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Clinical Trials at Penn Vet


Here are all of the active clinical trials taking place at Penn Vet. Browse our list, which can be filtered by animal and trial type. 

Search All Penn Vet Trials

Effectiveness and Safety of Torsemide Compared to Furosemide for the Treatment of Pulmonary Edema Related to Congestive Heart Failure in Dogs

This trial aims to evaluate the safety and effectiveness of a novel diuretic medication, torsemide, compared to furosemide for the treatment of pulmonary edema related to congestive heart failure in dogs.

pulmonary edema torsemide Anna Gelzer congestive heart failure active

Impact of staged dietary approach on quality and quantity of life in cats with chronic kidney disease

The study will be a randomized, placebo controlled, blinded prospective clinical trial of cats with diagnosed chronic kidney disease as IRIS Stage 1 (phase 1), Stage 2 (phase 2), and Stage 3 (phase 3).

nutrition trial nutrition chronic kidney disease in cats cats clinical trial active CKD chronic kidney disease

Community Population Prevalence of SARS-CoV-2 in Cats and Dogs

A study to determine the prevalence of SARS-CoV-2 (the virus that causes COVID-19) in the local pet population

Covid in pets COVID-19 coronavirus active

Immunotherapy Clinical Trial for Dogs with Solid Tumors

New clinical trial using a sting agonist for various solid tumor types with a moderate to high risk of metastasis

cancer active active tumor surgery tumor surgery sting agonist squamous cell carcinoma soft tissue sarcoma osteosarcoma mass mammary carcinoma malignant melanoma immunotherapy growth dog cancer dog cancer

A pilot study to evaluate the effectiveness and field safety of SB-009 as a monotherapy for the management of diabetes mellitus in cats

SB-009 for diabetes mellitus in cats

active diabetes mellitus diabetes cats

Intraoperative Detection and Resection of Tumors in Canines Using an Integrated Spectroscopy and Imaging System

A clinical trial to determine if near-infrared imaging can improve the surgeon’s ability to see cancer and cancer margins during surgery to remove primary lung tumors in dogs.

cancer active tumor surgery primary lung tumor Oncology metastasis mass margins lung tumor lung mass lung infrared Imaging Dr. David Holt diagnostic imaging comprehensive cancer care canine tumor canine lung tumor canine cancer cancer center cancer advanced imaging active

Treatment of Canine perianal fistulas with intra-lesionally injected human embryonic stem cell-derived mesenchymal stem cells (HMCs)

A clinical trial looking at the clinical outcome of dogs with varying degrees of inflammation and wounds due to perianal fistulas, which is treated with a new, single, intra-lesional injection therapy to manage perianal fistulas.

derm dermatology Dr. Christine Cain lesion fistulas fistula butt anus anal gland anal fistulas anal fistula active

New treatment for heart failure in dogs

Clinical trial of a new oral medication using plant-based encapsulation technology, which allows oral administration of drugs that would otherwise need to be given by injection.

active ryan cardiology trial ryan cardiology Myxomatous mitral valve disease mitral valve disease heart failure

New blood-based markers of disease in dogs

Penn Vet Companion Animal Cardiology in the process of discovering new blood-based markers of heart disease.

ryan cardiology trial ryan cardiology heart disease CSAM Trial blood-based markers active

Pilot Study of xenograft chimeric antigen receptor T cell therapy for drug resistant or refractory CD20+ B cell Lymphoma

T cell therapy for drug resistant B cell Lymphoma

Mason Active lymphoma dogs canine cancer active cancer B-cell lymphoma active

Elbow Osteoarthritis - A Randomized placebo controlled pilot study to evaluate A-18 in dogs with pain due to elbow osteoarthritis

A-18 for dogs with elbow osteoarthritis

active elbow pain Elbow osteoarthritis elbow arthritis arthritis

Evaluation of Nemo Binding Domain (NBD) peptide for dogs with soft tissue sarcoma

NBD Peptide for Soft Tissue Sarcoma

Mason Active tumor soft tissue sarcoma sarcoma mass cancer center Cancer Care cancer active

Comparison of the efficacy & impact on suppressor cells of CHOP vs. LOPP chemotherapy in canine T-cell lymphoma

CHOP vs. LOPP chemotherapy for T-cell Lymphoma

cancer active active lymphoma lymph node chemotherapy cancer

Evaluation of Flash Proton RT in Dogs with Bone Cancer of the Leg

A new type of radiation therapy for dogs with appendicular osteosarcoma

cancer center radiation therapy leg tumor leg cancer large dog cancer large breed cancer bone tumor bone cancer amputation active

Soft Tissue Sarcoma & Mammary Carcinoma - Photoacoustic System for Identifying Tumor Edges (PSITE)

cancer active tumor removal tumor soft tissue sarcoma mammary carcinoma cancer center cancer active

Clinical & Safety Evaluation of SOCS1-KIR for the Treatment of Horses with Uveitis

This study evaluates the safety and effectiveness associated with the administration a new medication to positively impact comfort of the eye and prolong vision in horses diagnosed with unilateral or bilateral uveitis.

active vision in horses unilateral uveitis ophthalmology equine uveitis bilateral uveitis

Myasthenia Gravis - Determination of pathological autoantibodies in dogs with myasthenia gravis

Blood collection to assist in development of a biomarker that predicts the severity and prognosis of myathenia gravis

active weakness Neurology myasthenia gravis muscle weakness acetylcholine receptors

Evaluating the intestinal microbiome as a possible trigger for IMHA in dogs

The purpose of this study is to investigate whether the bacterial population of the GI tract may be a contributing factor to the onset of immune-mediated hemolytic anemia or thrombocytopenia in dogs.

active immune-mediated hemolytic anemia IMHA anemia

Coagulation in Septic Peritonitis in Dogs

We are testing a heparin derivative that is anti-inflammatory without being anticoagulant.

abdomen septic belly septic abdomen septic peritonitis active

Use of Near-infrared Imaging in Surgical Accuracy for Feline Soft-Tissue Sarcomas

Penn Vet is conducting a study to determine if near-infrared imaging can improve the surgeon’s ability to see cancer and cancer margins during surgery to remove feline soft tissue sarcomas.

cancer active ryan surgery infrared imaging feline soft tissue sarcoma david holt active

Re-directed Autologous T cell Therapy for B cell lymphoma or B Cell Leukemia

Immune cells (known as T cells) are taken from the peripheral blood, stimulated, expanded and genetically modified in the laboratory to express a surface receptor that recognizes B cells

Mason Active immunotherapy comprehensive cancer care canine lymphoma canine cancer cancer center cancer active cancer b-cell malignancies B-cell lymphoma active

Long term study assessing outcome of knee arthritis in dogs with cruciate ligament (CCL) rupture

A clinical trial evaluating the outcome of dogs with patellofemoral osteoarthritis due to the rupture of the Cranial Cruciate Ligament in one stifle, then stabilized with the Tibial Plateau Leveling Osteotomy (TPLO) procedure

Dr. Kimberly Agnello VCIC TPLO tibial plateau leveling osteotomy stifle osteoarthritis orthopedic limping ligament rupture knee joint cruciate tear cruciate cranial cruciate ligament CCL arthritis Agnello active ACL