New Bolton Center Kennett Square, PA
Emergencies & Appointments:
Ryan Hospital Philadelphia, PA


Assistant Professor, Neurology and Neurosurgery, Clinician Educator, University of Pennsylvania School of Veterinary Medicine
Contact Information:

My research includes translational neuro-oncology and neuro-aging and primarily focuses on developing a comprehensive understanding of the regulatory signals that govern the immune system mobilization and/or exhaustion in patients suffering from CNS tumors and Canine Cognitive Dysfunction.

My clinical interests focus on management of canine patients with spontaneously occurring brain and spinal cord tumors as well as age-related neurodegenerative disorders.

Mondino, A., Khan, M., Case, B., Fefer, G., Panek, W. K., Gruen, M. E., Olby, N. J. Winning the race with aging: age-related changes in gait speed and its association with cognitive performance in dogs Front Vet Sci 10: 1150590, 2023.

Salzman, M. M., Merten, N., Panek, W. K., Fefer, G., Mondino, A., Westermeyer, H. D., Gruen, M. E., Olby, N. J., Mowat, F. M. Age-associated changes in electroretinography measures in companion dogs Doc Ophthalmol 147: 15-28, 2023.

Fefer, G., Khan, M. Z., Panek, W. K., Case, B., Gruen, M. E., Olby, N. J. Relationship between hearing, cognitive function, and quality of life in aging companion dogs Journal of Veterinary Internal Medicine 36: 1708-1718, 2022.

Fefer, G., Panek, W. K., Khan, M. Z., Singer, M., Westermeyer, H. D., Mowat, F. M., Murdoch, D. M., Case, B., Olby, N. J., Gruen, M. E. Use of cognitive testing, questionnaires, and plasma biomarkers to quantify cognitive impairment in an aging pet dog population Journal of Alzheimer's Disease 87: 1367-1378, 2022.

Hebel, M., Panek, W. K., Ruszkowski, J. J., Nabzdyk, M., Niedzielski, D., Pituch, K. C., Jackson, A. M., Kielbowicz, M., Pomorska-Mol, M. Computed tomography findings in a cohort of 169 dogs with elbow dysplasia - a retrospective study BMC Veterinary Research 17: 296, 2021.

Panek, W. K., Murdoch, D. M., Gruen, M. E., Mowat, F. M., Marek, R. D., Olby, N. J. Plasma amyloid beta concentrations in aged and cognitively impaired pet dogs Molecular Neurobiology 58: 483-489, 2021.

Rashidi, A., Miska, J., Lee-Chang, C., Kanojia, D., Panek, W. K., Lopez-Rosas, A., Zhang, P., Han, Y., Xiao, T., Pituch, K. C., Kim, J. W., Talebian, M., Fares, J., Lesniak, M. S. GCN2 is essential for CD8(+) T cell survival and function in murine models of malignant glioma Cancer Immunology, Immunotherapy 69: 81-94, 2020.

Kanojia, D., Panek, W. K., Cordero, A., Fares, J., Xiao, A., Savchuk, S., Kumar, K., Xiao, T., Pituch, K. C., Miska, J., Zhang, P., Kam, K. L., Horbinski, C., Balyasnikova, I. V., Ahmed, A. U., Lesniak, M. S. BET inhibition increases betaIII-tubulin expression and sensitizes metastatic breast cancer in the brain to vinorelbine Science Translational Medicine 12: , 2020.

Panek, W. K., Gruen, M. E., Murdoch, D. M., Marek, R. D., Stachel, A. F., Mowat, F. M., Saker, K. E., Olby, N. J. Plasma neurofilament light chain as a translational biomarker of aging and neurodegeneration in dogs Molecular Neurobiology 57: 3143-3149, 2020.

Cordero, A., Kanojia, D., Miska, J., Panek, W. K., Xiao, A., Han, Y., Bonamici, N., Zhou, W., Xiao, T., Wu, M., Ahmed, A. U., Lesniak, M. S. FABP7 is a key metabolic regulator in HER2+ breast cancer brain metastasis Oncogene 38: 6445-6460, 2019.

Panek, W. K., Pituch, K. C., Miska, J., Kim, J. W., Rashidi, A., Kanojia, D., Lopez-Rosas, A., Han, Y., Yu, D., Chang, C. L., Kane, J. R., Zhang, P., Cordero, A., Lesniak, M. S. Local application of autologous platelet-rich fibrin patch (PRF-P) suppresses regulatory T cell recruitment in a murine glioma model Molecular Neurobiology 56: 5032-5040, 2019.

Miska, J., Lee-Chang, C., Rashidi, A., Muroski, M. E., Chang, A. L., Lopez-Rosas, A., Zhang, P., Panek, W. K., Cordero, A., Han, Y., Ahmed, A. U., Chandel, N. S., Lesniak, M. S. HIF-1alpha is a metabolic switch between glycolytic-driven migration and oxidative phosphorylation-driven immunosuppression of tregs in glioblastoma Cell Reports 27: 226-237 e4, 2019.

Zhang, P., Miska, J., Lee-Chang, C., Rashidi, A., Panek, W. K., An, S., Zannikou, M., Lopez-Rosas, A., Han, Y., Xiao, T., Pituch, K. C., Kanojia, D., Balyasnikova, I. V., Lesniak, M. S. Therapeutic targeting of tumor-associated myeloid cells synergizes with radiation therapy for glioblastoma Proceedings of the National Academy of Sciences of the United States of America 116: 23714-23723, 2019.

Pituch, K. C., Miska, J., Krenciute, G., Panek, W. K., Li, G., Rodriguez-Cruz, T., Wu, M., Han, Y., Lesniak, M. S., Gottschalk, S., Balyasnikova, I. V. Adoptive transfer of IL13Ralpha2-specific chimeric antigen receptor t cells creates a pro-inflammatory environment in glioblastoma Molecular Therapy 26: 986-995, 2018.

Kim, Julius W, Pituch, Katarzyna C, Xiao, Annie, Young, Jacob S, Panek, Wojciech K, Muroski, Megan E, Rashidi, Aida, Kane, J Robert, Kanojia, Deepak, Lesniak, Maciej S Gene/viral treatment approaches for malignant brain cancer : 211-227, 2018.

Kim, J. W., Kane, J. R., Panek, W. K., Young, J. S., Rashidi, A., Yu, D., Kanojia, D., Hasan, T., Miska, J., Gomez-Lim, M. A., Ulasov, I. V., Balyasnikova, I. V., Ahmed, A. U., Wainwright, D. A., Lesniak, M. S. A dendritic cell-targeted adenoviral vector facilitates adaptive immune response against human glioma antigen (CMV-IE) and prolongs survival in a human glioma tumor model Neurotherapeutics 15: 1127-1138, 2018.

Kim, J. W., Miska, J., Young, J. S., Rashidi, A., Kane, J. R., Panek, W. K., Kanojia, D., Han, Y., Balyasnikova, I. V., Lesniak, M. S. A comparative study of replication-incompetent and -competent adenoviral therapy-mediated immune response in a murine glioma model Mol Ther Oncolytics 5: 97-104, 2017.

Panek, W. K., Kane, J. R., Young, J. S., Rashidi, A., Kim, J. W., Kanojia, D., Lesniak, M. S. Hitting the nail on the head: combining oncolytic adenovirus-mediated virotherapy and immunomodulation for the treatment of glioma Oncotarget 8: 89391-89405, 2017.

Panek, W. K., Khan, O. F., Yu, D., Lesniak, M. S. Multiplexed nanomedicine for brain tumors: nanosized Hercules to tame our Lernaean Hydra inside? Nanomedicine (Lond) 12: 2435-2439, 2017.

Yu, D., Khan, O. F., Suva, M. L., Dong, B., Panek, W. K., Xiao, T., Wu, M., Han, Y., Ahmed, A. U., Balyasnikova, I. V., Zhang, H. F., Sun, C., Langer, R., Anderson, D. G., Lesniak, M. S. Multiplexed RNAi therapy against brain tumor-initiating cells via lipopolymeric nanoparticle infusion delays glioblastoma progression Proceedings of the National Academy of Sciences of the United States of America 114: E6147-E6156, 2017.

DVM (Veterinary Medicine) Wroclaw University of Environmental and Life Sciences, Poland., 2013

University of California-Davis Veterinary Medical Teaching Hospital (2020 to 2023)
Resident in Small Animal Neurology/Neurosurgery

North Carolina State University, Department of Clinical Sciences, College of Veterinary Medicine. (2018 to 2020)
Post-Doctoral Fellow in Age-related Neurodegenerative Diseases in Companion Dogs

Northwestern University Feinberg School of Medicine, Chicago, IL. Department of Neurological Surgery. (2016 to 2018)
Post-Doctoral Fellow in Neuro-Oncology