Penn Vet | All Clinical Trials
New Bolton Center Kennett Square, PA
Emergencies & Appointments:
Ryan Hospital Philadelphia, PA

Clinical Trials at Penn Vet

Here are all of the active clinical trials taking place at Penn Vet. Browse our list, which can be filtered by animal and trial type. 

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Intraoperative assessment of marginal tissue after BCS resection using in-vivo topical application of a cathepsin-targeted molecular probe.

Evaluating the efficacy of a new near-infrared imaging agent when applied topically to tumor during surgery in dogs with mammary gland tumors

mastectomy near-infrared imaging NIRI breast cancer mammary adenocarcinoma mgt mammary gland tumor mammary tumor mammary carcinoma active massie holt clinical trial Holt

Amantadine in conjunction with carprofen for improvement of lameness and pain secondary to osteoarthritis in dogs

The purpose of this study is to determine the efficacy of amantadine in combination with carprofen, a non-steroidal anti-inflammatory drug (NSAID) already approved for use in dogs, to manage refractory pain associated with osteoarthritis in dogs

active osteoarthritis Amantadine Agnello

Intraoperative detection of oral squamous cell carcinoma margins in dogs using cathepsin-activated near-infrared (NIR) imaging

A clinical trial evaluating a new near-infrared (NIR) imaging agent to detect cancerous tissue in dogs with oral squamous cell carcinoma (SCC) during surgical excision.

active surgery squamous cell carcinoma skin cancer SCC oral tumor NIRI near-infrared imaging mouth Holt Griffin epithelium epidermis Castejon cancer

Use of a newly available glargine (Semglee®) for treatment of diabetes mellitus in cats

This clinical trial will help determine if Semglee is as effective as glargine in regulating diabetes in cats.

clinical trial diabetes feline active

Sentinel lymph node mapping for canine thyroid carcinoma

A clinical trial to develop SLN mapping techniques in dogs with thyroid tumors (to aid in early detection and removal of cancerous lymph nodes) and to evaluate their utility and agreement.

thyroid carcinoma cancer clinical trial active

Untargeted plasma metabolomics and biomarker, DNA, and microbiome assessments in cats with and without chronic kidney disease

This study is looking to identify unique biomarkers in cats with chronic kidney disease and improve outcomes.

urinary clinical trial chronic kidney disease active

Evaluation of FLASH Proton RT in Naturally Occurring Canine Head and Neck Cancer

The purpose of this study is to evaluate the safety and feasibility of a novel form of radiation therapy (RT) called FLASH proton radiation therapy for head and neck cancers in dogs.

cancer Oncology radiation active clinical trial

The role of chronic inflammation on behavior and cognition of aging cats

Cognition in older cats

active cognitive function healthy aging inflammation cats healthy Siracusa behavior cognition aging aging pets

CLASSIC Plus: Cancer Lifetime Assessment Screening Study in Canines (CLASSiC)

Assessing the use of ONCOK9, a multi-cancer early detection test

cancer monitoring healthy aging healthy cancer screening cancer active Brian Flesner

The Utility of OncoK9 Liquid Biopsy for the Detection of Canine Insulinoma

This trial will be determine if Oncok9 Liquid Biopsy kit can detect insulinoma cells in the blood of dogs.

active pancreatic cancer Insulinoma clinical trial dog

Cathepsin-activated near-infrared (NIR) imaging for intraoperative detection of insulinomas

A clinical trial evaluating a new near-infrared imaging agent to detect cancerous tissue in dogs with Insulinoma during surgical excision.

pancreatic Insulinoma clinical trial cancer active

Sentinel lymph node mapping for canine apocrine gland anal sac adenocarcinoma

The aims of this study are to develop SLN mapping techniques in dogs with anal sac tumors (to aid in early detection and removal of cancerous lymph nodes) and to evaluate their utility and agreement.

active sacculectomy lymph node AGASACA carcinoma anal gland cancer anal sac tumor dog

Evaluation of Bendamustine as a Novel Chemotherapy Agent for Relapsed Canine Lymphoma

The purpose of this study is to evaluate different doses of bendamustine in dogs with lymphoma to evaluate its safety and effectiveness.

active chemotherapy lymphoma dogs

The use of exercise to improve treatment for insulin-treated diabetic dogs

The FreeStyle Libre glucose monitoring system will help determine if exercise can improve glucose regulation in dogs with diabetes.

dogs with diabetes diabetic dogs insulin treatment in dogs active

New oral combination treatment for insulin-treated diabetic dogs

Penn Vet is conducting a clinical trial with an oral medication that is used, in combination with insulin, for treatment of diabetes in humans, and has been given safely to dogs.

diabetes blood glucose diabetes in dogs active

Clinical evaluation of propranolol and doxorubicin for the treatment of splenic hemangiosarcoma in the dog

In this trial, we will be evaluating Propranolol’s effect on survival time and quality of life when given in combination with the standard chemotherapy treatment.

doxorubicin active splenic HSA splenic hemangiosarcoma spleen propranolol PPL HSA hemangiosarcoma Dr. Pascal Salah Dr. Jennifer Mahoney chemotherapy cancer center cancer active cancer

Fosmidomycin Otic Trial for dogs

Dermatology is currently enrolling in a clinical trial evaluating a novel, topical antimicrobial for dogs with bilateral otitis.

ear infection in dogs canine otitis active

Community Population Prevalence of SARS-CoV-2 in Cats and Dogs

A study to determine the prevalence of SARS-CoV-2 (the virus that causes COVID-19) in the local pet population

Covid in pets COVID-19 coronavirus active

Immunotherapy Clinical Trial for Dogs with Solid Tumors

New clinical trial using a sting agonist for various solid tumor types with a moderate to high risk of metastasis

cancer active active tumor surgery tumor surgery sting agonist squamous cell carcinoma soft tissue sarcoma osteosarcoma mass mammary carcinoma malignant melanoma immunotherapy growth dog cancer dog cancer

Intraoperative Detection and Resection of Tumors in Canines Using an Integrated Spectroscopy and Imaging System

A clinical trial to determine if near-infrared imaging can improve the surgeon’s ability to see cancer and cancer margins during surgery to remove primary lung tumors in dogs.

cancer active tumor surgery primary lung tumor Oncology metastasis mass margins lung tumor lung mass lung infrared Imaging Dr. David Holt diagnostic imaging comprehensive cancer care canine tumor canine lung tumor canine cancer cancer center cancer advanced imaging active

Pilot Study of xenograft chimeric antigen receptor T cell therapy for drug resistant or refractory CD20+ B cell Lymphoma

T cell therapy for drug resistant B cell Lymphoma

Mason Active lymphoma dogs canine cancer active cancer B-cell lymphoma active

Evaluation of Nemo Binding Domain (NBD) peptide for dogs with soft tissue sarcoma

NBD Peptide for Soft Tissue Sarcoma

Mason Active tumor soft tissue sarcoma sarcoma mass cancer center Cancer Care cancer active

Comparison of the efficacy & impact on suppressor cells of CHOP vs. LOPP chemotherapy in canine T-cell lymphoma

CHOP vs. LOPP chemotherapy for T-cell Lymphoma

cancer active active lymphoma lymph node chemotherapy cancer

Coagulation in Septic Peritonitis in Dogs

We are testing a heparin derivative that is anti-inflammatory without being anticoagulant.

abdomen septic belly septic abdomen septic peritonitis active

Re-directed Autologous T cell Therapy for B cell lymphoma or B Cell Leukemia

Immune cells (known as T cells) are taken from the peripheral blood, stimulated, expanded and genetically modified in the laboratory to express a surface receptor that recognizes B cells

Mason Active immunotherapy comprehensive cancer care canine lymphoma canine cancer cancer center cancer active cancer b-cell malignancies B-cell lymphoma active

Long term study assessing outcome of knee arthritis in dogs with cruciate ligament (CCL) rupture

A clinical trial evaluating the outcome of dogs with patellofemoral osteoarthritis due to the rupture of the Cranial Cruciate Ligament in one stifle, then stabilized with the Tibial Plateau Leveling Osteotomy (TPLO) procedure

Dr. Kimberly Agnello VCIC TPLO tibial plateau leveling osteotomy stifle osteoarthritis orthopedic limping ligament rupture knee joint cruciate tear cruciate cranial cruciate ligament CCL arthritis Agnello active ACL