Intraoperative detection of oral squamous cell carcinoma margins in dogs using cathepsin-activated near-infrared (NIR) imaging
Squamous cell carcinoma (SCC) is a common cancer of the epidermis, or outer layer of the skin, and oral tissues in dogs. The skin, oral cavity, and digits are the most common sites of SCC. In this study, we will be assessing dogs with oral SCC. Surgical excision of the tumor is regarded as the best treatment option for local disease control.
The aim of this study is to improve detection of surgical margins at the time of surgery to remove the tumor. This is vital in both veterinary and human surgical oncology to minimize the chance of local recurrence. We are using a new near-infrared (NIR) imaging agent, injected intravenously, and a novel imaging system to identify the tumor and its margins during surgery. This imaging adds no more than 15 minutes to a surgical procedure.
Eligibility:
- Dogs with diagnosed oral SCC that are eligible for surgical excision
- No prior/current treatments (including surgery, radiation, and chemotherapy) for this cancer
- No other significant health concerns that are an immediate threat to life outside of trial.
- Ability to attend visits at PennVet in Philadelphia
Benefits:
$3500 paid towards the cost of surgeryd abdominal ultrasound fees. If your dog needs sedation for any of the study related procedures, the study will cover the cost of the sedation as well.
Contact the VCIC at 215-573-0302 or email vcic@vet.upenn.edu for more information.