New Bolton Center Kennett Square, PA
Emergencies & Appointments:
Ryan Hospital Philadelphia, PA
Comparative Pathology Core

Comparative Pathology Core

Phase I Research Support

The Comparative Pathology Core will resume all Phase 1 research support activities on June 8, 2020.

Please be aware that while we accept requests from all labs campus-wide, investigators who are not Penn Vet employees are not allowed to access the CPC's facilities during Phase 1.

For this reason, a contact-free sample drop off/pick up point has been arranged in the Hill Pavilion lobby (380 South University Avenue, Philadelphia PA, 19104). Access to the Hill Pavilion will be allowed with a valid Penn ID on Tuesdays and Thursdays from 9 AM to 1 PM

Detailed guidelines on how to drop off/pick up samples

  • Drop-Off
    • Inform our staff members that you intend to submit samples. To do so, please send an email to Juli Burns ( and Brona Ranieri ( including the 4 digit CPC service request number as reference.
    • Bring the samples to the lobby of Hill Pavilion (380 South University Avenue, Philadelphia PA, 19104) during the available time slots (Tuesdays and Thursdays from 9 AM to 1 PM).
    • Check-in at the security desk.
    • Put your sample in the designated CPC SAMPLES DROP-OFF bin. When dropping samples, please include a print-out of the finalized request/s as accompanying paper (samples without the appropriate accompanying paper will be discarded).
    • Complete the sign-in sheet sitting next to the bin.
  • Pick-Up
    • When your request is completed, a notification will be sent to you via email.
    • At that point, you can come to the lobby of Hill Pavilion to pick-up your samples at the next available time slot.
    • Check-in at the security desk.
    • Pick-up your samples from the designated CPC SAMPLES PICK-UP bin
    • Complete the sign-in sheet sitting next to the bin.
  • Temperature-Sensitive Samples

    Drop-off/Pick-up of samples that are temperature-sensitive must be arranged on a case-by-case basis with one of our staff members. Please contact Juli Burns ( and Brona Ranieri ( to coordinate the drop-off/pick-up.

For further information please contact

The Comparative Pathology Core (CPC), an Abramson Cancer Center shared resource, provides expert pathological characterization and validation of mouse and other animal models used in biomedical research by offering the expertise of board-certified veterinary pathologists and access to state-of-the-art histology, immunohistochemistry, and digital pathology services.

Learn more about the services we offer.

Contact Us

Accessing the Comparative Pathology Core Service

If you are a University of Pennsylvania research investigator interested in utilizing our services, you can register to use the Comparative Pathology Core Service by using your PennKey.

In order to complete the registration, you will need the name, phone number and PennKey username of your Business Administrator/Manager, and the grant number and expiration date.

Access to to Our Services

  • As of June 10th, 2019, all accounts must be setup in CAMS to access our services.
  • Please contact your business administrator to configure your account in CAMS.
  • Please refer to the documentation that can be found at

Our Services

  • Consultation

    Experimental design planning (especially concerning pathological endpoints) and slide review.

  • Histology service


    • High-quality histology services including preparation of sections from frozen and paraffin-embedded tissues, routine H&E and histochemical staining.
    • Generation of customized tissue microarrays (TMA) from both paraffin-embedded and frozen tissues.


  • Immunostaining platform

    Automated staining platform (Leica BOND RXm) for chromogenic immunohistochemistry, immunofluorescence or in situ hybridization on paraffin-embedded or frozen tissue sections and cytological preparations.

  • Slide evaluation

    Histopathological examination performed by certified veterinary comparative pathologists with a final interpretative report.

  • Mouse phenotyping & toxicologic pathology

    Complete necropsy (with gross pathology and organ weight) and histolopathological examination of genetically engineered or test article-treated mice and matched controls.

  • Clinical Pathology

    The Comparative Pathology Core offers clinical pathology testing options in collaboration with the Penn Vet Clinical Pathology Laboratory.

    Dr. Natalie Hoepp, a veterinary clinical pathologist, is the clinical pathology coordinator for the CPC. Dr. Hoepp provides interpretive reports for cytology and hematology submissions, consults on sample acquisition and appropriate testing to meet study goals, assists investigators with planning first time submissions, coordinates repeat time points with the laboratory, and facilitates account set up with the hospital.

    Please review the service description and fee schedule (PDF).

    Dr. Hoepp may be contacted by email:

  • Photomicroscopy

    Composites for publication with legends are formatted in Adobe Photoshop to the journal specifications.

  • Digital pathology and Imaging

    Aperio VERSA 200 platform for whole slide scanning (both brightfield and fluorescent application) and automated digital image analysis.

  • Training & Education


    • Complete necropsy demonstration and proper tissue handling techniques.
    • Slides review and discussion with investigators at a multi-headed teaching microscope.


View Samples of Our Work

Visit our gallery of pathology samples to see examples of the range of stains and techniques we use in our diagnostic process.