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    Lab CREATE

    For Veterinary Diagnostics Labs

    These documents are intended for use by veterinary clinical microbiology laboratories.
    If your laboratory is in need of a protocol or verification help, please contact us at CREATE@vet.upenn.edu.

    Downloadable Lab CREATE Documents

    Guidance on Reporting CRE (PDF): This document provides best practices for reporting of CRE isolates to clinical veterinarians. It aims to provide clear, accurate, and timely results.

    Laboratory Protocols (PDF): This document is a collection of protocols used by the CREATE reference lab for implementation in your laboratory as needed. These methods have been validated in our laboratory by extensive use and comparison to Cepheid GeneXpert Carba-R PCR Assay which is considered a gold standard test.

    Reporting Requirements by State (PDF): Reporting of CRE from companion animals varies in different jurisdictions. This document is updated annually and aims to provide the best information. This document is not focused on smaller jurisdictions such as counties or cities which may have their own requirements. This document is meant only as a guide and it is the isolating laboratory’s responsibility to confirm accuracy. Please contact us if information needs to be changed for your region.

    CREATE Reference Lab

    For CRE Screening and Testing

    The Clinical Microbiology Lab at Penn Vet Diagnostic Labs offers gold standard testing of veterinary specimens and environmental specimens at an “at cost” rate to help stop the spread of CRE in Companion Animals. Prices and specimen requirements can be found on the submission form.

    Tests Offered

    • Patient Screening by Culture
    • Patient Screening by PCR
    • Environment Screening by Culture
    • Isolate Genotypic Characterization
    • Isolate Whole Genome Sequencing and Analysis
    CREATE testing

    Living Review

    For Everyone

    In order to track CRE among companion animals in real time as reports are published in the peer-reviewed literature, CREATE has developed a living and interactive review. This resource is available in two formats:

    Please Note: The Living Review is updated monthly.

    A Filterable Spreadsheet

    filterable spreadsheet

    A Mind Map

    mind map

    CREATE

    Carbapenem Resistant Enterobacterales Animal Testing and Epidemiology