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BORIS STRIEPEN, PhD

Professor, Pathobiology, University of Pennsylvania School of Veterinary Medicine

Research Areas: Cell biology and molecular biology of protozoan parasites
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We are interested in the cell and molecular biology of protozoan parasites. Most of our work is focused on members of the phylum Apicomplexa. Organisms in this group cause a number of important diseases including malaria, severe opportunistic infections associated with AIDS, and fetal and early childhood diseases. We use a broad array of modern genomic, genetic, cell biological and biochemical approaches to understand fundamental parasite biology and use this knowledge to identify and develop targets for intervention.

Manjunatha, U. H., Vinayak, S., Zambriski, J. A., Chao, A. T., Sy, T., Noble, C. G., Bonamy, G. M. C., Kondreddi, R. R., Zou, B., Gedeck, P., Brooks, C. F., Herbert, G. T., Sateriale, A., Tandel, J., Noh, S., Lakshminarayana, S. B., Lim, S. H., Goodman, L. B., Bodenreider, C., Feng, G., Zhang, L., Blasco, F., Wagner, J., Leong, F. J., Striepen, B., Diagana, T. T. A Cryptosporidium PI(4)K inhibitor is a drug candidate for cryptosporidiosis Nature 546: 376-380, 2017.

Hulverson, M. A., Vinayak, S., Choi, R., Schaefer, D. A., Castellanos-Gonzalez, A., Vidadala, R. S. R., Brooks, C. F., Herbert, G. T., Betzer, D. P., Whitman, G. R., Sparks, H. N., Arnold, S. L. M., Rivas, K. L., Barrett, L. K., White, A. C., Maly, D. J., Riggs, M. W., Striepen, B., Van Voorhis, W. C., Ojo, K. K. Bumped-Kinase Inhibitors for Cryptosporidiosis Therapy J Infect Dis 215: 1275-1284, 2017.

Arnold, S. L. M., Choi, R., Hulverson, M. A., Schaefer, D. A., Vinayak, S., Vidadala, R. S. R., McCloskey, M. C., Whitman, G. R., Huang, W., Barrett, L. K., Ojo, K. K., Fan, E., Maly, D. J., Riggs, M. W., Striepen, B., Van Voorhis, W. C. Necessity of Bumped Kinase Inhibitor Gastrointestinal Exposure in Treating Cryptosporidium Infection J Infect Dis 216: 55-63, 2017.

Fellows, J. D., Cipriano, M. J., Agrawal, S., Striepen, B. A Plastid Protein That Evolved from Ubiquitin and Is Required for Apicoplast Protein Import in Toxoplasma gondii MBio 8: , 2017.

Vinayak, S., Pawlowic, M. C., Sateriale, A., Brooks, C. F., Studstill, C. J., Bar-Peled, Y., Cipriano, M. J., Striepen, B. Genetic modification of the diarrhoeal pathogen Cryptosporidium parvum Nature 523: 477-480, 2015.

Francia, M. E., Striepen, B. Cell division in apicomplexan parasites Nat Rev Microbiol 12: 125-136, 2014.

Striepen, B. Parasitic infections: Time to tackle cryptosporidiosis Nature 503: 189-191, 2013.

van Dooren, G. G., Striepen, B. The algal past and parasite present of the apicoplast Annu Rev Microbiol 67: 271-289, 2013.

Striepen, B., Dubremetz, J. F., Schwarz, R. T. Glucosylation of glycosylphosphatidylinositol membrane anchors: identification of uridine diphosphate-glucose as the direct donor for side chain modification in Toxoplasma gondii using carbohydrate analogues Biochemistry 38: 1478-1487, 1999.

Striepen, B., Zinecker, C. F., Damm, J. B., Melgers, P. A., Gerwig, G. J., Koolen, M., Vliegenthart, J. F., Dubremetz, J. F., Schwarz, R. T. Molecular structure of the "low molecular weight antigen" of Toxoplasma gondii: a glucose alpha 1-4 N-acetylgalactosamine makes free glycosyl-phosphatidylinositols highly immunogenic J Mol Biol 266: 797-813, 1997.

PhD (Biochemistry, Cell Biology and Genetics) Philipps-Universität, Marburg, Germany, 1995