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Science & Research News


mRNA

Penn Vet Announces mRNA Research Initiative to Advance Veterinary Vaccine Science

The University of Pennsylvania (Penn) School of Veterinary Medicine (Penn Vet) announced the launch of the School’s mRNA Research Initiative to fast-track the development of veterinary mRNA-based vaccines and host-directed therapies.

Woman works in a lab.

Understanding chronic wasting disease in deer

A new collaborative study with Penn Vet researchers analyzed fecal samples to shed light on how the fatal disease impacts the gut microbiome in deer, providing a promising tool for disease surveillance.

Artist's interpretation of human lungs and a virus.

Researchers breathe new life into lung repair

A collaborative effort from teams across Penn culminates in new techniques to repair lung tissue after damage from flu and COVID-19.

fMRI activity

Using fMRI, new vision study finds promising model for restoring cone function

School of Veterinary Medicine and Perelman School of Medicine researchers identified a retinal disease to evaluate the success of gene and cell replacement therapy.

Oriol Sunyer-thumb copy

Scientists at the University of Pennsylvania’s School of Veterinary Medicine Shed New Light on the Evolution of Adaptive Immunity in Cold-Blooded Vertebrates

[December 1, 2023; Philadelphia, PA] – Upon infection or immunization, all jawed vertebrate species generate proteins called antibodies that bind and neutralize pathogens. Strong and long-lasting antibody responses in warm-blooded species such as mammals are produced in secondary lymphoid microstructures (SLMs) among which germinal centers (GCs) are the centerpiece.

From left, Camila Amorim, Phillip Scott, Elizabeth A. Grice, Daniel P. Beiting, and Tej Singh

Uncovering the role of skin microbiome and immune response in cutaneous leishmaniasis

Two new studies led by Phillip Scott of the School of Veterinary Medicine and Elizabeth Grice of the Perelman School of Medicine demonstrate how bacteria found in leishmaniasis skin lesions and an associated immune response drive disease burden and treatment failure—and suggest new possibilities for treatment of the parasitic disease.

Nicola Mason and Antonia Rotolo

Study shows promise for iNKT cell platform to treat cancer

Researchers from the School of Veterinary Medicine and Perelman School of Medicine have shown that invariant natural killer T cells from a healthy donor can persist in MHC-mismatched canines, demonstrating a reliable platform to inform human clinical trials.

Stroma targeting CAR T Cells suround a tumor

Removing the barrier surrounding solid tumors clears path for T cells

Penn researchers uncover a new way to target solid tumors. Using CAR T cells to remove cancer-associated fibroblasts surrounding pancreatic tumors allows T cells to infiltrate and attack the tumor cells.

colorectal cancer

Genetic switch turns tumor suppressor into oncogene in colorectal cancer

Researchers from the School of Veterinary Medicine have shown that an enzyme that suppresses early-stage colorectal cancer switches to become an oncogene as the cancer progresses.

students studying the galapagos, sitting on waterfront

Social ecology and community work in the Galápagos

Daniel Beiting, PhD, associate director of the Institute for Infectious and Zoonotic Diseases, expanded his work this summer in the Galápagos, giving Stephanie Sila, V’25, an ideal opportunity to gain first-hand experience in identifying different mosquito species and human disease cases on the island.

Dipti Pitta petting a cow's head.

Could we breed cows that emit less methane?

In a new study, researchers from the School of Veterinary Medicine identified attributes of low-methane-emitting dairy cows that could be used as targets for selective breeding.

Ali Nabavizadeh

What fossils tell us about the dining habits of dinosaurs

More than a century of research is vividly shared in ‘An Illustrated Guide to Dinosaur Feeding Biology’ by Ali Nabavizadeh of the School of Veterinary Medicine and David B. Weishampel of Johns Hopkins University.

Tom Parsons speaking to another faculty member

Cross-disciplinary collaboration for a healthier planet

The Environmental Innovations Initiative announces a third round of funded research communities to catalyze interdisciplinary research at Penn, investigating issues from regenerative agriculture to project-based learning for global climate justice.

A 3D rendering of the mpox virus, a viral disease that can spread between people and certain animals.

From outbreaks to breakthroughs: Tackling infectious and zoonotic diseases

Three years into what feels like a never-ending pandemic, science news has become more than an afterthought to many; it’s a ring buoy for those drowning in a sea of misleading information. The ongoing COVID-19 situation points to the increasingly difficult position science journalists face as they work to disseminate accurate and timely information to the public.

brodsky_yersinia

The immune system does battle in the intestines to keep bacteria in check

New research from Penn Vet demonstrates that Yersinia pseudotuberculosis, a relative of the bacterial pathogen that causes plague, triggers the body’s immune system to form lesions in the intestines called granulomas.

primordial germ cells

Rewiring blood cells to give rise to precursors of sperm

School of Veterinary Medicine researchers teamed with scientists at the University of Texas at San Antonio to transform blood cells to regain a flexible fate, growing into a precursor of sperm cells.

A dog sniffing a jar

Trained dogs can sniff out a deadly deer disease

Charlie, Jari, and Kiwi are pet dogs with a superpower: Their sensitive noses can distinguish between a healthy deer and one sick with chronic wasting disease (CWD), all from a whiff of the deer’s poop.

Ebola

Harnessing an innate protection against Ebola

In their evolutionary battle for survival, viruses have developed strategies to spark and perpetuate infection. Once inside a host cell, the Ebola virus, for example, hijacks molecular pathways to replicate itself and eventually make its way back out of the cell into the bloodstream, where it can spread further.

beltran-header2

Dr. William Beltran named One of Eight Penn professors elected 2022 AAAS Fellows

Eight faculty from four University of Pennsylvania schools have been elected 2022 American Association for the Advancement of Science (AAAS) Fellows. They are among more than 500 researchers honored for their “scientifically and socially distinguished achievements.” 

how-sex-differences-may-influence-lung-injury

How sex differences may influence lung injury

Comparing lung cells from male and female mice, Penn Vet scientists found gene expression differences that may explain why older males are at a higher risk than females for worse outcomes from COVID-19 and similar diseases.