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Comparative Pathology Core

Comparative Pathology Core


The Comparative Pathology Core (CPC), an Abramson Cancer Center shared resource, provides expert pathological characterization and validation of mouse and other animal models used in biomedical research by offering the expertise of board-certified veterinary pathologists and access to state-of-the-art histology, immunohistochemistry, and digital pathology services.

Learn more about the services we offer.

Contact Us

Our Services

  • Consultation

    Experimental design planning (especially concerning pathological endpoints) and slide review.

  • Histology service

     

    • High-quality histology services including preparation of sections from frozen and paraffin-embedded tissues, routine H&E and histochemical staining.
    • Generation of customized tissue microarrays (TMA) from both paraffin-embedded and frozen tissues.

     

  • Immunostaining platform

    Automated staining platform (Leica BOND RXm) for chromogenic immunohistochemistry, immunofluorescence or in situ hybridization on paraffin-embedded or frozen tissue sections and cytological preparations.

  • Slide evaluation

    Histopathological examination performed by certified veterinary comparative pathologists with a final interpretative report.

  • Mouse phenotyping & toxicologic pathology

    Complete necropsy (with gross pathology and organ weight) and histolopathological examination of genetically engineered or test article-treated mice and matched controls.

  • Clinical Pathology

    Hematology (CBC, blood smear review, bone marrow evaluation), clinical chemistry, fluid analysis, and cytologic evaluation of mass lesions.

  • Photomicroscopy

    Composites for publication with legends are formatted in Adobe Photoshop to the journal specifications.

  • Digital pathology and Imaging

    Aperio VERSA 200 platform for whole slide scanning (both brightfield and fluorescent application) and automated digital image analysis.

  • Training & Education

     

    • Complete necropsy demonstration and proper tissue handling techniques.
    • Slides review and discussion with investigators at a multi-headed teaching microscope.

     


Accessing the Comparative Pathology Core Service

If you are a University of Pennsylvania research investigator interested in utilizing our services, you can register to use the Comparative Pathology Core Service by using your PennKey.

In order to complete the registration, you will need the name, phone number and PennKey username of your Business Administrator/Manager, and the grant number and expiration date.


View Samples of Our Work

Visit our gallery of pathology samples to see examples of the range of stains and techniques we use in our diagnostic process.