing a multi-species comparative approach. Identification and appraisal of novel targets for T cell-based immunotherapy in clinical trials of canine patients with spontaneous and aggressive tumors bearing translational importance for human oncology.

Medical oncology

Zhang, H., Yu, P., Tomar, V. S., Chen, X., Atherton, M. J., Lu, Z., Zhang, H. G., Li, S., Ortiz, A., Gui, J., Leu, N. A., Yan, F., Blanco, A., Meyer-Ficca, M. L., Meyer, R. G., Beiting, D. P., Li, J., Nunez-Cruz, S., O'Connor, R. S., Johnson, L. R., Minn, A. J., George, S. S., Koumenis, C., Diehl, J. A., Milone, M. C., Zheng, H., Fuchs, S. Y. Targeting PARP11 to avert immunosuppression and improve CAR T therapy in solid tumors Nat Cancer 3: 808-820, 2022.

Gedney, A., Salah, P., Mahoney, J. A., Krick, E., Martins, R., Scavello, H., Lenz, J. A., Atherton, M. J. Evaluation of the anti-tumour activity of Coriolus versicolor polysaccharopeptide (I''m-Yunity) alone or in combination with doxorubicin for canine splenic hemangiosarcoma Veterinary and Comparative Oncology 20: 688-696, 2022.

Atherton, M. J., Rotolo, A., Haran, K. P., Mason, N. J. Case report: clinical and serological hallmarks of cytokine release syndrome in a canine B cell lymphoma patient treated with autologous CAR-T cells Front Vet Sci 9: 824982, 2022.

Atherton, M. J., Mason, N. J. Bite-size introduction to canine hematologic malignancies Blood Adv 6: 4073-4084, 2022.

Rotolo, A., Atherton, M. J., Kasper, B. T., Haran, K. P., Mason, N. J. Genetic re-direction of canine primary T cells for clinical trial use in pet dogs with spontaneous cancer STAR Protoc 2: 100905, 2021.

Lenz, J. A., Assenmacher, C. A., Costa, V., Louka, K., Rau, S., Keuler, N. S., Zhang, P. J., Maki, R. G., Durham, A. C., Radaelli, E., Atherton, M. J. Increased tumor-infiltrating lymphocyte density is associated with favorable outcomes in a comparative study of canine histiocytic sarcoma Cancer Immunology, Immunotherapy : , 2021.

LeBlanc, A. K., Atherton, M., Bentley, R. T., Boudreau, C. E., Burton, J. H., Curran, K. M., Dow, S., Giuffrida, M. A., Kellihan, H. B., Mason, N. J., Oblak, M., Selmic, L. E., Selting, K. A., Singh, A., Tjostheim, S., Vail, D. M., Weishaar, K. M., Berger, E. P., Rossmeisl, J. H., Mazcko, C. Veterinary Cooperative Oncology Group-Common Terminology Criteria for Adverse Events (VCOG-CTCAE v2) following investigational therapy in dogs and cats Veterinary and Comparative Oncology 19: 311-352, 2021.

Benjamin, S. E., Sorenmo, K. U., Krick, E. L., Salah, P., Walsh, K. A., Weinstein, N. M., Keuler, N. S., Avery, A. C., Atherton, M. J., Lenz, J. A. Response-based modification of CHOP chemotherapy for canine B-cell lymphoma Veterinary and Comparative Oncology 19: 541-550, 2021.

Pol, J. G., Atherton, M. J., Stephenson, K. B., Bridle, B. W., Workenhe, S. T., Kazdhan, N., McGray, A. R., Wan, Y., Kroemer, G., Lichty, B. D. Enhanced immunotherapeutic profile of oncolytic virus-based cancer vaccination using cyclophosphamide preconditioning J Immunother Cancer 8: , 2020.

Panjwani, M. K., Atherton, M. J., MaloneyHuss, M. A., Haran, K. P., Xiong, A., Gupta, M., Kulikovsaya, I., Lacey, S. F., Mason, N. J. Establishing a model system for evaluating CAR T cell therapy using dogs with spontaneous diffuse large B cell lymphoma Oncoimmunology 9: 1676615, 2020.

Atherton, M. J., Lenz, J. A., Mason, N. J. Sarcomas-A barren immunological wasteland or field of opportunity for immunotherapy? Veterinary and Comparative Oncology 18: 447-470, 2020.

Pol, J. G., Acuna, S. A., Yadollahi, B., Tang, N., Stephenson, K. B., Atherton, M. J., Hanwell, D., El-Warrak, A., Goldstein, A., Moloo, B., Turner, P. V., Lopez, R., LaFrance, S., Evelegh, C., Denisova, G., Parsons, R., Millar, J., Stoll, G., Martin, C. G., Pomoransky, J., Breitbach, C. J., Bramson, J. L., Bell, J. C., Wan, Y., Stojdl, D. F., Lichty, B. D., McCart, J. A. Preclinical evaluation of a MAGE-A3 vaccination utilizing the oncolytic Maraba virus currently in first-in-human trials Oncoimmunology 8: e1512329, 2019.

Pol, J. G., Atherton, M. J., Bridle, B. W., Stephenson, K. B., Le Boeuf, F., Hummel, J. L., Martin, C. G., Pomoransky, J., Breitbach, C. J., Diallo, J. S., Stojdl, D. F., Bell, J. C., Wan, Y., Lichty, B. D. Development and applications of oncolytic Maraba virus vaccines Oncolytic Virother 7: 117-128, 2018.

Atherton, M. J., Stephenson, K. B., Tzelepis, F., Bakhshinyan, D., Nikota, J. K., Son, H. H., Jirovec, A., Lefebvre, C., Dvorkin-Gheva, A., Ashkar, A. A., Wan, Y., Stojdl, D. F., Belanger, E. C., Breau, R. H., Bell, J. C., Saad, F., Singh, S. K., Diallo, J. S., Lichty, B. D. Transforming the prostatic tumor microenvironment with oncolytic virotherapy Oncoimmunology 7: e1445459, 2018.

Atherton, M. J., Stephenson, K. B., Nikota, J. K., Hu, Q. N., Nguyen, A., Wan, Y., Lichty, B. D. Preclinical development of peptide vaccination combined with oncolytic MG1-E6E7 for HPV-associated cancer Vaccine 36: 2181-2192, 2018.

BVSc (Veterinary Medicine) University of Bristol, 2005

PhD (Medical Sciences-Infection & Immunity) McMaster University , 2017

Diplomate European College of Veterinary Internal Medicine-Companion Animals (Oncology)

Royal Veterinary College, University of London (2008 to 2009)

Small Animal Hospital-University of Glasgow (2009 to 2013)

Department of Pathology & Molecular Medicine-McMaster University (2017 to 2018)
Post-doctoral Fellowship

Department of Biomedical Sciences-University of Pennsylvania School of Veterinary Medicine (2018 to 2021)
Shuman Translational Research Fellow