Randomized Controlled Trial of One Versus Two Lung Ventilation in Elective Open Lung Lobectomy

One-lung ventilation (OLV) is an anesthesia technique by which only the lung not undergoing surgery receives oxygen and gas. When the lung that is undergoing surgery is no longer inflated with gas, the lung becomes much smaller creating more space for the surgeon to work. The improved access within the surgical field may result in reduced surgical time which is associated with decreased surgical complications.

The aim of this clinical trial is to compare the impact of one versus two lung ventilation on surgical time, rates of surgical and anesthetic complications, surgeon workload and intraoperative patient blood oxygenation status in dogs undergoing elective open lung lobectomy. The findings of this study may help improve the anesthetic and surgical management of dogs undergoing open chest surgery and optimize patient outcomes.

• All surgical procedures and recovery monitoring will be performed according to standard of care.
• Dogs are enrolled for the period of their surgery and up to 48 hours post procedure. No follow visits are required.

Dogs are ELIGIBLE if they:

• Are undergoing intercostal thoracotomy for lung lobectomy for one of the following procedures:
  • Pulmonary tumor resection
  • Pulmonary abscess resection
  • Lung biopsy
  • Stable lung lobe torsion

Dogs are EXCLUDED if they:

• Have pulmonary hypertension
• Have severe hypoxemia (paO2 </= 60mmHg)
• Require emergency surgery
• Undergo thorascopic surgery
• Have intraluminal masses precluding establishment of one lung ventilation

Costs of all study specific procedures are covered including:

• The one lung ventilation (OLV) device or standard endotracheal tube
• Anesthesia time required to place the OLV
• All those related to the equipment utilized to achieve placement of the OLV device
• Four arterial blood gasses performed during the procedure

For more information please contact the VCIC (vet-vcic@vet.upenn.edu); 215-573-0302