Contact
New Bolton Center Kennett Square, PA
Emergencies & Appointments:
610-444-5800
Directions
Ryan Hospital Philadelphia, PA
Emergencies:
215-746-8911
Appointments:
215-746-8387
Directions

New Bolton Center
Research  Centers & Laboratories


Our faculty at New Bolton Center are engaged in ongoing groundbreaking research in topics ranging from Laminitis to Botulism. Here are examples of research centers and laboratories and the projects being investigated at New Bolton Center.

  • Animal Model Core & Comparative Orthopedic Research Lab (CORL)

    The Animal Model Core at Penn Vet New Bolton Center at the intersection of science and the rapid advancements in health care technology is an ecosystem supporting the continuum from discovery to invention to innovation in medical translation. We are invested in understanding the value proposition of emerging technologies under consideration and how they target unmet clinical needs. This process informs animal model development to enhance scientific rigor during in vivo studies in experimental or naturally occurring disease models. Studies can be iterative starting on a small scale leading towards pivotal non-clinical IND/IDE-enabling trials in support of FDA or OUS-FDA submissions.

    Read More About The Animal Model Core & Comparative Orthopedic Research Lab (CORL)
  • ASMG Laboratory - Microbial Genomics

    asmg-lab-new-bolton-center 500

    The Role of Microbes in Mediating Methane Emissions Final Colloquium Report Released

    Increased greenhouse gases leading to climate change are recognized as the main driver of record-breaking global heatwaves, which threaten human health and well-being. Microorganisms are important producers and consumers of major greenhouse gases, including methane (CH4). CH4 is ~80 times as po- tent as CO2 on a mass basis at trapping heat in the atmosphere over a 20-year period, significantly contributing to a warming planet. More.


    Could we breed cows that emit less methane?

    [August 2, 2023; Philadelphia, PA] Reducing methane emissions from livestock would benefit farmers and the environment. In a first step towards breeding low-methane-emitting cows, researchers from the University of Pennsylvania School of Veterinary Medicine and Pennsylvania State University have identified key differences between cows that naturally emit less methane than average. More.


    Dipti Pitta, PhD, Named Mark Whittier and Lila Griswold Allam Associate Professor at the University of Pennsylvania’s School of Veterinary Medicine

    [October 10, 2022; Philadelphia, PA] – Andrew M. Hoffman, DVM, DVSc, DACVIM, Gilbert S. Kahn Dean of the School of Veterinary Medicine at the University of Pennsylvania (Penn Vet) has named Dipti Pitta, PhD, an internationally recognized scholar working at the interface of microbiology, agriculture, and dairy nutrition, the Mark Whittier and Lila Griswold Allam Associate Professor. More.


    The Agricultural Systems and Microbial Genomics (ASMG) Laboratory was established to support Dr. Dou and Dr. Pitta in their research endeavors

    Dr. Pitta is the ruminant nutritionist and microbiologist at the Center for Animal Health and Productivity (CAHP), New Bolton Center, University of Pennsylvania.

    new-bolton-center-asmg-lab-microbial-genomics 400

    Research at the ASMG lab focuses primarily on the gut microbial composition of ruminants utilizing advanced molecular methodologies. The alimentary tract of a ruminant is colonized by millions of microbes living in a symbiotic relationship with the host. Therefore, knowledge of the microbial composition of the entire gut can provide insights into improving the overall health and productivity of the animal.

    The advent of next generation sequencers has greatly enhanced our ability to explore community microbial populations. The ASMG lab has the capabilities to isolate bacteria and methanogens from the gastrointestinal contents of different ruminant species as well as apply multi-omic approaches to better characterize and understand the functional potential of rumen microbiota. The primary areas of focus include deciphering dietary-microbe, microbe-microbe and host-microbe interactions that play essential roles in maintaining health and production while also minimizing negative impacts on the environment. Research efforts at ASMG are to understand the role of microbiota in ruminal methanogenesis and determine the impacts of different inhibitors on enteric methane inhibition, application of precision technologies to advance animal productivity and early life microbial interventions to improve health and welfare, and productivity of dairy cattle. Please research projects for further details.

    In addition, The ASMG group collaborates with other researchers and clinicians both within the University of Pennsylvania as well as at other institutions. Research findings are disseminated via publications and are presented at conferences. The ASMG group strives to educate and train next generation students in application of microbial genomics to help address global issues such as Food Insecurity, Climate Change, Sustainable Agricultural Systems, and Mitigation of Antimicrobial Resistance. Opportunities for students from diverse backgrounds, ranging from high school through postdoctoral are available at ASMG laboratory to further their careers in microbial genomics and its applications

    Read More About The ASMG Laboratory - Microbial Genomics
  • Equine Pharmacology Research Laboratory

    Dr. Mary Robinson, Equine Pharmacology

    Our Mission: The mission of the Equine Pharmacology Laboratory at New Bolton Center is to promote the welfare of the working horse and the integrity of sport through pharmacological and forensic research.

    Learn about us and our research...

     

    Read More About The Equine Pharmacology Research Laboratory
  • Havemeyer Equine Behavior Research Lab

    Semi-feral pony herd at New Bolton Center

    The Equine Behavior Program and Laboratory at New Bolton Center has grown from within the Section of Reproductive Studies.  Since the early 1980s the program, has had research as its core activity.  The program has included involvement in related clinical and teaching in the veterinary school and continuing education programs nationally and internationally.  The initial research focus of the laboratory was on stallion reproductive physiology and behavior. 

    Early research concentrated on the physiology and pharmacology of libido, erection, and ejaculation, with immediate application to clinical problems in breeding stallions and with relevance to the understanding of human sexual dysfunction. 

    Another long-standing research interest of our laboratory has been the effects of experience on sexuHavemeyer Barnal function.  In the 1990s our research and clinical work expanded beyond stallions to include reproductive and general behavior problems of horses.

    The Behavior Lab is housed in The Havemeyer Barn at The Georgia and Philip Hofmann Center for Animal Reproduction. 

    Read More About The Havemeyer Equine Behavior Research Lab
  • Marshak Dairy

    Marshak Dairy, New Bolton Center

    The Marshak Dairy is named in honor of Robert Marshak, the ninth dean of the School of Veterinary Medicine whose support was instrumental in establishing the farm. Built in 1996, the greenhouse dairy was the first of its kind and was recognized as a dairy of distinction in 1998. The greenhouse design uses natural lighting and excellent ventilation within the barn to promote a healthy environment for the cows.

    The Marshak Dairy provides an easily accessible working dairy farm for research trials. In addition, the Dairy serves as a laboratory for teaching students on topics related to cow healthcare, preventive medicine, nutrition and food safety.

    Read More About The Marshak Dairy
  • Ortved Orthopedic Regenerative Medicine Laboratory

    Joint injuries are overwhelmingly common in both human and equine athletes. Chondrocytes, the sole cell type in cartilage, are responsible for producing and maintaining the extra-cellular matrix (ECM), which affords remarkable tensile and compressive strength to the joint surface. Once damaged, cartilage has little to no ability to heal itself. Therefore, post-traumatic osteoarthritis (PTOA) commonly develops following joint trauma, whether sustained during an acute injury or accumulated overtime.

    Lab Mission

    • To improve cartilage repair using stem cell and gene therapy.
    • To limit the long-term effects of joint trauma through gene therapy immunomodulation of the joint.
    • To further elucidate the pathogenesis of post-traumatic osteoarthritis (PTOA).
        Read More About The Ortved Orthopedic Regenerative Medicine Laboratory
  • PEARL-Penn Equine Assisted Reproduction Laboratory

    PEARL ICSI ProcedureLed by Katrin Hinrichs, DVM, PhD, DACT, the Harry Werner Endowed Professor of Equine Medicine and Chair of the Department of Clinical Studies-New Bolton Center, the Penn Equine Assisted Reproduction Laboratory (PEARL) performs both research and clinical work in equine assisted reproduction. The Laboratory conducts research into equine sperm capacitation (readiness for fertilization), oocyte maturation, intracytoplasmic sperm injection (ICSI), standard in vitro fertilization, and equine embryo development, and is one of the few laboratories in the United States performing clinical ICSI to produce foals from client mares and stallions. Dr. Hinrichs has pioneered research in these areas, producing the first foal from ICSI and embryo culture in North America in 2003, and the first cloned horse foal in North America in 2005. 

    Dr. Hinrichs’ research has established methods for equine assisted reproductive techniques that are now used clinically worldwide, including methods for successfully holding and shipping equine oocytes, for performing equine embryo biopsy, which allows genetic diagnosis of embryos before transfer to avoid production of foals with genetic diseases, and methods for successful vitrification (freezing) of expanded equine blastocysts, which allows embryos to be produced from older or valuable mares year-round while still supporting the production of foals that have early birth dates.

    Read More About The PEARL-Penn Equine Assisted Reproduction Laboratory
  • Reference Andrology Laboratory

    The Reference Andrology Laboratory provides complete testing of neat, cooled and frozen-thawed semen from mammalian and avian species. The primary purpose of these services is to aid practitioners in their differential diagnosis of individual/herd/flock reproductive problems.

    These services are also frequently used by practitioners and studs as a third-party quality control component in an ongoing stud auditing process.

    The laboratory strives to perform objective, validated techniques for assessing samples for the basic spermiogram parameters of sample volume, motility, morphology, and concentration. With advanced notification, we will also try to accommodate requests for supplemental assessment techniques on sperm subcellular structures. We also offer semen extender analysis and microbiological testing of the extended semen product and purified water used in extenders. 

    Read More About The Reference Andrology Laboratory
  • Swine Teaching and Research Center
    Penn Vet's Swine facilityToday the US swine industry finds itself confronted with rapidly changing public opinion and policy on how gestating sows should be housed. Penn Vet is uniquely positioned to provide the industry with relevant scientific data collected from this living laboratory. Read More About The Swine Teaching and Research Center
  • van Eps Laminitis Laboratory

    The van Eps Laminitis and Endocrinology Laboratory at New Bolton Center is focused on understanding the key events that drive laminitis under different circumstances in order to develop reliable means of prevention and treatment.  

    We take a multidisciplinary approach to the study of laminitis utilizing 

    • Advanced imaging and sensor-based techniques to evaluate structure and function of the foot in health and disease 
    • Molecular techniques to examine events at a tissue level. 
    • Biomechanical testing to study mechanical function both in vivo and ex vivo 

    We are also focused on developing and refining tests and novel biomarkers of endocrine dysfunction, the most common cause of laminitis in horses and ponies.

    More about the van Eps Lab

    Read More About The van Eps Laminitis Laboratory