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    Pathobiology

    Michael J. Hogan, PhD

    Assistant Professor, Department of Pathobiology

    Additional Titles:

    Cell and Molecular Biology Graduate Group (GTV, MVP)

    The overarching goals of Dr. Hogan’s research laboratory are to uncover the mechanisms by which T cells mediate protection from viral infections and to translate these lessons into the design of new and improved mRNA vaccines against various diseases. Previously, he received his PhD from Penn under the mentorship of Drs. Drew Weissman (recipient of the 2023 Nobel Prize in Medicine) and Jim Hoxie, where he developed vaccine candidates against Zika virus and HIV. More recently, he did his postdoctoral training at Children’s Hospital of Philadelphia in the lab of Dr. Ike Eisenlohr, where he learned the skills he is currently using to study cellular immunity to mRNA vaccines. Find out more about the mRNA Initiative.

    View Pub Med Publications

    Hogan, M. J., Maheshwari, N., Begg, B. E., Nicastri, A., Hedgepeth, E. J., Muramatsu, H., Pardi, N., Miller, M. A., Reilly, S. P., Brossay, L., Lynch, K. W., Ternette, N., Eisenlohr, L. C.Cryptic MHC-E epitope from influenza elicits a potent cytolytic T cell response Nature Immunology 24: 1933-1946, 2023.

    Hogan, M. J., Pardi, N. mRNA vaccines in the COVID-19 pandemic and beyond Annual Review of Medicine 73: 17-39, 2022.

    Verbeke, R., Hogan, M. J., Lore, K., Pardi, N. Innate immune mechanisms of mRNA vaccines Immunity 55: 1993-2005, 2022.

    Saunders, K. O., Pardi, N., Parks, R., Santra, S., Mu, Z., Sutherland, L., Scearce, R., Barr, M., Eaton, A., Hernandez, G., Goodman, D., Hogan, M. J., Tombacz, I., Gordon, D. N., Rountree, R. W., Wang, Y., Lewis, M. G., Pierson, T. C., Barbosa, C., Tam, Y., Matyas, G. R., Rao, M., Beck, Z., Shen, X., Ferrari, G., Tomaras, G. D., Montefiori, D. C., Weissman, D., Haynes, B. F.Lipid nanoparticle encapsulated nucleoside-modified mRNA vaccines elicit polyfunctional HIV-1 antibodies comparable to proteins in nonhuman primates npj Vaccines 6: 50, 2021.

    Pardi, N., Hogan, M. J., Weissman, D. Recent advances in mRNA vaccine technology Current Opinion in Immunology 65: 14-20, 2020.

    Laczko, D., Hogan, M. J., Toulmin, S. A., Hicks, P., Lederer, K., Gaudette, B. T., Castano, D., Amanat, F., Muramatsu, H., Oguin, T. H., 3rd, Ojha, A., Zhang, L., Mu, Z., Parks, R., Manzoni, T. B., Roper, B., Strohmeier, S., Tombacz, I., Arwood, L., Nachbagauer, R., Kariko, K., Greenhouse, J., Pessaint, L., Porto, M., Putman-Taylor, T., Strasbaugh, A., Campbell, T. A., Lin, P. J. C., Tam, Y. K., Sempowski, G. D., Farzan, M., Choe, H., Saunders, K. O., Haynes, B. F., Andersen, H., Eisenlohr, L. C., Weissman, D., Krammer, F., Bates, P., Allman, D., Locci, M., Pardi, N. A single immunization with nucleoside-modified mRNA vaccines elicits strong cellular and humoral immune responses against SARS-CoV-2 in mice Immunity 53: 724-732 e7, 2020.

    Lederer, K., Castano, D., Gomez Atria, D., Oguin, T. H., 3rd, Wang, S., Manzoni, T. B., Muramatsu, H., Hogan, M. J., Amanat, F., Cherubin, P., Lundgreen, K. A., Tam, Y. K., Fan, S. H. Y., Eisenlohr, L. C., Maillard, I., Weissman, D., Bates, P., Krammer, F., Sempowski, G. D., Pardi, N., Locci, M. SARS-CoV-2 mRNA vaccines foster potent antigen-specific germinal center responses associated with neutralizing antibody generation Immunity 53: 1281-1295 e5, 2020.

    Bresk, C. A., Hofer, T., Wilmschen, S., Krismer, M., Beierfuss, A., Effantin, G., Weissenhorn, W., Hogan, M. J., Jordan, A. P. O., Gelman, R. S., Montefiori, D. C., Liao, H. X., Schmitz, J. E., Haynes, B. F., von Laer, D., Kimpel, J. Induction of tier 1 HIV neutralizing antibodies by envelope trimers incorporated into a replication competent vesicular stomatitis virus vector Viruses 11: , 2019.

    Hogan, M. J., Conde-Motter, A., Jordan, A. P. O., Yang, L., Cleveland, B., Guo, W., Romano, J., Ni, H., Pardi, N., LaBranche, C. C., Montefiori, D. C., Hu, S. L., Hoxie, J. A., Weissman, D.Increased surface expression of HIV-1 envelope is associated with improved antibody response in vaccinia prime/protein boost immunization Virology 514: 106-117, 2018.

    Pardi, N., Hogan, M. J., Porter, F. W., Weissman, D. mRNA vaccines – a new era in vaccinology Nature Reviews: Drug Discovery 17: 261-279, 2018.

    Pardi, N., Hogan, M. J., Naradikian, M. S., Parkhouse, K., Cain, D. W., Jones, L., Moody, M. A., Verkerke, H. P., Myles, A., Willis, E., LaBranche, C. C., Montefiori, D. C., Lobby, J. L., Saunders, K. O., Liao, H. X., Korber, B. T., Sutherland, L. L., Scearce, R. M., Hraber, P. T., Tombacz, I., Muramatsu, H., Ni, H., Balikov, D. A., Li, C., Mui, B. L., Tam, Y. K., Krammer, F., Kariko, K., Polacino, P., Eisenlohr, L. C., Madden, T. D., Hope, M. J., Lewis, M. G., Lee, K. K., Hu, S. L., Hensley, S. E., Cancro, M. P., Haynes, B. F., Weissman, D. Nucleoside-modified mRNA vaccines induce potent T follicular helper and germinal center B cell responses Journal of Experimental Medicine 215: 1571-1588, 2018.

    Pardi, N., Hogan, M. J., Pelc, R. S., Muramatsu, H., Andersen, H., DeMaso, C. R., Dowd, K. A., Sutherland, L. L., Scearce, R. M., Parks, R., Wagner, W., Granados, A., Greenhouse, J., Walker, M., Willis, E., Yu, J. S., McGee, C. E., Sempowski, G. D., Mui, B. L., Tam, Y. K., Huang, Y. J., Vanlandingham, D., Holmes, V. M., Balachandran, H., Sahu, S., Lifton, M., Higgs, S., Hensley, S. E., Madden, T. D., Hope, M. J., Kariko, K., Santra, S., Graham, B. S., Lewis, M. G., Pierson, T. C., Haynes, B. F., Weissman, D. Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination Nature 543: 248-251, 2017.

    Boyd, D. F., Peterson, D., Haggarty, B. S., Jordan, A. P., Hogan, M. J., Goo, L., Hoxie, J. A., Overbaugh, J. Mutations in HIV-1 envelope that enhance entry with the macaque CD4 receptor alter antibody recognition by disrupting quaternary interactions within the trimer Journal of Virology 89: 894-907, 2015.

    My research interests relate to understanding how protective immune responses are generated against viral diseases, with focuses on: the impact and mechanisms of unconventional T cell responses (e.g. non-classical MHC restriction, non-canonical open reading frames, and other unconventional epitopes), elucidating the interactions between CD4 T cells, CD8 T cells, and B cell responses to protect from viral illnesses, mechanisms of mRNA vaccine immunogenicity, and testing the immunogenicity of various mRNA vaccine designs in different animal species.

    Children’s Hospital of Philadelphia (2017 to 2023)
    Postdoctoral Fellow, Immunology

    Education:

    PhD (Cell and Molecular Biology) University of Pennsylvania, 2017
    BS (Biochemistry) Brown University, 2011

    Contact:

    Email:mihogan@upenn.edu

    University of Pennsylvania

    School of Veterinary Medicine

    3800 Spruce Street

    Philadelphia, PA 19104