New Bolton Center Kennett Square, PA
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Ryan Hospital Philadelphia, PA
Transgenesis, Penn Vet

Penn Vet Transgenic Mouse Core

The Transgenic Mouse Core located in the School of Veterinary Medicine is a state-of-the-art fee-for-service facility that offers a full line of embryological manipulation services, focused on, but not limited to, murine model systems.  These services primarily enable the generation of genetically modified murine models, as well as experimental research in germ cell function and early embryonic development.

  • About Transgenesis

    Over the past 30 years, techniques have been developed that enable the modification of individual genes in animals and plants and thereby precisely alter inherited traits. These genetically altered organisms, called transgenic, and are of enormous value in medicine and agriculture. Scientists at the School of Veterinary Medicine performed pioneering studies in the development of transgenic techniques and were responsible for production of the first transgenic mice and farm animals. 

    Capitalizing on years of foundation research, the Center for Animal Transgenesis and Germ Cell Research was established in 1998. Our primary mission is to undertake innovative research on stem cell biology, germ cell development, and animal transgenesis. A major objective of this research is to improve the health and productivity of domestic animals by genetic modification and to develop animal models for biomedical research.  To achieve these goals, the School of Veterinary Medicine has established the Transgenic Mouse Core.

    An improved understanding of the basic processes governing germ cell and embryo development and of the biology of gametes (sperm and oocytes) and embryonic stem cells will enable us to improve reproductive efficiency, generate animal models of human and animal disease and help provide the knowledge base for regenerative medicine, as well as toward the treatment of infertility.