Ashley Boyle, DVM, DACVIM, published Boyle AG, Timoney JF, Newton JR, Hines MT, Waller AS, Buchanan BR. Streptococcus equi Infections in Horses: Guidelines for Treatment, Control and Prevention of Strangles—Revised Consensus Statement in Journal of Veterinary Internal Medicine and Pesato ME, Boyle AG, Fecteau ME, Hamberg A, Smith BI. Gastrointestinal spindle cell tumor of the rumen with metastasis to the liver in a goat in Journal of Veterinary Diagnostic Investigation.
She also presented the following research abstracts at the ACVIM forum in Seattle, Washington in June: Boyle AG, O’Shea K, Stefanovski D, Rankin SC. Propidium Monoazide-quantitative Realtime Polymerase Chain Reaction for the Detection of Viable Streptococcus equi and Boyle AG, Mitchell C, Stefanovski D, Waller, A. Combined Antigen A and C Serologic Response in Horses Vaccinated for Strangles with a Modified Live Intranasal Vaccine.
Boyle was also appointed the Assistant Chair of the ACVIM Forum Program Committee and a Member of Board of Regents for ACVIM. Along with the Equine Field Service Team — Liz Arbittier, VMD; Meagan Smith, DVM; and Jenn Linton, VMD — Boyle won the New Bolton Service Excellence July Award.
Rumela Chakrabarti, PhD, published Notch ligand Dll1 mediates cross-talk between mammary stem cells and the macrophageal niche in Science 2018 Jun 29;360 (6396) with Celià-Terrassa T, Kumar S, Hang X, Wei Y, Choudhury A, Hwang J, Peng J, Nixon B, Grady JJ, DeCoste C, Gao J, van Es JH, Li MO, Aifantis I, Clevers H, Kang Y.
Hannah Galantino-Homer, VMD, PhD, published from a multi-institutional, collaborative epidemiology study funded by the AAEP Foundation Case-control study of risk factors for pasture-and endocrinopathy-associated laminitis in North American horses in the Journal of the American Veterinary Medical Association, 2018 Aug 15;253(4):470-478. doi: 10.2460/javma.253.4.470 with Coleman MC, Belknap JK, Eades SC, Hunt RJ, Geor RJ, McCue ME, McIlwraith CW, Moore RM, Peroni JF, Townsend HG, White NA, Cummings KJ, Ivanek-Miojevic R, Cohen ND.
Oliver Garden, BVetMed, PhD, participated as Co-Chairperson for two American College of Veterinary Internal Medicine consensus statement panels for the 2018 Small Animal Internal Medicine consensus statement: A Review of Evidence for Trigger Factors for Immune-Mediated Hemolytic Anemia and Diagnostic Recommendations for Idiopathic Immune-Mediated Hemolytic Anemia and Recommendations for Rational Immunosuppressive Therapy for Idiopathic Immune-Mediated Hemolytic Anemia.
Urs Giger, DrMedVet, received the 2018 Distinguished Lecture Ramsey Award from Iowa State University for his outstanding research contributions in veterinary medicine. He was also the organizer and invited speaker of a Symposium on Hereditary Diseases and Animal Welfare at the annual NAVC-VMX conference in Orlando.
Karina Guziewicz, PhD, published Guziewicz, K.E., Cideciyan, A.V., Beltran, W.A., Komáromy, A.M., Dufour, V.L., Swider, M., Iwabe, S., Sumaroka, A., Kendrick, B.T., Ruthel, G., Chiodo, V.A., Héon, E., Hauswirth, W.W., Jacobson, S.G., Aguirre, G.D. (2018): BEST1 Gene Therapy Corrects a Diffuse Retinawide Microdetachment Modulated by Light Exposure. Proc Natl Acad Sci U S A, 115(12): E2839-E2848; PMCID: PMC5866594; and Guziewicz, K.E., McTish, E., Dufour, V.L., Zorych, K., Dhingra, A., Boesze-Battaglia K., Aguirre, G.D. (2018): Underdeveloped RPE Apical Domain Underlies Lesion Formation in Canine Bestrophinopathies. Advances in Experimental Medicine and Biology, 1074: 309-315; PMCID PMC6035728; (Participating labs: Aguirre and Beltran labs).
Ronald Harty, PhD, published Han, Z., Schwoerer, M.P., Hicks, P., Liang, J., Ruthel, G., Berry, C.T., Freedman, B.D., Sagum, C.A., Bedford, M.T., Sidhu, S.S., Sudol, M., and Harty, R.N. 2018. Host Protein BAG3 is a Negative Regulator of Lassa VLP Egress. Diseases: 6, (in press). NIH/NIAID R21-AI139392
Mark Haskins, VMD, PhD, received the Life for MPS Scientific Award at the 15th International Symposium on Mucopolyaccharidosis and Related Diseases in San Diego on August 2. From the National MPS Society, which granted the award: “With a career spanning over 40 years working in lysosomal storage diseases, he has been a pioneer in the field. Dr. Haskins has worked extensively with animal models and has been innovative in his application of therapeutic approaches, including bone marrow transplantation, enzyme replacement therapies, gene therapy, and medical therapies.”
De’Broski Herbert, PhD, presented a National Institutes of Health WALS Lecture — LINGO Proteins: a New Language for the Mucosal Barrier— in June.
Sabina Hlavaty was selected as a Howard Hughes Medical Institute (HHMI) Medical Research Fellow for the 2018-2019 year, co-mentored by Oliver Garden, BVetMEd, PhD, and Dr. Dmitry Gabrilovich at the Wistar Institute, to continue the lab’s research on canine myeloid-derived suppressor cells (MDSC). She also presented a poster at the Myeloid Cells Keystone Symposium in Breckenridge, Colorado in April.
Anna Kashina, PhD, published The makings of the ‘actin code’: regulation of actin’s biological function at the amino acid and nucleotide level and nucleotide level in Journal of Cell Science. 2018 May 8;131(9). pii: jcs215509. doi: 10.1242/jcs.215509. Review. PMID: 29739859; Rapid and dynamic arginylation of the leading edge β-actin is required for cell migration, Pavlyk I, Leu NA, Vedula P, Kurosaka S, Kashina A. Traffic, 2018 Apr;19(4):263-272. doi: 10.1111/tra.12551. Epub 2018 Mar 8. PMID: 29384244; and Diverse functions of homologous actin isoforms are defined by their nucleotide, rather than their amino acid sequence, Vedula P, Kurosaka S, Leu NA, Wolf YI, Shabalina SA, Wang J, Sterling S, Dong DW, Kashina A. eLife. 2017 Dec 15;6. pii: e31661. doi: 10.7554/eLife.31661. PMID: 29244021
Meryl Littman, VMD, contributed to the new ACVIM Lyme consensus update: Littman MP, Gerber B, Goldstein RE, Labato MA, Lappin MR, Moore GE. ACVIM consensus update on Lyme borreliosis in dogs and cats. Journal of Veterinary Internal Medicine, 2018;32(3):887-903.
David McDevitt, PhD, Emeritus Professor of Biomedical Sciences, received the Anna Freeman Davies Award for service from the College Settlement Camps. McDevitt was a member of the camp’s Board of Trustees for more than ten years, and associated for more than 30 years with the overnight camp that was founded in early 1900s for immigrant children.
Cindy Otto, DVM, PhD, launched the RACE-approved Penn Vet Working Dog Practitioner Program (www.workingdogpractitioner.com) and published Hare E, Kelsey KM, Serpell J, Otto CM. Behavior Differences between Urban Search-and-Rescue and Pet Dogs in Frontiers in Veterinary Science, 05 June 2018.
Jonathan Palmer, VMD, joined the ranks of the emeritus faculty in August. Palmer graduated from Penn Vet in 1977, and after a year in private practice returned as a resident in Medicine. Following completion of his residency, he joined the faculty in the Section of Medicine, and never left. In the early part of his career, Palmer earned a national reputation for is work in Large Animal Gastroenterology, publishing studies on Salmonellosis, Potomac Horse Fever (when it was an emerging disease!), and the seminal article on abomasal ulcers in cattle. His career pivoted to Neonatology and Perinatology, and he deftly guided Penn Vet’s programs in those areas for many years. He is recognized as one of the giants in this field. Palmer’s influence extends far beyond the borders of New Bolton Center, having trained many of the internists working in Neonatology around the world. After 40 years of service to Penn Vet and New Bolton Center, he has certainly earned the “Emeritus” title.
Chelsea Reinhard, DVM, MPH, became a Diplomate of the American College of Veterinary Preventive Medicine.
Alexander Reiter, Dipl. Tzt., gave didactic lectures and tutored hands-on laboratories at various continuing education events in Vienna, Austria in December 2017, and in 2018 in Las Vegas, Nevada in January, Halmstad, Sweden in February, Charlotte, North Carolina in March, Kromeriz, Czech Republic in April, Rimini, Italy in May, and Innsbruck, Austria in June.
James Serpell, PhD, published Dodman, N.H., Brown, D.C. and Serpell, J.A.* 2018. Associations between owner personality and psychological status and the prevalence of canine behavior problems in PLOS ONE, 13(2): e0192846; and Farhoody, P., Mallawaarachchi, I., Tarwater, P.M., Serpell, J.A., Duffy, D.L. and Zink, M.C. 2018. Aggression toward familiar people, strangers, and conspecifics in gonadectomized and intact dogs in Frontiers in Veterinary Science, 5: 18; and McGreevy, P.D., Wilson, B., Starling, M. and Serpell, J.A. 2018. Behavioral risks in male dogs with minimal lifetime exposure to gonadal hormones may complicate population-control benefits of desexing in PLOS ONE, 13(5): e0196284. He also published Hare, E., Kelsey, K., Serpell, J.A. and Otto, C.M. 2018. Behavior differences between urban search-and-rescue and pet dogs in Frontiers in Veterinary Science, 5 June 2018 and Perez, G.E., Conte, A., Garde, E.J., Messori, S., Vanderstichel, R. and Serpell, J.A. 2018. Movement and home range of owned free-roaming dogs in Puerto Natales, Chile in Applied Animal Behaviour Science, 205: 74-82, https://doi. org/10.1016/j.applanim.2018.05.022.
Patricia Sertich, VMD, presented research on the sonographic appearance of the late gestation equine fetal intestine at the International Symposium Equine Reproduction XII in July in Cambridge, England. (Participating lab: Georgia and Philip Hofmann Research Center for Animal Reproduction) (Project collaborators: Morgan Agnew, VMD, JoAnn Slack, DVM, Darko Stefanovski, PhD, Jennifer Linton, VMD).
Deborah Silverstein, DVM, was promoted to full professor in the CE track in the department of Clinical Studies and Advanced Medicine. She also recently published Evaluation of the placement and maintenance of central venous jugular catheters in critically ill dogs and cats, Reminga CL, Silverstein DC, Drobatz KJ, Clarke DL in Journal of Veterinary Emergency and Critical Care 2018. May;28(3):232-243.
Carlo Siracusa, DVM, PhD, was voted President Elect of the American College of Veterinary Behaviorists, at the Annual General Meeting in Denver, Colorado in July.
Corinne Sweeney, DVM, was reappointed by Governor Tom Wolf to a three-year term as a member of the Pennsylvania State Horse Racing Commission.
Susan Volk, VMD, PhD, was promoted to Associate Professor of Small Animal Surgery (tenure track). She spoke at the Society for Advanced Wound Care/Wound Healing Society meeting in Charlotte, North Carolina in April and the European Wound Management Association meeting in Krakow Poland in May.
Grants
Gustavo Aguirre, VMD, PhD: $163,389 for Molecular Genetic Studies of Inherited Cataracts in the American Cocker Spaniel from American Spaniel Club Health & Rescue Foundation (1/1/18-12/31/21)
Montserrat Anguera, PhD: $2,611,414 for Gene regulation from the inactive X in activated B cells from NIH RO1 AI134834 (6/2018–5/2023); $524,590.19 for Role for abnormal gene expression from the inactive X in female-biased lupus disease from USAMRAA (DOD) Impact Award (September 2018 - August 2021); $314,945 for Gene regulation from the inactive X in activated B cells from NIH/NIAID (7/2018-5/2019); $50,000 for Role of X-chromosome Inactivation maintenance on the microbiome during autoimmunity from University Research Foundation (URF) (9/2018-8/2019) (Project collaborator: Michael Atchison, PhD)
Michael Atchison, PhD: $1,051,361 to support VMD-PhD training in infectious disease related research from NIH T32AI070077 (5 years); $616,120 for veterinary students to perform short-term research projects from NIH T35OD010919 (5 years); $20,000 for veterinary students to perform short-term research projects from Boehringer Ingelheim (one year)
William Beltran, DVM, PhD: $2,887,683 for Gene therapy for treatment of rhodopsin-mediated autosomal-dominant Retinitis Pigmentosa (adRP) from OPHTHOTECH (6/1/18–5/31/2021)
Andres Blanco, PhD: $21,047 for Screen for FDA-approved inhibitors that synergize with GSK-LSD1 to induce therapeutic differentiation in non-APL acute myeloid leukemia from McCabe Fund Pilot Grant (8/1/18-7/31/19)
Igor Brodsky, PhD: $442,750 for Novel role of CARD19 in cell death and antibacterial host defense from NIH R21 (6/8/18-5/31/20); $6,000 for Lab Retreat Travel from Burroughs Wellcome Fund (5/1/18-9/30/18)
Margret Casal, DVM, PhD: $12,960 for Microphthalmia and Delayed Growth Syndrome in the Portuguese Water Dog from AKC-Canine Health Foundation (11/1/17-10/31/19)
Rumela Chakrabarti, PhD: $170,000 for Understanding function of Notch signaling in Tamoxifen resistant breast cancer from Abramson Cancer Center-Emerson Collective Cancer Research Fund (2018-2019, 2 year grant)
Amy Durham, VMD: $329,185 for Aperio VERSA Digital Slide Scanner, eSlide Manager Database, and Advanced Image Analysis Software for the Comparative Pathology Core from NIH S10OD023465 (05/01/2018-04/30/2019) (Project collaborators: Bruce Freedman, VMD, PhD, Enrico Radaelli, DVM, PhD, Gordon Ruthel, PhD); $45,000 for Institutional Clinical and Translational Science Award from National Center for Advancing Translational Sciences/NIH (2/1/18-1/31/19)
Bruce Freedman, VMD, PhD: $275,000 for The Membrane Repair Channel TRPML1 Regulates Ebola Virus Budding from NIH/NIAID R21 (12/21/17-11/30/19)
Serge Fuchs, PhD: $193,764 for Negative regulation of myeloid-derived suppressive cells in cancer from NIH R01/ Wistar (12/18/17-11/30/18)
Oliver Garden, BVetMed, PhD: $14,945 for The impact of intravenous anesthetic agents on canine natural killer cell cytotoxic function: the Achilles heel in cancer diagnosis and surgery? from AKC-CHF (1/1/18-12/31/18) (Collaborator: Ciara Barr, VMD); $50,000 for The intestinal microbiome of dogs with idiopathic immune-mediated hemolytic anemia: an occult trigger for pathogenic autoimmunity? from Center for Host-Microbial Interactions PILOT (6/1/2018-5/31/19)
Ronald Harty, PhD: $275,000 for Dueling PPxY Motifs of Filovirus VP40 and Host Angiomotin: Effects on Innate Immune Defenses and Tight Junction Integrity at Immune Privileged Sites. from NIH/NIAID R21-AI139392 (6/3/18-5/31/20); $275,000 for Modular Domains of Host Proteins Regulate Filovirus Maturation. from NIH/NIAID R21 AI-138052 (1/15/18-12/31/20); $300,000 for Development of Small Molecule Therapeutics Targeting Hemorrhagic Fever Viruses. from NIH/NIAID R41 STTR AI138630 (6/1/18-5/31/20); $682,000 for Development of Host-Oriented Therapeutics Against Hemorrhagic Fever Viruses from The Wellcome Trust (2/10/18- 2/9/20); $45,000 for Regulation of Tight Junction Integrity by Ebola Virus VP40 from University Research Foundation (3/1/18- 2/28/19); $50,000 for Development of Small Molecule Therapeutics Targeting Hemorrhagic Fever Viruses from Fox Chase Chemical Diversity Center (6/1/18-5/31/19)
De’Broski Herbert, PhD: $6,000 for 22nd Annual Woods Hole Immunoparasitology (WHIP) Meeting from Burroughs Wellcome Fund (3/1/18-8/31/18)
Anna Kashina, PhD: $513,453 for Protein Arginylation as a Key Regulator of Cell Migration from NIH/GM R35 (8/31/18-8/31/2022); $50,633 for Development of Arginine Linkage-Specific Antibodies from Abzyme Therapeutics, LLC (11/27/17-08/31/18)
Christopher Lengner, PhD: $21,955 for Developing novel immunotherapy for metastatic colorectal cancer from Institutional Clinical and Translational Science Award (ITMAT) (2/1/18-1/31/19)
James Marx, DVM, PhD: $5,000 for 2018 ASLAP Foundation Summer Fellowship Program from American Society for Laboratory Animal Practitioners (6/1/18-8/31/18)
Nicola Mason, BVetMed, PhD: $297,300 for Preserving Cancer Stem Cells In Canine Blood Specimens from Leidos Biomedical research Inc. (12/1/17-6/30/18); $183,146 for Immune Targeting of the V600E B-Raf neo-Antigen in Canine Urothelial Carcinoma from AKC Canine Health Foundation (2/1/18-1/31/20); $86,400 for Precision Medicine for Canine Lymphoma from AKC Canine Health Foundation (3/1/118-2/29/20) (Project collaborator: Amy Durham, VMD); $300,000 for Clinical Advancement of CAR T cell therapy for dogs with B cell malignancies from Petco Foundation Pet Cancer Support (4/1/18-3/31/20); $250,000 for Evaluation of constitutive canonical NF-kB activity as the Achilles Heal of Soft Tissue Sarcoma — Funds will support a pilot clinical trial using local administration of an NF-kB inhibitor in dogs with soft tissue sarcomas — from Abramson Cancer Center Pilot (7/1/18-6/30/19) (Project collaborator: Karin Eisinger, PhD, Perelman School of Medicine)
Sue McDonnell, PhD: $34,748 for Reproductive Behavior and Physiology of Horses from Dorothy Russell Havemeyer FDN (11/1/17-10/31/18)
Keiko Miyadera, DVM, PhD: $60,775 for AAV Gene Therapy for Muscular and Ocular Diseases from UNC Chapel Hill/Tamid Bio, Inc. (2/1/18-11/30/18); $48,687 for Safe and Effective Therapy for Vision Loss in MPS1 Patients from UNC Chapel Hill/MPS Society (7/1/17-6/30/18)
Olivia Nathanson, VMD: $13,978 for Evaluation of procedural & maintenance data when esophagostomy tubes are used for nutritional support during acute and chronic illness and identify risk factors for short and long term complications from Nestle Purina (4/1/18-3/31/19) (Project collaborator: Dana Clarke, VMD)
Thomas Parsons, VMD, PhD: $72,509 for Impact of duration of farrowing crate closure on sow welfare and piglet mortality from National Pork Board (12/1/17-11/30/18)
Dipti Pitta, PhD: $72,719 for Influence of Valkalor AL 881 on Milk Production in Holstein Cows from Idena (10/1/17-9/30/18); $499,739 for Deciphering the crosstalk between bacteria – archaea interactions in the rumen and methaneyield phenotype of dairy cows from USDA NIFA (1/1/2018-12/31/20); $86,091 for The effects of 3-nitrooxyproponal (3NOP), a persistent methane inhibitor, on ruminal microbial gene expression profiles in dairy cows from DSM Nutritional Products AG (12/15/17-6/15/19)
Laurel Redding, VMD, PhD: $23,450 for Clostridium difficile in canine fecal samples from Center for Host-Microbial Interactions PILOT and additional $29,478.24 from PennCHOP Microbiome Program Pilot and Feasibility Award (1 year)
Adam Sateriale, PhD: $216,000 (for the first phase of program) for Investigation of subtelomeric gene families in Cryptosporidium from NIH K99 (5/5/18-4/30/20) (Mentor: Boris Striepen, PhD)
Thomas Schaer, VMD: $144,940 for Synovial Fluid and Joint Sepsis from NIH RO1 (with Thomas Jefferson University) (08/01/17 - 05/31/18); $135,056 for A Translational Approach Towards Ligament Regeneration from NIH/NIAMSK (with University of Connecticut Health Center) (5/1/18 – 1/31/19)
Deborah Silverstein, DVM: $37,500 for a videomicroscope that visualizes and enables assessment of the microcirculation and endothelial glycocalyx from a private donor; $7,271 for Method Comparison and Precision Study Evaluation of the NOVA StatSensor®; and the StatSensor® Xpress™ Hand Held Creatinine Monitor in Dogs from NOVA Biomedical (4/1/18-3/31/19)
Carlo Siracusa, DVM, PhD: $29,940 for Sileo (dexmedetomidine oromucosal gel) for Veterinary Visit Anxiety In Dogs: a randomized, doubleblind, placebo controlled pilot study from Zoetis (12/6/17-12/5/18)
Boris Striepen, PhD: $200,535 for Forward Genetic Technology for Cryptosporidium from Bill and Melinda Gates Foundation (6/1/17-5/31/18)
Andrew Vaughan, PhD: $30,000 for Transcriptional programming by Notch controls regenerative outcomes following influenza injury from Center for Host-Microbial Interactions PILOT (6/1/18-5/31/19)
Charles Vite, DVM, PhD: $807,263 for Creation of Feline NPC2 Using CRISPR/Cas9 genome editing from Leidos Biomedical Research Inc. (9/25/17-8/31/18); $397,503 for BioMarin MPSIIIA research project from BioMarin Pharmaceuticals Inc. (12/6/17-12/31/18)
Susan Volk, VMD, PhD: $442,750 for Type III Collagen as a suppressor of breast cancer progression and metastasis from NIH/NCI: 1R21CA216552-01 (7/2017-6/2019); $162,700 for Tumor permissive collagen signatures in canine mammary gland tumors: Development of Prognostic markers and targeted Therapies for Improved Outcomes from AKC Canine Health Foundation (3/1/18 to 2/29/20)
Brittany Watson, VMD, PhD: $15,000 for Student Ambassador Program from Petsmart Charities (9/1/17-9/1/18); $10,000 for Second Annual Shelter Medicine Educator Meeting from Petsmart Charities (10/1/17-12/31/17); $50,000 for Maddie’s Shelter Medicine Internship Grant from Maddie’s Fund - The Pet Rescue Foundation (7/1/18- 8/31/19)
Meghan Wynosky-Dolfi, PhD: $25,000 for Institutional Clinical and Translational Science Award from National Center for Advancing Translational Sciences/NIH (2/1/18-1/31/19) (Participating lab: Igor Brodsky, PhD)