Oyebola Oyesola, DVM, PhD

Loke P, Oyesola O. Is IFN-γ good or bad for the host during helminth infections? Trends Parasitol. 2025 Jul;41(7):514-515. doi: 10.1016/j.pt.2025.05.009. Epub 2025 Jun 2. PMID: 40461378.

Chen YH, Zaldana K, Yeung F, Vujkovic-Cvijin I, Downie AE, Lin JD, Yang Y, Herrmann C, Oyesola O, Rozenberg F, Schwartz RE, Kim D, Tio K, Belkaid Y, Loke P, Graham AL, Koralov SB, Cadwell K. Rewilding catalyzes maturation of the humoral immune system. Sci Adv. 2025 Mar 7;11(10):eads2364. doi: 10.1126/sciadv.ads2364. Epub 2025 Mar 7. PMID: 40053586; PMCID: PMC11887799.

Zhao M, Jankovic D, Link VM, Souza COS, Hornick KM, Oyesola O, Belkaid Y, Lack J, Loke P. Genetic variation in IL-4 activated tissue resident macrophages determines strain-specific synergistic responses to LPS epigenetically. Nat Commun. 2025 Jan 25;16(1):1030. doi: 10.1038/s41467-025-56379-8. PMID: 39863579; PMCID: PMC11762786.

Downie AE, Barre RS, Robinson A, Yang J, Chen YH, Lin JD, Oyesola O, Yeung F, Cadwell K, Loke P, Graham AL. Assessing immune phenotypes using simple proxy measures: promise and limitations. Discov Immunol. 2024 Jun 28;3(1):kyae010. doi: 10.1093/discim/kyae010. PMID: 39045514; PMCID: PMC11264049.

Oyesola O, Downie AE, Howard N, Barre RS, Kiwanuka K, Zaldana K, Chen YH, Menezes A, Lee SC, Devlin J, Mondragón-Palomino O, Souza COS, Herrmann C, Koralov SB, Cadwell K, Graham AL, Loke P. Genetic and environmental interactions contribute to immune variation in rewilded mice. Nat Immunol. 2024 Jul;25(7):1270-1282. doi: 10.1038/s41590-024-01862-5. Epub 2024 Jun 14. PMID: 38877178; PMCID: PMC11224019.

Watson NB, Patel RK, Kean C, Veazey J, Oyesola OO, Laniewski N, Grenier JK, Wang J, Tabilas C, Yee Mon KJ, McNairn AJ, Peng SA, Wesnak SP, Nzingha K, Davenport MP, Tait Wojno ED, Scheible KM, Smith NL, Grimson A, Rudd BD. The gene regulatory basis of bystander activation in CD8+ T cells. Sci Immunol. 2024 Feb 23;9(92):eadf8776. doi: 10.1126/sciimmunol.adf8776. Epub 2024 Feb 23. PMID: 38394230; PMCID: PMC11973513.

Downie AE, Oyesola O, Barre RS, Caudron Q, Chen YH, Dennis EJ, Garnier R, Kiwanuka K, Menezes A, Navarrete DJ, Mondragón-Palomino O, Saunders JB, Tokita CK, Zaldana K, Cadwell K, Loke P, Graham AL. Spatiotemporal-social association predicts immunological similarity in rewilded mice. Sci Adv. 2023 Dec 22;9(51):eadh8310. doi: 10.1126/sciadv.adh8310. Epub 2023 Dec 22. PMID: 38134275; PMCID: PMC10745690.

Oyesola OO, Hilligan KL, Namasivayam S, Howard N, Clancy CS, Zhao M, Oland SD, Kiwanuka KN, Garza NL, Lafont BAP, Johnson RF, Mayer-Barber KD, Sher A, Loke P. Exposure to lung-migrating helminth protects against murine SARS-CoV-2 infection through macrophage-dependent T cell activation. Sci Immunol. 2023 Aug 18;8(86):eadf8161. doi: 10.1126/sciimmunol.adf8161. Epub 2023 Aug 11. PMID: 37566678.

Smita S, Webb LM, Mooney B, Früh SP, Oyesola OO, Matheson MK, Peng SA, Wojno EDT. Basophil responses in susceptible AKR mice upon infection with the intestinal helminth parasite Trichuris muris. Parasite Immunol. 2023 Aug;45(8):e12999. doi: 10.1111/pim.12999. Epub 2023 Jul 6. PMID: 37415265; PMCID: PMC10513073.

Tee MZ, Er YX, Easton AV, Yap NJ, Lee IL, Devlin J, Chen Z, Ng KS, Subramanian P, Angelova A, Oyesola O, Sargsian S, Ngui R, Beiting DP, Boey CCM, Chua KH, Cadwell K, Lim YAL, Loke P, Lee SC. Gut microbiome of helminth-infected indigenous Malaysians is context dependent. Microbiome. 2022 Dec 7;10(1):214. doi: 10.1186/s40168-022-01385-x. PMID: 36476263; PMCID: PMC9727879.

Loke P, Lee SC, Oyesola OO. Effects of helminths on the human immune response and the microbiome. Mucosal Immunol. 2022 Jun;15(6):1224-1233. doi: 10.1038/s41385-022-00532-9. Epub 2022 Jun 22. PMID: 35732819.

Oyesola OO, Souza COS, Loke P. The Influence of Genetic and Environmental Factors and Their Interactions on Immune Response to Helminth Infections. Front Immunol. 2022 Apr 29;13:869163. doi: 10.3389/fimmu.2022.869163. PMID: 35572520; PMCID: PMC9103684.

Barshad G, Webb LM, Ting HA, Oyesola OO, Onyekwere OG, Lewis JJ, Rice EJ, Matheson MK, Sun XH, von Moltke J, Danko CG, Tait Wojno ED. E-Protein Inhibition in ILC2 Development Shapes the Function of Mature ILC2s during Allergic Airway Inflammation. J Immunol. 2022 Mar 1;208(5):1007-1020. doi: 10.4049/jimmunol.2100414. Epub 2022 Feb 18. PMID: 35181641; PMCID: PMC8881320.

Shanahan MT, Kanke M, Oyesola OO, Hung YH, Koch-Laskowski K, Singh AP, Peck BCE, Biraud M, Sheahan B, Cortes JE, Gong H, Sahoo DK, Cubitt R, Kurpios NA, Mochel JP, Allenspach K, McElroy SJ, Ding S, von Moltke J, Dekaney CM, Tait-Wojno ED, Sethupathy P. Multiomic analysis defines the first microRNA atlas across all small intestinal epithelial lineages and reveals novel markers of almost all major cell types. Am J Physiol Gastrointest Liver Physiol. 2021 Dec 1;321(6):G668-G681. doi: 10.1152/ajpgi.00222.2021. Epub 2021 Oct 13. PMID: 34643097; PMCID: PMC8887887.

Oyesola OO, Tait Wojno ED. Prostaglandin regulation of type 2 inflammation: From basic biology to therapeutic interventions. Eur J Immunol. 2021 Oct;51(10):2399-2416. doi: 10.1002/eji.202048909. Epub 2021 Sep 7. PMID: 34396535; PMCID: PMC8843787.

Oyesola OO, Shanahan MT, Kanke M, Mooney BM, Webb LM, Smita S, Matheson MK, Campioli P, Pham D, Früh SP, McGinty JW, Churchill MJ, Cahoon JL, Sundaravaradan P, Flitter BA, Mouli K, Nadjsombati MS, Kamynina E, Peng SA, Cubitt RL, Gronert K, Lord JD, Rauch I, von Moltke J, Sethupathy P, Tait Wojno ED. PGD2 and CRTH2 counteract Type 2 cytokine-elicited intestinal epithelial responses during helminth infection. J Exp Med. 2021 Sep 6;218(9):e20202178. doi: 10.1084/jem.20202178. Epub 2021 Jul 20. PMID: 34283207; PMCID: PMC8294949.

Douglas B, Oyesola O, Cooper MM, Posey A, Tait Wojno E, Giacomin PR, Herbert DR. Immune System Investigation Using Parasitic Helminths. Annu Rev Immunol. 2021 Apr 26;39:639-665. doi: 10.1146/annurev-immunol-093019-122827. Epub 2021 Mar 1. PMID: 33646858; PMCID: PMC8162934.

Früh SP, Saikia M, Eule J, Mazulis CA, Miller JE, Cowulich JM, Oyesola OO, Webb LM, Peng SA, Cubitt RL, Danko CG, Miller WH, Tait Wojno ED. Elevated circulating Th2 but not group 2 innate lymphoid cell responses characterize canine atopic dermatitis. Vet Immunol Immunopathol. 2020 Mar;221:110015. doi: 10.1016/j.vetimm.2020.110015. Epub 2020 Jan 24. PMID: 32058160.

Oyesola OO, Duque C, Huang LC, Larson EM, Früh SP, Webb LM, Peng SA, Tait Wojno ED. The Prostaglandin D2 Receptor CRTH2 Promotes IL-33-Induced ILC2 Accumulation in the Lung. J Immunol. 2020 Feb 15;204(4):1001-1011. doi: 10.4049/jimmunol.1900745. Epub 2020 Jan 3. PMID: 31900341; PMCID: PMC6994842.

Webb LM, Oyesola OO, Früh SP, Kamynina E, Still KM, Patel RK, Peng SA, Cubitt RL, Grimson A, Grenier JK, Harris TH, Danko CG, Tait Wojno ED. The Notch signaling pathway promotes basophil responses during helminth-induced type 2 inflammation. J Exp Med. 2019 Jun 3;216(6):1268-1279. doi: 10.1084/jem.20180131. Epub 2019 Apr 11. PMID: 30975892; PMCID: PMC6547860.

Oyesola OO, Früh SP, Webb LM, Tait Wojno ED. Cytokines and beyond: Regulation of innate immune responses during helminth infection. Cytokine. 2020 Sep;133:154527. doi: 10.1016/j.cyto.2018.08.021. Epub 2018 Sep 18. PMID: 30241895; PMCID: PMC6422760.

Completed List of Publication can be found here – https://www.ncbi.nlm.nih.gov/myncbi/1RQQhtkYavFk-/bibliography/public/

The Tissue Immunity and Immune Priming Laboratory is focused on understanding how previous infection and exposure to environmental antigens can reprogram the immune system to influence outcomes to subsequent insults and injury. To answer this question, we use various murine models, infection models, multicolor flow cytometry, and other single cell approaches to dissect the contributions of reprogrammed immune cells to the development of host resistance and/or susceptibility to other insults. We are also interested in the immune mechanism that mediate and influence the pathogenesis of this process

National Institute of Health – Visiting Postdoctoral Fellow 2021 -2023

National Institute of Health – Independent Research Scholar 2023 – 2025