Publications: Imaging Core Users

Do you have a publication that belongs in this list?  Please let us know of any publications that include work done using PVIC services, such as images acquired on core microscopes and analysis performed with software accessed through the core, by e-mailing the core manager at goruthel@vet.upenn.edu.  Thanks! 

2021

Role of nuclear localization in the regulation and function of T-bet and Eomes in exhausted CD8 T cells. McLane LM, Ngiow SF, Chen Z, Attanasio J, Manne S, Ruthel G, Wu JE, Staupe RP, Xu W, Amaravadi RK, Xu X, Karakousis GC, Mitchell TC, Schuchter LM, Huang AC, Freedman BD, Betts MR, Wherry EJ. Cell Rep. 2021 May 11;35(6):109120.

Persistent NF-κB activation in muscle stem cells induces proliferation-independent telomere shortening. Tichy ED, Ma N, Sidibe D, Loro E, Kocan J, Chen DZ, Khurana TS, Hasty P, Mourkioti F.  Cell Rep. 2021 May 11;35(6):109098.

LINGO3 regulates mucosal tissue regeneration and promotes TFF2 dependent recovery from colitis. Zullo KM, Douglas B, Maloney NM, Ji Y, Wei Y, Herbine K, Cohen R, Pastore C, Cramer Z, Wang X, Wei W, Somsouk M, Hung LY, Lengner C, Kohanski MH, Cohen NA, Herbert DR. Scand J Gastroenterol. 2021 May 3:1-15. Online ahead of print.

IL-33 promotes innate lymphoid cell-dependent IFN-γ production required for innate immunity to Toxoplasma gondii. Clark JT, Christian DA, Gullicksrud JA, Perry JA, Park J, Jacquet M, Tarrant JC, Radaelli E, Silver J, Hunter CA. Elife. 2021 Apr 30;10:e65614.

Collagen molecular phenotypic switch between non-neoplastic and neoplastic canine mammary tissues. Terajima M, Taga Y, Brisson BK, Durham AC, Sato K, Uzawa K, Saito T, Hattori S, Sørenmo KU, Yamauchi M, Volk SW. Sci Rep. 2021 Apr 21;11(1):8659.

Regulation of extracellular matrix assembly and structure by hybrid M1/M2 macrophages. Witherel CE, Sao K, Brisson BK, Han B, Volk SW, Petrie RJ, Han L, Spiller KL. Biomaterials. 2021 Feb;269:120667.

Dll1+ quiescent tumor stem cells drive chemoresistance in breast cancer through NF-κB survival pathway. Kumar S, Nandi A, Singh S, Regulapati R, Li N, Tobias JW, Siebel CW, Blanco MA, Klein-Szanto AJ, Lengner C, Welm AL, Kang Y, Chakrabarti R.  Nat Commun. 2021 Jan 18;12(1):432.

Angiomotin Counteracts the Negative Regulatory Effect of Host WWOX on Viral PPxY-Mediated Egress. Liang J, Ruthel G, Sagum CA, Bedford MT, Sidhu SS, Sudol M, Jaladanki CK, Fan H, Freedman BD, Harty RN. 2021. J Virol. 95:e00121-21. Online ahead of print.

2020

Distinct effects of different matrix proteoglycans on collagen fibrillogenesis and cell-mediated collagen reorganization.  Chen D, Smith LR, Khandekar G, Patel P, Yu CK, Zhang K, Chen CS, Han L, Wells RG.Sci Rep. 2020 Nov 4;10(1):19065.

Reconstitution of prospermatogonial specification in vitro from human induced pluripotent stem cells. Hwang YS, Suzuki S, Seita Y, Ito J, Sakata Y, Aso H, Sato K, Hermann BP, Sasaki K. Nat Commun. 2020 Nov 9;11(1):5656.

Loss of ELF5-FBXW7 stabilizes IFNGR1 to promote the growth and metastasis of triple-negative breast cancer through interferon-γ signalling. Singh S, Kumar S, Srivastava RK, Nandi A, Thacker G, Murali H, Kim S, Baldeon M, Tobias J, Blanco MA, Saffie R, Zaidi MR, Sinha S, Busino L, Fuchs SY, Chakrabarti R. Nat Cell Biol. 2020 May;22(5):591-602. Epub 2020 Apr 13.

Autophagy mitigates ethanol-induced mitochondrial dysfunction and oxidative stress in esophageal keratinocytes. Chandramouleeswaran PM, Guha M, Shimonosono M, Whelan KA, Maekawa H, Sachdeva UM, Ruthel G, Mukherjee S, Engel N, Gonzalez MV, Garifallou J, Ohashi S, Klein-Szanto AJ, Mesaros CA, Blair IA, Pellegrino da Silva R, Hakonarson H, Noguchi E, Baur JA, Nakagawa H. PLoS One. 2020 Sep 23;15(9):e0239625.

Hemostasis vs. homeostasis: Platelets are essential for preserving vascular barrier function in the absence of injury or inflammation. Gupta S, Konradt C, Corken A, Ware J, Nieswandt B, Di Paola J, Yu M, Wang D, Nieman MT, Whiteheart SW, Brass LF. Proc Natl Acad Sci U S A. 2020 Sep 14:202007642.

Critical Decrease in the Level of Axon Guidance Receptor ROBO1 in Rod Synaptic Terminals Is Followed by Axon Retraction. Appelbaum T, Santana E, Aguirre GD. Invest Ophthalmol Vis Sci. 2020 Mar 9;61(3):11.

Coordinated development of the mouse extrahepatic bile duct: Implications for neonatal susceptibility to biliary injury. Khandekar G, Llewellyn J, Kriegermeier A, Waisbourd-Zinman O, Johnson N, Du Y, Giwa R, Liu X, Kisseleva T, Russo PA, Theise ND, Wells RG. J Hepatol. 2020 Jan;72(1):135-145.

Intratumoral collagen signatures predict clinical outcomes in feline mammary carcinoma. Rosen S, Brisson BK, Durham AC, Munroe CM, McNeill CJ, Stefanovski D, Sørenmo KU, Volk SW. PLoS One. 2020 Aug 10;15(8):e0236516.

Alcohol-induced CYP2E1, mitochondrial dynamics and retrograde signaling in human hepatic 3D organoids.Angireddy R, Chowdhury AR, Zielonka J, Ruthel G, Kalyanaraman B, Avadhani NG. Free Radic Biol Med. 2020 Jul 29;159:1-14.

Angiomotin regulates budding and spread of Ebola virus. Han Z, Ruthel G, Dash S, Berry CT, Freedman BD, Harty RN, Shtanko O. J Biol Chem. 2020 Jun 19;295(25):8596-8601.

SKP1 drives the prophase I to metaphase I transition during male meiosis. Guan Y, Leu NA, Ma J, Chmátal L, Ruthel G, Bloom JC, Lampson MA, Schimenti JC, Luo M, Wang PJ. Sci Adv. 2020 Mar 25;6(13):eaaz2129.

Modular mimicry and engagement of the Hippo pathway by Marburg virus VP40: Implications for filovirus biology and budding. Han Z, Dash S, Sagum CA, Ruthel G, Jaladanki CK, Berry CT, Schwoerer MP, Harty NM, Freedman BD, Bedford MT, Fan H, Sidhu SS, Sudol M, Shtanko O, Harty RN. PLoS Pathog. 2020 Jan 6;16(1):e1008231.

Spatial mapping of polymicrobial communities reveals a precise biogeography associated with human dental caries. Kim D, Barraza JP, Arthur RA, Hara A, Lewis K, Liu Y, Scisci EL, Hajishengallis E, Whiteley M, Koo H. Proc Natl Acad Sci U S A. 2020 Jun 2;117(22):12375-12386.

2019

Deletion of Calcineurin Promotes a Protumorigenic Fibroblast Phenotype. Lieberman A, Barrett R, Kim J, Zhang KL, Avery D, Monslow J, Kim H, Kim BJ, Puré E, Ryeom S. Cancer Res. 2019 Aug 1;79(15):3928-3939. doi: 10.1158/0008-5472.CAN-19-0056. Epub 2019 Jun 12. PMID: 31189649

Fibroblast activation protein restrains adipogenic differentiation and regulates matrix-mediated mTOR signaling. Blomberg R, Beiting DP, Wabitsch M, Puré E. Matrix Biol. 2019 Oct;83:60-76.

Life cycle progression and sexual development of the apicomplexan parasite Cryptosporidium parvum. Tandel J, English ED, Sateriale A, Gullicksrud JA, Beiting DP, Sullivan MC, Pinkston B, Striepen B. Nat Microbiol. 2019 Dec;4(12):2226-2236.

Esophageal 3D organoids of MPV17-/- mouse model of mitochondrial DNA depletion show epithelial cell plasticity and telomere attrition. Guha M, Srinivasan S, Sheehan MM, Kijima T, Ruthel G, Whelan K, Tanaka K, Klein-Szanto A, Chandramouleeswaran PM, Nakagawa H, Avadhani NG. Oncotarget. 2019 Oct 22;10(58):6245-6259. doi: 10.18632/oncotarget.27264. eCollection 2019 Oct 22.

Analysis of Inflammasome Activation in Response to Yersinia Infection by Fluorescence Microscopy Detection of Active Caspase-1 Puncta. Zwack EE, Brodsky IE.  Methods Mol Biol. 2019;2010:231-240. doi: 10.1007/978-1-4939-9541-7_16.

Caspase-8 promotes c-Rel-dependent inflammatory cytokine expression and resistance against Toxoplasma gondii. DeLaney AA, Berry CT, Christian DA, Hart A, Bjanes E, Wynosky-Dolfi MA, Li X, Tummers B, Udalova IA, Chen YH, Hershberg U, Freedman BD, Hunter CA, Brodsky IE.  Proc Natl Acad Sci U S A. 2019 Jun 11;116(24):11926-11935. doi: 10.1073/pnas.1820529116. Epub 2019 May 30.

Equine or porcine synovial fluid as a novel ex vivo model for the study of bacterial free-floating biofilms that form in human joint infections. Gilbertie JM, Schnabel LV, Hickok NJ, Jacob ME, Conlon BP, Shapiro IM, Parvizi J, Schaer TP.  PLoS One. 2019 Aug 15;14(8):e0221012.

Dramatic changes in gene expression in different forms of Crithidia fasciculata reveal potential mechanisms for insect-specific adhesion in kinetoplastid parasites.

Filosa JN, Berry CT, Ruthel G, Beverley SM, Warren WC, Tomlinson C, Myler PJ, Dudkin EA, Povelones ML, Povelones M. PLoS Negl Trop Dis. 2019 Jul 29;13(7):e0007570.

Static and time-dependent mechanical response of organic matrix of bone. Saini K, Discher D, Kumar N. J Mech Behav Biomed Mater. 2019 Mar;91:315-325. doi: 10.1016/j.jmbbm.2018.12.031. Epub 2018 Dec 24.  

CD44-dependent inflammation, fibrogenesis, and collagenolysis regulates extracellular matrix remodeling and tensile strength during cutaneous wound healing.  Govindaraju P, Todd L, Shetye S, Monslow J, Puré E.  Matrix Biol. 2019 Jan;75-76:314-330. doi: 10.1016/j.matbio.2018.06.004. Epub 2018 Jun 9.

Comparative localization of cystathionine beta synthases and cystathionine gamma lyase in canine, non-human primate and human retina. Badiei A, Sudharsan R, Santana E, Dunaief JL, Aguirre GD. Exp Eye Res. 2019 Jan 14;181:72-84. doi: 10.1016/j.exer.2019.01.007. [Epub ahead of print]

2018

Ndr kinases regulate retinal interneuron proliferation and homeostasis. Léger H, Santana E, Leu NA, Smith ET, Beltran WA, Aguirre GD, Luca FC. Sci Rep. 2018 Aug 22;8(1):12544.

The single mitochondrion of the kinetoplastid parasite Crithidia fasciculata is a dynamic network. DiMaio J, Ruthel G, Cannon JJ, Malfara MF, Povelones ML. PLoS One. 2018 Dec 28;13(12):e0202711. doi: 10.1371/journal.pone.0202711. eCollection 2018.

Underdeveloped RPE Apical Domain Underlies Lesion Formation in Canine Bestrophinopathies. Guziewicz KE, McTish E, Dufour VL, Zorych K, Dhingra A, Boesze-Battaglia K, Aguirre GD. Adv Exp Med Biol. 2018;1074:309-315. doi: 10.1007/978-3-319-75402-4_38.

hnRNPA2 mediated acetylation reduces telomere length in response to mitochondrial dysfunction. Guha M, Srinivasan S, Johnson FB, Ruthel G, Guja K, Garcia-Diaz M, Kaufman BA, Glineburg MR, Fang J, Nakagawa H, Basha J, Kundu T, Avadhani NG. PLoS One. 2018 Nov 14;13(11):e0206897. doi: 10.1371/journal.pone.0206897.

Ndr kinases regulate retinal interneuron proliferation and homeostasis. Léger H, Santana E, Leu NA, Smith ET, Beltran WA, Aguirre GD, Luca FC. Sci Rep. 2018 Aug 22;8(1):12544. doi: 10.1038/s41598-018-30492-9.

Microglial control of astrocytes in response to microbial metabolites. Rothhammer V, Borucki DM, Tjon EC, Takenaka MC, Chao CC, Ardura-Fabregat A, de Lima KA, Gutiérrez-Vázquez C, Hewson P, Staszewski O, Blain M, Healy L, Neziraj T, Borio M, Wheeler M, Dragin LL, Laplaud DA, Antel J, Alvarez JI, Prinz M, Quintana FJ. Nature. 2018 May;557(7707):724-728. doi: 10.1038/s41586-018-0119-x. Epub 2018 May 16.

CD44-dependent inflammation, fibrogenesis, and collagenolysis regulates extracellular matrix remodeling and tensile strength during cutaneous wound healing.  Govindaraju P, Todd L, Shetye S, Monslow J, Puré E.  Matrix Biol. 2018 Jun 9. pii: S0945-053X(18)30127-6. doi: 10.1016/j.matbio.2018.06.004. [Epub ahead of print]

Host Protein BAG3 is a Negative Regulator of Lassa VLP Egress.  Han Z, Schwoerer MP, Hicks P, Liang J, Ruthel G, Berry CT, Freedman BD, Sagum CA, Bedford MT, Sidhu SS, Sudol M, Harty RN.  Diseases. 2018 Jul 13;6(3). pii: E64. doi: 10.3390/diseases6030064.

Atypical pharmacology of schistosome TRPA1-like ion channels.  Bais S, Berry CT, Liu X, Ruthel G, Freedman BD, Greenberg RM. PLoS Negl Trop Dis. 2018 May 10;12(5):e0006495. doi: 10.1371/journal.pntd.0006495. [Epub ahead of print]

Extracellular matrix directs phenotypic heterogeneity of activated fibroblasts.  Avery D, Govindaraju P, Jacob M, Todd L, Monslow J, Puré E.  Matrix Biol. 2018 Apr;67:90-106. doi: 10.1016/j.matbio.2017.12.003. Epub 2017 Dec 14.

Bacterial-derived exopolysaccharides enhance antifungal drug tolerance in a cross-kingdom oral biofilm. Kim D, Liu Y, Benhamou RI, Sanchez H, Simón-Soro Á, Li Y, Hwang G, Fridman M, Andes DR, Koo H. ISME J. 2018 Jun;12(6):1427-1442. doi: 10.1038/s41396-018-0113-1. Epub 2018 Apr 18.

Structure and Distribution of an Unrecognized Interstitium in Human Tissues. Benias PC, Wells RG, Sackey-Aboagye B, Klavan H, Reidy J, Buonocore D, Miranda M, Kornacki S, Wayne M, Carr-Locke DL, Theise ND. Sci Rep. 2018 Mar 27;8(1):4947. doi: 10.1038/s41598-018-23062-6.

BEST1 gene therapy corrects a diffuse retina-wide microdetachment modulated by light exposure. Guziewicz KE, Cideciyan AV, Beltran WA, Komáromy AM, Dufour VL, Swider M, Iwabe S, Sumaroka A, Kendrick BT, Ruthel G, Chiodo VA, Héon E, Hauswirth WW, Jacobson SG, Aguirre GD. Proc Natl Acad Sci U S A. 2018 Mar 5. pii: 201720662.

Novel Endodontic Disinfection Approach Using Catalytic Nanoparticles. Bukhari S, Kim D, Liu Y, Karabucak B, Koo H. J Endod. 2018 May;44(5):806-812. doi: 10.1016/j.joen.2017.12.003. Epub 2018 Feb 14.

2017

Guanylate Binding Proteins Regulate Inflammasome Activation in Response to Hyperinjected Yersinia Translocon Components. Zwack EE, Feeley EM, Burton AR, Hu B, Yamamoto M, Kanneganti TD, Bliska JB, Coers J, Brodsky IE. Infect Immun. 2017 Sep 20;85(10). pii: e00778-16. doi: 10.1128/IAI.00778-16. Print 2017 Oct.

Nonleachable Imidazolium-Incorporated Composite for Disruption of Bacterial Clustering, Exopolysaccharide-Matrix Assembly, and Enhanced Biofilm Removal.
Hwang G, Koltisko B, Jin X, Koo H. ACS Appl Mater Interfaces. 2017 Nov 8;9(44):38270-38280. doi: 10.1021/acsami.7b11558. Epub 2017 Oct 25.

Replication defective viral genomes exploit a cellular pro-survival mechanism to establish paramyxovirus persistence. Xu J, Sun Y, Li Y, Ruthel G, Weiss SR, Raj A, Beiting D, López CB. Nat Commun. 2017 Oct 6;8(1):799.

Biofilm three-dimensional architecture influences in situ pH distribution pattern on the human enamel surface. Xiao J, Hara AT, Kim D, Zero DT, Koo H, Hwang G. Int J Oral Sci. 2017 Jun;9(2):74-79. doi: 10.1038/ijos.2017.8. Epub 2017 Apr 28.

Ubiquitin ligase WWP1 interacts with ebola virus VP40 to regulate egress.  Han Z, Sagum CA, Takizawa F, Ruthel G, Berry CT, Kong J, Sunyer JO, Freedman BD, Bedford MT, Sidhu SS, Sudol M, Harty RN. J Virol. 2017Aug 2. pii: JVI.00812-17.

Identification of prognostic collagen signatures and potential therapeutic stromal targets in canine mammary gland carcinoma. Case A, Brisson BK, Durham AC, Rosen S, Monslow J, Buza E, Salah P, Gillem J, Ruthel G, Veluvolu S, Kristiansen V, Puré E, Brown DC, Sørenmo KU, Volk SW. PLoS One. 2017 Jul 6;12(7):e0180448.

Candida albicans mannans mediate Streptococcus mutans exoenzyme GtfB binding to modulate cross-kingdom biofilm development in vivo. Hwang G, Liu Y, Kim D, Li Y, Krysan DJ, Koo H. PLoS Pathog. 2017 Jun 15;13(6):e1006407. 

Cell origin, volume and arrangement are drivers of articular cartilage formation, morphogenesis and response to injury in mouse limbs. Decker RS, Um HB, Dyment NA, Cottingham N, Usami Y, Enomoto-Iwamoto M, Kronenberg MS, Maye P, Rowe DW, Koyama E, Pacifici M. Dev Biol. 2017 Jun 1;426(1):56-68.

CD11c-Expressing Cells Affect Regulatory T Cell Behavior in the Meninges during Central Nervous System Infection. O'Brien CA, Overall C, Konradt C, O'Hara Hall AC, Hayes NW, Wagage S, John B, Christian DA, Hunter CA, Harris TH. J Immunol. 2017 May 15;198(10):4054-4061.

T Regulatory Cells Support Plasma Cell Populations in the Bone Marrow. Glatman Zaretsky A, Konradt C, Dépis F, Wing JB, Goenka R, Atria DG, Silver JS, Cho S, Wolf AI, Quinn WJ, Engiles JB, Brown DC, Beiting D, Erikson J, Allman D, Cancro MP, Sakaguchi S, Lu LF, Benoist CO, Hunter CA. Cell Rep. 2017 Feb 21;18(8):1906-1916.

Candida albicans stimulates Streptococcus mutans microcolony development via cross-kingdom biofilm-derived metabolites. Kim D, Sengupta A, Niepa TH, Lee BH, Weljie A, Freitas-Blanco VS, Murata RM, Stebe KJ, Lee D, Koo H. Sci Rep. 2017 Jan 30;7:41332.

2016

Novel Teleost CD4-Bearing Cell Populations Provide Insights into the Evolutionary Origins and Primordial Roles of CD4+ Lymphocytes and CD4+ Macrophages. Takizawa F, Magadan S, Parra D, Xu Z, Korytář T, Boudinot P, Sunyer JO.  J Immunol. 2016 Jun 1;196(11):4522-35. doi: 10.4049/jimmunol.1600222. Epub 2016 May 4.

Mucosal immunoglobulins at respiratory surfaces mark an ancient association that predates the emergence of tetrapods. Xu Z, Takizawa F, Parra D, Gómez D, von Gersdorff Jørgensen L, LaPatra SE, Sunyer JO. Nat Commun. 2016 Feb 12;7:10728. doi: 10.1038/ncomms10728.

HnRNPA2 is a novel histone acetyltransferase that mediates mitochondrial stress-induced nuclear gene expression. Guha M, Srinivasan S, Guja K, Mejia E, Garcia-Diaz M, Johnson FB, Ruthel G, Kaufman BA, Rappaport EF, Glineburg MR, Fang J-K, Klein Szanto A, Nakagawa H, Basha J, Kundu T, Avadhani NG. Cell Discovery 2016; 2:16045.

Redefining the Chronic-Wound Microbiome: Fungal Communities Are Prevalent, Dynamic, and Associated with Delayed Healing. Kalan L, Loesche M, Hodkinson BP, Heilmann K, Ruthel G, Gardner SE, Grice EA. MBio. 2016 Sep 6;7(5). pii: e01058-16. 

Mouse Label-Retaining Cells Are Molecularly and Functionally Distinct From Reserve Intestinal Stem Cells. Li N, Nakauka-Ddamba A, Tobias J, Jensen ST, Lengner CJ.Gastroenterology. 2016 Aug;151(2):298-310.e7.

Quinoxaline-based inhibitors of Ebola and Marburg VP40 egress. Loughran HM, Han Z, Wrobel JE, Decker SE, Ruthel G, Freedman BD, Harty RN, Reitz AB. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3429-35.

Leishmania major Infection-Induced VEGF-A/VEGFR-2 Signaling Promotes Lymphangiogenesis That Controls Disease. Weinkopff T, Konradt C, Christian DA, Discher DE, Hunter CA, Scott P. J Immunol. 2016 Sep 1;197(5):1823-31.  

Acridine Orange Indicates Early Oxidation of Wood Cell Walls by Fungi. Houtman CJ, Kitin P, Houtman JC, Hammel KE, Hunt CG. PLoS One. 2016 Jul 25;11(7):e0159715.

Endothelial cells are a replicative niche for entry of Toxoplasma gondii to the central nervous system. Konradt C, Ueno N, Christian DA, Delong JH, Harms Pritchard G, Herz J, Bzik DJ,  Koshy AA, McGavern DB, Lodoen MB, Hunter CA. Nature Microbiology 1, Article number: 16001 (2016) doi:10.1038/nmicrobiol.2016.1

IL-10+ Innate-like B Cells Are Part of the Skin Immune System and Require α4β1 Integrin To Migrate between the Peritoneum and Inflamed Skin. Geherin SA, Gómez D, Glabman RA, Ruthel G, Hamann A, Debes GF. J Immunol. 2016 Mar 15;196(6):2514-2525.

T cell receptor-induced NF-κB signaling and transcriptional activation are regulated by STIM1- and Orai1-mediated calcium entry. Liu X, Berry CT, Ruthel G, Madara JJ, MacGillivray K, Gray CM, Madge LA, McCorkell KA, Beiting DP, Hershberg U, May MJ, Freedman BD. J Biol Chem. 2016 Apr 15;291(16):8440-52.

Ebola virus mediated infectivity is restricted in canine and feline cells. Han Z, Bart SM, Ruthel G, Vande Burgt NH, Haines KM, Volk SW, Vite CH, Freedman BD, Bates P, Harty RN. Vet Microbiol. 2016 Jan 15;182:102-7. 

2015

 Immunostimulatory Defective Viral Genomes from Respiratory Syncytial Virus Promote a Strong Innate Antiviral Response during Infection in Mice and Humans. Sun Y, Jain D, Koziol-White CJ, Genoyer E, Gilbert M, Tapia K, Panettieri RA Jr, Hodinka RL, López CB. PLoS Pathog. 2015 Sep 3;11(9):e1005122. 

Cranberry Flavonoids Modulate Cariogenic Properties of Mixed-Species Biofilm through Exopolysaccharides-Matrix Disruption. Kim D, Hwang G, Liu Y, Wang Y, Singh AP, Vorsa N, Koo H. PLoS One. 2015 Dec 29;10(12):e0145844. doi: 10.1371/journal.pone.0145844. eCollection 2015.

Matrix metalloproteinase-12 is an essential mediator of acute and chronic arterial stiffening.  Liu SL, Bae YH, Yu C, Monslow J, Hawthorne EA, Castagnino P, Branchetti E, Ferrari G, Damrauer SM, Puré E, Assoian RK. Sci Rep. 2015 Nov 26;5:17189.

Calcium Regulation of Hemorrhagic Fever Virus Budding: Mechanistic Implications for Host-Oriented Therapeutic Intervention. Han Z, Madara JJ, Herbert A, Prugar LI, Ruthel G, Lu J, Liu Y, Liu W, Liu X, Wrobel JE, Reitz AB, Dye JM, Harty RN, Freedman BD. PLoS Pathog. 2015 Oct 29;11(10):e1005220. doi: 10.1371/journal.ppat.1005220. eCollection 2015 Oct.

Disruption of cytochrome c oxidase function induces the Warburg effect and metabolic reprogramming. Srinivasan S, Guha M, Dong DW, Whelan KA, Ruthel G, Uchikado Y, Natsugoe S, Nakagawa H, Avadhani NG. Oncogene. 2015 Jul 6. doi: 10.1038/onc.2015.227. [Epub ahead of print]

The multifunctional Ebola virus VP40 matrix protein is a promising therapeutic target. Madara JJ, Han Z, Ruthel G, Freedman BD, Harty RN. Future Virol. 2015 May;10(5):537-546.

Identification of a Natural Viral RNA Motif That Optimizes Sensing of Viral RNA by RIG-I.  Xu J, Mercado-López X, Grier JT, Kim WK, Chun LF, Irvine EB, Del Toro Duany Y, Kell A, Hur S, Gale M Jr, Raj A, López CB. MBio. 2015 Oct 6;6(5):e01265-15. doi: 10.1128/mBio.01265-15.

Immunostimulatory Defective Viral Genomes from Respiratory Syncytial Virus Promote a Strong Innate Antiviral Response during Infection in Mice and Humans. Sun Y, Jain D, Koziol-White CJ, Genoyer E, Gilbert M, Tapia K, Panettieri RA Jr, Hodinka RL, López CB. PLoS Pathog. 2015 Sep 3;11(9):e1005122. doi: 10.1371/journal.ppat.1005122. eCollection 2015 Sep.

Spermatid head elongation with normal nuclear shaping requires ADP-ribosyltransferase PARP11 (ARTD11) in mice. Meyer-Ficca ML, Ihara M, Bader JJ, Leu NA, Beneke S, Meyer RG. Biol Reprod. 2015 Mar;92(3):80. doi: 10.1095/biolreprod.114.123661. Epub 2015 Feb 11.

Diverse roles for T-bet in the effector responses required for resistance to infection. Harms Pritchard G, Hall AO, Christian DA, Wagage S, Fang Q, Muallem G, John B, Glatman Zaretsky A, Dunn WG, Perrigoue J, Reiner SL, Hunter CA. J Immunol. 2015 Feb 1;194(3):1131-40. doi: 10.4049/jimmunol.1401617. Epub 2015 Jan 2.

Type III Collagen Directs Stromal Organization and Limits Metastasis in a Murine Model of Breast Cancer. Brisson BK, Mauldin EA, Lei W, Vogel LK, Power AM, Lo A, Dopkin D, Khanna C, Wells RG, Puré E, Volk SW. Am J Pathol. 2015 Mar 17. pii: S0002-9440(15)00128-5. doi: 10.1016/j.ajpath.2015.01.029. [Epub ahead of print]

Inflammasome activation in response to the Yersinia type III secretion system requires hyperinjection of translocon proteins YopB and YopD. Zwack EE, Snyder AG, Wynosky-Dolfi MA, Ruthel G, Philip NH, Marketon MM, Francis MS, Bliska JB, Brodsky IE. MBio. 2015 Feb 17;6(1):e02095-14. doi: 10.1128/mBio.02095-14.

Heterogeneous CD8+ T Cell Migration in the Lymph Node in the Absence of Inflammation Revealed by Quantitative Migration Analysis. Banigan EJ, Harris TH, Christian DA, Hunter CA, Liu AJ. PLoS Comput Biol. 2015 Feb 18;11(2):e1004058. doi: 10.1371/journal.pcbi.1004058. eCollection 2015 Feb.

2014

Functional fluorescent protein insertions in herpes simplex virus gB report on gB conformation before and after execution of membrane fusion. Gallagher JR, Atanasiu D, Saw WT, Paradisgarten MJ, Whitbeck JC, Eisenberg RJ, Cohen GH. PLoS Pathog. 2014 Sep 18;10(9):e1004373. doi: 10.1371/journal.ppat.1004373. eCollection 2014 Sep.

Sex differences in corticotropin-releasing factor receptor-1 action within the dorsal raphe nucleus in stress responsivity. Howerton AR, Roland AV, Fluharty JM, Marshall A, Chen A, Daniels D, Beck SG, Bale TL. Biol Psychiatry. 2014 Jun 1;75(11):873-83. doi: 10.1016/j.biopsych.2013.10.013. Epub 2013 Oct 23.

α-Synuclein Immunotherapy Blocks Uptake and Templated Propagation of Misfolded α-Synuclein and Neurodegeneration.  Tran HT, Chung CH, Iba M, Zhang B, Trojanowski JQ, Luk KC, Lee VM.  Cell Rep. 2014 Jun 11. pii: S2211-1247(14)00427-6. doi: 10.1016/j.celrep.2014.05.033. Epub 2014 Jun 12.

CXCR4 is dispensable for T cell egress from chronically inflamed skin via the afferent lymph. Geherin SA, Wilson RP, Jennrich S, Debes GF. PLoS One. 2014 Apr 21;9(4):e95626. doi: 10.1371/journal.pone.0095626. eCollection 2014.

Engagement of NKG2D on bystander memory CD8 T cells promotes increased immunopathology following Leishmania major infection. Crosby EJ, Goldschmidt MH, Wherry EJ, Scott P. PLoS Pathog. 2014 Feb 27;10(2):e1003970. doi: 10.1371/journal.ppat.1003970. eCollection 2014 Feb.

Differential induction of TLR3-dependent innate immune signaling by closely related parasite species. Beiting DP, Peixoto L, Akopyants NS, Beverley SM, Wherry EJ, Christian DA, Hunter CA, Brodsky IE, Roos DS. PLoS One. 2014 Feb 5;9(2):e88398. doi: 10.1371/journal.pone.0088398. eCollection 2014. 

Caspase-8 mediates caspase-1 processing and innate immune defense in response to bacterial blockade of NF-κB and MAPK signaling.  Philip NH, Dillon CP, Snyder AG, Fitzgerald P, Wynosky-Dolfi MA, Zwack EE, Hu B, Fitzgerald L, Mauldin EA, Copenhaver AM, Shin S, Wei L, Parker M, Zhang J, Oberst A, Green DR, Brodsky IE.  Proc Natl Acad Sci U S A. 2014 May 20;111(20):7385-90. doi: 10.1073/pnas.1403252111. Epub 2014 May 5.

Small-Molecule Probes Targeting the Viral PPxY-Host Nedd4 Interface Block Egress of a Broad Range of RNA Viruses. Han Z, Lu J, Liu Y, Davis B, Lee MS, Olson MA, Ruthel G, Freedman BD, Schnell MJ, Wrobel JE, Reitz AB, Harty RN.  J Virol. 2014 Jul 1;88(13):7294-7306. Epub 2014 Apr 16.

Disruption of TgPHIL1 alters specific parameters of Toxoplasma gondii motility measured in a quantitative, three-dimensional live motility assay. Leung JM, Rould MA, Konradt C, Hunter CA, Ward GE. PLoS One. 2014 Jan 29;9(1):e85763. doi: 10.1371/journal.pone.0085763. eCollection 2014.

Human classical monocytes control the intracellular stage of Leishmania braziliensis by reactive oxygen species.  Novais FO, Nguyen BT, Beiting DP, Carvalho LP, Glennie ND, Passos S, Carvalho EM, Scott P.  J Infect Dis. 2014 Apr 15;209(8):1288-96. doi: 10.1093/infdis/jiu013. Epub 2014 Jan 7.

Oxidative metabolism enables Salmonella evasion of the NLRP3 inflammasome. Wynosky-Dolfi MA, Snyder AG, Philip NH, Doonan PJ, Poffenberger MC, Avizonis D, Zwack EE, Riblett AM, Hu B, Strowig T, Flavell RA, Jones RG, Freedman BD, Brodsky IE. J Exp Med. 2014 Apr 7;211(4):653-68. doi: 10.1084/jem.20130627. Epub 2014 Mar 17. 

Canine retina has a primate fovea-like bouquet of cone photoreceptors which is affected by inherited macular degenerations.  Beltran WA, Cideciyan AV, Guziewicz KE, Iwabe S, Swider M, Scott EM, Savina SV, Ruthel G, Stefano F, Zhang L, Zorger R, Sumaroka A, Jacobson SG, Aguirre GD. PLoS One. 2014 Mar 5;9(3):e90390.

A Host-Oriented Inhibitor of Junin Argentine Hemorrhagic Fever Virus Egress. Lu J, Han Z, Liu Y, Liu W, Lee MS, Olson MA, Ruthel G, Freedman BD, Harty RN. J Virol. 2014 May;88(9):4736-43. doi: 10.1128/JVI.03757-13. Epub 2014 Feb 12

2013

Mitochondrial retrograde signaling induces epithelial-mesenchymal transition and generates breast cancer stem cells. Guha M, Srinivasan S, Ruthel G, Kashina AK, Carstens RP, Mendoza A, Khanna C, Van Winkle T, Avadhani NG.  Oncogene. 2013 Nov 4. doi: 10.1038/onc.2013.467. [Epub ahead of print]    

Buckling, symmetry breaking, and cavitation in periodically micro-structured hydrogel membranes. Wu G, Xia Y, Yang S.  Soft Matter 2013.  Epub 2013 Oct 29. 

Recombinant AAV-mediated BEST1 transfer to the retinal pigment epithelium: analysis of serotype-dependent retinal effects. Guziewicz KE, Zangerl B, Komáromy AM, Iwabe S, Chiodo VA, Boye SL, Hauswirth WW, Beltran WA, Aguirre GD. PLoS One. 2013 Oct 15;8(10):e75666. doi: 10.1371/journal.pone.0075666. eCollection 2013.

Sex Differences in Corticotropin-Releasing Factor Receptor-1 Action Within the Dorsal Raphe Nucleus in Stress Responsivity. Howerton AR, Roland AV, Fluharty JM, Marshall A, Chen A, Daniels D, Beck SG, Bale TL. Biol Psychiatry. 2014 Jun 1;75(11):873-83. doi: 10.1016/j.biopsych.2013.10.013. Epub 2013 Oct 23.

Alteration of poly(ADP-ribose) metabolism affects murine sperm nuclear architecture by impairing pericentric heterochromatin condensation. Meyer-Ficca ML, Lonchar JD, Ihara M, Bader JJ, Meyer RG. Chromosoma. 2013 Aug;122(4):319-35. doi: 10.1007/s00412-013-0416-y. Epub 2013 Jun 1.

Replication and distribution of Toxoplasma gondii in the small intestine after oral infection with tissue cysts.  Gregg B, Taylor BC, John B, Tait-Wojno ED, Girgis NM, Miller N, Wagage S, Roos DS, Hunter CA.  Infect Immun. 2013 May;81(5):1635-43. doi: 10.1128/IAI.01126-12. Epub 2013 Mar 4.

Cytotoxic T cells mediate pathology and metastasis in cutaneous leishmaniasis. Novais FO, Carvalho LP, Graff JW, Beiting DP, Ruthel G, Roos DS, Betts MR, Goldschmidt MH, Wilson ME, de Oliveira CI, Scott P. PLoS Pathog. 2013 Jul;9(7):e1003504. doi: 10.1371/journal.ppat.1003504. Epub 2013 Jul 18      

Host IQGAP1 and Ebola virus VP40 interactions facilitate virus-like particle egress.
Lu J, Qu Y, Liu Y, Jambusaria R, Han Z, Ruthel G, Freedman BD, Harty RN.
J Virol. 2013 Jul;87(13):7777-80.      

PKCδ is required for Jagged-1 induction of human mesenchymal stem cell osteogenic differentiation.  Zhu F, Sweetwyne MT, Hankenson KD.  Stem Cells. 2013 Jun;31(6):1181-92. doi: 10.1002/stem.1353.   

IL-17 mediates immunopathology in the absence of IL-10 following Leishmania major infection.  Gonzalez-Lombana C, Gimblet C, Bacellar O, Oliveira WW, Passos S, Carvalho LP, Goldschmidt M, Carvalho EM, Scott P.  PLoS Pathog. 2013 Mar;9(3):e1003243. doi: 10.1371/journal.ppat.1003243. Epub 2013 Mar 21.

Ezrin and moesin are required for efficient T cell adhesion and homing to lymphoid organs. Chen EJ, Shaffer MH, Williamson EK, Huang Y, Burkhardt JK. PLoS One. 2013;8(2):e52368. doi: 10.1371/journal.pone.0052368. Epub 2013 Feb 28.

2012

Disruption of Thrombospondin-2 accelerates ischemic fracture healing. Miedel E, Dishowitz MI, Myers MH, Dopkin D, Yu YY, Miclau TS, Marcucio R, Ahn J, Hankenson KD.  J Orthop Res. 2013 Jun;31(6):935-43. doi: 10.1002/jor.22302. Epub 2012 Dec 31.  

Tissue exit: a novel control point in the accumulation of antigen-specific CD8 T cells in the influenza a virus-infected lung.  Jennrich S, Lee MH, Lynn RC, Dewberry K, Debes GF.  J Virol. 2012 Apr;86(7):3436-45. doi: 10.1128/JVI.07025-11. Epub 2012 Jan 25. Erratum in: J Virol. 2012 Aug;86(16):8918.   

Protein tyrosine phosphatase PTP1B is involved in hippocampal synapse formation and learning.  Fuentes F, Zimmer D, Atienza M, Schottenfeld J, Penkala I, Bale T, Bence KK, Arregui CO.  PLoS One. 2012;7(7):e41536. doi: 10.1371/journal.pone.0041536. Epub 2012 Jul 23.  

Generalized Lévy walks and the role of chemokines in migration of effector CD8+ T cells.  Harris TH, Banigan EJ, Christian DA, Konradt C, Tait Wojno ED, Norose K, Wilson EH, John B, Weninger W, Luster AD, Liu AJ, Hunter CA.  Nature. 2012 Jun 28;486(7404):545-8. doi: 10.1038/nature11098.    

The skin, a novel niche for recirculating B cells.  Geherin SA, Fintushel SR, Lee MH, Wilson RP, Patel RT, Alt C, Young AJ, Hay JB, Debes GF.  J Immunol. 2012 Jun 15;188(12):6027-35. doi: 10.4049/jimmunol.1102639. Epub 2012 May 4. 

2011

Analysis of behavior and trafficking of dendritic cells within the brain during toxoplasmic encephalitis.  John B, Ricart B, Tait Wojno ED, Harris TH, Randall LM, Christian DA, Gregg B, De Almeida DM, Weninger W, Hammer DA, Hunter CA.  PLoS Pathog. 2011 Sep;7(9):e1002246. doi: 10.1371/journal.ppat.1002246. Epub 2011 Sep 15.   

Molecular consequences of BEST1 gene mutations in canine multifocal retinopathy predict functional implications for human bestrophinopathies. Guziewicz K.E., Slavik J., Lindauer, S.J., Aguirre G.D., Zangerl B. (2011) Invest Ophthalmol Vis Sci 52 (7): 4497-4505.

Genetic knockdown and pharmacological inhibition of parasite multidrug resistance transporters disrupts egg production in Schistosoma mansoni.  Kasinathan, R.S., Morgan, W.M., and Greenberg, R.M. (2011) PLoS Neglected Tropical Diseases 5, e1425.

The yeast Cbk1 kinase regulates mRNA localization via the mRNA-binding protein Ssd1. Kurischko C, Kim HK, Kuravi VK, Pratzka J, Luca FC.  J Cell Biol. 2011 Feb 21;192(4):583-98. doi: 10.1083/jcb.201011061.

CD4(+) lymphoid tissue-inducer cells promote innate immunity in the gut.  Sonnenberg GF, Monticelli LA, Elloso MM, Fouser LA, Artis D.  Immunity. 2011 Jan 28;34(1):122-34. doi: 10.1016/j.immuni.2010.12.009. Epub 2010 Dec 30.

CXCL10 is required to maintain T-cell populations and to control parasite replication during chronic ocular toxoplasmosis. Norose K, Kikumura A, Luster AD, Hunter CA, Harris TH.  Invest Ophthalmol Vis Sci. 2011 Jan 21;52(1):389-98. doi: 10.1167/iovs.10-5819. Print 2011 Jan. 

2010

The N terminus of a schistosome beta subunit regulates inactivation and current density of a Cav2 channel.  Salvador-Recatalà V, Greenberg RM.  J Biol Chem. 2010 Nov 12;285(46):35878-88. doi: 10.1074/jbc.M110.144725. Epub 2010 Sep 7.

Chemoattractant receptors and lymphocyte egress from extralymphoid tissue: changing requirements during the course of inflammation.  Brown MN, Fintushel SR, Lee MH, Jennrich S, Geherin SA, Hay JB, Butcher EC, Debes GF.  J Immunol. 2010 Oct 15;185(8):4873-82. doi: 10.4049/jimmunol.1000676. Epub 2010 Sep 10.

Advances in imaging the innate and adaptive immune response to Toxoplasma gondii.  John B, Weninger W, Hunter CA.  Future Microbiol. 2010 Sep;5(9):1321-8. doi: 10.2217/fmb.10.97. Review.

IgT, a primitive immunoglobulin class specialized in mucosal immunity.  Zhang YA, Salinas I, Li J, Parra D, Bjork S, Xu Z, LaPatra SE, Bartholomew J, Sunyer JO.  Nat Immunol. 2010 Sep;11(9):827-35. doi: 10.1038/ni.1913. Epub 2010 Aug 1.

Virulence of Toxoplasma gondii is associated with distinct dendritic cell responses and reduced numbers of activated CD8+ T cells.  Tait ED, Jordan KA, Dupont CD, Harris TH, Gregg B, Wilson EH, Pepper M, Dzierszinski F, Roos DS, Hunter CA.  J Immunol. 2010 Aug 1;185(3):1502-12. doi: 10.4049/jimmunol.0903450. Epub 2010 Jun 30.

Mouse MOV10L1 associates with Piwi proteins and is an essential component of the Piwi-interacting RNA (piRNA) pathway.  Zheng K, Xiol J, Reuter M, Eckardt S, Leu NA, McLaughlin KJ, Stark A, Sachidanandam R, Pillai RS, Wang PJ.  Proc Natl Acad Sci U S A. 2010 Jun 29;107(26):11841-6. doi: 10.1073/pnas.1003953107. Epub 2010 Jun 1.

NF-kappaB1 contributes to T cell-mediated control of Toxoplasma gondii in the CNS.  Harris TH, Wilson EH, Tait ED, Buckley M, Shapira S, Caamano J, Artis D, Hunter CA.  J Neuroimmunol. 2010 May;222(1-2):19-28. doi: 10.1016/j.jneuroim.2009.12.009. Epub 2010 Feb 13.

rAAV2/5 gene-targeting to rods:dose-dependent efficiency and complications associated with different promoters.  Beltran WA, Boye SL, Boye SE, Chiodo VA, Lewin AS, Hauswirth WW, Aguirre GD.  Gene Ther. 2010 Sep;17(9):1162-74. doi: 10.1038/gt.2010.56. Epub 2010 Apr 29.

Mitochondria-targeted cytochrome P450 2E1 induces oxidative damage and augments alcohol-mediated oxidative stress.  Bansal S, Liu CP, Sepuri NB, Anandatheerthavarada HK, Selvaraj V, Hoek J, Milne GL, Guengerich FP, Avadhani NG.  J Biol Chem. 2010 Aug 6;285(32):24609-19. doi: 10.1074/jbc.M110.121822. Epub 2010 Jun 7.

2009

Age-dependent disease expression determines remodeling of the retinal mosaic in carriers of RPGR exon ORF15 mutations.  Beltran WA, Acland GM, Aguirre GD.  Invest Ophthalmol Vis Sci. 2009 Aug;50(8):3985-95. doi: 10.1167/iovs.08-3364. Epub 2009 Feb 28.

IL-27 regulates homeostasis of the intestinal CD4+ effector T cell pool and limits intestinal inflammation in a murine model of colitis.  Troy AE, Zaph C, Du Y, Taylor BC, Guild KJ, Hunter CA, Saris CJ, Artis D.  J Immunol. 2009 Aug 1;183(3):2037-44. doi: 10.4049/jimmunol.0802918. Epub 2009 Jul 13.

Dynamic Imaging of CD8(+) T cells and dendritic cells during infection with Toxoplasma gondii.  John B, Harris TH, Tait ED, Wilson EH, Gregg B, Ng LG, Mrass P, Roos DS, Dzierszinski F, Weninger W, Hunter CA.  PLoS Pathog. 2009 Jul;5(7):e1000505. doi: 10.1371/journal.ppat.1000505. Epub 2009 Jul 3.

MHC class II-dependent basophil-CD4+ T cell interactions promote T(H)2 cytokine-dependent immunity.  Perrigoue JG, Saenz SA, Siracusa MC, Allenspach EJ, Taylor BC, Giacomin PR, Nair MG, Du Y, Zaph C, van Rooijen N, Comeau MR, Pearce EJ, Laufer TM, Artis D.  Nat Immunol. 2009 Jul;10(7):697-705. doi: 10.1038/ni.1740. Epub 2009 May 24.