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Science & Research News


Pinpointing how cancer cells turn aggressive-Dr. Christopher Lengner Lab

Pinpointing how cancer cells turn aggressive

Penn scientists have developed a new method for tracing the lineage and gene expression patterns of metastatic cancer at the single-cell level.

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Boris Striepen, PhD, Named the Mark Whittier and Lila Griswold Allam Professor of Microbiology and Immunology

Boris Striepen, PhD, Professor of Pathobiology, an internationally recognized parasitologist, has been named the Mark Whittier and Lila Griswold Allam Professor of Microbiology and Immunology at the University of Pennsylvania’s School of Veterinary Medicine (Penn Vet).

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Blocking viruses’ exit strategy

The Marburg virus, a relative of the Ebola virus, causes a serious, often-fatal hemorrhagic fever. Transmitted by the African fruit bat and by direct human-to-human contact, Marburg virus disease currently has no approved vaccine or antivirals to prevent or treat it.

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Leaky blood-brain barrier and schizophrenia

The blood-brain barrier keeps out anything that could lead to disease and dangerous inflammation—at least when all is functioning normally.

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With impressive accuracy, dogs can sniff out coronavirus

Many long for a return to a post-pandemic “normal,” which, for some, may entail concerts, travel, and large gatherings. But how to keep safe amid these potential public health risks?

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Turning back the clock on a severe vision disorder

Gustavo Aguirre and William Beltran, veterinary ophthalmologists and vision scientists at the University of Pennsylvania School of Veterinary Medicine, have studied a wide range of different retinal blinding disorders. But the one caused by mutations in the NPHP5 gene, leading to a form of Leber congenital amaurosis (LCA), is one of the most severe.

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Penn Vet's Carlo Siracusa Receives Morris Animal Foundation Mark L. Morris Jr. Investigator Award

DENVER/March 16, 2021 -- Morris Animal Foundation has awarded its second Mark L. Morris Jr. Investigator Award to Dr. Carlo Siracusa, Associate Professor of Clinical Behavior Medicine at the University of Pennsylvania's School of Veterinary Medicine (Penn Vet), for a groundbreaking study on how chronic inflammation affects cognition, behavior and the overall health of senior cats.

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From animals to people and back again

Last month, it was gorillas. Before that, it was mink. And earlier still, tigers and lions. All of these species have been confirmed to have had a diagnosis of COVID-19, infection with the SARS-CoV-2 virus.

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Gut cells sound the alarm when parasites invade

To effectively combat an infection, the body first has to sense it’s been invaded, and then the affected tissue must send signals to corral resources to fight the intruder.

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Penn Vet’s Gustavo D. Aguirre Wins the Sanford and Susan Greenberg Prize for Ending Blindness

Penn Vet's Dr/ Gustavo D. Aguirre is the recipient of the Sanford and Susan Greenberg End Blindness Outstanding Achievement Prize which distinguishes scientists for their groundbreaking medical contributions to eradicate blindness.

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AAEP Bestows Research Award upon Renowned Theriogenologist Dr. Katrin Hinrichs

The American Association of Equine Practitioners presented the 2020 AAEP Research Award to Katrin Hinrichs, DVM, Ph.D., DACT, whose pioneering research in the field of equine assisted reproductive techniques (ART) has transformed the state of equine reproductive practice around the world.

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Inaugural Penn Vet New Bolton Center, MARS Equestrian™ research program to accelerate transformative advancements in equine musculoskeletal health

Together with MARS Equestrian™, the University of Pennsylvania’s School of Veterinary Medicine (Penn Vet) has launched an innovative educational research program dedicated to advancing critical frontiers in equine health.

 

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Parasitic worms offer ‘the missing link’ on the dual nature of a key immune regulator

De’Broski Herbert has a philosophy that’s guided his career researching helminths, or parasitic worms, and their interaction with their hosts’ immune systems: “Follow the worm.”

 

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Five Penn faculty elected to the National Academy of Medicine

Five faculty members from Penn have been elected to the National Academy of Medicine (NAM), one of the nation’s highest honors in the fields of health and medicine, including Penn Vet's Dr. William Beltran.

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Novel canine scent detection program holds promise in PA’s fight against Spotted Lanternfly

A new pilot training program from the University of Pennsylvania’s School of Veterinary Medicine (Penn Vet) points to a promising solution in Pennsylvania’s efforts to thwart the Spotted Lanternfly. By utilizing scent detection dogs to identify Spotted Lanternfly egg masses, Penn Vet researchers hope to proactively neutralize the destructive insects before they become a fully realized threat as a mature adult.

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Creating ‘Farms of the Future’: New Penn-led webinar series to host grassroots discussions about sustainable, regenerative agriculture

A new virtual symposium series presented by the University of Pennsylvania’s School of Veterinary Medicine (Penn Vet), in collaboration with PennPraxis, the community engagement arm at the University of Pennsylvania Stuart Weitzman School of Design, will explore the advantages, challenges, and opportunities surrounding animal agriculture and food production systems within Pennsylvania, the surrounding region, and across the United States. 

 

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Progress toward a treatment for Krabbe disease

In one out of 100,000 infants, a mutation in the GALC gene causes an incurable, always fatal disorder known as infantile Krabbe disease, or globoid cell leukodystrophy. Most children with the condition die before they turn 2. 

Penn Vet's Sherrill Davison reminds poultry owners to collect eggs often. Eggs that sit for too long in the nest may have an increased risk of infection.

Poultry in a pandemic: Getting the facts on keeping backyard flocks

With the COVID-19 pandemic wearing on, many Americans are turning to raising poultry to fill their extra time at home. While raising backyard birds is a great idea – whether for food, for educational purposes, or as a hobby – the influx of new flocks has put humans, as well as the birds they care for, at risk of Salmonella sickness.

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Getting gene therapy to the brain

A lone genetic mutation can cause a life-changing disorder with effects on multiple body systems. Lysosomal storage diseases, for example, of which there are dozens, arise due to single mutations that affect production of critical enzymes required to metabolize large molecules in cells. These disorders affect multiple organs including, notably, the brain, causing intellectual disability of varying degrees.  

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Bats and COVID

COVID-19 is a zoonotic disease. For the 200+ bats currently in wildlife rehabilitation facilities across Pennsylvania, this presents a threat. Eman Anis, a microbiologist with Penn Vet’s New Bolton Center, is leading a study to test for the presence of SARS-CoV-2 in North American bats, work being done with associate professors Lisa Murphy and Julie Ellis and Pennsylvania Game Commission biologist Greg Turner.