New Bolton Center Kennett Square, PA
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Ryan Hospital Philadelphia, PA
Comparative Pathology Core

Comparative Pathology Core

Phase II Research Support

The Comparative Pathology Core continues to provide research support activities during Phase II of research resumption.

  • Please be aware that samples can be dropped off and picked up in front of the Histology lab on Mondays, Wednesdays and Fridays, from 9am to 1pm. Access to the Histology lab is permitted through the main lobby of the Veterinary Hospital and through the Hill Pavilion with a valid Penn (or CHOP) ID and a cleared (green) PennOpen Pass. 
  • Please coordinate with the lab via email ( and if you want to drop off or pick up samples. 

 For further information please contact

The Comparative Pathology Core (CPC), an Abramson Cancer Center shared resource, provides expert pathological characterization and validation of mouse and other animal models used in biomedical research by offering the expertise of board-certified veterinary pathologists and access to state-of-the-art histology, immunohistochemistry, and digital pathology services.

Learn more about the services we offer.

Contact Us

Accessing the Comparative Pathology Core Service

If you are a University of Pennsylvania research investigator interested in utilizing our services, you can register to use the Comparative Pathology Core Service by using your PennKey.

In order to complete the registration, you will need the name, phone number and PennKey username of your Business Administrator/Manager, and the grant number and expiration date.

Access to to Our Services

  • As of June 10th, 2019, all accounts must be setup in CAMS to access our services.
  • Please contact your business administrator to configure your account in CAMS.
  • Please refer to the documentation that can be found at

Our Services

  • Consultation

    Experimental design planning (especially concerning pathological endpoints) and slide review.

  • Histology service


    • High-quality histology services including preparation of sections from frozen and paraffin-embedded tissues, routine H&E and histochemical staining.
    • Generation of customized tissue microarrays (TMA) from both paraffin-embedded and frozen tissues.


  • Immunostaining platform

    Automated staining platform (Leica BOND RXm) for chromogenic immunohistochemistry, immunofluorescence or in situ hybridization on paraffin-embedded or frozen tissue sections and cytological preparations.

  • Slide evaluation

    Histopathological examination performed by certified veterinary comparative pathologists with a final interpretative report.

  • Mouse phenotyping & toxicologic pathology

    Complete necropsy (with gross pathology and organ weight) and histolopathological examination of genetically engineered or test article-treated mice and matched controls.

  • Clinical Pathology

    The Comparative Pathology Core offers clinical pathology testing options in collaboration with the Penn Vet Clinical Pathology Laboratory.

    Dr. Natalie Hoepp, a veterinary clinical pathologist, is the clinical pathology coordinator for the CPC. Dr. Hoepp provides interpretive reports for cytology and hematology submissions, consults on sample acquisition and appropriate testing to meet study goals, assists investigators with planning first time submissions, coordinates repeat time points with the laboratory, and facilitates account set up with the hospital.

    Please review the service description and fee schedule (PDF).

    Dr. Hoepp may be contacted by email:

  • Photomicroscopy

    Composites for publication with legends are formatted in Adobe Photoshop to the journal specifications.

  • Digital pathology and Imaging

    Aperio VERSA 200 platform for whole slide scanning (both brightfield and fluorescent application) and automated digital image analysis.

  • Training & Education


    • Complete necropsy demonstration and proper tissue handling techniques.
    • Slides review and discussion with investigators at a multi-headed teaching microscope.


View Samples of Our Work

Visit our gallery of pathology samples to see examples of the range of stains and techniques we use in our diagnostic process.