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New Bolton Center Kennett Square, PA
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610-444-5800
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Ryan Hospital Philadelphia, PA
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215-746-8911
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215-746-8387
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RONALD N. HARTY, BS, Ph.D., Postdoc

Professor of Pathobiology and Microbiology, University of Pennsylvania School of Veterinary Medicine

Lab Head, Infectious Diseases & Immunology, Infectious Diseases & Immunology

Research Areas: Antiviral immune responses, Ebola, Marburg, Rabies, VSV, Lassa Fever, Junin, Innate immunity, Innate Immune Defense, Virus-host interaction, Zoonotic diseases, Antiviral therapeutics
PubMed Link
Contact Information:
Rosenthal Building Room 412
3800 Spruce St

Our research is focused on three main areas:

1. The molecular dynamics and biological significance of virus-host interactions during late stages of RNA virus assembly and egress.

2. The identification and development of host-oriented therapeutics as a new class of antiviral inhibitors.

3. The interplay between the host innate immune response and RNA virus infection.

Our model virus systems to interrogate these topics include:

Filoviruses (Ebola and Marburg viruses)
Arenaviruses (Lassa fever and Junín viruses)
Rhabdoviruses (VSV)
Retroviruses (HIV-1 and HTLV-1)

Han Ziying, Schwoerer Michael P, Hicks Philip, Liang Jingjing, Ruthel Gordon, Berry Corbett T, Freedman Bruce D, Sagum Cari A, Bedford Mark T, Sidhu Sachdev S, Sudol Marius, Harty Ronald N Host Protein BAG3 is a Negative Regulator of Lassa VLP Egress. Diseases (Basel, Switzerland) 6: , 2018.

Han Ziying, Sagum Cari A, Takizawa Fumio, Ruthel Gordon, Berry Corbett T, Kong Jing, Sunyer J Oriol, Freedman Bruce D, Bedford Mark T, Sidhu Sachdev S, Sudol Marius, Harty Ronald N Ubiquitin Ligase WWP1 Interacts with Ebola Virus VP40 To Regulate Egress. Journal of virology 91: , 2017.

Liang Jingjing, Sagum Cari A, Bedford Mark T, Sidhu Sachdev S, Sudol Marius, Han Ziying, Harty Ronald N Chaperone-Mediated Autophagy Protein BAG3 Negatively Regulates Ebola and Marburg VP40-Mediated Egress. PLoS pathogens 13: e1006132, 2017.

Han Ziying, Sagum Cari A, Bedford Mark T, Sidhu Sachdev S, Sudol Marius, Harty Ronald N ITCH E3 Ubiquitin Ligase Interacts with Ebola Virus VP40 To Regulate Budding. Journal of virology 90: 9163-71, 2016.

Han Ziying, Bart Stephen M, Ruthel Gordon, Vande Burgt Nathan H, Haines Kathleen M, Volk Susan W, Vite Charles H, Freedman Bruce D, Bates Paul, Harty Ronald N Ebola virus mediated infectivity is restricted in canine and feline cells. Veterinary microbiology 182: 102-7, 2016.

Han Ziying, Madara Jonathan J, Herbert Andrew, Prugar Laura I, Ruthel Gordon, Lu Jianhong, Liu Yuliang, Liu Wenbo, Liu Xiaohong, Wrobel Jay E, Reitz Allen B, Dye John M, Harty Ronald N, Freedman Bruce D Calcium Regulation of Hemorrhagic Fever Virus Budding: Mechanistic Implications for Host-Oriented Therapeutic Intervention. PLoS pathogens 11: e1005220, 2015.

Han Ziying, Madara Jonathan J, Liu Yuliang, Liu Wenbo, Ruthel Gordon, Freedman Bruce D, Harty Ronald N ALIX Rescues Budding of a Double PTAP/PPEY L-Domain Deletion Mutant of Ebola VP40: A Role for ALIX in Ebola Virus Egress. The Journal of infectious diseases 212 Suppl 2: S138-45, 2015.

Okumura Atsushi, Rasmussen Angela L, Halfmann Peter, Feldmann Friederike, Yoshimura Akihiko, Feldmann Heinz, Kawaoka Yoshihiro, Harty Ronald N, Katze Michael G Suppressor of Cytokine Signaling 3 Is an Inducible Host Factor That Regulates Virus Egress during Ebola Virus Infection. Journal of virology 89: 10399-406, 2015.

Han Ziying, Lu Jianhong, Liu Yuliang, Davis Benjamin, Lee Michael S, Olson Mark A, Ruthel Gordon, Freedman Bruce D, Schnell Matthias J, Wrobel Jay E, Reitz Allen B, Harty Ronald N Small-molecule probes targeting the viral PPxY-host Nedd4 interface block egress of a broad range of RNA viruses. Journal of virology 88: 7294-306, 2014.

Lu Jianhong, Han Ziying, Liu Yuliang, Liu Wenbo, Lee Michael S, Olson Mark A, Ruthel Gordon, Freedman Bruce D, Harty Ronald N A host-oriented inhibitor of Junin Argentine hemorrhagic fever virus egress. Journal of virology 88: 4736-43, 2014.

BS (Biology) University of Lowell, Massachusetts, 1985

Ph.D. (Microbiology/Virology) Louisiana State University Medical Center, 1991

Postdoc (Virology) Mount Sinai School of Medicine, New York, 1993