New Bolton Center Kennett Square, PA
Emergencies & Appointments:
Ryan Hospital Philadelphia, PA
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Welcome to the CREATE Website

Carbapenem-Resistant Enterobacterales (CRE) are among one of the greatest threats to animal and human health given that they are often impossible to treat with antibiotics. They can spread silently throughout veterinary hospitals while setting up environmental reservoirs and spread to animals and possibly people. The CREATE website aims to be a resource to veterinarians, veterinary hospital administrators and veterinary laboratory to help prepare for, respond to and appropriately detect CRE.

About the CREATE Project

The CREATE Project was founded by Dr. Stephen Cole and Dr. Shelley Rankin at the University of Pennsylvania to disseminate the “lesson’s learned” following an outbreak of NDM-5 Escherichia coli at the Small Animal Teaching Hospital. The founders encourage active discussion and collaboration with regards to CRE outbreaks and cases in veterinary medicine settings.  Please contact them if you have any questions or comments. Development of the resources of the CREATE website has been sponsored by capacity grant funding (U18-FDA00006984) from the Food and Drug Administration’s Veterinary Laboratory Investigation and Response Network (Vet-LIRN).

Get in Touch

Questions, feedback or insights? Email us at

About the CREATE Project Director

Dr. Stephen Cole. Penn VetDr. Stephen Cole, MS, VMD, is an Assistant Professor of Clinical Microbiology (CE) in the Department of Pathobiology. He obtained his MS in microbiology from the College of William and Mary in 2011 and his VMD from the University of Pennsylvania School of Veterinary Medicine in 2015. He became boarded in bacteriology and immunology in 2018 and virology in 2020 by the American College of Veterinary Microbiologists.

Dr. Cole’s research focuses how to understand and mitigate the spread of antibiotic resistant bacteria in companion animals. Through his work, he aims (1) to characterize the clinical and molecular epidemiology of extensively drug resistant bacteria (i.e. carbapenem-resistant Enterobacterales) of dogs and cats and (2) to establish best educational practices in antimicrobial stewardship to promote proper use of these critical drugs.

Additional Resources