New Bolton Center Kennett Square, PA
Emergencies & Appointments:
Ryan Hospital Philadelphia, PA

SUSAN W. VOLK, B.A., V.M.D., Ph.D.

Diplomate, American College of Veterinary Surgeons

Corinne R. and Henry Bower Professor of Surgery, University of Pennsylvania, School of Veterinary Medicine

Faculty, Bioengineering Graduate Group

Clinical Specialties: Soft-Tissue Surgery,
Research Areas: Wound repair and regeneration Extracellular Matrix Scar formation and fibrosis Regenerative medicine Cell-based therapies Tumor microenvironment
PubMed Link
Contact Information:
Section of Surgery
Department of Clinical Studies - Philadelphia
University of Pennsylvania School of Veterinary Medicine
312 Hill Pavilion
380 S. University Ave

The goals of the Volk laboratory are to understand regulatory mechanisms governing dynamic interactions between cells and their surrounding extracellular matrix in the wound healing-fibrosis-cancer progression triad and to apply this knowledge to develop innovative regenerative and oncologic therapies for veterinary and human patients.

As a board-certified veterinary surgeon, I see clinical surgical appointments, perform surgery at the Ryan Veterinary Hospital of the University of Pennsylvania, and teach small animal surgery to veterinary students. My clinical interest focuses on cutaneous wounds and reconstruction with specific expertise in regenerative medical therapies. I have a specific interest in cell-based therapies and hope that my research focus in this field will lead to the development of novel approaches to improve healing of various organs/tissues in my veterinary patients as well as humans.

Ortiz Angelica, Gui Jun, Zahedi Farima, Yu Pengfei, Cho Christina, Bhattacharya Sabyasachi, Carbone Christopher J, Yu Qiujing, Katlinski Kanstantsin V, Katlinskaya Yuliya V, Handa Simran, Haas Victor, Volk Susan W, Brice Angela K, Wals Kim, Matheson Nicholas J, Antrobus Robin, Ludwig Sonja, Whiteside Theresa L, Sander Cindy, Tarhini Ahmad A, Kirkwood John M, Lehner Paul J, Guo Wei, Rui Hallgeir, Minn Andy J, Koumenis Constantinos, Diehl J Alan, Fuchs Serge Y An Interferon-Driven Oxysterol-Based Defense against Tumor-Derived Extracellular Vesicles. Cancer cell 35: 33-45.e6, 2019.

Garden O A, Volk S W, Mason N J, Perry J A Companion animals in comparative oncology: One Medicine in action. Veterinary journal (London, England : 1997) 240: 6-13, 2018.

Raposo-Ferreira Talita M M, Brisson Becky K, Durham Amy C, Laufer-Amorim Renee, Kristiansen Veronica, Puré Ellen, Volk Susan W, Sorenmo Karin Characteristics of the Epithelial-Mesenchymal Transition in Primary and Paired Metastatic Canine Mammary Carcinomas. Veterinary pathology 55: 622-633, 2018.

Case Ashley, Brisson Becky K, Durham Amy C, Rosen Suzanne, Monslow James, Buza Elizabeth, Salah Pascale, Gillem Julie, Ruthel Gordon, Veluvolu Sridhar, Kristiansen Veronica, Puré Ellen, Brown Dorothy C, Sørenmo Karin U, Volk Susan W Identification of prognostic collagen signatures and potential therapeutic stromal targets in canine mammary gland carcinoma. PloS one 12: e0180448, 2017.

Glennie Nelson D, Volk Susan W, Scott Phillip Skin-resident CD4+ T cells protect against Leishmania major by recruiting and activating inflammatory monocytes. PLoS pathogens 13: e1006349, 2017.

Sebastian Anil, Volk Susan W, Halai Poonam, Colthurst James, Paus Ralf, Bayat Ardeshir Enhanced Neurogenic Biomarker Expression and Reinnervation in Human Acute Skin Wounds Treated by Electrical Stimulation. The Journal of investigative dermatology 137: 737-747, 2017.

Rak Gregory D, Osborne Lisa C, Siracusa Mark C, Kim Brian S, Wang Kelvin, Bayat Ardeshir, Artis David, Volk Susan W IL-33-Dependent Group 2 Innate Lymphoid Cells Promote Cutaneous Wound Healing. The Journal of investigative dermatology 136: 487-96, 2016.

Han Ziying, Bart Stephen M, Ruthel Gordon, Vande Burgt Nathan H, Haines Kathleen M, Volk Susan W, Vite Charles H, Freedman Bruce D, Bates Paul, Harty Ronald N Ebola virus mediated infectivity is restricted in canine and feline cells. Veterinary microbiology 182: 102-7, 2016.

Shen Yu-I, Song Hyun-Ho G, Papa Arianne E, Burke Jacqueline A, Volk Susan W, Gerecht Sharon Acellular Hydrogels for Regenerative Burn Wound Healing: Translation from a Porcine Model. The Journal of investigative dermatology 135: 2519-29, 2015.

Glennie Nelson D, Yeramilli Venkata A, Beiting Daniel P, Volk Susan W, Weaver Casey T, Scott Phillip Skin-resident memory CD4+ T cells enhance protection against Leishmania major infection. The Journal of experimental medicine 212: 1405-14, 2015.

Brisson Becky K, Mauldin Elizabeth A, Lei Weiwei, Vogel Laurie K, Power Ashley M, Lo Albert, Dopkin Derek, Khanna Chand, Wells Rebecca G, Puré Ellen, Volk Susan W Type III Collagen Directs Stromal Organization and Limits Metastasis in a Murine Model of Breast Cancer. The American journal of pathology 185: 1471-86, 2015.

Miedel Emily L, Brisson Becky K, Hamilton Todd, Gleason Hadley, Swain Gary P, Lopas Luke, Dopkin Derek, Perosky Joseph E, Kozloff Kenneth M, Hankenson Kurt D, Volk Susan W Type III collagen modulates fracture callus bone formation and early remodeling. Journal of orthopaedic research : official publication of the Orthopaedic Research Society 33: 675-84, 2015.

Sebastian Anil, Iqbal Syed A, Colthurst James, Volk Susan W, Bayat Ardeshir Electrical stimulation enhances epidermal proliferation in human cutaneous wounds by modulating p53-SIVA1 interaction. The Journal of investigative dermatology 135: 1166-74, 2015.

Wormser C, Mariano A, Holmes E S, Aronson L R, Volk S W Post-transplant malignant neoplasia associated with cyclosporine-based immunotherapy: prevalence, risk factors and survival in feline renal transplant recipients. Veterinary and comparative oncology : , 2014.

Ud-Din Sara, Volk Susan W, Bayat Ardeshir Regenerative healing, scar-free healing and scar formation across the species: current concepts and future perspectives. Experimental dermatology 23: 615-9, 2014.

Volk Susan W, Shah Shalin R, Cohen Arthur J, Wang Yanjian, Brisson Becky K, Vogel Laurie K, Hankenson Kurt D, Adams Sherrill L Type III collagen regulates osteoblastogenesis and the quantity of trabecular bone. Calcified tissue international 94: 621-31, 2014.

Volk Susan W, Iqbal Syed Amir, Bayat Ardeshir Interactions of the Extracellular Matrix and Progenitor Cells in Cutaneous Wound Healing. Advances in wound care 2: 261-272, 2013.

Gordillo Gayle M, Bernatchez Stephanie F, Diegelmann Robert, Di Pietro Luisa A, Eriksson Elof, Hinz Boris, Hopf Harriet W, Kirsner Robert, Liu Paul, Parnell Laura K S, Sandusky George E, Sen Chandan K, Tomic-Canic Marjana, Volk Susan W, Baird Andrew Preclinical Models of Wound Healing: Is Man the Model? Proceedings of the Wound Healing Society Symposium. Advances in wound care 2: 1-4, 2013.

Volk Susan W, Bohling Mark W Comparative wound healing--are the small animal veterinarian's clinical patients an improved translational model for human wound healing research? Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 21: 372-81, 2013.

Volk Susan W, Theoret Christine Translating stem cell therapies: the role of companion animals in regenerative medicine. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 21: 382-94, 2013.

Adams Sherrill L, Margulies Susan, Volk Susan W Phoebe S. Leboy, groundbreaking activist for women in STEM. DNA and cell biology 31: 1439, 2012.

Volk Susan W, Wang Yanjian, Hankenson Kurt D Effects of donor characteristics and ex vivo expansion on canine mesenchymal stem cell properties: implications for MSC-based therapies. Cell transplantation 21: 2189-200, 2012.

Anwer Cona, Schwarz Tobias, Volk Susan W, Vite Charles BAER testing in a dog with bilateral external ear canal atresia. Journal of the American Animal Hospital Association 47: 370-4, 2011.

Volk SW*, Y Wang, EA Mauldin, KW Liechty and SL Adams Diminished type III collagen promotes myofibroblast differentiation and increases scar deposition in cutaneous wound healing. Cells, Tissues, Organs 194: 25-37, 2011.

B.A. University of Pennsylvania College of Arts and Sciences, 1991

V.M.D. University of Pennsylvania, 1995

Ph.D. University of Pennsylvania, 1998

Diplomate, American College of Veterinary Surgeons

School of Veterinary Medicine, University of Pennsylvania Philadelphia, PA (2000 to 2003)

School of Veterinary Medicine, University of Pennsylvania Philadelphia, PA (1999 to 2000)
Rotating Intern

Department of Biochemistry, School of Dental Medicine University of Pennsylvania, Philadelphia, PA (1998 to 1999)
Post-Doctoral Researcher