1962 B.Sc. Karnataka University, Dharwar, India Chemistry
1968 Ph.D. University of Bombay, Department of Chemical Technology, Bombay, India Biochemistry

1. Mechanisms of dual targeting of cytochrome P450 and related proteins to ER and mitochondria and mechanisms of activation of the chimeric N-terminal signal by cAMP and other physiological factors.
2. Characterization of a novel mitochondria-to-nucleus stress signaling in cells subjected to mitochondrial specific genetic, and or, metabolic stress, which operates through altered [Ca2+]c, and the role of mitochondrial stress signaling in tumor progression and metastasis.
3. Regulation of cytochrome oxidase gene expression, and modulation of enzyme assembly/activity under chemical and oxidative stress conditions.
4. Role of mitochondrial stress signaling in Embryonic Stem Cell function/differentiation, and mammalian mitochondrial transcription under chemical and oxidative stress in ES cells.

• Prabu SK, Anandatheerthavarada HK, Raza H, Srinivasan S, Spear JF, Avadhani NG. Protein kinase A-mediated phosphorylation modulates cytochrome C oxidase function and augments hypoxia and myocardial ischemia related injury. J Biol Chem. 2005 Nov 22; [Epub ahead of print]
• Biswas G, Anandatheerthavarada HK, Avadhani NG. Mechanism of mitochondrial stress-induced resistance to apoptosis in mitochondrial DNA-depleted C2C12 myocytes. Cell Death Differ. 2005; 3:266-78.
• Boopathi E, Lenka N, Prabu SK, Fang JK, Wilkinson F, Atchison M, Giallongo A, Avadhani NG.  Regulation of murine cytochrome c oxidase Vb gene expression during myogenesis: YY-1 and heterogeneous nuclear ribonucleoprotein D-like protein (JKTBP1) reciprocally regulate transcription activity by physical interaction with the BERF-1/ZBP-89 factor. J Biol Chem. 2004; 279:35242-54.
• Butow RA, Avadhani NG. Mitochondrial signaling: the retrograde response. Mol Cell. 2004; 9;14(1):1-15. Review.
• Raza H, Prabu SK, Robin MA, Avadhani NG. Elevated mitochondrial cytochrome P450 2E1 and glutathione S-transferase A4-4 in streptozotocin-induced diabetic rats: issue-specific variations and roles in oxidative stress. Diabetes. 2004; 53:185-94.
• Biswas G, Anandatheerthavarada HK, Zaidi M, Avadhani NG. Mitochondria to nucleus stress signaling: a distinctive mechanism of NFkappaB/Rel activation through calcineurin-mediated inactivation of IkappaBbeta. J Cell Biol. 2003; 161:507-19.
• Anandatheerthavarada HK, Biswas G, Robin MA, Avadhani NG. Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells. J Cell Biol. 2003; 161:41-54.
• Robin MA, Prabu SK, Raza H, Anandatheerthavarada HK, Avadhani NG.  Phosphorylation enhances mitochondrial targeting of GSTA4-4 through increased affinity for binding to cytoplasmic Hsp70. J Biol Chem. 2003; 278:18960-70.
• Amuthan G, Biswas G, Ananadatheerthavarada HK, Vijayasarathy C, Shephard HM, Avadhani NG. Mitochondrial stress-induced calcium signaling, phenotypic changes and invasive behavior in human lung carcinoma A549 cells. Oncogene. 2002; 51:7839-49.
• Robin MA, Anandatheerthavarada HK, Biswas G, Sepuri NB, Gordon DM, Pain D, Avadhani NG.  Bimodal targeting of microsomal CYP2E1 to mitochondria through activation of an N-terminal chimeric signal by cAMP-mediated phosphorylation. J Biol Chem. 2002; 277:40583-93.
• Anandatheerthavarada HK, Amuthan G, Biswas G, Robin MA, Murali R, Waterman MR, Avadhani NG.  Evolutionarily divergent electron donor proteins interact with P450MT2 through the same helical domain but different contact points. EMBO J. 2001; 20:2394-403.
• Accumulation of mitochondrial P450MT2, N-terminal truncated P4501A1 in rat brain during chronic treatment with b-naphthoflavone: A role in the metabolism of neuroactive drugs. Boopathi, E., H. K. Anadatheerthavarada, S. V. Bhagwat, G. Biswas, J-K. Fang, and N. G. Avadhani. J. Biol. Chem. In Press.
• Physiological role of the N-terminal processed P4501A1 targeted to mitochondria in erythromycin metabolism and reversal of erythromycin mediated inhibition of  mitochondrial protein synthesis: H. K. Anandatheerthavarada, C. Vijayasarathy, S.V. Bhagwat, G. Biswas, J. Mullick, and N. G. Avadhani. J. Biol. Chem. 274: 6617-6625, 1999.
• Retrograde Ca2+ signaling in C2C12 skeletal Myocytes in response to mitochondrial genetic and metabolic stress: A Novel mode of Inter-Organelle crosstalk. G. Biswas, O. A. Adebanjo, B. D. Freedman, H. K. Anandatheerthavarada, C. Vijayasarathy, M. Zaidi, M. Kotlikoff, and N. G. Avadhani. EMBO J. 18:522-533, 1999.
• Dual targeting property of the N- terminal signal of P4501A1: targeting of heterologous proteins to both the endoplasmic reticulum and mitochondria: S. V. Bhagwat, G. Biswas, H. K. Anandatheerthavarada, S. Addya, and N. G. Avadhani. J. Biol. Chem., 274: 24014-24022, 1999.
• CD-38/ADP-Ribosyl Cyclase: A New Role in Nuclear Calcium Homeostasis.; O.A. Adebanjo, H. K. Anandatheerthavarada, B. Moonga, G. Biswas, L. Sun, C. L. H. Huang, N. G. Avadhani, and M. Zaidi. Nature Cell Biol. 1:409-414, 1999.
• Dual targeting of Cytochrome P4502B1 to mitochondria and microsomes involves a novel signal activation by phospharylation at ser 128. H. K. Anandatheerthavarada, G. Biswas, J. Mullick, S. V. N. Babu, O. Laszlo, D. Pain and N. G. Avadhani. EMBO J. 18:5494-5504, 1999.
• Tissue Variant effects of heme inhibitors on the mouse cytochrome c oxidase gene expression and catalytic activity of the enzyme complex. C. Vijayasarathy, S. Damle, N. Lenka and N. G. Avadhani. Eur. J. Biochem., 266:191-200, 1999.
• Variations in the subunit content and catalytic activity of the cytochrome c oxidase complex from different tissues and different cardiac compartments. C. Vijayasarathy, I. Biunno, N. Lenka, M. Yang, A. Basu, I. P. Hall and N.G. Avadhani. Biochim. Biophys. Acta. 1371:71-82, 1998.
• Interaction of adrenodoxin with P450 1A1 and its truncated form P450MT2 through different domains: Differential modulation of enzyme activities: H.K. Anandatheerthavarada, S. Addya, J. Mullick and N.G. Avadhani. Biochemistry, 37:1150-1160, 1998.
• Targeting of NH2-terminal-processed microsomal protein to mitochondria: A Novel pathway for the biogenesis of hepatic mitochondrial P450MT2. S. Addya, H.K. Anandatheerthavarada, G. Biswas, S.V. Bhagwat, J. Mullick, and N.G. Avadhani. J.Cell.Biol.139: 589-599, 1997.