Research Area

    Diagram showing R-loop processing and R-loop dynamics parallel apoptotic progression in IRD.

    Penn Vet Researchers Uncover a Shared Cellular Stress Signal that May Drive Vision Loss in Retinitis Pigmentosa

    Study finds buildup of unusual RNA-DNA loops in degenerating photoreceptors, pointing to a shared molecular stress pathway across distinct genetic forms of inherited blindness.

    A person in a light blue buttom up shirt stands in a hallway.

    Behind the Breakthroughs: David Holt

    In this edition, we sit down with small animal Professor of Surgery, David Holt, BVSc, DACVS. Dr. Holt is redefining how cancer is seen and removed during surgery. A Diplomate…

    A black lab being trained to sniff for specific items.

    Sniffing out cancer: Trained dogs can detect hemangiosarcoma by scent (link is external)

    Penn Vet’s Cynthia M. Otto and Clara Wilson and colleagues show that trained dogs can identify the odor of hemangiosarcoma, a devastating canine cancer, offering the hope of a better…

    Two people standing in a lab.

    Newly Identified Gene Deletion in Standard Poodles Sheds Light on Severe Vision Disorder

    Inherited retinal diseases form a broad and complex group of genetic conditions that cause progressive vision loss and blindness. Dogs, like humans, are susceptible to many such disorders. Because of…

    An image of a website that has images of a dogs retina.

    Vision Scientists at Penn Vet Launch DogAEye, a Novel AI-Based Tool To Improve Early Diagnosis of Retinal Degeneration in Dogs

    Veterinary ophthalmologists and vision scientists at the University of Pennsylvania’s School of Veterinary Medicine (Penn Vet) have announced the release of DogAEye, an innovative artificial intelligence (AI)–based clinical decision support…

    Three people standing together in front of a projector.

    Penn Vet’s Annual Research Retreat Calls for the Power of Synergy in Challenging Times

    Noting the challenges ahead, but celebrating the many breakthroughs at hand, the University of Pennsylvania School of Veterinary Medicine (Penn Vet) community gathered for their 31st annual Research Retreat held…

    A person is examining a dog with an electronic device

    A New Penn Vet Clinic Brings Support and Hope for Dogs with Retinal Disease

    Zoey the cockapoo greeted life with tail-wagging joy. A mass of tawny curls, she loved everyone, and they loved her back.

    a diagram showing the process of using messenger RNA to make a protein

    Researchers Advance mRNA Delivery to the Retina Using Stabilized Lipid Carriers

    Efficient delivery of synthetic mRNA to the retina remains one of the key hurdles in developing mRNA-based treatments for vision loss.

    William Beltran

    Penn Vet Researchers Evaluate a New Device That Could Streamline Vision-Saving Therapies

    Retinal blindness caused by the death of photoreceptors, the light-sensing cells within the retina, affects millions of people worldwide. Novel gene and cell therapies to prevent or rescue vision loss…

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