Animal Model Core & Comparative Orthopedic Research Laboratory
What We do
The Animal Model Core & Comparative Orthopedic Research Laboratory (AMC-CORL) is part of the Institute for Medical Translation at Penn Vet New Bolton Center. It functions as an ecosystem for medical translation and multidisciplinary collaboration providing a bridge to support the continuum from discovery to invention to innovation.
About AMC-CORL
The AMC-CORL group leads, supports and collaborates on many federal and industry funded projects at the intersection of science and the rapid advancements in healthcare technology. This multidisciplinary collaboration provides an immersive experience for mentoring of graduate and undergraduate students in the translational and regulatory sciences through our unique training opportunities.
The core is staffed by four to five veterinarians with surgical experience, a Study Director (GLP), a Quality Assurance and Quality Control Officer (GLP), two to three research technicians, and five to ten research assistants. Our staff are responsible for day-to-day operations (24/7 365 days a year), project design and management, animal care, data collection, and evaluation of in vivo and ex vivo components of a given study.
Services
Our SERVICE CORE designs and executes studies from proof of concept to pivotal IND/IDE-enabling trials (GLP/VICH-9) in support of regulatory submissions and offers a wide variety of animal models (Animal Core).
Research
Our RESEARCH CORE initiates and collaborates with academia on hypothesis driven research using animal models in support of investigations in regenerative medicine, tissue engineering, orthopedic trauma, spinal deformities, microbial-host interactions and biofilm infections.
Support & Partners
Our program is supported by the various specialty services at the New Bolton Center Large Animal Hospital, including Anesthesia, Radiology, Emergency and Critical Care, Surgery, Microbiology and Veterinary Pathology. Studies starting on a small scale may take advantage of our large biobank of specimens prior to moving into in vivo trials which may culminate in pivotal non-clinical trials (GLP/VICH GL-9) in support of FDA or OUS-FDA submissions. We host PI’s, trainees, and sponsors during clinical procedures to support and enrich their experience in a cross-functional team setting. This animal model core platform at Penn Vet New Bolton Center provides opportunities across most common model species (rodents, rabbits, mini-pig, Yorkshire pig, sheep, goats, lama/alpaca, calf/cow and horse).
We have deep and multifaceted subject matter expertise and logistical capabilities in the translational research enterprise in support of your in vivo research. Together, we benefit principal investigators, associated faculty, and industry sponsors to continue to pioneer, enhance, and support the translational research enterprise of the University of Pennsylvania and beyond.
Director, AMC-CORL
Thomas Schaer, VMD, PhD
Associate Professor of Comparative Orthopedic Surgery (CE)
Training Opportunities
One of the foundational tenets of our lab is to foster the growth of the next generation of scientists and researchers. Through our programs we support undergraduate and post-doctoral students in their professional and intellectual development, providing mentorship and hands-on opportunities in the field of translational research.
If you have any questions related a future opportunity please contact us for more information.
Find Us
University of Pennsylvania
School of Veterinary Medicine
3800 Spruce Street
Philadelphia, PA 19104-4539
Our Team
Claire Brady
Leslie Brewer, DVM
Nicole DeLizzio
Carly Dillulio
Amanda Girgis
Catherine Johnson
Lily Koster
Delaney Oeth
Paige Pierson
Alexis Rabinovitch
Seline Stoop
Kimberly Weingarten
