Dr. Stefanovski’s research focus is in the field of the biomedical sciences, at the intersection of integrative physiology, statistics and computational biology. For over a decade, he has been involved in research studying obesity and its association with insulin resistance, a state of impaired glucose tolerance, and subsequent pathologies, such as Type 2 Diabetes. Current research indicates that the metabolic syndrome, as a combination of medical disorders, is not only associated with the cardiovascular disease and diabetes, but also with some types of cancer. His diverse background has enabled him to approach the complexity of the metabolic syndrome with a multitude of methodologies, including mathematical modeling, statistical analysis, molecular dynamics, molecular biology, and animal model experiments. His current research involves the study of the effects of rear variants of hepatic glucokinase and its repressor protein GKRP on glucose metabolism and development of novel mathematical model of free fatty acids (FFA) kinetics capable of quantifying whole-body insulin sensitivity of FFA metabolism. Additionally, he is studying the biophysical principles of ions selectivity.
Stefanovski Darko, Tang George, Wawrowsky Kolja, Boston Raymond C, Lambrecht Nils, Tajbakhsh Jian Prostate cancer diagnosis using epigenetic biomarkers, 3D high-content imaging and probabilistic cell-by-cell classifiers. Oncotarget 8: 57278-57301, 2017.Morton Gregory J, Muta Kenjiro, Kaiyala Karl J, Rojas Jennifer M, Scarlett Jarrad M, Matsen Miles E, Nelson Jarrell T, Acharya Nikhil K, Piccinini Francesca, Stefanovski Darko, Bergman Richard N, Taborsky Gerald J, Kahn Steven E, Schwartz Michael W Evidence That the Sympathetic Nervous System Elicits Rapid, Coordinated, and Reciprocal Adjustments of Insulin Secretion and Insulin Sensitivity During Cold Exposure. Diabetes 66: 823-834, 2017.Boyle Ashley G, Stefanovski Darko, Rankin Shelley C Comparison of nasopharyngeal and guttural pouch specimens to determine the optimal sampling site to detect Streptococcus equi subsp equi carriers by DNA amplification. BMC veterinary research 13: 75, 2017.Zeng W, Alpaugh W, Stefanovski D, Schlingmann K, Dobrinski I, Turner R M Xenografting of isolated equine (Equus caballus) testis cells results in de novo morphogenesis of seminiferous tubules but not spermatogenesis. Andrology 5: 336-346, 2017.Shin Mi-Kyung, Han Woobum, Joo Hoon, Bevans-Fonti Shannon, Shiota Masakazu, Stefanovski Darko, Polotsky Vsevolod Y The effect of adrenal medullectomy on metabolic responses to chronic intermittent hypoxia in the frequently sampled intravenous glucose tolerance test. Journal of applied physiology (Bethesda, Md. : 1985) 122: jap.00975.2016, 2017.Boyle AG, Stefanovski D, Rankin SC Determining optimal sampling site for Streptococcus equi subsp equi carriers using loop-medicated isothermal amplication. BMC veterinary research 13: , 2017.Luethy D, Owens S D, Stefanovski D, Nolen-Walston R, Giger U Comparison of Tube, Gel, and Immunochromatographic Strip Methods for Evaluation of Blood Transfusion Compatibility in Horses. Journal of veterinary internal medicine 30: 1864-1871, 2016.Darnaud S J M, Southwood L L, Aceto H W, Stefanovski D, Tomassone L, Zarucco L Are horse age and incision length associated with surgical site infection following equine colic surgery? Veterinary journal (London, England : 1997) 217: 3-7, 2016.Shankar Sudha S, Vella Adrian, Raymond Ralph H, Staten Myrlene A, Calle Roberto A, Bergman Richard N, Cao Charlie, Chen Danny, Cobelli Claudio, Dalla Man Chiara, Deeg Mark, Dong Jennifer Q, Lee Douglas S, Polidori David, Robertson R Paul, Ruetten Hartmut, Stefanovski Darko, Vassileva Maria T, Weir Gordon C, Fryburg David A Standardized Mixed-Meal Tolerance and Arginine Stimulation Tests Provide Reproducible and Complementary Measures of ß-Cell Function: Results From the Foundation for the National Institutes of Health Biomarkers Consortium Investigative Series. Diabetes care 39: 1602-13, 2016.Vellanki Priyathama, Smiley Dawn D, Stefanovski Darko, Anzola Isabel, Duan Wenlan, Hudson Megan, Peng Limin, Pasquel Francisco J, Umpierrez Guillermo E Randomized Controlled Study of Metformin and Sitagliptin on Long-Term Normoglycemia Remission in African American Patients With Hyperglycemic Crises. Diabetes care 39: 1948-1955, 2016.