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Penn Vet Extracellular Vesicle Core

Extracellular Vesicle Core


Located in the Rosenthal Building at Penn's School of Veterinary Medicine (Penn Vet), the Extracellular Vesicle (EV) Core Facility provides comprehensive or selected services in the necessary isolation, quantification and characterization of EVs.  

Isolation of EV is based on size exclusion using high-performance (SEC-HPLC) or gravity fed (e.g. iZon column) liquid chromatography, ultracentrifugation, and/or density gradient ultracentrifugation.  We can accurately characterize EV particle size distribution and concentration using resistive pulse sensing techniques (nCS1, Spectradyne, LLC) and Nanoparticle tracking analysis.  Immunophenotype can be accomplished using nanoscale flow cytometry and/or chip array (ExoViewTM) techniques.   

Additionally, we provide services in training and education for individuals and lab groups in all methods above and study design consultation to ensure that your EV work is of the highest quality and prepared for high impact publication in this exciting and rapidly growing field.

2021 Research Maintenance Plan


EV Core is currently offering full-services options at the prices listed under “Services”. Our other remote-based services including, grant and publication support, and general consultations (either one-on-one or in small working groups) are also still in effect.

To book services and sample transfers and to receive updates about this and all other EV Core business, please email Rachel DeRita at rmderita@upenn.edu.

The EV Core is also excited to announce that in addition to our laboratory services, we will continue our bi-weekly EV Core webinar series in which experts in the field are invited to speak about their research and to discuss various topics related to EV research such as quantification and characterization techniques, experimental design and cutting edge discoveries. We provide a safe space for faculty and their trainees at any level to present their research related to EVs and spark a dialog within the group via a round table discussion and Q&A session. Anyone interested in attending these online webinar meetings or presenting via Microsoft Teams please contact Dr. Rachel DeRita at rmderita@upenn.edu

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