Comparative Immunotherapy Program Publications

Covers of scientific journals

  1. Bagley SJ, Logun M, Fraietta JA, Wang X, Desai AS, Bagley LJ, Nabavizadeh A, Jarocha D, Martins R, Maloney E, Lledo L, Stein C, Marshall A, Leskowitz R, Jadlowsky JK, Christensen S, Oner BS, Plesa G, Brennan A, Gonzalez V, Chen F, Sun Y, Gladney W, Barrett D, Nasrallah MP, Hwang WT, Ming GL, Song H, Siegel DL, June CH, Hexner EO, Binder ZA, O'Rourke DM. Intrathecal bivalent CAR T cells targeting EGFR and IL13Rα2 in recurrent glioblastoma: phase 1 trial interim results. Nat Med. 2024 May;30(5):1320-1329. doi: 10.1038/s41591-024-02893-z. Epub 2024 Mar 13. PMID: 38480922.

  2. Hogan MJ, Maheshwari N, Begg BE, Nicastri A, Hedgepeth EJ, Muramatsu H, Pardi N, Miller MA, Reilly SP, Brossay L, Lynch KW, Ternette N, Eisenlohr LC. Cryptic MHC-E epitope from influenza elicits a potent cytolytic T cell response. Nat Immunol. 2023 Nov;24(11):1933-1946. doi: 10.1038/s41590-023-01644-5. Epub 2023 Oct 12. PMID: 37828378.

  3. Lee J, Boas FE, Duran-Struuck R, Gaba RC, Schachtschneider KM, Comin-Anduix B, Galic Z, Haile S, Bassir A, Chiang J. Pigs as Clinically Relevant Models for Synergizing Interventional Oncology and Immunotherapy. J Vasc Interv Radiol. 2024 Jun;35(6):809-817.e1. doi: 10.1016/j.jvir.2024.01.005. Epub 2024 Jan 12. PMID: 38219903.

  4. Rissi DR, Miller AD, Demeter EA, Church ME, Koehler JW. Diagnostic immunohistochemistry of primary and secondary central nervous system neoplasms of dogs and cats. J Vet Diagn Invest. 2024 Mar;36(2):153-168. doi: 10.1177/10406387231221858. Epub 2024 Jan 17. PMID: 38234003; PMCID: PMC10929637.

  5. Sho Yoshimoto, Nicholas Chester, Ailian Xiong, Enrico Radaelli, Hong Wang, Marc Brillantes, Gayathri Gulendran, Patrick Glassman, Don L. Siegel & Nicola J. Mason (2023) Development and pharmacokinetic assessment of a fully canine anti-PD-1 monoclonal antibody for comparative translational research in dogs with spontaneous tumors, mAbs, 15:1, DOI: 10.1080/19420862.2023.2287250
  6. Chong ACN, Vandana JJ, Jeng G, Li G, Meng Z, Duan X, Zhang T, Qiu Y, Duran-Struuck R, Coker K, Wang W, Li Y, Min Z, Zuo X, de Silva N, Chen Z, Naji A, Hao M, Liu C, Chen S. Checkpoint kinase 2 controls insulin secretion and glucose homeostasis. Nat Chem Biol. 2023 Nov 9. doi: 10.1038/s41589-023-01466-4. Epub ahead of print. PMID: 37945898. https://pubmed.ncbi.nlm.nih.gov/37945898/
  7. Rotolo A, Whelan EC, Atherton MJ, Kulikovskaya I, Jarocha D, Fraietta JA, Kim MM, Diffenderfer ES, Cengel KA, Piviani M, Radaelli E, Duran-Struuck R, Mason NJ. Unedited allogeneic iNKT cells show extended persistence in MHC-mismatched canine recipients. Cell Rep Med. 2023 Oct 17;4(10):101241. doi: 10.1016/j.xcrm.2023.101241. PMID: 37852175; PMCID: PMC10591065.
    https://pubmed.ncbi.nlm.nih.gov/37852175/
  8. Linnerbauer M, Beyer T, Nirschl L, Farrenkopf D, Lößlein L, Vandrey O, Peter A, Tsaktanis T, Kebir H, Laplaud D, Oellinger R, Engleitner T, Alvarez JI, Rad R, Korn T, Hemmer B, Quintana FJ, Rothhammer V. PD-L1 positive astrocytes attenuate inflammatory functions of PD-1 positive microglia in models of autoimmune neuroinflammation. Nat Commun. 2023 Sep 9;14(1):5555. doi: 10.1038/s41467-023-40982-8. PMID: 37689786; PMCID: PMC10492803. https://pubmed.ncbi.nlm.nih.gov/37689786/
  9. Woodrow JS, Hines M, Sommardahl C, Flatland B, Lo Y, Wang Z, Sheats MK, Lennon EM. Initial investigation of molecular phenotypes of airway mast cells and cytokine profiles in equine asthma. Front Vet Sci. 2023 Jan 11;9:997139. doi: 10.3389/fvets.2022.997139. PMID: 36713876; PMCID: PMC9875299. https://pubmed.ncbi.nlm.nih.gov/36713876/
  10. Gould EN, Szule JA, Wilson-Robles H, Steiner JM, Lennon EM, Tolbert MK. Esomeprazole induces structural changes and apoptosis and alters function of in vitro canine neoplastic mast cells. Vet Immunol Immunopathol. 2023 Feb;256:110539. doi: 10.1016/j.vetimm.2022.110539. Epub 2022 Dec 22. PMID: 36592548. https://pubmed.ncbi.nlm.nih.gov/36592548/
  11. Fuller AM, DeVine A, Murazzi I, Mason NJ, Weber K, Eisinger KT. Comparative oncology reveals DNMT3B as a therapeutic vulnerability in undifferentiated pleomorphic sarcoma. Cell Oncol. 2022 Dec; 45(6):1277-1295 doi: 10.1007/s13402-022-00717-1 https://pubmed.ncbi.nlm.nih.gov/36181640/
  12. Ellis GI, Deng MZ, Winn DW, Coker KE, Shukla D, Bhoj V, Milone MC, Duran-Struuck R, Riley JL. Generation of non-human primate CAR Tregs using artificial antigen-presenting cells, simian tropic lentiviral vectors, and antigen-specific restimulation. STAR Protoc. 2022 Nov 5;3(4):101784. doi: 10.1016/j.xpro.2022.101784. PMID: 36386869; PMCID: PMC9641266. https://pubmed.ncbi.nlm.nih.gov/36386869/
  13. Christian DA, Adams TA 2nd, Shallberg LA, Phan AT, Smith TE, Abraha M, Perry J, Ruthel G, Clark JT, Pritchard GH, Aronson LR, Gossa S, McGavern DB, Kedl RM, Hunter CA. cDC1 coordinate innate and adaptive responses in the omentum required for T cell priming and memory. Sci Immunol. 2022 Sep 30;7(75):eabq7432. doi: 10.1126/sciimmunol.abq7432. Epub 2022 Sep 30. PMID: 36179012; PMCID: PMC9835709. https://pubmed.ncbi.nlm.nih.gov/36179012/
  14. Rotolo, A., Atherton, M.J., Kasper, B.T., Haran, K.P., Mason, N.J.Genetic re-direction of canine primary T cells for clinical trial use in pet dogs with spontaneous cancer. STAR Protoc. 2021 Oct 22;2(4):100905. doi: 10.1016/j.xpro.2021.100905. https://pubmed.ncbi.nlm.nih.gov/34746864/
  15. Wang G., Wu M., Durham AC., Mason NJ., Roth DB. Canine Oncopanel: a capture-based, NGS platform for evaluating the mutational landscape and detecting driver mutations in canine cancers. Veterinary and Comparative Oncology. 19 July 2021https://doi.org/10.1111/vco.12746
  16. Church ME, Ceja G, McGeehan M, Miller MC, Farias P, Sánchez MD, Swain GP, Assenmacher CA, Stopa EG, Vite CH, Bar-Or A, Alvarez JI. Meningeal B Cell Clusters Correlate with Submeningeal Pathology in a Natural Model of Multiple Sclerosis. J Immunol. 2021 Jul 1;207(1):44-54. doi: 10.4049/jimmunol.2000514. Epub 2021 Jun 23. PMID: 34162727; PMCID: PMC8695639.
    https://pubmed.ncbi.nlm.nih.gov/34162727/
  17. LeBlanc, A., Atherton, M., Bentley, T.R., Boudreau, E., Burton, J., Curran, K., Dow, S., Giuffrida, M., Kellihan, H., Mason, N., Oblak, M., Selmic, L., Selting, K., Singh, A., Tjostheim, S., Vail, D., Weishaar, K., Berger, E., Rossmeisl, J., Mazcko, C. Veterinary Cooperative Oncology Group - Common Terminology Criteria for Adverse Events (VCOG-CTCAE v2) Following Investigational Therapy in Dogs and Cats. Vet Comp Oncol. 2021 Jun;19(2):311-352. doi: 10.1111/vco.12677.
    https://pubmed.ncbi.nlm.nih.gov/33427378/
  18. Mason NJ, Chester N., Xiong A., Rotolo A., Wu Y., Glassman P., Gulendran G., Siegel DL.Development of a fully canine anti-canine CTLA4 monoclonal antibody for comparative translational research in dogs with spontaneous tumors. MAbs. Jan-Dec 2021;13(1):2004638.doi: 10.1080/19420862.2021.2004638. https://pubmed.ncbi.nlm.nih.gov/34856888/
  19. Coppock GM, Aronson LR, Park J, Qiu C, Park J, DeLong JH, Radaelli E, Suszták K, Hunter CA. Loss of IL-27Rα Results in Enhanced Tubulointerstitial Fibrosis Associated with Elevated Th17 Responses. J Immunol. 2020 Jul 15;205(2):377-386. doi: 10.4049/jimmunol.1901463. Epub 2020 Jun 10. PMID: 32522836; PMCID: PMC7368461. https://pubmed.ncbi.nlm.nih.gov/32522836/