New Bolton Center Kennett Square, PA
Emergencies & Appointments:
Ryan Hospital Philadelphia, PA
Penn Vet Extracellular Vesicle Core

Extracellular Vesicle Core

Located in the Rosenthal Building at Penn's School of Veterinary Medicine (Penn Vet), the Extracellular Vesicle (EV) Core Facility provides comprehensive or selected services in the necessary isolation, quantification and characterization of EVs.

Isolation of EV is based on size exclusion using high-performance liquid chromatography (SEC-HPLC; Agilent) or gravity fed columns (coupled with an automatic fraction collector (Izon), ultracentrifugation, and/or density gradient ultracentrifugation. We can accurately characterize EV particle size distribution and concentration using resistive pulse sensing techniques (nCS1, Spectradyne, LLC) and/or Nanoparticle tracking analysis. Immunophenotype can be accomplished using nanoscale flow cytometry (NanoFCM) and/or chip array (ExoViewTM) techniques (Unchained Labs).   

Additionally, we provide services in training and education for individuals and lab groups in all methods above and study design consultation to ensure that your EV work is of the highest quality and prepared for high impact publication in this exciting and rapidly growing field.

Requesting Services

If you are interested in requesting services from the Penn Vet Extracellular Vesicle Core, please do so here:

Submit your request

Research Maintenance Plan

EV Core is currently offering full-services options at the prices listed under “Services”. Our other remote-based services including, grant and publication support, and general consultations (either one-on-one or in small working groups) are also still in effect.

To book services and sample transfers and to receive updates about this and all other EV Core business, please email Dr. Luca Musante at

The EV Core is also excited to announce that in addition to our laboratory services, we will continue our bi-weekly EV Core webinar series in which experts in the field are invited to speak about their research and to discuss various topics related to EV research such as quantification and characterization techniques, experimental design and cutting edge discoveries. We provide a safe space for faculty and their trainees at any level to present their research related to EVs and spark a dialog within the group via a round table discussion and Q&A session. Anyone interested in attending these online webinar meetings or presenting via Microsoft Teams please contact Dr. Luca Musante at

Contact Penn Vet EVC