New Bolton Center Kennett Square, PA
Emergencies & Appointments:
Ryan Hospital Philadelphia, PA


Assistant Professor, Pathobiology, University of Pennsylvania School of Veterinary Medicine

Research Areas: Host-pathogen interactions, Vector biology, Malaria, Complement, Innate immunity
PubMed Link
Contact Information:
Department of Pathobiology
School of Veterinary Medicine
3800 Spruce St., Room 390 ED

Our main research interest is innate immune recognition and elimination of pathogens. Our work focuses on the interaction between mosquitoes and the animal and human pathogens they transmit. As insects are the most species-rich group of animals on the planet and occupy a vast array of ecological niches, they are a fantastic example of the potentcy of innate defenses.

Rather than passive carriers of malaria, mosquitoes are actually amazing parasite killers. In fact, the vast majority of the parasites ingested when a mosquito bites a malarious person are attacked and eliminated before they can mount an infection. It is the few parasites that survive (even one is sufficient), that are ultimately responsible for disease transmission.

Some of the questions we are addressing:

-What is the basis of pathogen recognition by the mosquito innate immune system and how do some pathogens manage to escape?

-What is the biochemical mechanism leading from innate recognition to pathogen killing?

-How does mosquito physiology interface with innate immune activation?

Arthropod vectors such as mosquitoes, sand flies and ticks are responsible for transmission of a large number of animal and human diseases worldwide. Studying these organisms may reveal general insights about innate immune defense mechanisms as well as provide novel avenues for controlling the terrible diseases they spread.

Upton LM, Povelones M, Christophides GK. Anopheles gambiae blood feeding initiates an anticipatory defense response to Plasmodium berghei Journal of Innate Immunity 7: , 2015.

Neafsey DE, Waterhouse RM, Abai MR, Aganezov SS, Alekseyev MA, Allen JE, Amon J, Arcà B, Arensburger P, Artemov G, Assour LA, Basseri H, Berlin A, Birren BW, Blandin SA, Brockman AI, Burkot TR, Burt A, Chan CS, Chauve C, Chiu JC, Christensen M, Costantini C, Davidson VL, Deligianni E, Dottorini T, Dritsou V, Gabriel SB, Guelbeogo WM, Hall AB, Han MV, Hlaing T, Hughes DS, Jenkins AM, Jiang X, Jungreis I, Kakani EG, Kamali M, Kemppainen P, Kennedy RC, Kirmitzoglou IK, Koekemoer LL, Laban N, Langridge N, Lawniczak MK, Lirakis M, Lobo NF, Lowy E, MacCallum RM, Mao C, Maslen G, Mbogo C, McCarthy J, Michel K, Mitchell SN, Moore W, Murphy KA, Naumenko AN, Nolan T, Novoa EM, O'Loughlin S, Oringanje C, Oshaghi MA, Pakpour N, Papathanos PA, Peery AN, Povelones M, Prakash A, Price DP, Rajaraman A, Reimer LJ, Rinker DC, Rokas A, Russell TL, Sagnon N, Sharakhova MV, Shea T, Simão FA, Simard F, Slotman MA, Somboon P, Stegniy V, Struchiner CJ, Thomas GW, Tojo M, Topalis P, Tubio JM, Unger MF, Vontas J, Walton C, Wilding CS, Willis JH, Wu YC, Yan G, Zdobnov EM, Zhou X, Catteruccia F, Christophides GK, Collins FH, Cornman RS, Crisanti A, Donnelly MJ, Emrich SJ, Fontaine MC, Gelbart W, Hahn MW, Hansen IA, Howell PI, Kafatos FC, Kellis M, Lawson D, Louis C, Luckhart S, Muskavitch MA, Ribeiro JM, Riehle MA, Sharakhov IV, Tu Z, Zwiebel LJ, Besansky NJ. Mosquito genomics. Highly evolvable malaria vectors: the genomes of 16 Anopheles mosquitoes Science 347: , 2015.

Midega Janet, Blight Joshua, Lombardo Fabrizio, Povelones Michael, Kafatos Fotis, Christophides George K Discovery and characterization of two Nimrod superfamily members in Anopheles gambiae. Pathogens and global health 107: 463-74, 2013.

Povelones Michael, Christophides George K Meeting report of the Mosquito Kolymbari Meeting 2013. Pathogens and global health 107: 393-9, 2013.

Povelones Michael, Bhagavatula Lavanya, Yassine Hassan, Tan Lee Aun, Upton Leanna M, Osta Mike A, Christophides George K The CLIP-domain serine protease homolog SPCLIP1 regulates complement recruitment to microbial surfaces in the malaria mosquito Anopheles gambiae. PLoS pathogens 9: e1003623, 2013.

Povelones Michael, Upton Leanna M, Sala Katarzyna A, Christophides George K Structure-function analysis of the Anopheles gambiae LRIM1/APL1C complex and its interaction with complement C3-like protein TEP1. PLoS pathogens 7: e1002023, 2011.

Waterhouse Robert M, Povelones Michael, Christophides George K Sequence-structure-function relations of the mosquito leucine-rich repeat immune proteins. BMC genomics 11: 531, 2010.

Jaramillo-Gutierrez Giovanna, Rodrigues Janneth, Ndikuyeze Georges, Povelones Michael, Molina-Cruz Alvaro, Barillas-Mury Carolina Mosquito immune responses and compatibility between Plasmodium parasites and anopheline mosquitoes. BMC microbiology 9: 154, 2009.

Povelones Michael, Waterhouse Robert M, Kafatos Fotis C, Christophides George K Leucine-rich repeat protein complex activates mosquito complement in defense against Plasmodium parasites. Science (New York, N.Y.) 324: 258-61, 2009.

Chen Wei-Shen, Antic Dragana, Matis Maja, Logan Catriona Y, Povelones Michael, Anderson Graham A, Nusse Roel, Axelrod Jeffrey D Asymmetric homotypic interactions of the atypical cadherin flamingo mediate intercellular polarity signaling. Cell 133: 1093-105, 2008.

BA (Chemistry) Columbia University, 1995

PhD (Developmental Biology) Stanford University School of Medicine, 2004

Laboratory of Immunogenomics Imperial College London (2006 to 2013)
Vector-parasite interactions