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    Clinical Studies-New Bolton Center

    Kyla Ortved, DVM, PhD, DACVS, DACVSMR

    Associate Professor of Large Animal Surgery (CE)

    Additional Titles:

    Jacques Jenny Endowed Chair in Orthopedic Surgery

    Founding Fellow, Minimally Invasive Surgery, Large Animal Orthopedics

    Dr. Ortved is an Associate Professor of Large Animal Surgery at New Bolton Center, University of Pennsylvania in Kennett Square, PA. She received her DVM degree from the University of Guelph in 2006 and completed her large animal surgical residency training at Cornell University in 2010. Kyla became boarded with the American College of Veterinary Surgeons in 2011. Following her residency, Kyla went on to obtain a PhD in gene therapy for equine cartilage repair at Cornell. In February 2016, Kyla became boarded with the American College of Veterinary Sports Medicine and Rehabilitation. She joined the large animal surgery faculty at New Bolton Center in 2016 as an equine orthopedic surgeon and was named the Jacques Jenny Endowed Chair of Orthopedic Surgery in 2019. Her research program focuses on understanding the pathophysiology of equine osteoarthritis and developing gene and cell-based therapies to improve cartilage repair and prevent osteoarthritis.

    View Pub Med Publications

    Gale AL, Mammone RM, Linardi RL, McClung G, Ortved KF*.  Comparison of the chondrogenic differentiation potential of equine synovial membrane-derived and bone marrow-derived mesenchymal stem cells. Frontiers Vet Regen Med, 6:178, 2019.

    Moss KL, Jiang Z, Linardi RL, Gale AL, Dodson ME, Grzybowski C, Haughan J, Robinson M, Ortved KF*. Sustained interleukin-10 transgene expression following intraarticular AAV5-IL-10 administration to horses. Human Gene Therapy, 31:110-118, 2020.

    Chapman HS, Gale AL, Dodson ME, Linardi RL, Ortved KF*. The effect of autologous platelet lysate on the differentiation potential of equine bone marrow-derived mesenchymal stem cells. Stem Cells Dev, 29:144-155, 2020.

    Brown KA, Davidson EJ, Johnson A, Wulster KB, Ortved KF*. Inflammatory cytokines in horses with cervical articular process osteoarthritis on standing cone beam computed tomography. Equine Vet J, 49:590-599, 2021.

    Farnham M, Ortved KF, Homer JS, Wagner NJ, Burris DL, Price C. Lubricant effects on articular cartilage sliding biomechanics under physiological fluid load support. Tribology Letters, 69:56;1-14, 2021.

    Farnham M, Ortved KF, Burris DL, Price C. Articular cartilage friction, strain, and viability under physiological to pathological benchtop sliding conditions. Cell Mol Bioeng, 14:349-363, 2021.

    Connard SS, Linardi RL, Even KM, Berglund AK, Schnabel LV, Ortved KF*. Effects of continuous passage on the immunomodulatory properties of equine bone marrow-derived mesenchymal stem cells in vitro. Vet Immunol Immunopathol, 234:110203, 2021.

    Cameron AD, Even KM, Linardi RL, Berglund AK, Schnabel LV, Engiles JE, Ortved KF*. Adeno-associated virus-mediate overexpression of interleukin-10 affects the immunomodulatory properties of equine bone marrow-derived mesenchymal stem cells. Human Gene Therapy, 32:907-918, 2021.

    Gaesser AM, Underwood C, Linardi RL, Even KM, Reef VB, Shetye SS, Mauck RL, King WJ, Engiles JE, Ortved KF*. Evaluation of autologous protein solution injection for treatment of superficial digital flexor tendonitis in an equine model. Frontiers Vet Sci, 8:a697551, 2021.

    Cianci JM, Wulster KB, Richardson DW, Stefanovski D, Ortved KF*. Computed tomographic assessment of fracture characteristics and subchondral bone injury in Thoroughbred racehorses with lateral condylar fractures and their relationship to outcome. Vet Surg, 51:426-437, 2022.

    Even KM, Gaesser AM, Ciamillo SA, Linardi RL, Ortved KF*. Comparing the immunomodulatory properties of equine BM-MSCs culture expanded in autologous platelet lysate, pooled platelet lysate, equine serum and fetal bovine serum supplemented culture media. Frontiers Vet Sci, 9:958724, 2022.

    Ciamillo SA, Wulster KB, Gassert TM, Richardson DW, Brown KA, Stefanovski D, Ortved KF*. Prospective, longitudinal assessment of subchondral bone morphology and pathology using standing, cone-beam computed tomography (CBCT) in fetlock joints of 2-year-old Thoroughbred racehorses in their first year of training. Equine Vet J, 57: 126-139, 2024.

    Ortved KF, Alward L, Cowles B, Linardi RL, Barot D, Usimaki A, Fedie J, Amodie D, Goodrich LR. Use of quantitative mass spectrometry-based proteomics and ELISA to compare the alpha 2 macroglobulin concentration in equine blood-based products processed by three different orthobiologic devices. Frontiers Veterinary Science, 11:1335972, 2024.

    Gaesser AM, Usimaki A, Barot D, Linardi RL, Molugu S, Musante L, Ortved KF*. Equine mesenchymal stem cell-derived extracellular vesicle productivity but not overall yield is improved via 3-D culture with chemically defined media. JAVMA, 262:S97-S108 2024.

    Connard SS, Gaesser AM, Clarke EJ, Linardi RL, Even KM, Engiles JB, Peffers MJ, Koch DW, Ortved KF*. Plasma and synovial fluid extracellular vesicles display altered microRNA profiles in horses with naturally occurring post-traumatic osteoarthritis: an exploratory study. JAVMA, 262:S83-S96, 2024.

    Usimaki A, Ciamillo SA, Barot D, Linardi RL, Engiles JB, Ortved KF*. Effect of intraarticular autologous protein solution in horses with acute IL-1b-induced synovitis. EVJ, online ahead of print, 2024.

    Elkhenany HA, Linardi RL, OrtvedKF*. Differential modulation of inflammatory cytokines by recombinant IL-10 in IL-1β and TNF-α ̶ stimulated equine chondrocytes and synoviocytes: Impact of washing and timing on cytokine responses. BMC Vet Res, 20:546, 2024.

    Barot D, Usimaki A, Linardi RL, Arensberg CM, Ortved KF*. Equine autologous blood-based products contain variable quantities of TGF-b1, IL-1Ra and alpha-2-macroglobulin. AJVR, 30:1-8, 2025.

    Establishing regenerative medicine therapies to improve musculoskeletal healing using the horse as a model for human disease. Specifically, my research program is targeted towards elucidating the pathophysiology of posttraumatic osteoarthritis (PTOA), immunomodulation of the posttraumatic joint, and developing gene, signal, and cell-based therapies to improve cartilage repair and prevent osteoarthritis.

    Department of Large Animal Medicine, University of Georgia, USA (2006-2007)
    Internship in Large Animal Medicine and Surgery

    Department of Clinical Sciences, Cornell University, USA (2007-2010)
    Residency in Large Animal Surgery

    Clinical Specialties:

    Equine orthopedic surgery; Fracture repair; Arthroscopy; Tenoscopy; Regenerative medicine

    Research:

    Hospital & Services:

    Education:

    PhD (Comparative Biomedical Sciences) Cornell University, 2014
    DVM (Veterinary Medicine) University of Guelph, 2006
    BSc. (Animal Biology) University of British Columbia, 2001

    Board Certification:

    Diplomate, American College of Veterinary Surgeons Diplomate, American College of Veterinary Sports Medicine & Rehabilitation

    Contact:

    Phone:610-925-6195
    Email:kortved@vet.upenn.edu

    University of Pennsylvania

    School of Veterinary Medicine

    New Bolton Center

    382 West Street Road

    Kennett Square, PA 19348