Recent Publications

– 2021 –

  1. Farnham M, Ortved KF, Homer JS, Wagner NJ, Burris DL, Price C. Lubricant effects on articular cartilage sliding biomechanics under physiological fluid load support. Tribology Letters, 2021.
  2. Farnham M, Ortved KF, Burris DL, Price C. Articular cartilage friction, strain, and viability under physiological to pathological benchtop sliding conditions. Cellular and Molecular Bioengineering, 14:349-363, 2021.
  3. Connard SS, Linardi RL, Even KM, Berglund AK, Schnabel LV, Ortved KF. Effects of continuous passage on the immunomodulatory properties of equine bone marrow-derived mesenchymal stem cells in vitro. Vet Immunol Immunopathol, 234:110203, 2021.
  4. Cameron AD, Even KM, Linardi RL, Berglund AK, Schnabel LV, Engiles JE, Ortved KF. Investigation of the effects of AAV-mediated overexpression of IL-10 on the immunomodulatory properties of equine BM-MSCs. Human Gene Therapy, 2021.
  5. Gaesser AM, Underwood C, Even KM, Linardi RL, Reef VB, Engiles JE, Ortved KF. Evaluation of autologous protein solution injection for treatment of superficial digital flexor tendonitis in an equine model. Frontiers Vet Regen Med, 2021.
  6. Cianci JM, Wulster KB, Richardson DW, Stefanovski D, Ortved KF. Computed tomographic assessment of fracture characteristics and subchondral bone injury in Thoroughbred racehorses with lateral condylar fractures and their relationship to outcome. Vet Surg, 2021.

– 2020 –

  1. Moss KL, Jiang Z, Linardi RL, Gale AL, Dodson ME, Grzybowski C, Haughan J, Robinson M, Ortved KF. Sustained interleukin-10 transgene expression following intraarticular AAV5-IL-10 administration to horses. Human Gene Therapy, 31:110-118, 2020.
  2. Chapman HS,  Gale AL, Dodson ME, Linardi RL,Ortved KF. The effect of autologous platelet lysate on the differentiation potential of equine bone marrow-derived mesenchymal stem cells. Stem Cells Dev, 29:144-155, 2020.
  3. Brown KA, Davidson EJ, Johnson A, Wulster KB, Ortved KF. Assessment of intra-synovial inflammatory cytokines in horses with standing cone bean computed tomographic evidence of cervical articular process joint osteoarthritis. EVJ, 2020.
  4. Haughan J, Jiang Z, Stefanovski D, Moss KL, Ortved KF, Robinson MA. Detection of intra-articular gene therapy in horses using quantitative real time PCR in synovial fluid and plasma. Drug Testing and Analysis, 2020.

– 2019 –

  1. Doering AK, Reesink HR, Leudke LK, Moore C, Nixon AJ, Fortier LA, Ducharme NG, Ross MW, Richardson DW, Ortved KF. Return to racing after internal fixation of carpal slab fractures in Thoroughbred and Standardbred racehorses. Veterinary Surgery, 2019.
  2. Linardi RL, Dodson ME, Moss KL, King WJ. Ortved KF. The effect of autologous protein solution on the inflammatory cascade in stimulated equine chondrocytes. Frontiers Vet Regen Med, 6:64, 2019.
  3. Gale AL, Mammone RM, Linardi RL, McClung G, Ortved KF.  Comparison of the chondrogenic differentiation potential of equine synovial membrane-derived and bone marrow-derived mesenchymal stem cells. Frontiers Vet Regen Med, 6:2019.
  4. Gale AL, Linardi RL, Dodson ME, Ortved KF.  The effect of hypoxia on chondrogenesis of equine synovial membrane-derived and bone marrow-derived mesenchymal stem cells. BMC Vet Research, 15:201, 2019.
  5. Chapman H, Richardson DW, Ortved KF. Arthrodesis of the metacarpophalangeal and metatarsophalangeal joint to treat osteoarthritis in 17 horses. Veterinary Surgery, 48:850-857, 2019.

– 2012 - 2018 –

  1. Ortved KF, Begum L, Stefanovski D, Nixon AJ. AAV-mediated overexpression of IL-10 mitigates the inflammatory cascade in stimulated chondrocyte pellets. Current Gene Therapy, 18:171-179, 2018.
  2. Ortved KF, Goodale MB, Ober C, Maylin GA, Fortier LA. Plasma firocoxib concentrations after intra-articular injection of autologous conditioned serum prepared from firocoxib positive horses. Vet J, 2017.
  3. Griffin  D, Ortved KF, Nixon AJ, Bonassar L. Mechanical properties and structure- function relationships in articular cartilage repair using IGF-I gene therapy. Journal of Orthopedic Research, 34:149-153, 2016.
  4. Ortved KF, Austin BS,  Scimeca MS, Nixon  AJ. RNA interference mediated interleukin-1β silencing in inflamed chondrocytes decreases target and downstream catabolic responses. Arthritis 2016: 3484961, 2016.
  5. Ortved KF, Nixon AJ. Cell-based cartilage repair strategies for horses. Vet J 208:1-12, 2016.
  6. Ortved KF, Begum L, Mohammed HO, Nixon AJ. Implantation of rAAV5-IGF-I transduced autologous chondrocytes improves cartilage repair in full-thickness defects in the equine model. Molecular Therapy, 23:363-373, 2015.
  7. Ortved KF, Wagner B, Calcedo R, Wilson JM, Schaefer DM, Nixon AJ. Humoral and cell-mediated immune response, and growth factor synthesis after direct intra-articular injection of rAAV2-IGF-I or rAAV5-IGF-I in the equine middle carpal joint. Human Gene Therapy, 26:161-171, 2015.
  8. Ortved KF, Nixon AJ, Mohammed HO, Fortier LA. Treatment of subchondral bone cysts of the medial femoral condyle in mature horses with growth factor enhanced chondrocyte grafts: A retrospective study of 49 cases. Equine Vet J 44:606-613, 2012.