New Bolton Center Kennett Square, PA
Emergencies & Appointments:
Ryan Hospital Philadelphia, PA

Research Laboratories at Penn Vet

Penn Vet faculty are engaged in ongoing groundbreaking research. Here are examples of faculty laboratories and the projects being investigated, both at our Philadelphia campus and at New Bolton Center.

  • Anguera Laboratory

    XIST FISH, Anguera Lab, Penn VetOur laboratory investigates X-chromosome Inactivation, and how this epigenetic process contributes to female-biased autoimmunity.

    We are investigating how female lymphocytes maintain X-chromosome Inactivation, which is an epigenetic process responsible for equalizing gene expression between sexes.  X-chromosome Inactivation silences one X-chromosome in female cells, and this process is initiated and maintained by the long noncoding RNA Xist.

    Lab Mission:

    • To understand the female bias underlying autoimmune disorders such as lupus
    • To investigate how X-Chromosome Inactivation is maintained in female lymphocytes and becomes mis-regulated in female-biased autoimmune disorders
    • To investigate the function and mechanisms for novel X-linked long noncoding RNAs important for early human development
    • To identify therapeutic opportunities for correcting X-linked dosage imbalances in autoimmune disorders 

    Interested in Working With Us?

    We are always seeking highly motivated students and post-doctoral fellows with an interest in:

    • Epigenetics, X-chromosome Inactivation, Imprinting
    • Immunology and female-biased autoimmune disorders
    • Long noncoding RNAs
    • Genetics
    • Bioinformatics

    Interested post-doctoral candidates should inquire by sending e-mail to

    Interested graduate students should visit the Department of Cellular and Molecular Biology (CAMB) at UPenn or inquire by sending e-mail to:

    Read More About The Anguera Laboratory
  • Animal Model Core & Comparative Orthopedic Research Lab (CORL)

    The Animal Model Core at Penn Vet New Bolton Center at the intersection of science and the rapid advancements in health care technology is an ecosystem supporting the continuum from discovery to invention to innovation in medical translation. We are invested in understanding the value proposition of emerging technologies under consideration and how they target unmet clinical needs. This process informs animal model development to enhance scientific rigor during in vivo studies in experimental or naturally occurring disease models. Studies can be iterative starting on a small scale leading towards pivotal non-clinical IND/IDE-enabling trials in support of FDA or OUS-FDA submissions.

    Read More About The Animal Model Core & Comparative Orthopedic Research Lab (CORL)
  • ASMG Laboratory - Microbial Genomics

    asmg-lab-new-bolton-center 500

    PLOS ONE Paper Among 100 Most Read Worldwide

    Editors have selected Dr. Pitta's PLOS ONE paper, “Temporal changes in the fecal bacterial community in Holstein dairy calves from birth through the transition to a solid diet,” to be highlighted on the journal homepage. The journal's editor, Nicola Stead, PhD, Senior Editor, PLOS ONE, states, "We very much enjoyed reading about your work and would like to thank you for submitting your paper to PLOS ONE."

    The Agricultural Systems and Microbial Genomics Laboratory (ASMG Laboratory) was established to support Dr. Dou and Dr. Pitta in their research endeavors.

    Dr. Pitta is the ruminant nutrition and microbiologist at the Center for Animal Health and Productivity (CAHP), New Bolton Center, University of Pennsylvania.

    new-bolton-center-asmg-lab-microbial-genomics 400

    Research at the ASMG lab focuses primarily on the gut microbial composition of ruminants utilizing advanced molecular methodologies. The alimentary tract of a ruminant is colonized by millions of microbes living in a symbiotic relationship with the host. Therefore, knowledge of the microbial composition of the entire gut can provide insights into improving the overall health and productivity of the animal. Our research  also has broad environmental implications into such diverse applications as methane mitigation, reduction of the spread of antibiotic resistance, and human health.

    The recent advent of next generation sequencers has greatly enhanced our ability to explore community microbial populations. The ASMG lab has the capabilities to perform genomic, metagenomic, and metatranscriptomic studies including sample preparation, genomic DNA and RNA extraction, and generation of 16S amplicon libraries for sequencing on next-generation platforms. The sequenced data is analyzed at the ASMG laboratory utilizing the appropriate bioinformatics tools for data interpretation.

    The ASMG group collaborates with other researchers and clinicians both within the University of Pennsylvania as well as at other institutions. Our research is routinely published and presented at conferences. We also work with students from multiple backgrounds, ranging from high school through postdoctoral, who have used their time in our lab to further develop their knowledge of microbial genomics and its applications. 

    Read More About The ASMG Laboratory - Microbial Genomics
  • Avadhani Laboratory
    The research in Dr. Avadhani's laboratory is focused on the following aspects of mitochondrial genetics and regulation of mitochondrial membrane biogenesis in mammalian cells:

    1. Mechanisms of dual targeting of cytochrome P450 and related proteins to ER and mitochondria and mechanisms of activation of the chimeric N-terminal signal by cAMP and other physiological factors. 

    2. Characterization of a novel mitochondria-to-nucleus stress signaling in cells subjected to mitochondrial specific genetic, and or, metabolic stress, which operates through altered [Ca2+]c, and the role of mitochondrial stress signaling in tumor progression and metastasis.

    3. Regulation of cytochrome oxidase gene expression, and modulation of enzyme assembly/activity under chemical and oxidative stress conditions. 

    4. Role of mitochondrial stress signaling in Embryonic Stem Cell function/differentiation, and mammalian mitochondrial transcription under chemical and oxidative stress in ES cells. Read More About The Avadhani Laboratory
  • Beiting Laboratory

    We study the biological basis of diseases caused by microbes -- whether it be a parasitic worm, a pathogenic bacterium, or a complex microbial community in the gut. Our group makes up the Center for Host-Microbial Interactions, at Penn Vet, and our research leverages a diverse skill set that cuts across the disciplines of genomics, microbiology and immunology. We engage in collaborative projects that benefit from close interactions with veterinarians and human clinicians alike. Our research embodies the idea of 'One-Health' - that humans, animals and the environment are interconnected, and that we all live in a microbial world. We are located at the The University of Pennsylvania, in The Department of Pathobiology at the School of Veterinary Medicine.

    Read More About The Beiting Laboratory
  • Brinster Laboratory of Reproductive Physiology

     Our research has involved studies on mammalian germ cells and early embryos. Initially, Ralph Brinster on transgenesiswe developed a culture system and manipulation techniques for mouse eggs that are the foundation for subsequent mammalian egg and embryo experiments in the field, including nuclear transfer and in vitro fertilization of human eggs.

    We then used these methods to show that mouse blastocysts can be colonized by foreign stem cells and result in chimeric adults, which led to the development of embryonic stem cells. Subsequently, we used these culture and manipulation techniques to develop transgenic mice. In recent years, our research has focused on male germline stem cells, and these studies demonstrated that spermatogonial stem cells (SSCs) from a fertile male mouse can be transplanted to the testes of an infertile male where they will colonize the seminiferous tubules and generate donor cell-derived spermatozoa, thereby restoring fertility.

    In addition, SSCs of mice and other rodents can be cultured in vitro and their number increased, and the SSCs can be frozen and preserved for long periods. The ability to culture, transplant and cryopreserve SSCs makes the germline of individual males immortal. The transplantation and freezing methods are readily transferrable to the SSCs of all mammalian species.

    Ralph Brinster in ScienceHowever, a culture system for SSCs of nonrodent species has proven to be difficult to develop, and published reports of success have not been independently confirmed and are not universally accepted. Therefore, in recent studies we have attempted to develop a reliable system to culture human SSCs, which is essential to preserve and expand for later use the SSCs of prepubertal boys who will receive germ cell destroying treatment for cancer.

    As part of these studies, we are establishing the genes and regulating mechanism used by mouse and human SSCs to survive and replicate, which will contribute to the understanding necessary for human SSC culture and expansion. In the long term, a culture system will also allow the development of techniques to support SSC differentiation in vitro with production of spermatozoa capable of fertilizing eggs.

    In addition, the SSC assay system provides a powerful technique in which to test the conversion of somatic cells to functional SSCs. Over the past 10 years, we and others have identified transcription factors and micro RNAs that play key roles in SSC self-renewal. In current research, we plan to use this information to reprogram somatic cells into germ cells, specifically SSCs. The transplantation assay provides an unequivocal conformation of this reprogramming for a single cell.

    Moreover, it allows for the identification of gene activation during the differentiation process in vivo and production of progeny from sperm produced from reprogrammed cells. In the future, the approach could be used to address fertility problems in humans and possibly the correction of genetic defects.

    This research is supported by grants from National Institutes of Child Health and Human Development and the Robert J. Kleberg, Jr. and Helen C. Kleberg Foundation.

    Read More About The Brinster Laboratory of Reproductive Physiology
  • Dou Laboratory

    Nitrogen, Phosphorus, and Integrated Management

    Nitrogen and phosphorus are essential nutrients for growing plants and animals. Insufficient nutrients diminish yields; excessive applications translate to wasted resources and environmental pollution. The work of Dr. Dou’s group features an integrated system nutrient management approach, coupling nutrient optimization in animal feeding with manure management and targeted nutrient application to crops for enhanced production efficiency and reduced environmental footprint.

    • Please see relevant projects and publications in 'Research Projects' and 'Publications' tab below.

    Integrated whole farm management based on nutrients (pathogen) flow pathway


    Whole Farm Management 

    Pathogens, Antimicrobial Resistance (AMR), and Livestock Farming 

    Livestock animals are important reservoirs of zoonotic pathogens as well as antimicrobial resistant determinants (antibiotic residues, AMR microbes, and AMR genes).  What happens to these “microbial pollutants” in the post-shed environment? How long do they survive under different management conditions? What is their distribution pattern in the intrinsically linked farming sectors and the dissemination pathways to the broader terrestrial and aquatic ecosystems? What intervention may help mitigate relevant risks associated with animal farming concerning food safety and public health? The research of Dr. Dou’s group addresses some of these critical issues.

    • Please see relevant projects and publications in 'Research Projects' and 'Publications' tab below.

    Food Waste, Food Security, and Sustainability

    Sustainable food security is an issue that intersects many of the contemporary challenges the world is struggling to deal with today, e.g. water scarcity, water pollution, resource limitation, land degradation, habitat and biodiversity loss, climate change, and hunger and poverty.  Dr. Dou collaborates with national and international experts to examine sustainable food security issues from multiple dimensions, such as food waste reduction and reuse, engaging, and empowering smallholder farmers, etc. 

    • Please see relevant projects and publications in 'Research Projects' and 'Publications' tab below.
    Read More About The Dou Laboratory
  • Equine Pharmacology Research Laboratory

    Dr. Mary Robinson, Equine Pharmacology

    Our Mission: The mission of the Equine Pharmacology Laboratory at New Bolton Center is to promote the welfare of the working horse and the integrity of sport through pharmacological and forensic research.

    Learn about us and our research...


    Read More About The Equine Pharmacology Research Laboratory
  • Experimental Retinal Therapies

    Restore Vision News

    The Division of Experimental Retinal Therapies (ExpeRTs) is actively engaged in multiple research projects relating to the inheritance of retinal degenerations in dogs, humans, and other mammals. These include efforts to identify the genes and locate the mutations associated with several separately inherited forms of progressive retinal atrophy (PRA), a significant disease of dogs that is also the genetic analog of retinitis pigmentosa, a group of retinal degenerations inherited in human families. In parallel to these studies, the Division of ExpeRTs is involved in developing or applying novel therapeutic approaches for the treatment of inherited retinal degenerations.

    Read More About The Experimental Retinal Therapies
  • Galantino-Homer Laminitis Laboratory
    LDD Gross Composite

    Laminitis is a common and debilitating disease that affects the folded and interdigitating tissues, called the lamellae, which connect the hoof wall to the underlying tissues of the horse’s foot. The lamellae normally allow the transfer of the horse's weight from the skeletal elements of the digit to the hoof wall.

    Dr. Galantino-Homer founded the Laminitis Laboratory at New Bolton Center in 2008. The Laminitis Laboratory was formed in part due to the tragic loss of the 2006 Kentucky Derby winner, Barbaro, to laminitis in January, 2007.

    Our goal is to employ cell and molecular biology methods to better understand laminitis pathogenesis in order to improve the prevention, diagnosis, and treatment of this disease.

    Our studies include the investigation of laminitis pathogenesis using protein biochemistry, gene expression, and histological analysis, identification of diagnostic serum biomarkers for laminitis, characterization of the keratin proteins that determine the mechanical properties of the hoof lamellae and the effect of laminitis on keratins and associated cell adhesion proteins, the impact of cell stress pathways on laminitis, characterization of the epidermal stem cell population in the lamellae, and establishing an in vitro culture system for equine hoof epidermal cells to minimize the use of live horses for laminitis research.

    Learn About Our Work

    From the Laminitis Discovery Database (LDD) to ongoing, collaborative research studies, the Galantino-Homer Laminitis Laboratory has focused on this all too common disease for more than two decades. Learn more about our work. Explore what we do.

    Read More About The Galantino-Homer Laminitis Laboratory
  • Garden & Luo Immune Regulation Lab

    The Garden & Luo Immune Regulation Lab has expertise in two key areas: (1) the biology of regulatory cells of lymphoid and myeloid origin in the context of the cancer microenvironment and autoimmune disease, particularly myasthenia gravis, immune-mediated hemolytic anemia, and other immune-mediated diseases; and (2) the development of antigen-specific vaccinal immunotherapies for antibody-mediated autoimmune diseases, including myasthenia gravis and anti-N-methyl D-aspartate receptor encephalitis.  

    Dr. Oliver Garden, the Henry and Corinne R. Bower Professor of Medicine and Chair of the Department of Clinical Sciences & Advanced Medicine, is the principal investigator of the Garden Immune Regulation Laboratory at the School of Veterinary Medicine (Penn Vet).

    Previously a member of the Comparative Physiology and Medicine and Infection and Immunity research themes at the Royal Veterinary College (RVC), University of London, Oliver led the Oncology Special Interest Group (part of Comparative Physiology and Medicine) from 2012 to December 2016. He currently holds a Visiting Professorship at the RVC.
    Read More About The Garden & Luo Immune Regulation Lab
  • Harty Laboratory

    At the Harty Laboratory, we focus our research on three main areas:

    1. The molecular dynamics and biological significance of virus-host interactions during late stages of RNA virus assembly and egress.
    2. The identification and development of host-oriented therapeutics as a new class of antiviral inhibitors.
    3. The interplay between the host innate immune response and RNA virus infection.

    Our model virus systems to interrogate these topics include:

    • Filoviruses (Ebola and Marburg viruses)
    • Arenaviruses (Lassa fever and Junín viruses)
    • Rhabdoviruses (VSV)
    • Retroviruses (HIV-1 and HTLV-1)
    Read More About The Harty Laboratory
  • Havemeyer Equine Behavior Research Lab

    Semi-feral pony herd at New Bolton Center

    The Equine Behavior Program and Laboratory at New Bolton Center has grown from within the Section of Reproductive Studies.  Since the early 1980s the program, has had research as its core activity.  The program has included involvement in related clinical and teaching in the veterinary school and continuing education programs nationally and internationally.  The initial research focus of the laboratory was on stallion reproductive physiology and behavior. 

    Early research concentrated on the physiology and pharmacology of libido, erection, and ejaculation, with immediate application to clinical problems in breeding stallions and with relevance to the understanding of human sexual dysfunction. 

    Another long-standing research interest of our laboratory has been the effects of experience on sexuHavemeyer Barnal function.  In the 1990s our research and clinical work expanded beyond stallions to include reproductive and general behavior problems of horses.

    The Behavior Lab is housed in The Havemeyer Barn at The Georgia and Philip Hofmann Center for Animal Reproduction. 

    Read More About The Havemeyer Equine Behavior Research Lab
  • Hunter Laboratory

    T gondii in the retina, Hunter Lab

    Dr. Christopher Hunter's research team has been working on various aspects of basic parasitology since 1984.

    For nearly 25 years, Dr. Hunter's team has focused on understanding how the immune response to Toxoplasma gondii is regulated to allow the development of protective immunity as well as to limit T cell mediated pathology in multiple sites including the gut and brain.

    Read More About The Hunter Laboratory
  • Kubin Laboratory

    Laboratory of Neurochemical Mechanisms of REM Sleep and Sleep-Related Respiratory Disorders

    We are interested in neural mechanisms of cardiorespiratory disorders during sleep associated with a common disorder known as the Obstructive Sleep Apnea (OSA) Syndrome. We also explore the basic mechanisms responsible for the generation of Rapid Eye Movement (REM) stage of sleep. Research is led by Dr. Leszek Kubin.

    Read More About The Kubin Laboratory
  • Lengner Laboratory

    Our lab is broadly interested in the mechanisms by which stem cells acquire and maintain developmental potency. We are also exploring how deregulation of these mechanisms can contribute to oncogenic transformation, tumorigenesis, and tissue regeneration in response to injury, while looking forward to learn how we might manipulate these mechanisms for application in disease modeling and regenerative medicine.
    In the mammalian soma, tissue-specific stem cells capable of maintaining the proliferative output necessary for tissue organization and function exist in a state Lengner image 6 copyof multipotency (the ability to generate any cell type of that particular tissue, in contrast to the pluripotent state embodied by embryonic stem cells capable of generating all cell types of the mammalian organism). In highly proliferative tissues such as the epithelial lining of the intestine, data from our lab and others has begun to establish a model in the stem cell compartment is organized into a hierarchy, with a mostly dormant population of long-live, radio-resistant reserve stem cells at the top of this hierarchy. When activated, these reserve stem cells give rise to a second, highly proliferative, radiosensitive short-term stem cell that bears the daily proliferative burden required to maintain tissue homeostasis.  
    Our lab is focused on understanding the relationship between these two stem cell populations, the molecular determinants of reserve intestinal stem cell activation, and how deregulation of the reserve intestinal stem cell compartment contributes to disease states such as colorectal cancer or acute gastrointestinal radiation injury.
    We have recently identified the Msi family of RNA binding proteins as potent oncoproteins in both hematopoietic and intestinal malignancies. Msi proteins are expressed in putative somatic Lengner image 8 copystem cell compartments, are frequently found to be overexpressed in advanced cancers, and are known to govern asymmetric cell division in Drosophila melanogaster (a process thought to maintain the somatic stem cell niche in mammals). Using mouse genetic approaches integrated with human patient data, we have recently demonstrated that MSI2 acts as an intestinal oncogene, driving activation of the mTORC1 complex and uncontrolled stem cell expansion. We are currently pursuing the role of Msi proteins in epithelial stem cell compartments using tissue-specific gene ablation and drug-inducible gene activation. The effects of Msi proteins on stem cell maintenance and oncogenic transformation are being tied to their RNA binding capacity using CLIP-Seq analysis (immunoprecipitation of Msi-interacting RNAs followed by massively parallel sequencing) in order to determine how specific Msi-RNA interactions affect stem cell self-renewal and oncogenic transformation.
    While murine genetic systems are the primary tool of the laboratory, we also work to model human genetic gastrointestinal disorders using induced pluripotent stem (iPS) cells generated from patients. Generation of isogenic diseased and disease-allele corrected iPS cell lines using nuclease-mediated homologous recombination followed by directed differentiation into intestinal tissue provides a controlled platform not only for studying the molecular mechanisms underlying  

    Photos above: Label retaining cells of the intestinal crypts are identified by loading all cells with a Histone H2B protein fused to a green fluorescent protein (left). Several weeks later, only cells that do not divide retain the fluorescent label in their chromatin.

    A glimpse of the rare reserve intestinal stem cell (red).   This cell is capable of regenerating the entire intestinal lining after injury such as exposure to high doses of radiation. Read More About The Lengner Laboratory
  • Lennon Mucosal Immunology Laboratory

    Lennon Lab Team 760

    Welcome to the Lennon Mucosal Immunology Laboratory where we study Inflammatory Bowel Disease (IBD).

    We believe that by studying naturally occurring IBD in dogs and cats we can improve treatment for people and pets with this debilitating condition. 

    Interested in Working With Us?

    We are always seeking highly motivated students, post-doctoral fellows, or veterinarians who are interested in becoming involved in research.

    Read More About The Lennon Mucosal Immunology Laboratory
  • Marshak Dairy

    Marshak Dairy, New Bolton Center

    The Marshak Dairy is named in honor of Robert Marshak, the ninth dean of the School of Veterinary Medicine whose support was instrumental in establishing the farm. Built in 1996, the greenhouse dairy was the first of its kind and was recognized as a dairy of distinction in 1998. The greenhouse design uses natural lighting and excellent ventilation within the barn to promote a healthy environment for the cows.

    The Marshak Dairy provides an easily accessible working dairy farm for research trials. In addition, the Dairy serves as a laboratory for teaching students on topics related to cow healthcare, preventive medicine, nutrition and food safety.

    Read More About The Marshak Dairy
  • Mason Immunotherapy Research Laboratory

    Dr. Mason's lab currently focuses on immunotherapy approaches to treat osteosarcoma, hemangiosarcoma, and lymphoma, among other cancers. 

    Read More About The Mason Immunotherapy Research Laboratory
  • Miyadera Laboratory
    Miyadera Lab, ocular image

    We are interested in the genetic basis of hereditary ocular diseases in animals and people.

    By learning from our canine friends affected with the ocular diseases, we strive to to understanding the molecular mechanisms of the equivalent diseases affecting human patients.

    Our goal is to develop safe and effective therapies such as AAV gene therapy to prevent or reverse vision-loss in animals and people affected.


    Interested in Working With Us?

    Landing page_KM w dogs 250

    We are always seeking highly motivated students and scholars interested in investigating the genetics and therapeutics of inherited ocular diseases. Please contact Dr. Keiko Miyadera ( with your background and CV.

    Read More About The Miyadera Laboratory
  • Ortved Laboratory

    The Ortved Laboratory at New Bolton Center is focused on understanding the pathophysiology of post-traumatic osteoarthritis (PTOA) and developing gene and cell-based therapies to help regenerate cartilage and prevent the development of PTOA following joint injury.

    Due to the many similarities in joint biomechanics and propensity for PTOA, our lab uses the horse as a large animal model for human joint disease. Our goal is to develop translational regenerative therapies that would benefit both the equine and human patient.

    Lab Mission

    • To improve cartilage repair using stem cell and gene therapy.
    • To limit the long-term effects of joint trauma through gene therapy immunomodulation of the joint.
    • To further elucidate the pathogenesis of post-traumatic osteoarthritis (PTOA).

    Dr. Kyla Ortved, New Bolton Center

    Interested in Working With Us?

    We are always seeking highly motivated students and post-doctoral fellows with an interest in:

    • Orthopedic research
    • Joint disease
    • Stem cell therapy
    • Gene therapy
    • Regenerative medicine
    • Cartilage biology

    Contact: Dr. Kyla Ortved at

    Read More About The Ortved Laboratory
  • PennGen

    The Section of Medical Genetics at the University of Pennsylvania's School of Veterinary Medicine has been in the forefront of reporting and characterizing hereditary diseases in companion animals for more than 40 years, including research to uncover the genetic basis and developing genetic tests for canine and feline diseases.

    PennGen is a genetic testing facility operated through the Section of Medical Genetics as a collection of not-for-profit laboratories offering testing for a variety of genetic diseases, metabolic screening for inborn errors of metabolism, hematological, and other diagnostic services. 

    Read More About The PennGen
  • Povelones Laboratory

    Research Interests


    Our main research interest is innate immune recognition and elimination of pathogens. Our work focuses on the interaction between mosquitoes and the animal and human pathogens they transmit. As the most species-rich group of animals on the planet occupying a vast array of ecological niches, insects are a fantastic example of the potency of innate defenses.

    PoveLab on TV and in the news:
    ★ The changing landscape of mosquito- and tick-borne diseases
    ★ News piece by Tom Avril in
    ★ TV spot by John McDevitt for CBS 3 Philly
    ★ See us on Xploration Awesome Planet "Insects" (Season 3 Episode 10)
    ★ View UPenn Spotlight on Our Work

    Rather than passive or willing carriers of pathogenic organism, mosquitoes are actually amazing pathogen killers. Taking mosquito interactions with malaria parasites as an example, the vast majority of the parasites ingested when a mosquito bites a malarious person are attacked and eliminated before they can mount an infection in the mosquito. It is the few parasites that survive (even one is sufficient), that are ultimately responsible for disease transmission. Similar interactions occur between mosquitoes and the other pathogens they transmit, like canine heartworm (Dirofilaria) and arboviruses (Zika, Dengue, Yellow Fever, West Nile, and Chikungunya).

    Arthropod vectors such as mosquitoes, sand flies and ticks are responsible for transmission of a large number of animal and human diseases worldwide. Studying these organisms may reveal general insights about innate immune defense mechanisms as well as provide novel avenues for controlling the terrible diseases they spread.

    Some of the questions we are addressing:

    • What is the basis of pathogen recognition by the mosquito innate immune system and how do some pathogens manage to escape?
    • What is the biochemical mechanism leading from innate recognition to pathogen killing?
    • How is mosquito complement regulated?
    • How does steroid hormone signaling regulate mosquito immunity?
    Read More About The Povelones Laboratory
  • Reference Andrology Laboratory

    Impact of COVID-19 on Our Operations

    As of Friday, March 13, 2020, Penn Vet New Bolton Center’s Reference Andrology Laboratory (RAL) remains open and fully operational for normal business hours and services.

     We will continue to provide our regular services in response to client needs. Please contact us at 610-925-6562 for any questions.

    The Reference Andrology Laboratory provides complete testing of neat, cooled and frozen-thawed semen from mammalian and avian species. The primary purpose of these services is to aid practitioners in their differential diagnosis of individual/herd/flock reproductive problems.

    These services are also frequently used by practitioners and studs as a third-party quality control component in an ongoing stud auditing process.

    The laboratory strives to perform objective, validated techniques for assessing samples for the basic spermiogram parameters of sample volume, motility, morphology, and concentration. With advanced notification, we will also try to accommodate requests for supplemental assessment techniques on sperm subcellular structures. We also offer semen extender analysis and microbiological testing of the extended semen product and purified water used in extenders. 

    Read More About The Reference Andrology Laboratory
  • Sasaki Laboratory

    All cells consisting of our body are originated from a single cell called zygote, which is formed by a fusion of a sperm and egg. However, little is known about the origin of eggs and sperms and how they are formed in humans. In Sasaki lab, we employ genetic, stem cell and system biology approaches to uncover the mystery of germ cell development occurring in early human life.

    The mission of the Sasaki Laboratory is We will continue to develop robust and innovative research in human reproduction to transform humanity and overcome diseases and death.

    Visit our site and learn more about our research and who we are. 

    Read More About The Sasaki Laboratory
  • Scott Laboratory

    Dr. Scott's current research is focused on understanding the development, regulation and maintenance of CD4+ and CD8+ T cells in order to design new vaccines and immunotherapies for infectioleishmaniaus diseases.

    The laboratory primarily focuses on experimental murine infections with the protozoan parasite, Leishmania, which provides a well-characterized model of T helper cell differentiation.

    Read More About The Scott Laboratory
  • Striepen Laboratory

    Welcome to the Striepen lab

    We study the cell and molecular biology of parasites, and use our findings to develop new treatments. Most of our research is focused on Cryptosporidium and Toxoplasma, two protozoan parasites that threaten small children and those with weakened immune systems.

    For the latest updates on our research, please visit

    Read More About The Striepen Laboratory
  • Sunyer Laboratory

    Sunyer nature fig 1 The studies of Dr. Sunyer's lab focus on basic and applied aspects of the fish immune system. Moreover, as teleost fish represent the most ancient living bony species with an immunoglobulin-based adaptive immune system, we use these species to study key aspects of the evolution of sunyer JLB fig 2adaptive immunity. Our main animal model is Rainbow trout.  While earlier work focused on investigating the structure, function and evolution of fish complement  (see below refs# 1-7), during the last 7 years our studies have mainly focused on B cells and mucosal immunity aspects of teleost fish.

    Read More About The Sunyer Laboratory
  • van Eps Laminitis Laboratory

    Over the last decade, the members of the van Eps Laboratory have recognized key differences (and some similarities) in the initial events that lead to the three types of laminitis:

    1. Sepsis-related laminitis (SRL)
    2. Endocrinopathic laminitis (associated with insulin dysregulation/hyperinsulinemia)
    3. Supporting limb laminitis (SLL)

    A focus on these early events is leading to a better understanding of why laminitis occurs in different clinical situations and is helping to identify therapeutic targets.

    Our goal is to identify the key pathophysiological events that lead to different forms of laminitis in order to develop clinically applicable means of preventing this crippling equine disease. 

    Read More About The van Eps Laminitis Laboratory
  • Vaughan Laboratory

    Check out the new Vaughan Laboratory Website

    Dr. Vaughan’s research is focused on defining and understanding the relevant cell types and molecular mechanisms by which the mammalian lung is able to regenerate after severe injury. He is especially interested in elucidating the means by which epithelial progenitors contribute to repaired airway and alveolar units after various lung insults (influenza, ARDS, fibrosis). His studies suggest that physiological lung function is in fact dictated by progenitor cell fate choices after injury.

    Dr. Vaughan and his group have developed a novel orthotopic cell transplantation assay which allows for the direct assessment of engraftment, proliferation, and differentiation potential of these stem cells. Further, he is actively investigating the roles of the Notch, Wnt, and BMP pathways in regulating the differentiation potential and fate of expanded progenitor cells post-injury.

    Dr. Vaughan is part of the CAMB (DSRB) graduate group, and is a member of the Penn Institute for Regenerative Medicine (IRM).

    Interested in Working in the Vaughan Lab?

    Dr. Vaughan is currently seeking new graduate students to join his laboratory team. He welcomes inquiries for potential rotations from incoming students. Contact Dr. Vaughan directly at

    Read More About The Vaughan Laboratory
  • Vite Laboratory

    The focus of the Vite lab is to improve the characterization and treatment of neurological Niemann-Pick Disease, Penn Vet, Vite Laboratorydiseases by studying naturally-occurring feline and canine models of human diseases.

    Our lab develops and identifies ante-mortem biochemical and nuclear magnetic resonance markers of disease severity and progression and uses these markers to evaluate the efficacy of gene therapy, cell-based therapy, and pharmacotherapy to treat disease. 

    Read More About The Vite Laboratory
  • Volk Laboratory
    extracellular-matrix-protein The goals of the Volk laboratory are to understand regulatory mechanisms governing dynamic interactions between cells and their surrounding extracellular matrix in the wound healing-fibrosis-cancer progression triad and to apply this knowledge to develop innovative regenerative and oncologic therapies for veterinary and human patients. Read More About The Volk Laboratory
  • Wang Laboratory

    Our group focuses on the study of regulation of meiosis and the biology of small non-coding RNAs - piRNAs in mice and humans.

    Meiosis, a cell division unique to germ cells, allows the reciprocal exchange of genetic material between paternal and maternal genomes. Meiosis generates the genetic diversity necessary for evolution of species.

    Abnormality in meiosis is a leading cause of birth defects and infertility. Our research interests include molecular genetics of chromosomal synapsis, DNA double-strand break repair, homologous recombination, genetic causes of male infertility in humans, piRNA biogenesis, and epigenetic silencing of transposable elements.

    We have performed two genome-wide screens to identify novel factors that regulate germ cell development in mice: a genomics screen has identified 36 germ cell-specific genes; a proteomics screen has uncovered more than 50 meiotic chromatin-associated proteins.

    Functional characterization of a number of new genes in our laboratory has uncovered novel regulatory mechanisms underlying key biological processes unique to germ cells. On one hand, our studies provide molecular insights into the development of germ cells in mice. On the other hand, these mouse studies have important implications for understanding the genetic causes of male infertility in humans.

    We employ a battery of the state-of-the-art technologies in our research: gene targeting, genome editing, genomics, proteomics, cell biological and molecular biological approaches.

    Read More About The Wang Laboratory
  • Wolfe Laboratory

    Welcome to the Wolfe Lab, supervised by John H. Wolfe, Professor of Pathology and Medical Genetics in Pediatrics and Director, Walter Flato Goodman Center for Comparative Medical Genetics.

     Description of Research 

    Our lab works on transferring disease correcting genes into the central nervous system (CNS) in animal models of human genetic diseases. In these diseases, the CNS is often not rescued by the therapies that help the rest of the body. The lab studies both ex vivo gene transfer into neural stem cells that are then transplanted and in vivo transfer using vectors injected directly into the brain.

    Our studies involve comparisons of both the vectors used to introduce the genes into cells and the properties of the genes themselves. Additionally, we examine the ability of different cell types and subregions of the brain to be corrected. We also pursue new methods to follow the corrected cells and the expression of the correcting gene in the live animal using MRI and PET techniques. For a complete understanding of the therapy, we also are working on achieving a better understanding of the mechanism of these diseases in the brain.


    Projects involve the molecular design and engineering of vectors, the understanding of the fate of vector-transferred genes in the brain, the regulation of gene expression from vectors, the biology of neural stem cell, the study of induced pluripotent stem cells (iPS), the use of imaging studies in genetic disease and gene therapy, and the proteomic and genomics analysis of the neurodegenerative brain. For students, projects can be tailored to interests, learning goals, and experience.

    Read More About The Wolfe Laboratory