New Bolton Center Kennett Square, PA
Emergencies & Appointments:
Ryan Hospital Philadelphia, PA
Extracellular Vesicle Core


La Salvia S, Musante L, Lannigan J, Gigliotti JC, Le TH, Erdbrügger U. T cell-derived extracellular vesicles are elevated in essential HTN. Am J Physiol Renal Physiol. 319:F868-F875, 2020

Musante L, Bontha SV, La Salvia S, Fernandez-Piñeros A, Lannigan J, Le TH, Mas V, Erdbrügger U. Rigorous characterization of urinary extracellular vesicles (uEVs) in the low centrifugation pellet - a neglected source for uEVs. Sci Rep. 28:3701, 2020

Good ME, Musante L, La Salvia S, Howell NL, Carey RM, Le TH, Isakson BE, Erdbrügger U. Circulating Extracellular Vesicles in Normotension Restrain Vasodilation in Resistance Arteries. Hypertension.  75:218-228, 2020

Musante L, Tataruch-Weinert D, Kerjaschki D, Henry M, Meleady P, Holthofer H. Residual urinary extracellular vesicles in ultracentrifugation supernatants after hydrostatic filtration dialysis enrichment. J Extracell Vesicles.  6:1267896, 2017

Tataruch-Weinert D, Musante L, Kretz O, Holthofer H. Urinary extracellular vesicles for RNA extraction: optimization of a protocol devoid of prokaryote contamination. J Extracell Vesicles. 5:30281, 2016

Musante L, Tataruch D, Gu D, Liu X, Forsblom C, Groop PH, Holthofer H. Proteases and protease inhibitors of urinary extracellular vesicles in diabetic nephropathy. J Diabetes Res.  2015:289734, 2015

Musante L, Tataruch D, Gu D, Benito-Martin A, Calzaferri G, Aherne S, Holthofer H. A simplified method to recover urinary vesicles for clinical applications, and sample banking. Sci Rep.  23; 4:7532, 2014

Borel, F., Sun, H., Zieger, M., Cox, A., Cardozo, B., Li, W., Oliveira, G., Davis, A., Gruntman, A., Flotte, T. R., Brodsky, M. H., Hoffman, A. M., Elmallah, M. K., Mueller, C. Editing out five Serpina1 paralogs to create a mouse model of genetic emphysema Proc Natl Acad Sci U S A 115: 2788-2793, 2018.

Yang, V. K., Tai, A. K., Huh, T. P., Meola, D. M., Juhr, C. M., Robinson, N. A., Hoffman, A. M. Dysregulation of valvular interstitial cell let-7c, miR-17, miR-20a, and miR-30d in naturally occurring canine myxomatous mitral valve disease PLoS One 13: e0188617, 2018.

Davis, A. M., Thane, K. E., Hoffman, A. M. Practical methods for assessing emphysema severity based on estimation of linear mean intercept (lm) in the context of animal models of alpha-1 antitrypsin deficiency Methods Mol Biol 1639: 93-106, 2017.

Yang, V. K., Loughran, K. A., Meola, D. M., Juhr, C. M., Thane, K. E., Davis, A. M., Hoffman, A. M. Circulating exosome microRNA associated with heart failure secondary to myxomatous mitral valve disease in a naturally occurring canine model J Extracell Vesicles 6: 1350088, 2017.

Wichtel M, Gomez D, Burton S, Wichtel J, Hoffman AM. Relationships between equine airway reactivity measured by flowmetric plethysmography and specific indicators of airway inflammation in horses with suspected inflammatory airway disease. Equine Vet J 48: 466-71, 2016.

Platz, J., Bonenfant, N. R., Uhl, F. E., Coffey, A. L., McKnight, T., Parsons, C., Sokocevic, D., Borg, Z. D., Lam, Y. W., Deng, B., Fields, J. G., DeSarno, M., Loi, R., Hoffman, A. M., Bianchi, J., Dacken, B., Petersen, T., Wagner, D. E., Weiss, D. J.Comparative decellularization and recellularization of wild-type and alpha 1,3 galactosyltransferase knockout pig lungs: A model for ex vivo xenogeneic lung bioengineering and transplantation Tissue Eng Part C Methods 22: 725-39, 2016.

Bellas, E., Rollins, A., Moreau, J. E., Lo, T., Quinn, K. P., Fourligas, N., Georgakoudi, I., Leisk, G. G., Mazan, M., Thane, K. E., Taeymans, O., Hoffman, A. M., Kaplan, D. L., Kirker-Head, C. A. Equine model for soft-tissue regeneration J Biomed Mater Res B Appl Biomater 103: 1217-1227, 2015.

Houtsma, A., Bedenice, D., Pusterla, N., Pugliese, B., Mapes, S., Hoffman, A. M., Paxson, J., Rozanski, E., Mukherjee, J., Wigley, M., Mazan, M. R. Association between inflammatory airway disease of horses and exposure to respiratory viruses: a case control study Multidiscip Respir Med 10: 33, 2015.

Cruz, F. F., Borg, Z. D., Goodwin, M., Sokocevic, D., Wagner, D. E., Coffey, A., Antunes, M., Robinson, K. L., Mitsialis, S. A., Kourembanas, S., Thane, K., Hoffman, A. M., McKenna, D. H., Rocco, P. R., Weiss, D. J. Systemic administration of human bone marrow-derived mesenchymal stromal cell extracellular vesicles ameliorates aspergillus hyphal extract-induced allergic airway inflammation in immunocompetent mice Stem Cells Transl Med 4: 1302-16, 2015.

Rettmer, H., Hoffman, A. M., Lanz, S., Oertly, M., Gerber, V. Owner-reported coughing and nasal discharge are associated with clinical findings, arterial oxygen tension, mucus score and bronchoprovocation in horses with recurrent airway obstruction in a field setting Equine Vet J 47: 291-5, 2015.

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