Chronic Wasting
Disease (CWD)
Chronic Wasting Disease (CWD) is caused by misfolded
prion proteins and is adversely affecting Pennsylvania deer
populations and poses a threat to their native elk
population. The Wildlife Futures Program is testing field
collected and hunter harvested samples for CWD and
advising the Pennsylvania Game Commission on best
management practices to ensure the health of our native
deer population.
In collaboration with the Pennsylvania Game Commission
and Penn State University, we have recently launched a
CWD field project. We are collaring white-tailed deer within
an established Disease Management Area (DMA 2) to inform
models of disease spread and to understand CWD-
associated mortality in Pennsylvania. A major aspect of this
work includes continued improvement of diagnostic testing
of samples from live animals. This will enable us to know the
CWD disease status of collared deer and provide the ability
to track them over time. The overarching goals are to
improve estimates of CWD prevalence and better
understand population level effects of CWD on
Pennsylvania deer.
With close ties to Pennsylvania Animal Diagnostic Lab
System’s (PADLS), the Wildlife Futures Program is
researching new ways to detect CWD from a diagnostic
standpoint. A newer technology, Real-Time Quaking
Induced Conversion (RT-QuIC), allows for sensitive and
specific identification of CWD prions from ever-increasing
sample sources. Sample types can include the current
standard for postmortem identification (lymph or brain
tissue), but can also include additional, easier to obtain
postmortem samples, antemortem samples, and even
environmental contamination sources.
Read the Fact Sheet on Chronic Wasting Disease