The purpose of this study is to determine the efficacy of amantadine in combination with carprofen, a non-steroidal anti-inflammatory drug (NSAID) already approved for use in dogs, to manage refractory pain associated with osteoarthritis in dogs.

Dogs will be enrolled for approximately 8 weeks and will come to Penn Vet for a total of three visits. Enrolled dogs will receive carprofen for the duration of the study and will be randomized to also receive either amantadine or a placebo along with the carprofen for the second half of the enrollment period.

Eligibility

• Dogs weighing more than 15kg (33 lbs)
• Dogs with osteoarthritis associated lameness for at least 3 months duration despite historic use of an NASID.
• Dogs with evidence of osteoarthritis on orthopedic exam and x-ray.
• Dogs with NO instability in any joint (such as from a cruciate ligament tear).
• Dogs who have NOT received an injection into a joint within 6 months of enrollment.
• Dogs who have NOT had any orthopedic surgery within one year of enrollment.
• Owners able to administer twice daily medication and complete questionnaires.

Benefits

• Orthopedic exams, bloodwork, urinalysis, and x-ray at no charge
• All study visits and study medications at no charge
• $75 gift card upon completion of all study visits

If you have a dog that may be eligible, please contact the VCIC at 215-573-0302 or VCIC@vet.upenn.edu.