Research Newsletter | Winter 2023
Announcements
2024 Martin and Pamela Winter Infectious Disease Pre-Doctoral Fellowship
The Institute for Infectious and Zoonotic Diseases (IIZD) is offering fellowships for pre-doctoral students keen on exploring infectious diseases in humans and wildlife. The fellowships span one to two years, contingent on progress and ongoing funding availability, providing financial support of $35,000 per year. The sponsor laboratory is expected to provide the additional funds required to support the applicant. The application deadline is March 1, 2024.
Qualifications:
- University of Pennsylvania student enrolled in a doctoral degree program in the biomedical sciences.
- International students enrolled in graduate programs in other countries or U.S. institutions with written permission to interrupt their current schooling and return within one year of completing their degree-granting program.
- Candidates from low- or middle-income countries (LMIC) or U.S. underrepresented minorities are encouraged to apply. Participation is contingent upon applicable immigration rules and regulations.
JAVMA & AJVR Digital Back Issues From the 1990s Now Available
Thanks to a collaboration among the AVMA and veterinary libraries (including Penn Vet), past issues of both JAVMA and AJVR are being digitized. Readers can now view all issues from the 1990s on the journals’ websites. AVMA will continue to digitize issues from the 1980s and 1970s as the year progresses, and will load that content by decade as it is completed.
New Interactive Virtual Anatomy Resource: Biosphera
Interactive models explore animal anatomy through fully virtual dissections, with layers for the different body systems (skin, muscle, skeleton, respiratory, circulatory, nervous, digestive, urogenital, lymphatic, and endocrine). Penn Libraries subscribes to ten modules: bird, bovine, cat, dog, horse, pig, rat, fish, frog and frog skeleton. Here’s a feature preview.
The modules are housed on Penn Vet’s Remote Desktop Lab for access anywhere. Follow this link for access instructions.
Poster Printing Is Back at the Holman Biotech Commons
Poster printing is back at the Holman Biotech Commons. Paper and flexible formats available.
Going somewhere? You can borrow an expandable poster tube with strap from the Penn Vet Library.
Upcoming Library Workshops
Data Basics: Ethically Making & Sharing Data
Wednesday, February 21, 2024, 12:00—1:00 p.m.
Location: In person at the Research Data and Digital Scholarship Exchange (RDDSx), Van Pelt-Dietrich Library Center
Intro to Web Scraping
Wednesday, February 28, 2024, 11:00 a.m.—12:00 p.m.
Location: In person at the Research Data and Digital Scholarship Exchange (RDDSx), Van Pelt-Dietrich Library Center
Research Data Management for Teams
Wednesday, March 19, 2024, 11:00 a.m.—12:00 p.m.
Location: Online
Updated Core Facilities Finder Video Presentations
The content on the Core Facilities Finder webpage has been refreshed. The page is designed to be a go-to resource for both core facility directors and potential customers. In conjunction with this refresh, core facility video presentations are now available as a resource to share with interested users. Please contact April Weakley (aweakley@pennmedicine.upenn.edu) if you would like to provide updates or additional content.
A Recent Opinion Article from Nature on the Importance of Basic Science
Join Penn Vet’s Artificial Intelligence Interest Group
Drs. Fuyu Guan and Darko Stefanovski have started a schoolwide Artificial Intelligence Interest Group. If you are interested in joining the group, please contact Dr. Guan.
FEATURED ARTICLE
Dr. Klaus Hopster: Innovating at the Forefront of Large Animal Anesthesia
Klaus Hopster, DVM, PhD, DECVAA, is the Marilyn M. Simpson Associate Professor of Large Animal Anesthesia in the Department of Clinical Studies—New Bolton Center. Dr. Hopster studied veterinary medicine at the Hannover School of Veterinary Medicine in Germany and received his DVM degree from Hannover in 2006. He then performed a rotating internship at the Hannover Equine Hospital while enrolled in a doctoral program that he completed in 2007, with a thesis entitled, Open-lung-concept ventilation during general anesthesia of the horse and its influence on the early post-operative period. During this time, his research focused on pulmonary gas exchange in anesthetized horses.
From 2007 to 2011, Dr. Hopster was enrolled in an ECVAA-approved veterinary anesthesia and analgesia residency program. During these four years, he developed experience with all veterinary species, including small animals, large animals, exotic species, and laboratory animals, and with a wide variety of procedures, including elective and emergency surgical and diagnostic procedures. After the successful conclusion of this program, he obtained the ECVAA diplomate status.
Upon finishing his training program, Dr. Hopster accepted the position of Senior Lecturer in Anesthesia, Pain Management, and Critical Care at the Hannover School of Veterinary Medicine’s Equine Hospital. He held this position until his departure to the University of Pennsylvania in 2016. During this time, his research, including his habilitation thesis, strongly focused on developing new strategies to prevent ventilation/perfusion mismatching during general anesthesia. Further, he was involved in the development of multiple ventilation approaches and concepts to improve ventilation and pulmonary mechanics in compromised patients, as well as in the development of new technologies and monitoring devices, including a thermal-mass flowmeter, to establish and improve non-invasive, real-time pulmonary diagnostics.
Since joining the University of Pennsylvania faculty, his research focus has been a mix of experimental in vivo models focused on pulmonary function and clinical studies to improve the clinical service and impact how we practice and train the next generation of anesthesiologists. As an example of Dr. Hopster’s clinical and teaching methodology, the main research emphasis is advancement in understanding the developmental pathways of pulmonary impairments under general anesthesia. During his postdoc career, this approach was recognized and rewarded with the Wiley Blackwell Award and the Hippiatrika Award for excellence in veterinary medicine-related research.
In addition to clinical improvements in ventilation and aeration of the equine lung, several original publications spearheaded changes in the hospital management of high-risk patients. These published ventilation strategies are continually modified and updated to a program entitled Large Animal Anesthesia Workstation Tafonius, which provides simple and effective ways to improve ventilation of the horse during general anesthesia.
Another focus of Dr. Hopster’s work was the construct and impact of various carrier gases during large animal anesthesia and how low-density gases are superior to pure oxygen in certain clinical situations with lung pathologies. Heliox, a combination of helium and oxygen, is now routinely used at New Bolton Center for complex upper airway surgeries.
The large animal anesthesia service at New Bolton Center is also a leader in large animal analgesia, incorporating epidural anesthesia as a routine technique that provides suitable long-term analgesia for large animal patients experiencing chronic pain. The large animal anesthesia service has employed the use of long-term epidural catheterization as one method of bettering the quality of life and animal welfare in the New Bolton Center hospital environment. It has successfully extended this technique, historically limited to the pelvic limbs, to the thoracic limbs using a cranial cervical approach for such clinical problems as equine laminitis. The use of a new transversus abdominis plane block in small ruminants and a pressure-sensing device further expands the analgesia toolbox for the large animal patient. These advances in local analgesia significantly improve animal welfare and anesthesia outcomes, as supported by colleagues in human medicine.
Dr. Hopster’s research focuses on pulmonary oxygen uptake and oxygen delivery to the peripheral circulation and tissues. The main reasons for hypoxemia during general anesthesia are: 1.) poorly or non-aerated lung tissue; 2.) atelectasis resulting in substantial ventilation-perfusion mismatch; and 3.) pulmonary shunting equaling up to 33% of cardiac output. These anesthetic changes are the cause of high anesthesia-related morbidity, resulting in a protracted hospital stay, post-operative colic, and a high mortality rate in the horse.
Dr. Hopster’s doctoral and habilitation theses (Dr. rer. nat.) in the field of pulmonary pathophysiology and its treatment under general anesthesia prepared him for his professional journey in the specialty of clinical anesthesia. Collaborative research projects in ventilation and oxygen delivery are ongoing with colleagues at the University of Michigan, University of Copenhagen, University of Pennsylvania, University of Delaware, University of Illinois, University of Texas, University of Hannover, University of Vienna, and University of Glasgow.
A new ventilation modality for large animals with the potential to change how we ventilate large animal patients was developed by Dr. Hopster with the assistance of Penn Vet’s anesthesia group. The design is a FLow-controlled EXpiration (FLEX) ventilation method that actively decreases the rate of lung emptying and modulates the otherwise passive expiration phase. This is achieved by reducing the initial high-expiratory peak flow and causing the expiratory gas flow to persist throughout the expiratory phase. FLEX improves oxygenation and gas exchange in horses by altering the distribution of inspired ventilation due to more uniform homogeneous lung emptying during expiration.
Latest Research
Highlighted News
Uncovering the role of skin microbiome and immune response in cutaneous leishmaniasis (link is external)
Two new studies led by Phillip Scott of the School of Veterinary Medicine and Elizabeth Grice of the Perelman School of Medicine demonstrate how bacteria found in leishmaniasis skin lesions…
Study shows promise for iNKT cell platform to treat cancer (link is external)
Researchers from the School of Veterinary Medicine and Perelman School of Medicine have shown that invariant natural killer T cells from a healthy donor can persist in MHC-mismatched canines, demonstrating…
Removing the barrier surrounding solid tumors clears path for T cells (link is external)
Penn researchers uncover a new way to target solid tumors. Using CAR T cells to remove cancer-associated fibroblasts surrounding pancreatic tumors allows T cells to infiltrate and attack the tumor…
Genetic switch turns tumor suppressor into oncogene in colorectal cancer (link is external)
Researchers from the School of Veterinary Medicine have shown that an enzyme that suppresses early-stage colorectal cancer switches to become an oncogene as the cancer progresses.
New Bolton Center and the Pennsylvania Equine Toxicology and Research Laboratory (PETRL) were well represented at the 23rd International Conference of Racing Analysts and Veterinarians, which was held in Hong Kong, China, September 15—23, 2023. Five abstracts were presented by the laboratory of Mary Robinson, VMD, PhD, DACVCP (below).
Guan F, Adreance MA, McGoldrick LK, You Y, Robinson MA. Identification of Bicarbonate in a Confiscation Sample by Electrospray Ionization High-Resolution Mass Spectrometry.
Guan F, Adreance MA, McGoldrick LK, You Y, Robinson MA. Identification of Recombinant Human Erythropoietin and Recombinant Human Granulocyte-Stimulating Factor in Confiscation Samples.
You Y, Missanelli J, Proctor R, Haughan J, Robinson MA. Simultaneous Analysis of Oxycodone and Its Metabolites in Equine Urine by UHPLC-MS/MS.
Jiang Z, Haughan J, Robinson MA. Designing and Evaluating Primers for PCR to Distinguish AAV2-Mediated Gene Doping from Wild Type AAVS Infection.
Haughan JE, Missanelli J, Stefanovski D, You Y, Robinson MA. Measuring Oxycodone Metabolites in Plasma and Urine Enhances Detection of Oral Oxycodone Administration to Horses.
Penn Vet’s Annual Research Retreat was held on Friday, October 6, 2023, at the Inn at Swarthmore. The organizing committee was led by Dr. Montserrat C. Anguera and included faculty members Matthew J. Atherton, Charles W. Bradley, Anna M. Massie, Michael J. May, Andrew J. Modzelewski, Louise H. Moncla, Mary A. Robinson, and Phillip Scott.
The program included 12 faculty speakers, three from each of Penn Vet’s four departments. The Robert R. Marshak Lecture was delivered by Brian Hare, PhD, Professor of Evolutionary Anthropology, Duke University. Dr. Hare delivered a fascinating and very entertaining talk entitled, Is cognition the secret to dogs’ success?
An unprecedented 46 poster abstracts were received. Academic prizes were awarded for four outstanding poster presentations. Prizes were awarded to Jennifer Alexander, PhD; Madeline Boyes, DVM; Jennifer Kwok, DVM; and Daniel Sorobetea, PhD.
The retreat culminated with the granting of the Zoetis Award for Veterinary Research Excellence to Kotaro Sasaki, MD, PhD. The award recognizes researchers whose innovative studies have advanced the scientific standing of veterinary medicine. Dr. Chris Lengner, Chair of the Department of Biomedical Sciences, presented the award and noted that Dr. Sasaki’s research at Penn Vet has led to unprecedented insights into development and disease in the urogenital, reproductive, and endocrine organ systems.
The organizers are already working on plans for the 2024 Research Retreat, which will mark the 30th anniversary of the event. The Research Retreat was conceived by Dean Alan M. Kelly (1994—2005) to create a scientific event to bring basic science and clinical faculty together from Philadelphia and New Bolton Center to meet one another and learn about each other’s work. The first retreat was held on June 14, 1994.
Alexandra V. Crooks, VMD, DACVIM (Cardiology), is an Assistant Professor of Cardiology in the Department of Clinical Sciences and Advanced Medicine. She obtained her VMD in 2016 from the University of Pennsylvania. She stayed at the University of Pennsylvania to perform a small animal rotating internship followed by a residency in cardiology, which she completed in July 2020. After working in private practice for two years, she returned to the University of Pennsylvania as a cardiology lecturer before beginning her faculty appointment. Her research interests include the utility of cardiac biomarkers and the management of congestive heart failure. She is also interested in the diagnosis and treatment of canine myocardial disease, particularly arrhythmogenic right ventricular cardiomyopathy.
Daniela Luethy, MPH, DVM, DACVIM (LAIM), is an Assistant Professor of Large Animal Medicine in the Department of Clinical Studies – New Bolton Center. She received her veterinary degree from the University of California Davis School of Veterinary Medicine in 2014. After graduation, she completed a rotating internship in large animal surgery, medicine, and emergency/critical care at the University of Pennsylvania’s New Bolton Center, followed by a residency in large animal internal medicine at New Bolton Center, achieving board certification in large animal internal medicine in 2018. After her residency, she worked at New Bolton Center as a lecturer for two years and then was recruited by the University of Florida College of Veterinary Medicine as a Clinical Assistant Professor of Large Animal Medicine, before returning to University of Pennsylvania in her current role. Her research interests include large animal oncology, small ruminant medicine, and veterinary epidemiology.
Honors & Achievements
Penn Vet Cancer Center Announces 2023 Pilot Research Program Awardees
Congratulations to the 2023 Penn Vet Cancer Center Pilot Research Program awardees:
Drs. Matthew J. Atherton and Jennifer Lenz: Developing anti-CCR4 CAR T cells to target Tregs in canine solid cancers.
Drs. Erin Gibson and Maureen Griffin: Randomized double-blinded evaluation of patient outcomes in dogs with hepatocellular carcinoma receiving embolization or chemoembolization.
Dr. Amy Durham Receives ACVP Presidential Award
Amy C. Durham, MS, VMD, DACVP, received the 2023 Presidential Award from the American College of Veterinary Pathologists (ACVP) at its annual meeting. The award was bestowed upon Dr. Durham in recognition of her exceptional service and dedication to the College and its members through her role as chief operations officer (COO) on the board of directors. In the presentation of the award, ACVP President Jerry Ritchey described the role of COO as the board’s most vital position, noting that Dr. Durham has set an extremely high bar as the first holder of this position.
Dr. Kenneth Drobatz Receives Gary L. Stamp Award from VECCS
Kenneth J. Drobatz, MSCE, DVM, DACVIM, DACVECC, is the 2023 recipient of the Gary L. Stamp Award. This award is given to an individual who has demonstrated exceptional commitment and dedication to fostering the relationship between the Veterinary Emergency and Critical Care Society (VECCS) and the American College of Veterinary Emergency and Critical Care (ACVECC).
Dr. Jorge Alvarez Invited to Lecture at the Americas School of Neuroimmunology
Jorge I. Alvarez, BSc, PhD, has been invited as a lecturer at the fifth Americas School of Neuroimmunology (ANSI), which will take place at the University of Toronto, July 22—25, 2024. He has been invited to lecture on the topic of the neuroimmunology of central nervous system (CNS) barriers.
ASNI is a regional school of the International Society of Neuroimmunology (ISNI) with a focus on educating trainees and investigators on various aspects of neuroimmunology. The target audience comes from North, Central, and South America. Approximately 200 trainees from across the neuroimmunology spectrum, or PIs wishing to retool their immunology expertise, are expected.MD, PhD, and Jorge I. Alvarez, PhD.
Select Publications and Grants
Read the latest scholarly publication and grant information from Penn Vet researchers.
Ackerman R, Watson B, Serpell J, Reinhard CL, and Powell L. Understanding the motivations of foster caregivers at animal shelters. Animals (Basel) 2023;13. https://www.mdpi.com/2076-2615/13/17/2694https://doi.org/10.3390/ani13172694
Barr CA, Haughan J, Gianotti G, Varner K, Drobatz KJ, Stefanovski D, Robinson M, Pennington M, McGuire A, and Otto CM.Pharmacokinetics and pharmacodynamics of intranasal and intramuscular administration of naloxone in working dogs administered fentanyl. J Vet Intern Med 2023;37:2422-2428. https://onlinelibrary.wiley.com/doi/10.1111/jvim.16901
Beaudoin AL, Bollig ER, Burgess BA, Cohn LA, Cole SD, Dear JD, Fellman CL, Frey E, Goggs R, Johnston A, Kreuder AJ, KuKanich KS, LeCuyer TE, Menard J, Reagan KL, Sykes JE, Veir JK, Viviano K, Wayne A, and Granick JL. Prevalence of antibiotic use for dogs and cats in United States veterinary teaching hospitals, August 2020. J Vet Intern Med 2023;37:1864-1875. https://onlinelibrary.wiley.com/doi/10.1111/jvim.16814
Bellone RR, Tanaka J, Esdaile E, Sutton RB, Payette F, Leduc L, Till BJ, Abdel-Ghaffar AK, Hammond M, and Magdesian KG. A de novo 2.3 kb structural variant in MITF explains a novel splashed white phenotype in a Thoroughbred family. Anim Genet 2023;54:752-762. https://onlinelibrary.wiley.com/doi/10.1111/age.13352
Berlin N, Pfaff A, Rozanski EA, Chalifoux NV, Hess RS, Donnino MW, and Silverstein DC. Establishment of a reference interval for thiamine concentrations in healthy dogs and evaluation of the prevalence of absolute thiamine deficiency in critically ill dogs with and without sepsis using high-performance liquid chromatography. J Vet Emerg Crit Care (San Antonio) 2023. https://onlinelibrary.wiley.com/doi/10.1111/vec.13341
Bowyer AN, Lassaline ME, and Holt E. An evaluation of intracapsular lens extraction and transcorneal lens reduction for treatment of anterior lens luxation in dogs. Vet Ophthalmol 2023. https://onlinelibrary.wiley.com/doi/10.1111/vop.13159
Boyle AG, O’Shea K, Stefanovski D, and Rankin SC. Detection of viable Streptococcus equi equi using propidium monoazide polymerase chain reaction. J Equine Vet Sci 2023;128:104893. https://doi.org/10.1016/j.jevs.2023.104893
Brandly JE, Levine DG, Stefanovski D, and Aitken MR. In vitro evaluation of the effect of tris-EDTA and 0.0005% chlorhexidine solution on the strength of two absorbable sutures. Vet Surg 2023. https://onlinelibrary.wiley.com/doi/10.1111/vsu.14029
Brito LFC. Nutrition and sexual development in bulls. Vet Clin North Am Food Anim Pract 2023. https://doi.org/10.1016/j.cvfa.2023.08.002
Bullock G, Johnson GS, Pattridge SG, Mhlanga-Mutangadura T, Guo J, Cook J, Campbell RS, Vite CH, and Katz ML. A homozygous MAN2B1 missense mutation in a Doberman Pinscher dog with neurodegeneration, cytoplasmic vacuoles, autofluorescent storage granules, and analphamannosidase deficiency. Genes (Basel) 2023;14. https://www.mdpi.com/2073-4425/14/9/1746
Burke JE, Hess RS, McEntee EP, Griffin MA, Harmon SM, and Silverstein DC. Hepatic abscessation in dogs: A multicenter study of 56 cases (2010-2019). J Vet Emerg Crit Care (San Antonio) 2023;33:665-675. https://onlinelibrary.wiley.com/doi/10.1111/vec.13340
Cantu A, Gutierrez MC, Dong X, Leek C, Anguera M, and Lingappan K. Modulation of recovery from neonatal hyperoxic lung injury by sex as a biological variable. Redox Biol 2023;68. https://doi.org/10.1016/j.redox.2023.102933
Chen T, Wang Q, Wang Y, Dou Z, Yu X, Feng H, Wang M, Zhang Y, and Yin J. Using fresh vegetable waste from Chinese traditional wet markets as animal feed: Material feasibility and utilization potential. Sci Total Environ 2023;902:166105. https://doi.org/10.1016/j.scitotenv.2023.166105
Chong ACN, Vandana JJ, Jeng G, Li G, Meng Z, Duan X, Zhang T, Qiu Y, Duran-Struuck R, Coker K, Wang W, Li Y, Min Z, Zuo X, de Silva N, Chen Z, Naji A, Hao M, Liu C, and Chen S. Checkpoint kinase 2 controls insulin secretion and glucose homeostasis. Nat Chem Biol 2023. https://doi.org/10.1038/s41589-023-01466-4
Cohn IS, and Hunter CA. Mining for crypto protection: a search for Cryptosporidium antibodies reveals antigens associated with immunity. J Clin Invest 2023;133. https://doi.org/10.1172/JCI171966
Cole SD, Dietrich J, and Rankin SC. Use of a chromogenic medium with and without selective enrichment to screen for carbapenemase-producing Enterobacterales (CPE) from canine and feline fecal specimens during an outbreak of NDM-5-producing Escherichia coli. J Vet Diagn Invest 2023:10406387231204560. https://journals.sagepub.com/doi/10.1177/10406387231204560
Coll-Roman LM, Cabrera C, VanderBroek AR, Bauck AG, Kelleman AA, Pozor MA, Stockler JW, Wiley C, Scully C, Mackay EE, Depenbrock SM, Fecteau ME, Abraham M, Leduc L, Noll CV, Hernandez JA, and Luethy D. Multicenter study of uterine tears and other reproductive complications in periparturient goats presented to veterinary teaching hospitals. J Vet Intern Med 2023;37:2623-2630. https://onlinelibrary.wiley.com/doi/10.1111/jvim.16858
Delaney LJ, Isguven S, Hilliard R, Lacerda Q, Oeffinger BE, Machado P, Schaer TP, Hickok NJ, Kurtz SM, and Forsberg F. In vitroand in vivo evaluation of ultrasound-triggered release from novel spinal device. J Ultrasound Med 2023;42:2357-2368. https://onlinelibrary.wiley.com/doi/10.1002/jum.16263
Desai DN, Mahal A, Varshney R, Obaidullah AJ, Gupta B, Mohanty P, Pattnaik P, Mohapatra NC, Mishra S, Kandi V, Rabaan AA, and Mohapatra RK. Nanoadjuvants: Promising bioinspired and biomimetic approaches in vaccine innovation. ACS Omega 2023;8:27953-27968. https://pubs.acs.org/doi/10.1021/acsomega.3c02030
Ede T, von Keyserlingk MAG, and Weary DM. Exploring the effect of pain on response to reward loss in calves. Sci Rep 2023;13:15403. https://doi.org/10.1038/s41598-023-42740-8
Embersics C, Bannasch D, Batcher K, Boudreau EC, Church M, Miller A, Platt S, Koehler J, Olby N, Rossmeisl J, Rissi D, Grahn R, Donner J, and Dickinson PJ. Association of the FGF4L2 retrogene with fibrocartilaginous embolic myelopathy in dogs. J Vet Intern Med 2023. https://onlinelibrary.wiley.com/doi/10.1111/jvim.16925
Enriquez CK, Morrow JK, Graves A, and Johnson A. Evaluation of real-time polymerase chain reaction for the diagnosis of protozoal myeloencephalitis in horses using cerebrospinal fluid. J Vet Intern Med 2023;37:1893-1898. https://onlinelibrary.wiley.com/doi/10.1111/jvim.16826
Eyre AW, Zapata I, Hare E, Serpell JA, Otto CM, and Alvarez CE. Machine learning prediction and classification of behavioral selection in a canine olfactory detection program. Sci Rep 2023;13:12489. https://doi.org/10.1038/s41598-023-39112-7
Falk KL, Laeseke PF, Kisting MA, Zlevor AM, Knott EA, Smolock AR, Bradley C, Vlaisavljevich E, Lee FT, Jr., and Ziemlewicz TJ. Clinical translation of abdominal histotripsy: A review of preclinical studies in large animal models. Int J Hyperthermia 2023;40:2272065. https://www.tandfonline.com/doi/full/10.1080/02656736.2023.2272065
Farias Amorim C, Lovins VM, Singh TP, Novais FO, Harris JC, Lago AS, Carvalho LP, Carvalho EM, Beiting DP, Scott P, and Grice EA. Multiomic profiling of cutaneous leishmaniasis infections reveals microbiota-driven mechanisms underlying disease severity. Sci Transl Med 2023;15:eadh1469. https://www.science.org/doi/10.1126/scitranslmed.adh1469
Feld L, Bhandari A, Allen J, Saxena S, Stefanovski D, and Afolabi-Brown O. The impact of obstructive sleep apnea in children with sickle cell disease and asthma. Pediatr Pulmonol 2023;58:3188-3194. https://onlinelibrary.wiley.com/doi/10.1002/ppul.26643
Fischer C, Chalifoux N, and Reineke E. Emesis induction is successful for recovery of gastric foreign objects in cats. J Am Vet Med Assoc 2023;261:1363-1367. https://doi.org/10.2460/javma.23.03.0176
Fleischman DA, Mauldin EA, Lowe A, Cain CL, and Bradley CW. Clinical and histopathological features of rostrolateral nasal alar arteriopathy of German shepherd dogs. Vet Dermatol 2023;34:441-451. https://onlinelibrary.wiley.com/doi/10.1111/vde.13173
Fontes GS, McGrath AM, Chen CL, Truong JM, Gleason HE, Lapsley JM, and Selmic LE. Long-term outcomes associated with a modified versus traditional closed anal sacculectomy for treatment of canine anal sac neoplasia. J Am Vet Med Assoc 2023;261:1-7. https://doi.org/10.2460/javma.23.05.0239
Frankel JS, Gardiner KL, Brice AK, Hagan L, Manzi TJ, and Makaron L. Avascular necrosis of the femoral head in a cynomolgus macaque (Macaca fascicularis). J Med Primatol 2023;52:283-285. https://onlinelibrary.wiley.com/doi/10.1111/jmp.12653
Friday SE, Oyama MA, Massey LK, and Aronson LR. Effect of metastatic calcification on complication rate and survival in 74 renal transplant cats (1998-2020). Vet Surg 2023;52:952-960. https://onlinelibrary.wiley.com/doi/10.1111/vsu.13984
Gao S, Tang AT, Wang M, Buchholz DW, Imbiakha B, Yang J, Chen X, Hewins P, Mericko-Ishizuka P, Leu NA, Sterling S, August A, Jurado KA, Morrisey EE, Aguilar-Carreno H, and Kahn ML. Endothelial SARS-CoV-2 infection is not the underlying cause of COVID-19-associated vascular pathology in mice. Front Cardiovasc Med 2023;10:1266276. https://doi.org/10.3389/fcvm.2023.1266276
Griffin MA, Altwal J, Culp WTN, Seguin B, and Wustefeld-Janssens B. Modified hemipelvectomy techniques in dogs and cats appear well tolerated with good functional outcomes. J Am Vet Med Assoc 2023;261:1-9. https://doi.org/10.2460/javma.22.12.0592
Guo Y, Li TD, Modzelewski AJ, and Siomi H. Retrotransposon renaissance in early embryos. Trends Genet 2023. https://doi.org/10.1016/j.tig.2023.10.010
Guzman KMH, and Harkin K. Suspected Fluoroquinolone-induced exacerbation of myasthenia gravis in dogs. J Am Anim Hosp Assoc 2023;59:249-254. https://meridian.allenpress.com/jaaha/article-abstract/59/5/249/495091/Suspected-Fluoroquinolone-Induced-Exacerbation-of?redirectedFrom=fulltext
Hargy J, and Sasaki K. The developmental dynamics of the human male germline. Development 2023;150. https://journals.biologists.com/dev/article/150/17/dev202046/326593/The-developmental-dynamics-of-the-human-male
Herrmann BI, Grayczyk JP, and Brodsky IE. Collab or Cancel? Bacterial influencers of inflammasome signaling. Annual Review of Microbiology: Annual Reviews Inc., 2023;451-477. https://doi.org/10.1146/annurev-micro-032521-024017
Hildebrandt I, Culp WTN, and Griffin MA. A systematic review of canine cystectomy: Indications, techniques, and outcomes. Animals (Basel) 2023;13. https://www.mdpi.com/2076-2615/13/18/2896
Hobbs K, Luethy D, Davis J, Mallicote M, Torcivia C, Kulp J, Stefanovski D, Futterman C, Cooper F, and van Eps A. The effects of orally administered trazodone on ambulation and recumbency in healthy horses. J Vet Intern Med 2023;37:1899-1906. https://onlinelibrary.wiley.com/doi/10.1111/jvim.16821
Ivanova DL, Thompson SB, Klarquist J, Harbell MG, Kilgore AM, Lasda EL, Hesselberth JR, Hunter CA, and Kedl RM. Vaccine adjuvant-elicited CD8(+) T cell immunity is co-dependent on T-bet and FOXO1. Cell Rep 2023;42:112911. https://doi.org/10.1016/j.celrep.2023.112911
Jiwrajka N, Toothacre NE, Beethem ZT, Sting S, Forsyth KS, Dubin AH, Driscoll A, Stohl W, and Anguera MC. Impaired dynamic X-chromosome inactivation maintenance in T cells is a feature of spontaneous murine SLE that is exacerbated in female-biased models. J Autoimmun 2023;139:103084. https://doi.org/10.1016/j.jaut.2023.103084
Jung EJ, Sung KW, Bae TH, Kim HY, Choi HR, Kim SH, Jung CH, Mun SR, Son YS, Kim S, Suh YH, Kashina A, Park JW, and Kwon YT. The N-degron pathway mediates lipophagy: The chemical modulation of lipophagy in obesity and NAFLD. Metabolism 2023;146:155644. https://doi.org/10.1016/j.metabol.2023.155644
Jung JW, Castejón-González AC, Stefanovski D, and Reiter AM. Etiology, clinical presentation, and outcome of temporomandibular joint luxation in cats: 21 cases (2000–2018). Frontiers in Veterinary Science 2023;10. https://doi.org/10.3389/fvets.2023.1274193
Katsuda T, Cure H, Sussman J, Simeonov KP, Krapp C, Arany Z, Grompe M, and Stanger BZ. Rapid in vivo multiplexed editing (RIME) of the adult mouse liver. Hepatology 2023;78:486-502. https://doi.org/10.1002/hep.32759
Kenny SA, Cook MR, Lenz JA, Maritato KC, Skorupski KA, Wustefeld-Janssens BG, Pellin MA, Silveira CJ, Veytsman S, Selmic LE, and Husbands BD. Clinical outcomes in cats with renal carcinoma undergoing nephrectomy: A retrospective study. Vet Comp Oncol 2023;21:587-594. https://onlinelibrary.wiley.com/doi/10.1111/vco.12921
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