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Clifton, G.T., M.L. Rothenberg, P. Ascierto, G. Begley, M. Cecchini, P. Eder, F. Ghiringelli, A. Italiano, M. Kochetkova, R. Li, F. Mechta-Grigoriou, S. Pai, P. Provenzano, E. Puré, A. Ribas, K.A. Schalper, W.H. Fridman. 2023. Defining Immune Exclusion: Results of a modified Delphi Workshop. J. Immunother. Cancer. 11:e006773 doi10.1136/jitc-2023-006773. PMID 37290925 PMCID:PMC 10254706.
Zhong, W., Z. Xiao, Z. Qin, J. Yang, Y. Wen, Z. Yu, Y. Li, N.C. Sheppard, S. Fuchs, X. Xu, M. Herlyn, C.H. June, E. Puré and W. Guo. 2023. Tumor-derived small extracellular vesicles inhibit the efficacy of CAR T cells against solid tumors. Cancer Res. 83:2790-2806. PMID:37115855.
Espinet, E., L. Klein, E. Puré and S.K. Singh. 2022. Mechanisms of PDAC subtype heterogeneity and therapy response. In Press. Trends in Cancer. 8:1060-1071. PMID: 36117109.
Lee, I., E. Noguera-Ortega, Z. Xiao, L. Todd, J. Scholler, D. Song, M. Liouisa, K. Lohith. K.Xu, K. Edwards, M. Farwell, C.H. June, S. Albelda, E. Puré and M. Sellmyer. 2022. Monitoring therapeutic response to anti-fibroblast activation protein (FAP) CAR T cells using [18F]AIF-FAPI-74 PET. Clinical Cancer Research. 28:5330-5342. PMID: 35972732; PMCID: PMC9771904 (available 2023-06-15).
Verginadis, I.I., H. Avgousti, J. Monslow, G. Skoufos, F. Chinga, N.M. Leli, I.V. Karagounis, B.I. Bell, A. Velalopoulou, C.S. Salinas, V.S. Wu, Y. Li, J. Ye; D.A. Scott, A.L. Osterman, A. Sengupta, A. Weljie, M. Huang, D. Zhang, E. Radaelli, J.W. Tobias, F. Rambow, P. Karras, J.-C. Marine; X. Xu, A.G. Hatzigeorgiou, S. Ryeom, A.J. Diehl, S.Y. Fuchs, E. Puré and C. Koumenis. 2022. A stromal integrated stress response activates perivascular cancer-associated fibroblasts to drive support angiogenesis and tumor progression. Nature Cell Biol. 24:940-953. PMID:35654839.
Roby, K.C., Jr, A. Lieberman, B.J. Kim, N. Zaragoza Rodríguez, J.M. Posimo, T. Tsang, J. Verginadis3, E. Puré, D.C. Brady, C. Koumenis, S. Ryeom. 2022. Loss of p19Arf Promotes Fibroblast Survival During Leucine Deprivation Enhancing Tumor Progression. Biology Open. 11: bio058728.
Rurik, J.G., I. Tombácz, A. Yadegari, P.O. Mendez Fernandez, S.V. Shewale, L. Li, T. Kimura, O.Y. Soliman, T.E. Papp, Y.K. Tam, B.L. Mui, S.M. Albelda, E. Puré, C.H. June, H. Aghajanian, D. Weissman, H. Parhiz and J. A. Epstein. 2022. CAR T cells produced in vivo to treat cardiac injury. Science.375:91-96.
Gui, J., F. Zahedi, A. Ortiz,, C. Cho, K. Katlinski, K. Alicea-Torres, J. Li, L. Todd, D.P. Beiting, C. Sander, J.M. Kirkwood, B.E. Snow, A.C. Wakeham, T.W. Mak, J.A. Diehl, C. Koumenis, S.W. Ryeom, B.Z. Stanger, E. Puré, D.I. Gabrilovich and S.Y. Fuchs. 2020. Activation of the p38α stress-activated protein kinase drives the formation of the pre-metastatic niche in the lungs. Nature Cancer 1:603-619.
Monslow, J., L. Todd, J.E. Chojnowski, P.K. Govindaraju, R.K. Assoian and E. Puré. 2020. Fibroblast activation protein regulates lesion burden and the fibroinflammatory response in apoE-deficient mice in a sexually dimorphic manner. Amer. J. Pathology. 190:1118-1136. PMID: 32084369; PMCID: PMC7237832.
Vickman, R.E., D.V. Faget, P. Beachy, D. Bebee, N.A. Bhowmick, E. Cukierman, W.-M. Deng, J.G. Granneman, J. Hildesheim, R. Kalluri, K.S. Lau, E. Lengyel, J. Lundeberg, J. Moscat, P.S. Nelson, K. Pietras, K. Politi, E. Puré, R. Scherz-Shouval, M.H. Sherman, D. Tuveson, A.T. Weeraratna, R.M. White, M.H. Wong, E.C. Woodhouse, Y.Zheng, S.W. Hayward, S.A. Stewart. 2020. Deconstructing tumor heterogeneity: The stromal perspective. Oncotarget 11(40):3621-3632. PMID: 33088423. PMCID: PMC7546755.
Cho,C., R. Mukherjee, A.R. Peck, Y. Sun, N. McBrearty, K.V. Katlinski, J. Gui, P.K. Govindaraju, E. Puré, H. Rui and S.Y. Fuchs. 2020. Cancer-associated fibroblasts downregulate type I interferon receptor to stimulate intratumoral stromagenesis. Oncogene. 39(38):6129-6137. PMID:32807917. PMCID: PMC7502515.
Sahai, E., I. Astaturov, E. Cukierman, D. DeNardo, M. Egeblad, R.M. Evans, D. Fearon, F.R. Greten, S.R. Hingorani, T. Hunter, R.O. Hynes, R.K. Jain, T. Janowitz, C. Jorgensen, A. Kimmelman, M. Kolonin, R. Maki, S. Powers, E. Puré, D. Ramirez, R. Scherz-Shouval, M.H. Sherman, S. Stewart, T. Tlsty, D. Tuveson, F.M. Watt, V. Weaver, A. Weeraratna and Z. Werb. 2020. A framework for advancing our understanding of cancer-associated fibroblasts. Nat Rev Cancer. 20(3):174-186. PMID: 31980749 PMCID: PMC7046529.
Aghajanian, H., T. Kimura, J.G. Rurik, A.S. Hancock, M.S. Leibowitz, L. Li, J. Scholler, J. Monslow, A. Lo, W. Han, T. Wang, K. Bedi, M.P. Morley, R.A. Linares Saldana, N.A. Bolar, K. McDaid, C-A. Assenmacher, C.L. Smith, D. Wirth, C.H. June, K.B. Margulies, R. Jain, E. Puré, S.M. Albelda, J.A. Epstein. 2019. Targeting Cardiac Fibrosis with Engineered T cells. Nature. 573:430-433. PMID: 31511695.
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Blomberg, R., D.P. Beiting, M. Wabitsch and E. Puré. 2019 Fibroblast activation protein restrains adipogenic differentiation and regulates matrix-mediated mTOR signaling. Matrix Biol. 83:60-76. PMID: 31325484. PMCID: PMC6881546.
Lieberman, A., R. Barrett, J. Kim, K. Zhan, D. Avery, J. Monslow, H. Kim, B.-J. Kim, E. Puré and S, Ryeom. 2019. Deletion of calcineurin promotes a pro-tumorigenic fibroblast phenotype. Cancer Research. 79:3928-3939. PMID: 31189649.
Liu, S.-L., Bajpai, A., Hawthorne,E.A., Bae, Y., Castagnino, P., Monslow, J, Puré, E., Spiller, K.L. and R.K. Assoian. 2019. Cardiovascular protection in females linked to estrogen-dependent inhibition of arterial stiffening and macrophage MMP12. JCI Insight. 4:122742. PMCID: PMC6485356. PMID: 30626744.
Cremasco, V., J. Astarita, A.L. Grauel, S. Keerthivasan, K. MacIsaa, M.C. Woodruf, M. Wu, L. Spel, S. Santoro, Z. Amoozgar, K.W. Wucherpfennig, E. Puré, G. Dranoff, M.C. Carroll, S.J. Turley. 2018. FAP delineates heterogeneous and functionally divergent stromal cells in immune-excluded breast tumors. Cancer Immunol. Res. 6:1472-1485. PMID: 30266714. PMCID: PMC6597261.
Puré, E. and R. Blomberg. 2018. Pro-tumorigenic roles of fibroblast activation protein in cancer: back to the basics. PMID: 29720723. PMCID: PMC6092565.
Govindaraju, P., L. Todd, S. Shetye, J. Monslow, and E. Puré. 2018. CD44-dependent inflammation, fibrogenesis, and collagenolysis regulates extracellular matrix remodeling and tensile strength during cutaneous wound healing. Matrix Biol. 75-76:314-330. PMID: 29894820 PMCID: PMC6286871.
Avery, D., P. Govindaraju, M. Jacob, L. Todd, J. Monslow and E. Puré. 2018. Extracellular matrix directs phenotypic heterogeneity of activated fibroblasts. Matrix Biol. 67:90-106. PMID: 29248556 PMCID: PMC5910258.
Razinia, Z., P. Castaginino, T. Xu, A. Vasquez-Salgado, E. Puré and R.K. Assoian. 2017. Stiffness-dependent motility and proliferation uncoupled by deletion of CD44. Sci Rep. 7:16499. PMID: 29184125. PMCID: PMC5705666.
Kumar, V., L. Donthireddy, D. Marvel, T. Condamine, F. Wang, S. Lavilla-Alonso, A. Hashimoto, P. Vonteddu, R. Behara, M.A. Goins, C. Mulligan B. Nam, N. Hockstein, F. Denstman, S. Shakamuri, D.W. Speicher, A.T. Weeraratna, R.H. Vonderheide, L.R. Languino, P. Ordentlich, Q. Liu, X. Xu, A. Lo, E. Puré, C. Zhang, A. Loboda, M.A. Sepulveda, L.A. Snyder, D. Gabrilovich. 2017. Cancer-associated fibroblasts neutralize the anti-tumor effect of CSF-1 receptor blockade by inducing PMN-MDSC infiltration of tumors. Cancer Cell. 32:654-668. PMID: 28978805. PMCID: PMC5827952.
Lo, A., Li, C.-P., Buza, E.L., Blomberg, R., Govindaraju, P., Avery, D., Monslow, J., Hsiao, M., and E. Puré. 2017. Fibroblast activation protein augments progression and metastasis of pancreatic ductal adenocarcinoma. J. Clin. Invest. Insight. 2:92232 PMID: 28978805. PMCID: PMC5841864.
Katlinski, K.V, J. Gui, Y.V. Katlinskaya, A. Ortiz, R. Chakraborty, S. Bhattacharya, C.J. Carbone, D.P. Beiting, M.A. Girondo, A.R. Peck, E. Puré, P. Chatterji, A.K. Rustgi, J.A. Diehl, C. Koumenis, H. Rui and S.Y. Fuchs. 2017. Inactivation of interferon receptor promotes the establishment of immune-privileged tumor microenvironment. Cancer Cell. 31:194-207. PMID: 28196594 PMCID: PMC5313042.
Puré, E. and A. Lo. 2016. Masters In Immunology: Can targeting stroma pave the way to enhanced antitumor immunity and immunotherapy of solid tumors? Cancer Immunol Res, 4; 269–78 Invited contribution.
Liu, S.L., Y.H. Bae, C. Yu, J. Monslow, E.A. Hawthorne, P. Castagnino, E. Branchetti, G. Ferrari, S.M. Damrauer, E. Puré and R.K. Asssoian. 2015. Matrix metalloproteinase-12 is an essential mediator of acute and chronic arterial stiffening. Sci Rep. 5:17189. doi: 10.1038/srep17189. PMID: 26608672.
Fan, M.-H., Q. Zhu, H.-H. Li, H.-J. Ra, S. Majumdar, D.L. Gulick, J.A, Jerome, D.H. Madsen, M. Christofidou-Solomidou, D.W. Speicher, W.W. Bachovchin, C. Feghali-Bostwick, E. Puré. 2015. Fibroblast Activation Protein (FAP) Accelerates Collagen Degradation and Clearance from the Lung in Mice. J. Biol. Chem. 291:8070-89. PMID:26663085
Lo, A., L.-C.S. Wang, J. Scholler, J. Monslow, D. Avery, K. Newick, S. O’Brien, R.A. Evans, D.J. Bajor, C. Clendenin, A.C. Durham, E.L. Buza, R.H. Vonderheide, C.H. June, S.M. Albelda and E. Puré. 2015. Tumor-promoting desmoplasia is disrupted by depleting FAP-expressing stromal cells. Cancer Research. 75(14):2800-2810. PMID: 25979873 PMCID: PMC4506263
Brisson, B.K., E.A. Mauldin, W. Lei, L.K. Vogel, A.M. Power, A. Lo, D. Dopkin, C. Khanna, R.G. Wells, E. Puré and S.W. Volk. 2015. Type III collagen directs stromal organization and limits metastasis in a murine model of breast cancer. Am J Pathol. 185:1471-86. PMID:2579528 PMCID: PMC4419211
Murty, S., T. Gilliland, P. Qiao, T. Tabtieng, E. Higbee, A. Al Zaki, E. Puré and A. Tsourkas. 2014 Nanoparticles functionalized with collagenase exhibit improved tumor accumulation in a murine xenograft model. Part Part Syst Charact. 31(12):1307-1312. PMID: 26380538 PMCID: PMC4569138
Bae,Y., K. Mui, B. Hsu, S. Liu, A. Cretu, A. Cretu, Z. Razinia, T. Xu, E. Puré, and R.K. Assoian. 2014. A FAK-Cas-Rac-lamellipodin signaling module transduces extracellular matrix stiffness into mechanosensitive cell cycling stiffness and mechanosensitive cell proliferation. Sci Signal. 7(330):ra57. PMID: 24939893 PMCID: PMC4345117.
Chopra, A., M.E. Murray, F.J. Byfield, M.G. Menendez, R. Halleluyan, D.J. Restle, R.-B. Aroush P.A. Galie, F. Byfield, R. Bucki, C. Marcinkiewicz, G.D. Prestwich, T.I. Zarembinski, C.S. Chen, E. Puré, J.Y. Kresh, P.A. Janmey. 2014. Augmentation of integrin-mediated mechanotransduction by hyaluronic acid. Biomaterials. 35:71-82. PMID: 21420037 PMCID: PMC3930571.
Wang, L.-C.S., A. Lo, J. Scholler, J. Sun, R.S. Majumdar, V. Kapoor, M. Antzis, C.E. Cotner, L.A. Johnson, A.C. Durham, C.C. Solomides, C.H. June, E. Puré, S.M. Albelda. 2013. Targeting fibroblast activation protein in tumor stroma with Chimeric Antigen Receptor T Cells can inhibit tumor growth and augment host immunity without severe toxicity. Cancer Immunol Res. 2(2):154-166 PMID: 24778279 PMCID: PMC4007316108.
Eisinger-Mathason, T.S.K., M. Zhang, Q. Qiu, N. Skuli, M.S. Nakazawa, T. Karakasheva, C. Mucaj, J.E.S. Shay, L. Stangenberg, E. Puré, S.S. Yoon, D.G. Kirsch, M.C. Simon. 2013. Hypoxia-dependent modification of the collagen networks promotes sarcoma metastasis. Cancer Discovery. 3(10):1190-205. PMID:23906982 PMCID: PMC3822914.
Tchou, J., P.J. Zhang, Y.T. Bi., C. Satija, R. Majumdar, T.L. Stephen, H.Y. Chen, C. Mies, M. Herlyn, J. Conejo-Garcia, C.H. June and E. Puré. 2013. Fibroblast activation protein expression by stromal cells and tumor-associated macrophages in human breast cancer. Human Pathology. 44(11):2549-57. PMID:24074532 PMCID: PMC4283499.
El-Dakdouki M.H., E. Puré, Huang X. 2013. Development of drug loaded nanoparticles for tumor targeting. Part 2: Enhancement of tumor penetration through receptor mediated transcytosis in 3D tumor models. Nanoscale. 5(9) :3904-3911. PMID : 23549322 PMCID : PMC3643122.
El-Dakdouki, M.H., E. Puré, X. Huang. 2013. Development of drug loaded nanoparticles for tumor targeting. Part 1: synthesis, characterization, and biological evaluation in 2D cell cultures. Nanoscale. 5(9):3895-3903. PMID: 23529646 PMCID : PMC3638024.
Tchou, J., A.V. Kossenkov, L. Chang, C. Satija, M. Herlyn, L.C. Showe and E. Puré. 2012. Human breast cancer associated fibroblasts exhibit subtype specific gene expression profiles. BMC Med. Genom. 5:39. PMID: 22954256 PMCID:PMC3505468.
Kinder, M. J.E. Thompson, C. Wei, S.G. Shelat, I.A. Blair, M. Carroll and E. Puré. 2010. Interferon regulatory factor-8 driven myeloid differentiation is regulated by 12/15-lipoxygenase-mediated redox signaling. Exp Hematol., 38:1036-1046. PMID: 20647020 PMCID: PMC2963586.
Kinder, M.,C. Wei, S.G. Shelat, M. Kundu, L. Zhao, I.A. Blair, E. Puré. 2010. Hematopoietic stem cell function requires 12/15-lipoxygenase-dependent fatty acid metabolism. Blood, 115:5012-5022. PMID: 20357242 PMCID: PMC2890149.
Santos, A.M., J. Jung, N Aziz, J.L. Kissil and E. Puré. 2009. Targeting fibroblast activation protein inhibits tumor stromagenesis and growth. J Clin Invest. 119:3613-3625. PMID 19920354 PMC 2786791.
Jacob, M., L.A. Todd, R.S. Majumdar, Y. Li, K.I. Yamamoto and E. Puré. 2009. Endogenous cAbl regulates receptor endocytosis. Cellular Signal. 21:1308-1316. PMID: 19344757. [PubMed - indexed for MEDLINE]
Mrass, P., I. Kinjyo, LG Ng, S.L. Reiner, E. Puré and W. Weninger. 2008. CD44 mediates successful interstitial navigation by killer T cells and enables efficient antitumor immunity. Immunity. 29:971-985 (accompanying Preview). PMCID: PMC2757129.
Kothapalli, D., J. Flowers, T. Xu, E. Puré and R.K. Assoian. 2008. Differential activation of Erk and Rac mediates the proliferative and anti-proliferative effects of hyaluronan and CD44. J. Biol. Chem. 283:31823-31829. PMCID: PMC2581577.
Zhao, L., E. Lee, A.M. Zukas, M.K. Middleton, M. Kinder, P.S. Acharya, R. Yahil, J.A. Hall, D.J. Rader and E. Puré. 2008. CD44 expressed on both bone marrow-derived and non-bone marrow-derived cells promotes atherogenesis in apoE-deficient mice. Arterioscler. Thromb. Vasc. Biol. 28:1283-1289. PMID: 18420998 [PubMed - indexed for MEDLINE].
Acharya, P.S., S. Majumdar, M. Jacob, J. Hayden, P. Mrass, W. Weninger, R.K. Assoian and E. Puré. 2008. Fibroblast migration is mediated by CD44-dependent TGF-β activation. J. Cell Sci. 121: 1393-1402. PMID: 18397995 [PubMed - indexed for MEDLINE].
Jacob, M., L.A. Todd, M.F. Sampson and E. Puré. 2008. Dual role of Cbl links critical events in receptor endocytosis. International Immunology. 20:485-497. Featured article. PMID: 18283045 [PubMed - indexed for MEDLINE].
Huang,Q., K. Gumireddy, M. Schrier, C. le Sage, R. Nagel, S. Nair, D.A. Egan, A. Li, G. Huang, A.J. Klein-Szanto, P.A. Gimotty, D. Katsaros, G. Coukos, L. Zhang, E. Puré and R. Agami. 2008. The microRNAs miR-373 and miR-520C promote tumor migration and invasion. Nature Cell Biology. 10:202-210. PMID: 18193036 [PubMed - indexed for MEDLINE].
Zhao, L., J.A. Hall, N. Levenkova, M.K. Middleton, A.M. Zukas, E. Lee, D.J. Rader, J.J. Rux and E. Puré. 2007. CD44 regulates vascular gene expression in a pro-atherogenic environment. Arterioscler. Thromb. and Vascular. Biol. 27:886-892. PMID: 17272751 [PubMed - indexed for MEDLINE].
Middleton, M.K., A.M. Zukas, T. Rubinstein, L. Zhao, M. Jacob, P. Zhu, L. Zhao, I. Blair and E. Puré. 2006. Identification of 12/15-lipoxygenase as a suppressor of myeloproliferative disease. J. Exp. Med. 203:2529-2540. PMCID: PMC2118138.
Acharya, P.S., A.M. Zukas, V. Chandan, A.-L.A. Katzenstein and E. Puré. 2006. Fibroblast activation protein: A serine protease expressed at the remodeling interface in idiopathic pulmonary fibrosis. Human Pathology. 37:352-360. PMID: 16613331 [PubMed - indexed for MEDLINE].
Middleton, M., T. Rubinstein and E. Puré. 2006. Cellular and Molecular Mechanisms of the Selective Regulation of IL-12 Production by 12/15-Lipoxygenase. J. Immunol. 176:265-274. PMID: 16365418 [PubMed - indexed for MEDLINE].
Cichy, J., P. Kulig and E. Puré. 2005. Regulation of the release and function of tumor cell-derived soluble CD44. Biochim. Biophys. Acta. 1745:59-64. PMID: 16085055 [PubMed - indexed for MEDLINE].
Cichy, J. and E. Puré. 2004. Cytokines regulate the affinity of soluble CD44 for hyaluronan. FEBS Lett. 556:69-74. PMID: 14706828 [PubMed - indexed for MEDLINE].
Cichy, J., R. Bals, J. Potempa, A. Mani and E. Puré. 2002. Proteinase-mediated release of epithelial cell-associated CD44: Extracellular CD44 complexes with components of cellular matrices. J. Biol. Chem. 277:44440-44447. PMID: 12226094 [PubMed - indexed for MEDLINE].
Teder, P., R. W. Vandivier, D. Jiang, J. Liang, L. Cohn, E. Puré, P.M. Henson and P.W. Noble. 2002. Resolution of lung inflammation by CD44. Science 296:155-158. PMID: 11935029 [PubMed - indexed for MEDLINE].